Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1

EMBO Journal

Volumn 17, Issue 19, 1998, Pages 5606-5614

  Ferrigno, Paul ^a   Posas, Francesc ^a   Koepp, Deanna ^a   Saito, Haruo ^a   Silver, Pamela A ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

MAP kinase; Nuclear transport; Osmotic stress; Protein phosphorylation

Indexed keywords

GREEN FLUORESCENT PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN; KARYOPHERIN; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; CYTOPLASM; EUKARYOTIC CELL; NONHUMAN; OSMOLARITY; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; YEAST CELL;

BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARRIER PROTEINS; CELL COMPARTMENTATION; CELL NUCLEUS; CYTOPLASM; FUNGAL PROTEINS; GTP-BINDING PROTEINS; KARYOPHERINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MONOMERIC GTP-BINDING PROTEINS; NUCLEAR PROTEINS; OSMOTIC PRESSURE; PHOSPHORYLATION; PROTEIN KINASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES POMBE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

EUKARYOTA;

EID: 0032189837     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.19.5606     Document Type: Article

References (39)

1. Alberts, A.S. and Treisman, R. (1998) Activation of RhoA and SAPK/JNK signalling pathways by the RhoA-specific exchange factor mNET1. EMBO J., 17, 4075-4085.
2. Arts, G.J., Fornerod, M. and Mattaj, I.W. (1998) Identification of a nuclear export receptor for tRNA. Curr. Biol., 8, 305-314.
3. Baudin, A., Ozier-Kalogeropoulou, O., Denouel, A., Lacroute, F. and Cullin, C. (1993) A simple and efficient method of direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res., 21, 3329-3330.
4. Bonifaci, N., Moroianu, J., Radu, A. and Blobel, G. (1997) Karyopherin beta2 mediates nuclear import of a mRNA binding protein. Proc. Natl Acad. Sci. USA, 94, 5055-5060.
5. Brewster, J.L., de Valoir, T., Dwyer, N.D., Winter, E. and Gustin, M.C. (1993) An osmosensing signal transduction pathway in yeast. Science, 259, 1760-1763.
6. Corbett, A.H., Koepp, D.M., Schlenstedt, G., Lee, M.S., Hopper, A.K. and Silver, P.A. (1995) Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import. J. Cell Biol., 130, 1017-1026.
7. Engel, K., Kotlyarov, A. and Gaestel, M. (1998) Leptomycin B-sensitive export of MAPKAP kinase 2 is regulated by protein phosphorylation. EMBO J., 17, 3363-3371.
8. Ferrigno, P. and Silver, P.A. (1998) Analysis of nuclear transport in vivo. Methods Cell Biol., 58, 107-122.
9. Fridell, R.A., Truant, R., Thorne, L., Benson, R.E. and Cullen, B.R. (1997) Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor related to karyopherin-beta. J. Cell Sci., 110, 1325-1331.
10. Gaits, F., Degols, G., Shiozaki, K. and Russell, P. (1998) Phosphorylation and association with the transcription factor Atf1 regulate localization of Spc1/Sty1 stress-activated kinase in fission yeast. Genes Dev., 12, 1464-1473.
11. Gorlich, D. and Mattaj, I.W. (1996) Nucleocytoplasmic transport. Science, 271, 1513-1518.
12. Gorlich, D., Dabrowski, M., Bischoff, F.R., Kutay, U., Bork, P., Hartmann, E., Prehn, S. and Izaurralde, E. (1997) A novel class of RanGTP binding proteins. J. Cell Biol., 138, 65-80.
13. Hopper, A.K., Schultz, L.D. and Shapiro, R.A. (1980) Processing of intervening sequences: a new yeast mutant which fails to excise intervening sequences from precursor tRNAs. Cell, 19, 741-751.
14. Ip, Y.T. and Davis, R.J. (1998) Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell Biol., 10, 205-219.
15. Jacoby, T., Flanagan, H., Faykin, A., Seto, A.G., Mattison, C. and Ota, I. (1997) Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. J. Biol. Chem., 272, 17749-17755.
16. Kehlenbach, R.H., Dickmanns, A. and Gerace, L. (1998) Nucleocytoplasmic shuttling factors including ran and CRM1 mediate nuclear export of NFAT in vitro. J. Cell Biol., 141, 863-874.
17. Khokhlatchev, A.V., Canagarajah, B., Wilsbacher, J., Robinson, M., Atkinson, M., Goldsmith, E. and Cobb, M.H. (1998) Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell, 93, 605-615.
18. Koepp, D.M. (1998) PhD Thesis, Harvard University.
19. Koepp, D.M., Wong, D.H., Corbett, A.H. and Silver, P.A. (1996) Dynamic localization of the nuclear import receptor and its interactions with transport factors. J. Cell Biol., 133, 1163-1176.
20. Kutay, U., Lipowsky, G., Izaurralde, E., Bischoff, F.R., Schwarzmaier, P., Hartmann, E. and Görlich, D. (1998) Identification of a tRNA-Specific Nuclear Export Receptor. Mol. Cell, 1, 359-369.
21. Loeb, J.D., Schlenstedt, G., Pellman, D., Kornitzer, D., Silver, P.A. and Fink, G.R. (1995) The yeast nuclear import receptor is required for mitosis. Proc. Natl Acad. Sci. USA, 92, 7647-7651.
22. Maeda, T., Wurgler-Murphy, S.M. and Saito, H. (1994). A two-component system that regulates an osmo-sensing MAP kinase cascade in yeast. Nature, 369, 242-245.
23. Maeda, T., Takekawa, M. and Saito, H. (1995) Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science, 269, 554-558.
24. Melchior, F. and Gerace, L. (1998) Two-way trafficking with Ran. Trends Cell Biol., 8, 175-179.
25. Pemberton, L.F., Rosenblum, J.S. and Blobel, G. (1997) A distinct and parallel pathway for the nuclear import of an mRNA-binding protein. J. Cell Biol., 139, 1645-1653.
26. Pollard, V.W., Michael, W.M., Nakielny, S., Siomi, M.C., Wang, F. and Dreyfuss, G. (1996) A novel receptor-mediated nuclear protein import pathway. Cell, 86, 985-994.
27. Posas, F., Wurgler-Murphy, S.M., Maeda, T., Witten, E.A., Thai, T.C. and Saito, H. (1996) Yeast HOG1 MAP kinase cascade regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 'two-component' osmosensor. Cell, 86, 865-875.
28. Posas, F., Takekawa, M. and Saito, H. (1998) Signal transduction by MAP kinase cascades in budding yeast. Curr. Opin. Microbiol., 1, 175-182.
29. Seedorf, M. and Silver, P.A. (1997) Importin/karyopherin protein family members required for mRNA export from the nucleus. Proc. Natl Acad. Sci. USA, 94, 8590-8595.
30. Senger, B., Simos, G., Bischoff, F.R., Podtelejnikov, A., Mann, M. and Hurt, E. (1998) Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Np13p. EMBO J., 17, 2196-2207.
31. Sikorski, R.S. and Boeke, J.D. (1991) In vitro mutagenesis and plasmid shuffling: From cloned gene to mutant yeast. Methods Enzymol., 194, 302-318.
32. Siomai, M.C., Eder, P.S., Kataoka, N., Wan, L., Liu, Q. and Dreyfuss, G. (1997) Transportin-mediated nuclear import of heterogeneous nuclear RNP proteins. J. Cell Biol., 138, 1181-1192.
33. Stade, K., Ford, C.S., Guthrie, C. and Weis, K. (1997) Exportin 1 (Crm1p) is an essential nuclear export factor. Cell, 90, 1041-1050.
34. Toone, W.M., Kuge, S., Samuels, M., Morgan, B.A., Toda, T. and Jones, N. (1998) Regulation of the fission yeast transcription factor pap1 by oxidative stress: requirement for the nuclear export factor crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes Dev., 12, 1453-1463.
35. Traverse, S., Gomez, N., Paterson, H., Marshall, C. and Cohen, P. (1992) Sustained activation of the mitogen-activated protein MAP kinase cascade may be required for defferentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J., 288, 351-355.
36. Traverse, S., Seedorf, K., Paterson, H., Marshall, C.J., Cohen, P. and Ullrich, A. (1994) EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol., 4, 694-701.
37. Truant, R., Fridell, R.A., Benson, R.E., Bogerd, H., and Cullen, B.R. (1998) Identification and functional characterization of a novel nuclear localization signal present in the yeast Nab2 poly(A)+ RNA binding protein. Mol. Cell. Biol., 18, 1449-1458.
38. Wong, D.H., Corbett, A.H., Kent, H.M., Stewart, M. and Silver, P.A. (1997) Interaction between the small CTPase Ran/Gsp1p and Ntf2p is required for nuclear transport. Mol. Cell. Biol., 17, 3755-3767.
39. Wurgler-Murphy, S.M., Maeda, T., Witten, E.A. and Saito, H. (1997) Regulation of Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol. Cell. Biol., 17, 1289-1297.