A role for the Pkc1 MAP kinase pathway of Saccharomyces cerevisiae in bud emergence and identification of a putative upstream regulator

EMBO Journal

Volumn 16, Issue 16, 1997, Pages 4924-4937

  Gray, Joseph V ^a,b   Ogas, Joseph P ^a   Kamada, Yoshiaki ^c   Stone, Marion ^b   Levin, David E ^c   Herskowitz, Ira ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Bud emergence; G1 cyclins; Hcs77; Protein kinase C; Swi4

Indexed keywords

CYCLIN DEPENDENT KINASE; FUNGAL PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE C; TRANSCRIPTION FACTOR;

ARTICLE; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; ENZYME REGULATION; FUNGAL GENETICS; FUNGUS GROWTH; FUNGUS MUTANT; HEAT SHOCK; NONHUMAN; PRIORITY JOURNAL; REGULATOR GENE; SACCHAROMYCES CEREVISIAE;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL CYCLE; CYCLINS; FLOW CYTOMETRY; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUPPRESSION, GENETIC; TEMPERATURE; TRANSCRIPTION FACTORS; TRANSFORMATION, GENETIC;

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0030789480     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.16.4924     Document Type: Article

References (59)

1. Andrews, B.J. and Herskowitz, I. (1989) Identification of a DNA binding factor involved in cell-cycle control of the yeast HO gene. Cell, 57, 21-29.
2. Andrews, B.J. and Moore, L. (1992) Mutational analysis of a DNA sequence involved in linking gene expression to the cell cycle. Biochem. Cell Biol., 70, 1073-1080.
3. Antonsson, B., Montessuit, S., Friedli, L., Payton, M.A. and Paravicini, G. (1994) Protein kinase C in yeast. Characterization of the Saccharomyces cerevisiae PKC1 gene product. J. Biol. Chem., 269, 16821-16828.
4. Benton, B.K., Tinkelenberg, A.H., Jean, D., Driscoll Plump, S. and Cross, F.R. (1994) Genetic analysis of Cln/Cdc28 regulation of cell morphogenesis in budding yeast. EMBO J., 12, 5267-5275.
5. Brewster, J.L., de Valoir, T., Dwyer, N.D., Winter, E. and Gustin, M.C. (1993) An osmosensing signal transduction pathway in yeast. Science, 259, 1760-1763.
6. Costigan, C., Gehrung, S. and Snyder, M. (1992) A synthetic lethal screen identifies Slk1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth. Mol. Cell. Biol., 12, 1162-1178.
7. Cross, F.R. (1988) DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae. Mol. Cell Biol., 8, 4675-4684.
8. Davenport, K.R., Sohaskey, M. Kamada, Y., Levin, D.E. and Gustin, M.C. (1995) A second osmosensing signal transduction pathway in yeast. J. Biol. Chem., 270, 30157-30161.
9. Di Como, C.J., Chang, H. and Arndt, K.T. (1995) Activation of CLN1 and CLN2 G1 cyclin gene expression by BCK2. Mol. Cell. Biol., 15, 1835-1846.
10. Dirick, L., Böhm, T. and Nasmyth, K. (1995) Roles and regulation of Cln-Cdc28 kinases at the start of the cell cycle of Saccharomyces cerevisiae. EMBO J., 14, 4803-4813.
11. Dodou, E. and Treisman, R. (1997) The Saccharomyces cerevisiae MADS-box transcription factor Rlm1 is a target for the Mpk1 mitogen-activated protein kinase pathway. Mol. Cell. Biol., 17, 1848-1859.
12. Drubin, D.G. and Nelson, W.J. (1996) Origins of cell polarity. Cell, 84, 335-344.
13. Errede, B., Cailc, R.M., Yashar, B.M., Kamada, Y., Levin, D.E., Irie, K and Matsumoto, K. (1995) Dynamics and organization of MAP kinase signal pathways. Mol. Reprod. Dev., 42, 477-485.
14. Espinosa, F.H., Ogas, J., Herskowitz, I. and Morgan, D.O. (1994) Cell cycle control by a complex of the cyclin Hcs26 (Pc11) and the kinase Pho85. Science, 266, 1388-1391.
15. Huisman, O., Raymond, W., Froehlich, K., Errada, P., Kleckner, N., Botstein, D. and Hoyt, M.A. (1987) A Tn10-lacZ-kanR-URA3 gene fusion transposon for insertion mutagenesis and fusion analysis of yeast and bacterial genes. Genetics, 116, 191-199.
16. Igual, J.C., Johnson, A.L. and Johnston, L.H. (1996) Coordinated regulation of gene expression by the cell cycle transcription factor Swi4 and the protein kinase C MAP kinase pathway for yeast cell integrity. EMBO J., 15, 5001-5013.
17. Kaibuchi, K., Takai, Y. and Nishizuka, Y. (1985) Protein kinase C and calcium ion in mitogenic response of macrophage-depleted human peripheral lymphocytes. J. Biol. Chem., 260, 1366-1369.
18. Kamada, Y., Jung, U.S., Piotrowski, J. and Levin, D.E. (1995) The protein kinase C-activated MAP kinase pathway of Saccharomyces cerevisiae mediates a novel aspect of the heat shock response. Genes Dev., 9, 1559-1571.
19. Kamada, Y., Qadota, H., Python, C.P., Anraku, Y., Ohya, Y. and Levin, D.E. (1996) Activation of yeast protein kinase C by Rho1 GTPase. J. Biol. Chem., 271, 9193-9196.
20. Koch, C. and Nasmyth, K.A. (1994) Cell cycle regulated transcription in yeast. Curr. Opin. Cell Biol., 6, 451-459.
21. Koch, C., Moll, T., Neuberg, M., Ahorn, H. and Nasmyth, K.A. (1993) A role for the transcription factors Mbp1 and Swi4 in progression from G1 to S phase. Science, 261, 1551-1557.
22. Lee, K.S. and Levin, D.E. (1992) Dominant mutations in a gene encoding a putative protein kinase (BCK1) bypass the requirement for a Saccharomyces cerevisiae protein kinase C homolog. Mol. Cell. Biol., 12, 172-182.
23. Lee, K.S., Hines, L.K. and Levin, D.E. (1993a) A pair of functionally redundant yeast genes (PPZ1 and PPZ2) encoding type I-related protein phosphatases function within the Pkc1-mediated pathway. Mol. Cell. Biol., 13, 5843-5853.
24. Lee, K.S., Irie, K., Gotoh, Y., Watanabe, Y., Araki, H., Nishida, E., Matsumoto, K. and Levin, D.E. (1993b) A yeast mitogen-activated protein kinase homolog (Mpk1) mediates signalling by protein kinase C. Mol. Cell. Biol., 13, 3067-3075.
25. Levin, D.E., Fields, F.O., Kunisawa, R., Bishop, J.M. and Thorner, J. (1990) A candidate protein kinase C gene, PKC1, is required for the S.cerevisiae cell cycle. Cell, 62, 213-224.
26. Levin, D.E. and Bartlett-Heubusch, E. (1992) Mutants in the S.cerevisiae PKC1 gene display a cell-cycle-specific osmotic stability defect. J. Cell Biol., 116, 1221-1229.
27. Lew, D.J. and Reed, S.I. (1993) Morphogenesis in the yeast cell cycle: regulation by Cdc28 and cyclins. J. Cell Biol., 120, 1305-1320.
28. Madden, K., Sheu, Y.-J., Baetz, K., Andrews, B. and Snyder, M. (1997) SBF cell cycle regulator as a target of the yeast PKC-MAP kinase pathway. Science, 275, 1781-1784.
29. Marini, N.J., Meldrum, B.B., Hubberstey, A.V., Stone, D.E., Traynor-Kaplan, A. and Reed, S.I. (1996) A pathway in the yeast cell division cycle linking protein kinase C (Pkc1) to activation of Cdc28 at START. EMBO J., 15, 3040-3052.
30. McIntosh, E.M. (1993) MCB elements and the regulation of DNA replication in yeast. Curr. Genet., 24, 185-192.
31. Measday, V., Moore, L., Ogas, J.P. Tyers, M. and Andrews, B. (1994) The Pc12 (OrfD)-Pho85 cyclin-dependent kinase complex: a cell cycle regulator in yeast. Science, 266, 1391-1395.
32. Molero, G., Yuste-Rojas, M., Montesi, A., Vazquez, A., Nombela, C. and Sanchez, M. (1993) A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene. J. Bacteriol., 175, 6562-6570.
33. Mozzoni, C., Zarov, P., Rambourg, A. and Mann, C. (1993) The Slt2(Mpk1) MAP kinase homolog is involved in polarized cell growth in Saccharomyces cerevisiae. J. Cell Biol., 123, 1821-1833.
34. Mulholland, J., Preuss, D., Moon, A., Wong, A., Drubin, D. and Botstein, D. (1994) Ultrastructure of the yeast actin cytoskeleton and its association with the plasma membrane. J. Cell Biol., 125, 381-391.
35. Nasmyth, K.A. (1993) Regulating the HO endonuclease in yeast. Curr. Opin. Genet. Dev., 3, 286-294.
36. Nasmyth, K.A. and Dirick, L. (1991) The role of SWI4 and SWI6 in the activity of G1 cyclins in yeast. Cell, 66, 995-1013.
37. Newton, A.C. (1995) Protein kinase C: structure, function, and regulation. J. Biol. Chem., 270, 28495-28498.
38. Nonaka, H., Tanaka, K., Hirano, H., Fujiwara, T. Kohno, H., Umikawa, M., Mino, A. and Takai, Y. (1995) A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae. EMBO J., 14, 5931-5938.
39. Novick, P. and Botstein, D. (1985) Phenotypic analysis of temperature-sensitive yeast actin mutants. Cell, 40, 405-416.
40. Ogas, J.P. (1992) Identification and analysis of regulators of G1 progression in Saccharomyces cerevisiae. Ph.D. Thesis, University of California, San Francisco.
41. Ogas, J., Andrews, B.J. and Herskowitz, I. (1991) Transcriptional activation of CLN1, CLN2, and a putative new G1 cyclin (HCS26) by Swi4, a positive regulator of G1-specific transcription. Cell, 66, 1015-1026.
42. Ozaki, K., Tanoka, K., Imamura, H., Hihora, T., Kameyama, T., Nonaka, H., Hirano, H., Matsuura, Y. and Takai, Y. (1996) Rom1 and Rom2 are GDP/GTP exchange proteins (GEFs) for the Rho1 small GTP binding proteins in Saccharomyces cerevisiae. EMBO J., 15, 2196-2207.
43. Persons, D.A., Wilkinson, W.O., Bell, R.M. and Finn, O.J. (1988) Altered growth regulation and enhanced tumorigenicity of NIH 3T3 fibroblasts transfected with protein kinase C-1 cDNA. Cell, 52, 447-458.
44. Pringle, J.R. and Hartwell, L.H. (1981) The Molecular Biology of the Yeast Saccharomyces: Life Cycle and Inheritance. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 97-142.
45. Reed, S.I. (1992) The role of p34 kinases in the G1 to S-phase transition. Annu. Rev. Cell Biol., 8, 529-561.
46. Ridley, A.J. (1996) Rho: theme and variations. Curr. Biol., 6, 1256-1264.
47. Rose, A.H. (1975) Growth and handling of yeast. Methods Cell Biol., 12, 1-15.
48. 2+-sensitive phospholipid-dependent protein kinase. Proc. Natl Acad. Sci. USA, 81, 5748-5752.
49. Schneider, B.L., Yang, Q.H. and Futcher, A.B. (1996) Linkage of replication to start by the Cdk inhibitor Sic1. Science, 272, 560-562.
50. Sherman, F., Fink, G.R. and Hicks, J.B. (1982) Methods in Yeast Genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
51. Siliciano, P.G. and Tatchell, K. (1984) Transcription and regulatory signals at the mating type locus in yeast. Cell, 37, 969-978.
52. Sterky, F., Holmberg, A., Pettersson, B. and Uhlen, M. (1996) The sequence of a 30 kb fragment on the left arm of chromosome XV from Saccharomyces cerevisiae reveals 15 open reading frames, five of which correspond to previously identified genes. Yeast, 12, 1091-1095.
53. Sterns, M., Jensen, R. and Herskowitz, I. (1984) Five SWI genes are required for expression of the HO gene in yeast. J. Mol. Biol., 178, 853-868.
54. Stuart, D. and Wittenberg, C. (1995) Cln3, not positive feedback, determines the timing of CLN2 gene expression in cycling cells. Genes Dev., 9, 2780-2793.
55. Toone, W.M., Johnson, A.L., Banks, G.R., Toyn, J.H., Stuart, D., Wittenberg, C. and Johnston, L.H. (1995) Rme1, a negative regulator or meiosis, is also a positive activator of G1 cyclin gene expression. EMBO J., 14, 5824-5832.
56. Sic1 imposes the requirement for Cln G1 cyclin function at start. Proc. Natl Acad. Sci. USA, 93, 7772-7776.
57. Vai, M., Popolo, L. and Alberghina, L. (1987) Effect of tunicamycin on cell cycle progression in budding yeast. Exp. Cell Res., 171, 448-459.
58. Watanabe, B., Chen, C.-Y. and Levin, D.E. (1994) Saccharomyces cerevisiae PKC1 encodes a protein kinase C (PKC) homolog with a substrate specificity similar to that of mammalian PKC. J. Biol. Chem., 269, 16829-16836.
59. Zarzov, P., Mazzoni, C. and Mann, C. (1996) The Slt2(Mpk1) MAP kinase is activated during periods of polarized cell growth in yeast. EMBO J., 15, 83-91.