Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: Novel variations of STRE-mediated transcription control?

Molecular and General Genetics

Volumn 252, Issue 4, 1996, Pages 470-482

  Winderickx, Joris ^a   De Winde, Johannes H ^a   Crauwels, Marion ^a   Hino, Akihiro ^a,b   Hohmann, Stefan ^a,c   Van Dijck, Patrick ^a,d   Thevelein, Johan M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b NATIONAL FOOD RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

Nutrients; Ras cAMP pathway; Stress response; Stress responsive element (STRE); Trehalose synthase complex

Indexed keywords

CYCLIC AMP; SYNTHETASE; TREHALOSE;

ARTICLE; CARBOHYDRATE SYNTHESIS; CONTROLLED STUDY; ENZYME SUBUNIT; FERMENTATION; FUNGAL GENETICS; HEAT; NONHUMAN; ONCOGENE RAS; OSMOTIC STRESS; PRIORITY JOURNAL; PROMOTER REGION; SACCHAROMYCES CEREVISIAE; STARVATION; STRESS; TRANSCRIPTION REGULATION;

BETA-GALACTOSIDASE; BLOTTING, NORTHERN; CELL DIVISION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; DOWN-REGULATION; ENZYME ACTIVATION; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, FUNGAL; GLUCOSE; GLUCOSYLTRANSFERASES; HSP70 HEAT-SHOCK PROTEINS; MULTIENZYME COMPLEXES; PHOSPHORIC MONOESTER HYDROLASES; REGULATORY SEQUENCES, NUCLEIC ACID; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

SACCHAROMYCES CEREVISIAE;

EID: 0029845539     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004380050252     Document Type: Article

References (75)

1. App H, Holzer H (1989) Purification and characterisation of neutral trehalasc from the yeast ABYS1 mutant. J Biol Chem 264 : 17583-17588
2. Argülles JC (1994) Heat-shock response in a yeast tps1 mutant deficient in trehalose synthesis. FEBS Lett 350 : 266-270
3. Arguelles JC, Myombi K, Van Aelst L, Vanhalewyn M, Jans AWH, Thevelein JM (1990) Absence of glucose-induced cAMP signalling in the Saccharomyces cerevisiae mutants cat 1 and cat 3, which are deficient in derepression of glucose-repressible proteins. Arch Microbiol 154 : 199-205
4. Attfiel PV, Ramn A, Norhcott CJ (1992) Construction of Saccharomyces cerevisiae strains that accumulate relatively low levels of trehalose, and their application in testing the contribution of the disaccharide to stress tolerance. FEMS Microbiol Lett 94 : 271-276
5. Bell W, Klaassen P, Ohnacker M, Boller T, Herweijer M, Schoppink P, van der Zee P, Wiemken A (1992) Characterisation of the 56-kDa subunit of trehalose-6-phosphate synthase and cloning of its gene reveal its identity with the product of CIF 1, a regulator of carbon catabolite inactivation. Eur J Biochem 209 : 951-959
6. Beullens M, Mbonyi K, Geerts L, Gladines D, Detremerie K, Jans AWH, Thevelein JM (1988) Studies on the mechanism of the glucose-induced cAMP-signal in glycolysis- and glucose-repression mutants of the yeast Saccharomyces cerevisiae. Eur J Biochem 172 : 227-231
7. Boorstein WR, Craig EA (1990) Regulation of yeast HSP70 gene by a cAMP responsive transcription control element. EMBO J 9 : 2543-2553
8. Bossier P, Fernandez D, Rocha D, Rodigues-Pousada C (1993) Overexpression of Y AP2, coding for a new yAP protein, and YAP1 in Saccharomyces cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline. J Biol Chem 268 : 23640-23645
9. Cannon JF, Pringle JR, Fiechter A, Khalil M (1994) Characterisation of glycogen-deficient glc mutants of Saccharomyces cerevisiae. Genetics 136 : 485-503
10. Coote PJ, Jones MV, Edgar K, Cole MB (1992) TPK gene products mediate cAMP-independent thermotolerance in Saccharomyces cerevisiae. J Gen Microbiol 138 : 2551-2557
11. Coutinho CC, Silva JT, Panek AD (1992) Trehalase activity and its regulation during growth of Saccharomyces cerevisiae. Biochem Int 26 : 521-530
12. De Virgilio C, Biirckert N, Boller T, Wiemken A (1991) A method to study the rapid phosphorylation-related modulation of neutral trehalase activity by temperature shifts in yeast. FEBS Lett 291 : 355-358
13. De Virgilio C, Bürckert N, Bell W, Jenö P, Boller T, Wiemken A (1993) Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity. Eur J Biochem 212 : 315-323
14. Domdey H, Apostol B, Lin R-J, Newman A, Brody E, Abelson J (1984) Lariat structures are in vivo intermediates in yeast pre-mRNA splicing. Cell 39 : 611-621
15. Durnez P, Oris E, Argüelles JC, Mergelsberg H, Thevelein JM (1994) Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of cAMP-dependent protein kinase. Yeast 10 : 10149-1064
16. Entian K-D (1981) A carbon catabolite repression mutant of Saccharomyces cerevisiae with elevated hexokinase activity: evidence for regulatory control of hexokinase PII synthesis. Mol Gen Genet 184 : 278-282
17. François J, Eraso P, Gancedo C (1987) Changes in the concentration of cAMP, fructose-2,6-biphosphate and related metabolites and enzymes in Saccharomyces cerevisiae during growth on glucose. Eur J Biochem 164 : 369-373
18. François J, Neves M-J, Hers H-G (1991) The control of trehalose biosynthesis in Saccharomyces cerevisiae: evidence for a catabolite inactivation and repression of trehalose-6-phosphate synthase and trehalose-6-phosphate phosphatase. Yeast 7 : 575-587
19. Gallwitz D, Sures I (1980) Structure of a split yeast gene: complete nucleotide sequence of the actin gene in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 77 : 2546-2550
20. Gonzalez MI, Stucka R, Blazquez MA, Feldmann H, Gancedo C (1992) Molecular cloning of CIF1, a yeast gene necessary for growth on glucose. Yeast 8 : 183-192
21. Gounalaki N, Thireos G (1994) Yap1p, a yeast transcription activator that mediates multidrug resistance, regulates the metabolic stress response. EMBO J 13 : 4036-4041
22. Hirimburegama K, Durnez P, Keleman J, Oris E, Vergauwen R, Mergelsberg H, Thevelein JM (1992) Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger. J Gen Microbiol 138 : 2035-2043
23. Hohmann S, Neves MJ, de Koning W, Alijo R, Ramos J, Thevelein JM (1993) The growth and signalling defects in the ggs1 (fdp1/byp1) deletion mutant on glucose are suppressed by a deletion of the gene encoding hexokinase PII. Cum Genet 23:281-289
24. GLN(CAG): Ggsl Tps1 levels restraining growth on fermentable sugars and trehalose accumulation. Curr Genet 26 : 295-301
25. Hottiger T, Boller T, Wiemken A(1987a) Rapid changes of heat and dissication tolerance correlated with changes of trehalose content in Saccharomyces cerevisiae cells subjected to temperature shifts. FEBS Lett 220 : 113-115
26. Hottiger T, Schmutz P, Wiemken A (1987b) Heat-induced accumulation and futile cycling of trehalose in Saccharomyces cerevisiae. J Bacteriol 169 : 5518-5522
27. Hottiger T, Boller T, Wiemken A (1989) Correlation of trehalose content and heat resistance in yeast altered in the Ras/adenylate cyclase pathway: is trehalose a thermoprotectant? FEBS Lett 255 : 431-434
28. Jakobsen BK, Pelham HRB (1988) Constitutive binding of yeast heat shock factor to DNA in vivo. Mol Cell Biol 8 : 5040-5042
29. Kobayashi N, McEntee K (1990) Evidence for a heat shock transcription factor-independent mechanism for heat shock induction of transcription in Saccharomyces cerevisiae. Proc Nat Acad Sci USA 87 : 6550-6554
30. Kobayashi N, McEntee K (1993) Identification of cis and trans components of a novel heat shock stress regulatory pathway in Saccharomyces cerevisiae. Mol Cell Biol 13 : 248-256
31. Lillie SH, Pringle JR (1980) Reverse carbohydrate metabolism in Saccharomyces cerevisiae. Response to nutrient limitation. J Bacteriol 143 : 1384-1394
32. Mager WH, Moradas Ferreira P (1983) Stress response in yeast. Biochem J 290 : 1-13
33. Mager WH, De Kruijff AJJ (1995) Stress-induced transcriptional activation. Microbiol Rev 59 : 506-531
34. Marchler G, Schüller C, Adam G, Ruis H (1993) Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J 12 : 1997-2003
35. Matsumoto K, Uno I, Ishikawa T (1985) Genetic analysis of the role of cAM P in yeast. Yeast 1 : 15-24
36. McDougall J, Kaasen I, Ström AR (1993) A yeast gene for trehalose6-phosphate synthase and its complementation of an Escherichia coli otsA mutant. FEMS Microbiol Lett 107 : 25-30
37. Myers AM, Tzagoloff A, Kinney DM, Lusty CJ (1986) Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions. Gene 45 : 299-310
38. Neves M-J, François J (1992) On the mechanism by which a heat shock induces trehalose accumulation in Saccharomyces cerevisiae. Biochem J 288 : 859-864
39. Neves M-J, Hohmann S, Bell W, Dumortier F, Luyten K, Ramos J, Cobbaert P, de Koning W, Kaneva Z, Thevelein JM (1995) Control of glucose influx into glycolysis and pleiotropic effects studied in different isogenic sets of Saccharomyces cerevisiae mutants in trehalose biosynthesis. Curr Genet 27 : 306-308
40. Nikawa J, Cameron S, Toda T, Ferguson KW, Wigler M (1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev 1 : 931-937
41. Nwaka S, Kopp M, Burgert M, Deuchler I, Kienle I, Holzer H (1984) Is thermotolerance of yeast dependent on trehalose accumulation? FEBS Lett 344 : 255-228
42. Nwaka S, Kopp M, Holzer H (1995a) Expression and function of the trehalase genes NTH1 and YBR0106 in Saccharomyces cerevisiae. J Biol Chem 270 : 10193-10198
43. Nwaka S, Mechler B, Destruelle M, Holzer H (1995b) Phenotypic features of trehalase mutants in Saccharomyces cerevisiae. FEBS Lett 360 : 286-290
44. Panek AD (1991) Storage carbohydrates. In: Rose AH, Harrison JS (eds) The yeasts. Academic Press, New York, pp 655-678
45. Panek AD, Mattoon JR (1977) Regulation of energy metabolism in Saccharomyces cerevisiae. Relationship between carbolite repression, trehalose synthesis and mitochondrial development. Arch Biochem Biophys 183 : 306-316
46. Panek AD, Panek AC (1990) Metabolism and thermotolerance function of trehalose in Saccharomyces cerevisiae: a current perspective. J Biotechnol 14 : 229-238
47. Panek AC, de Araujo PS, Neto VK, Panek AD (1987) Regulation of the trehalose-6-phosphate synthase complex in Saccharomyces cerevisiae. Curr Genet 11 : 459-465
48. Panek AC, de Araujo PS, Poppe SC, Panek AD (1990) On the determination of trehalose-6-phosphate synthase in Saccharomyces cerevsiae. Biochem Int 21 : 695-704
49. Pernambuco MB, Winderickx J, Crauwels M, Griffioen G, Mager WH, Thevelein JM (1986) Differential requirement for sugar phosphorylation in cells of the yeast Saccharomyces cerevisiae grown on glucose or grown on non-fermentable carbon sources for glucose-triggered signalling phenomena. Microbiology 142 : 1775-1782
50. Rose MD, Winston F, Hieter P (1990) Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
51. Schüller C, Brewster JL, Alexander MR, Gustin MC, Ruis H (1994) The HOG pathway controls osmotic regulation of transcription via stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J 13 : 4382-4389
52. Singh KK, Norton RS (1991) Metabolic changes induced during adaptation of Saccharomyces cerevisiae to a water stress. Arch Microbiol 165 : 38-42
53. Sorger PK, Pelham HRB (1988) Yeast heat shock factor is an essential DNA-binding protein that exhibits temperature-dependent phosphorylation. Cell 54 : 855-864
54. Sur IP, Lobo Z, Maitra PK (1994) Analysis of PFK3 a gene involved in particulate phosphofructokinase synthesis reveals additional functions of TPS2 in Saccharomyces cerevisiae. Yeast 10 : 199-209
55. Thevelein JM (1984) Regulation of trehalose mobilisation in fungi. Microbiol Rev 48 : 42-59
56. Thevelein JM (1988) Regulation of trehalose activity by phosphorylation-dephosphorylation during developmental transitions in fungi. Exp Mycol 12 : 1-12
57. Thevelein JM (1991) Fermentable sugars and intracellular acidification as specific activators of the Ras adenylate cyclase signalling pathway in yeast. The relationship to nutrient-induced cell cycle control. Mol Microbiol 5 : 1301-1307
58. Thevelein JM (1994) Signal transduction in yeast. Yeast 10 : 1753-1790
59. Thevelein JM, Beullens M (1985) Cyelic AMP and the stimulation of trehalase activity in the yeast Saccharomyces cerevisiae by carbon sources, nitrogen sources and inhibitors of protein synthesis. J Gen Microbiol 131 : 3199-3209
60. Thevelein JM, Hohmann S (1995) Trehulose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci 20 : 3-10
61. Thomas BJ, Rothstein RJ (1989) Elevated recombination rates in transcriptionally active DNA. Cell 56 : 619-630
62. Toda T, Uno I, Ishikawa T, Powers S, Kataoka T, Brock D, Cameron S, Broach J, Matsumoto K, Wigler M (1985) in yeast, Ras proteins are controlling elements of adenylate cyclase. Cell 40 : 27-36
63. Toda T, Cameron S, Sass P, Zoller M, Scott JD, McBullen B, Hurwitz M, Krebs HG, Wigler M (1987a) Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7 : 1371-1377
64. Toda T, Cameron S, Sass P, Zoller M, Wigler M (1987b) Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50 : 277-287
65. Uno I, Matsumoto K, Adachi K, Ishikawa T (1983) Genetic and biochemical evidence that trehalase is a substrate of cAMP-dependent protein kinase in yeast. J Biol Chem 258 : 10867-10872
66. Van Aelst L, Hohmann S, Bulaya B, De Koning W, Sierkstra L, Neves MJ, Luyten K, Alijo R, Ramos J, Coccetti P, Martegani E, de Magelhaes-Rocha NM, Brandao RL, Van Dijck P. Van Halewyn M, Dumez P, Jans AWH, Thevelein JM (1993) Molecular cloning of a gene involved in glucose sensing in the yeast Saccharomyces cerevisiae. Mol Microbiol 8 : 927-943
67. Vandcrcammen A, François J, Hers H-G (1989) Characterisation of trehalose-6-phosphate synthetase and trehalose-6-phosphate phosphatase of Saccharomyces cerevisiae. Eur J Biochem 182 : 613-620
68. Van Dijck P, Colavizza D, Smet P, Thevelein JM (1995) Differential importance of trehalose in stress resistance in fermenting and nonfermenting Saccharomyces cerevisiae cells (1995) Appl Environ Microbiol 61 : 109-115
69. Varela JCS, van Beekvelt C, Planta RJ, Mager WH (1992) Osmostress-induced changes in yeast gene expression. Mol Microbiol 6 : 2183-2190
70. Varela JCS, Praekelt UM, Meacock PA, Planta RJ, Mager WH (1995) The Saccharomyces cerevisiae HSP12 gene is activated by the high-osmolarity glycerol pathway and negatively regulated by protein kinase A. Mol Cell Biol 15 : 6232-6245
71. Vuorio OE, Kalkkinen N, Londesborough J (1993) Cloning of two related genes encoding the 56-kDa and 123-kDa subunits of trehalose synthase from the yeast Saccharomyces cerevisiae. Fur J Biochem 216 : 848-861
72. Wiemken A (1990) Trehalose in yeast: stress protectant rather than reserve carbohydrate. Antonie van Leenwenhoek 58 : 209-217
73. Winderickx J, Hino A, Crauwels M, Cobbaert P, Thevelein JM (1994) Characterisation of the 'fermentable growth medium induced pathway in Saccharomyces cerevisiae. Arch Int Physiol Bioch Biophys 102 : B44
74. Wu A, Wemmie JA, Edgington NP, Goebl M, Guevara JL, Scott-Rowley W (1993) Yeast bZip proteins mediate pleiotropic drug and metal resistance. J Biol Chem 268 : 18850-18858
75. Zamenhoff S (1957) Preparation and assay of deoxyribonucleic acids from animal tissues. Methods Enzymol 3 : 696-704