A screen for upstream components of the yeast protein kinase C signal transduction pathway identifies the product of the SLG1 gene

Molecular and General Genetics

Volumn 258, Issue 1-2, 1998, Pages 148-155

  Jacoby, J J ^a   Nilius, S M ^a   Heinisch, J J ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Protein kinase C; Saccharomyces cerevisiae; Signal transduction; Transposon mutagenesis

Indexed keywords

CAFFEINE; FUNGAL PROTEIN; MAGNESIUM CHLORIDE; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C;

ARTICLE; CONTROLLED STUDY; DELETION MUTANT; DIPLOIDY; DNA INTEGRATION; FUNGAL GENETICS; FUNGUS MUTANT; HAPLOIDY; MUTAGENESIS; NONHUMAN; OSMOTIC PRESSURE; PRIORITY JOURNAL; REPORTER GENE; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSPOSON;

DNA TRANSPOSABLE ELEMENTS; GENES, FUNGAL; MEMBRANE PROTEINS; MUTAGENESIS; PROTEIN KINASE C; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0031900935     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050717     Document Type: Article

References (49)

1. Antonsson B, Montessuit S, Friedli L, Payton MA, Paravicini G (1994) Protein kinase C in yeast. Characteristics of the Saccharomyces cerevisiae PKC1 gene product. J Biol Chem 269:16821-16828
2. Arvanitidis A, Heinisch JJ (1994) Studies on the function of yeast phosphofructokinase subunits by in vitro mutagenesis. J Biol Chem 269:8911-8918
3. Baeuerle PA, Baltimore D (1988) IκB: a specific inhibitor of the NF-kappa B transcription factor. Science 242:540-546
4. Birnboim HC, Doly J (1979) A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 7:1513-1523
5. Burns N, Grimwade B, Ross-MacDonald PB, Choi E-Y, Finberg K, Roeder GS, Snyder M (1994) Large-scale analysis of gene expression, protein localization, and gene disruption in Saccharomyces cerevisiae. Genes Dev 8:1087-1105
6. Costigan C, Gehrung S, Snyder M (1992) A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol Cell Biol 12:1162-1178
7. Dekker LV, Parker PJ (1994) Protein kinase C a question of specificity. Trends Biochem Sci 19:73-77
8. Drgonová J, Drgon T, Tanaka K, Kollár R, Chen GC, Ford RA, Chan CSM, Takai Y, Cabib E (1996) Rholp, a yeast protein at the interface between cell polarization and morphogenesis. Science 272:277-279
9. Gietz RD, Sugino A (1988) New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 74:527-534
10. Gietz RD, Schiestl RH, Willems AR, Woods RA (1995) Studies on the transformation of intact yeast cells by the LiAc/ss-DNA/ PEG procedure. Yeast 11:355-360
11. Gray JV, Ogas JP, Kamada Y, Stone M, Levin DE, Herskowitz I (1997) A role for the Pkcl MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator. EMBO J 16:4924-4937
12. Güldener U, Heck S, Fiedler T, Beinhauer J, Hegemann JH (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res 24:2519-2524
13. Hanahan D (1985) Techniques for transformation of E.coli. In: Glover DM (ed) DNA cloning: a practical approach, vol. 1. IRL Press, Oxford, pp 109-120
14. Hill JE, Myers AM, Koerner TJ, Tzagoloff A (1986) Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast 2:163-167
15. Irie K, Takase M, Lee KS, Levin DE, Araki H, Matsumoto K, Oshima, Y (1993) MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C. Mol Cell Biol 13:3076-3083
16. Jacoby JJ, Schmitz HP, Heinisch JJ (1997) Mutants affected in the putative diacylglycerol binding site of yeast protein kinase C. FEBS-Lett 417:219-222
17. Kamada Y, Qadola H, Python CP, Anraku Y, Ohya Y, Levin DE (1996) Activation of yeast protein kinase C by Rhol GTPase. J Biol Chem 271:9193-9196
18. Kiehart DP (1981) Studies on the in vivo sensitivity of spindle microtubules to calcium ions and evidence for a vesicular calcium-sequestering system. J Cell Biol 88:604-617
19. Klebe RJ, Harriss JV, Sharp ZD, Douglas MG (1983) A general method for polyethylene-glycol-induced genetic transformation of bacteria and yeast. Gene 25:333-341
20. Leberer E, Dignard D, Harcus D, Thomas DY, Whiteway M (1992) The protein kinase homologue Ste20p is required to link the yeast pheromone response G-protein beta/gamma subunits to downstream signalling components. EMBO J 11:4815-4824
21. Lee KS, Levin DE (1992) Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog. Mol Cell Biol 12:172-182
22. Lee KS, Hines LK, Levin DE (1993a) A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type 1-related protein phosphatases function within the PKC1-mediated pathway. Mol Cell Biol 13:5843-5853
23. Lee KS, Irie K, Gotoh Y, Watanabe Y, Araki H, Nishida E, Matsumoto K, Levin DE (1993b) A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C. Mol Cell Biol 13:3067-3075
24. Levin DE, Errede B (1995) The proliferation of MAP kinase signaling pathways in yeast. Curr Opin Cell Biol 7:197-202
25. Levin DE, Fields FO, Kunisawa R, Bishop JM, Thorner J (1990) A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell 62:213-224
26. Levin DE, Bowers B, Chen CY, Kamada Y, Watanabe M (1994) Dissecting the protein kinase C/MAP kinase signalling pathway of Saccharomyces cerevisiae. Cell Mol Biol Res 40:229-239
27. Lussier M, White AM, Sheraton J, diPaolo T, Treadwell J, Southard SB, Horenstein CI, Chen-Weiner J, Ram AFJ, Kapteyn JC, Roemer TW, Vo DH, Bondoc DC, Hall J, Zhong WW, Sdicu AM, Davies J, Klis FM, Robbins PW, Bussey H (1997) Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics 147:435-450
28. Madden K, Sheu YJ, Baetz K, Andrews B, Snyder, M (1997) SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science 275:1781-1784
29. Marini NJ, Meldrum E, Buehrer B, Hubberstey AV, Stone DE, Traynor-Kaplan A, Reed SI (1996) A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START. EMBO J 15:3040-3052
30. Mazzoni C, Zarzov P, Rambourg A, Mann C (1993) The SLT2 (MPK1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae. J Cell Biol 123:1821-1833
31. Nakamura T, Ohmoto T, Hirata D, Tsuchiya E, Miyakawa T (1996) Genetic evidence for the functional redundancy of the calcineurin- and Mpk 1-mediated pathways in the regulation of cellular events important for growth in Saccharomyces cerevisiae. Mol Gen Genet 251:211-219
32. Nasmyth KA, Tatchell K (1980) The structure of transposable yeast mating type loci. Cell 19:753-764
33. Nonaka H, Tanaka K, Hirano H, Fujiwara T, Kohno H, Umikawa M, Mino A, Takai Y (1995) A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J 14:5931-5938
34. Ozaki K, Tanaka K, Imamura H, Hihara T, Kameyama T, Nonaka H, Hirano H, Matsuura Y, Takai Y (1996) Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae. EMBO J 15:2196-2207
35. Paravicini G, Cooper M, Friedli L, Smith DJ, Carpentier J-L, Klig LS, Payton MA (1992) The osmotic integrity of the yeast cell requires a functional PKC1 gene product. Mol Cell Biol 12:4896-4905
36. Qadota H, Python CP, Inoue SB, Arisawa M, Anraku Y, Zheng Y, Watanabe T, Levin DE, Ohya Y (1996) Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-b-glucan synthase. Science 272:279-281
37. Ram AF, Wolters A, Ten Hoopen R, Klis FM (1994) A new approach for isolating cell wall mutants in Saccharomyces cerevisiae by screening for hypersensitivity to calcofluor white. Yeast 10:1019-1030
38. Rodicio R, Heinisch JJ, Hollenberg CP (1993) Transcriptional control of yeast phosphoglycerate mutase-encoding gene. Gene 125:125-133
39. nd edn). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
40. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-termination inhibitors. Proc Natl Acad Sci USA 74:5463-5467
41. Schmidt A, Bickle M, Beck T, Hall MN (1997) The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88:531-542
42. Sherman F, Fink GR, Hicks JB (1986) Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. New York
43. Sterky F, Holmberg A, Pettersson B, Uhlen M (1996) The sequence of a 30-kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes. Yeast 12:1091-1105
44. Sutton A, Immanuel D, Arndt, KT (1991) The SIT4 protein phosphatase functions in late G1 for progression into S phase. Mol Cell Biol 11:2133-2148
45. Timson J (1977) Caffeine. Mutat Res 47:1-52
46. Verna J, Lodder A, Lee K, Vagts A, Ballester R (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 94:13804-13809
47. Watanabe M, Chen CY, Levin DE (1994) Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC. J Biol Chem 269:16829-16836
48. Zamenhoff S (1957) Preparation and assay of deoxyribonucleic acid from animal tissue. Methods Enzymol 3:702-704
49. Zarzov P, Mazzoni C, Mann C (1996) The SLT2 (MPK1) MAP kinase is activated during periods of polarized cell growth in yeast. EMBO J 15:83-91