Mitochondria as a pharmacological target

Pharmacological Reviews

Volumn 54, Issue 1, 2002, Pages 101-127

  Szewczyk, Adam ^a   Wojtczak, Lech ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; IMMUNOSUPPRESSIVE AGENT; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; SULFONYLUREA DERIVATIVE;

APOPTOSIS; CELLULAR DISTRIBUTION; DEGENERATIVE DISEASE; ENERGY METABOLISM; FATTY ACID OXIDATION; HEART PROTECTION; LIPID METABOLISM; MITOCHONDRION; OBESITY; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; THERMOGENESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; APOPTOSIS; BENZODIAZEPINES; ENERGY METABOLISM; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MEMBRANE LIPIDS; MITOCHONDRIA; POTASSIUM CHANNELS; SULFONYLUREA COMPOUNDS;

EID: 0036194529     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: 10.1124/pr.54.1.101     Document Type: Review

References (445)

1. Organ and subcellular distribution of fatty acid activation enzymes in the rat
2. Short-chain fatty acid activation in rat liver. A new assay procedure for the enzymes and studies on their intracellular localization
3. Local anesthetics: A new class of partial inhibitors of mitochondrial ATPase
4. Temperature dependence and mechanism of local anesthetic effects on mitochondrial adenosine triphosphatase
5. ATP channels
6. Cloning of the β cell high-affinity sulfonylurea receptor: A regulator of insulin secretion
7. Cardioprotective effect of diadenosine tetraphosphate (AP4A) preservation in hypothermic storage and its relation with mitochondrial ATP-sensitive potassium channels
8. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells
9. Cyclosporin ameliorates traumatic brain-injury-induced alterations of hippocampal synaptic plasticity
10. Protective effect of nupercaine on mitochondrial structure
11. Salicylate-induced kidney mitochondrial permeability transition is prevented by cyclosporin A
12. Ibuprofen-induced liver mitochondrial permeability transition
13. Carnitine palmitoyltransferase: A viable target for the treatment of NIDDM?
14. Antidiabetic agents: A new class of reversible carnitine transferase I inhibitors
15. Treatment of overactive bladder: Other drug mechanisms
16. Ubiquinol: An endogenous lipid-soluble antioxidant in animal tissues
17. Molecular characterization and mitochondrial density of a recognition site for peripheral-type benzodiazepine ligands
18. Purification and characterization of a protein associated with peripheral-type benzodiazepine binding sites
19. Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model
20. Nonsteroidal anti-inflammatory drugs and prevention of colorectal cancer
21. Mechanism of dibucaine-induced apoptosis in promyelocytic leukemia cells (HL-60)
22. ATP channel
23. The sulfonylurea receptor
24. Apoptosis control by death and decoy receptors
25. ATP openers
26. Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria
27. ATP channels
28. Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs
29. ATP channels and actin cytoskeleton
30. Inhibition of mitochondrial complex I by haloperidol: The role of thiol oxidation
31. Early migratory rat neural cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function
32. Mitochondria as cell targets of AZT (zidovudine)
33. Nonsteroidal anti-inflammatory drugs and cancer prevention
34. Mitochondrial dysfunction in neurodegenerative diseases
35. 10 attenuates the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced loss of striatal dopamine and dopaminergic axons in aged mice
36. Properties of the inner membrane anion channel in intact mitochondria
37. + fluxes in rat liver mitochondria
38. The reaction of superoxide radical with N-acetylcysteine
39. Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. Evidence that the pore can be opened by membrane depolarization
40. The permeability transition pore. Control points of a cyclosporin A-sensitive mitochondrial channel involved in cell death
41. Mitochondrial transport of cations: Channels, exchangers, and permeability transition
42. Recent progress on regulation of the mitochondrial permeability transition pore: A cyclosporin-sensitive pore in the inner mitochondrial membrane
43. The mitochondrial permeability transition
44. Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore
45. An analysis of the role of coenzyme Q in free radical generation and as an anti-oxidant
46. 2+ stores in induction and suppression of apoptosis in S49 cells
47. 2+
48. Peripheral benzodiazepine receptor agonists exhibit potent antiapoptotic activities
49. Uncoupling proteins 2 and 3 potential regulators of mitochondrial energy metabolism
50. Apoptosis: Checkpoint at the mitochondrial frontier
51. High densities of benzodiazepine receptors in human cortical areas
52. 3H]diazepam binding
53. The role of carnitine and carnitine supplementation during exercise in man and individuals with special needs
54. Contact sites between mitochondrial envelope membranes. Structure and function in energy- and protein-transfer
55. The glycerophosphate acyltransferases and their function in the metabolism of fatty acids
56. Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria
57. Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesis
58. Stereoselective and substrate-dependent inhibition of hepatic mitochondria β-oxidation and oxidative phosphorylation by the non-steroidal anti-inflammatory drugs ibuprofen, flurbiprofen, and ketorolac
59. 2+
60. ATP channel openers for the treatment of airways hyperreactivity
61. Does cyclosporin A generate free radicals?
62. Oxidative stress as a mediator of apoptosis
63. 2+ to the mitochondrial permeability transition induced by tertbutylhydroperoxide in rat hepatocytes
64. Mitochondrial free radical generation, oxidative stress, and aging
65. Thyromimetic action of the peroxisome proliferators clofibrate, perfluorooctanoic acid, and acetylsalicylic acid includes changes in mRNA levels for certain genes involved in mitochondrial biogenesis
66. Amiodarone-induced disruption of hamster lung and liver mitochondrial function: Lack of association with thiobarbituric acid-reactive substance production
67. ATP
68. A 45 kDa protein related to PPARγ2, induced by peroxisome proliferators, is located in the mitochondrial matrix
69. An evaluation of the role of mitochondria in neurodegenerative diseases: Mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
70. Reye syndrome revisited: A descriptive term covering a group of heterogeneous disorders
71. 3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors
72. ATP channels
73. Interaction of ion movements and local anesthetics in mitochondrial membranes
74. Hydroperoxide metabolism in mammalian organs
75. Triggering and modulation of apoptosis by oxidative stress
76. Pharmacokinetics of methyl palmoxirate, an inhibitor of β-oxidation, in rats and humans
77. Multiple sites of inhibition of transport by local anesthetics
78. Towards gene therapy of mitochondrial disorders
79. The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase
80. Isolation, purification and partial sequence of neuropeptide (diazepam-binding inhibitor) precursor of an anxiogenic putative ligand for benzodiazepine recognition site
81. Mitochondrion as a novel target in anticancer therapy
82. Mitochondrially targeted antioxidants and thiol reagents
83. Opening of potassium channels protects mitochondrial function from calcium overload
84. The mitochondrial permeability transition pore and its role in cell death
85. In vitro studies on the role of the peripheral-type benzodiazepine receptor in steroidogenesis
86. The role of mitochondrial potassium fluxes in controlling the protonmotive force in energized mitochondria
87. Uncoupling effects of local anesthetics on rat liver mitochondria
88. o in the inhibition of mitochondrial ATP synthase by phenothiazines
89. Mechanism of local anesthetics effect on mitochondrial synthase as deduced from photolabelling and inhibition studies with phenothiazine derivatives
90. Apoptosis-inducing factor (AIF): A ubiquitous mitochondrial oxidoreductase involved in apoptosis
91. Detection and prevention of NSAID-induced enteropathy
92. Antioxidants protect against reactive oxygen species associated with Adriamycin-treated cardiomyocytes
93. Activation of apoptosis pathways by anticancer treatment
94. Potassium channel openers depolarize mitochondria
95. Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents
96. Mitochondria in chemotherapy-induced apoptosis: A prospective novel target of cancer therapy
97. Hypoglycemic effects of a novel fatty acid oxidation inhibitor in rats and monkeys
98. Mitochondrial gene therapy: An arena for the biomedical use of inteins
99. Modulating apoptosis: Current applications and prospects for future drug development
100. AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins
101. Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver
102. Intracellular sites of lipid synthesis and the biogenesis of mitochondria
103. The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
104. The metabolic fate of 14C or 35S labelled tiadenol in rabbit after i.v. and oral administration
105. Mitochondria as the central control point of apoptosis
106. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
107. Reye syndrome
108. Modulation of ATP sensitive potassium channels
109. Formation and inactivation of endogenous cannabinoid anandamide in central neurons
110. Effect of local anesthetics ropivacaine on the energy metabolism of Ehrlich ascites tumor cells
111. Cytochrome c release from isolated rat liver mitochondria can occur independently of outer-membrane rupture: Possible role of contact sites
112. Lipophilic beta-blockers inhibit rat skeletal-muscle mitochondrial respiration
113. Potassium channel openers. Pharmacological effects and future uses
114. Mammalian caspases: Structure, activation, substrates, and functions during apoptosis
115. Mammalian mitochondrial β-oxidation
116. The pharmacology of ATP-sensitive potassium channels
117. Pharmacology of the potassium channel openers
118. Anticancer activity of targeted pro-apoptotic peptides
119. Mechanisms and functions of cell death
120. 2+ release from mitochondria by N-acylethanolamines, a class of lipids synthesized in ischemic heart tissue
121. N-Acylethanolamine accumulation in infarcted myocardium
122. Ubiquinol as a biological antioxidant: A review
123. p53 and tumor necrosis factor α regulate the expression of a mitochondrial chloride channel protein
124. The mitochondrial uncoupling proteln-2: Current status
125. Effect of the local anesthetic bupivacaine on the energy metabolism of Ehrlich ascites tumor cells
126. Effect of local anesthetic ropivacaine on isolated rat liver mitochondria
127. Rationale and application of fatty acid oxidation inhibitors in treatment of diabetes mellitus
128. Pharmacological strategies for reduction of lipid availability
129. Protection of the ischemic dog myocardium with carnitine
130. Progress on the mitochondrial permeability transition pore: Regulation by complex I and ubiquinone analogs
131. Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial particles
132. Zidovudine (AZT) induced alterations in mitochondrial biogenesis in rat striated muscles
133. Cyclosporin A, but not FK 506, protects mitochondria and neurons against hypoglycemic damage and implicates the mitochondrial permeability transition in cell death
134. Superoxide dismutase
135. Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism
136. Inhibition of mitochondrial β-oxidation as a mechanism of hepatotoxicity
137. Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines
138. Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor
139. Mitochondrial cation transport: A progress report
140. Cation transport in mitochondria - The potassium cycle
141. ATP in heart - What happens, and what does not happen
142. Studies on the mechanism of uncoupling by amine local anesthetics. Evidence for mitochondrial proton transport mediated by lipophilic ion pairs
143. On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein
144. + channels. Possible mechanism of cardioprotection
145. ATP channel as a receptor for potassium channel openers
146. In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells
147. Enigma of the peripheral benzodiazepine receptor
148. ATP channels as effectors of human myocardial preconditioning
149. The mechanism of inhibition of β-oxidation by aspirin metabolites in skin fibroblasts from Reye's syndrome
150. Current concepts in Reye's syndrome
151. Rat liver D-β-hydroxybutyrate dehydrogenase. 3. Inhibition by topical anesthetics
152. Mitochondria and apoptosis
153. Protective effects of low and high doses of cyclosporin A against reoxygenation injury in isolated rat cardiomyocytes are associated with differential effects on mitochondrial calcium levels
154. Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria
155. Effect of local anesthetics on mitochondrial membrane potential in living cells
156. Pharmacological characterization of BMS-191095, a mitochondrial K(ATP) opener with no peripheral vasodilator or cardiac action potential shortening activity
157. ATP-sensitive potassium channels: A review of their cardioprotective pharmacology
158. Proton conductance caused by long-chain fatty acids in phospholipid bilayer membranes
159. Salicylates and proton transport through lipid bilayer membranes: A model for salicylate-induced uncoupling and swelling in mitochondria
160. Aspirin, acetaminophen and proton transport through phospholipid bilayers and mitochondrial membranes
161. The mitochondrial permeability transition: Its molecular mechanism and role in reperfusion injury
162. Cyclosporin A binding to mitochondrial cyclophilin inhibits the permeability transition pore and protects hearts from ischaemia/reperfusion injury
163. Mitochondria and cell death
164. Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
165. Role of free radicals and catalytic metal ions in human diseases: An overview
166. Determination of the phospholipid precursor of anandamide and other N-acylethanolamine phospholipids before and after sodium azide-induced toxicity in cultured neocortical neurons
167. Hydrogen peroxide-induced formation of N-acylethanolamine phospholipids (NAPE) and N-acylethanolamine (NAE) in cortical neurons
168. N-Acylethanolamines and precursor phospholipids - Relation to cell injury
169. Formation of N-acyl-phosphatidylethanolamine and N-acylethanolamine (including anandamide) during glutamate-induced neurotoxicity
170. Lidocaine effects on brain mitochondrial metabolism in vitro
171. Lead and calcium produce rod photoreceptor cell apoptosis by opening the mitochondrial permeability transition pore
172. The biochemistry of apoptosis
173. Thyromimetic effect of peroxisomal proliferators in rat liver
174. Brown adipose tissue thermogenesis, energy balance, and obesity
175. Role of the mitochondrial permeability transition pore in apoptosis
176. + channels modulate cardiac mitochondrial function
177. Interaction of local anesthetics with cytochrome c oxidase
178. Nitric oxide induces apoptosis via triggering mitochondrial permeability transition
179. Subcellular and submitochondrial localization of the biosynthesis of cardiolipin and related phospholipids in rat liver
180. Antitumor diarylsulfonylureas: Novel agents with unfulfilled promise
181. Effects of thia-substituted fatty acids on mitochondrial and peroxisomal β-oxidation. Studies in vivo and in vitro
182. Novel agents effective against solid tumors: The diarylsulfonylureas. Synthesis, activities, and analysis of quantitative structure-activity relationships
183. Human mitochondrial diseases: Answering questions and questioning answers
184. 10 protect heart mitochondria from peroxidative damage during aging
185. Relationship between configuration, function, and permeability in calcium-treated mitochondria
186. Reconstitution of IKATP: An inward rectifier subunit plus the sulfonylurea receptor
187. + channel in the mitochondrial inner membrane
188. + channels in the cardiovascular system
189. Preservation of mitochondrial function by diazoxide during sustained ischaemia in the rat heart
190. Reactive oxygen intermediates as mediators of programmed cell death in plants and animals
191. ATP channel by glyburide and 5-hydroxydecanoate
192. Mitochondrial membrane permeabilization during the apoptotic process
193. ATP channel openers on mitochondria in hippocampal neurons
194. Glutathione-independent mechanism of apoptosis inhibition by curcumin in rat thymocytes
195. Apoptosis induction by a novel anti-prostate cancer compound, BMD188 (a fatty acid-containing hydroxamic acid), requires the mitochondrial respiratory chain
196. Adriamycin cardiomyopathy: Pathophysiology and prevention
197. Bax directly induces release of cytochrome c from isolated mitochondria
198. Cyclo-oxygenase isoenzymes: Physiological and pharmacological role
199. pH gradients across phospholipid membranes caused by fast flip-flop of unionized fatty acids
200. Induction of apoptosis by cancer chemotherapy
201. Inhibition of mitochondrial respiration and oxygen-dependent hepatotoxicity by six structurally dissimilar peroxisomal proliferating agents
202. L-Carnitine: Therapeutic applications of a conditionally-essential amino acid
203. Fatty acid import into mitochondria
204. Opening of mitochondrial potassium channels: A new target for graft preservation strategies?
205. Preconditioning by mitochondrial ATP-sensitive potassium channel openers: An effective approach for improving the preservation of heart transplants
206. Uncoupling protein - A useful energy dissipator
207. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
208. Palmitate-induced apoptosis in cardiomyocytes is mediated through alternation in mitochondria: Prevention by cyclosporin A
209. Effects of ATP-sensitive potassium channel regulators on chloride channels in the sarcoplasmic reticulum vesicles from rabbit skeletal muscle
210. 2+ is dependent on mitochondrial-generated reactive oxygen species
211. 2+
212. Mitochondrial control of apoptosis: An overview
213. The mitochondrial death/life regulator in apoptosis and necrosis
214. The biochemistry of programmed cell death
215. Mitochondrial control of apoptosis
216. Protein synthesis in mitochondria. III. On the effect of inhibitors on the incorporation of amino acids into proteins by intact mitochondria and digitonin fragments
217. The mitochondrial carrier family of transport proteins: Structural, functional, and evolutionary relationships
218. Apoptosis in isolated adult cardiomyocytes exposed to Adriamycin
219. Reye's syndrome
220. Revolution in mitochondrial medicine
221. Is there a therapeutic future for "potassium channel openers"
222. Potassium channel openers as potential therapeutic weapons in ion channel disease
223. ATP-sensitive potassium channels: An overview
224. Mitochondrial and energetic dysfunctions of the liver during normothermic reperfusion: Protective effect of cyclosporine and role of the mitochondrial permeability transition pore
225. 3H]PK11195, by thermodynamic studies
226. The shape of cell death
227. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death
228. Role of mitochondria in oxidative stress and aging
229. Mitochondria, oxidative stress, and antioxidant defects
230. Mitochondrial bioenergetics in aging
231. Mitochondrial toxicity of antiviral drugs
232. A novel hydroxamic acid compound, BMD188, demonstrates anti-prostate cancer effects by inducing apoptosis. I. In vitro studies
233. Cyclosporin A enhances survival, ameliorates brain damage, and prevents secondary mitochondrial dysfunction after a 30-minute period of transient cerebral ischemia
234. Mechanisms of protein import across the mitochondrial outer membrane
235. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
236. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection
237. Effect of flupirtine on cell death of human umbilical vein endothelial cells induced by reactive oxygen species
238. The development of mitochondrial medicine
239. A case of severe hypermetabolism of nonthyroid origin with a defect in the maintenance of mitochondrial respiratory control: A correlated clinical, biochemical, and morphological study
240. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
241. Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation
242. Effect of aspirin on mitochondrial lipids in experimental myocardial infarction in rats
243. Toward the molecular structure of the mitochondrial channel, VDAC
244. 2+·channel antagonist binding sites
245. 2+ release induced by Reye's plasma, allantoin, and salicylate
246. Reye's syndrome: Salicylates and mitochondrial functions
247. Cytochrome c release from mitochondria: All or nothing
248. The central role of the mitochondrial megachannel in apoptosis: Evidence obtained with intact cells, isolated mitochondria, and purified protein complexes
249. Zidovudine-induced experimental myopathy: Dual mechanism of mitochondrial damage
250. Diphenylamine as an important structure of nonsteroidal anti-inflammatory drugs to uncouple mitochondrial oxidative phosphorylation
251. Role of reactive oxygen species in apoptosis
252. Mechanism of action of cyclosporine
253. Blockade of the mitochondrial permeability transition pore diminishes infarct size in the rat after transient middle cerebral artery occlusion
254. The role of calcium in the regulation of apoptesis
255. AZT decreases rat myocardial cytochrome oxidase activity and increases β-myosin heavy chain content
256. The mitochondrial benzodiazepine receptor: Evidence for association with the voltage-depndent anion channel (VDAC)
257. Isolation of the mitochondrial benzodiazepine receptor: Association with the voltage-dependent anion channel and the adenine nucleotide carrier
258. Caruitine protection against Adriamycin-induced cardiomyopathy in rats
259. Transport of protons across membranes by weak acids
260. Inhibition and activation of calcium transport in mitochondria. Effect of lanthanides and local anesthetic drugs
261. Mitochondria and apoptosis
262. + channel in insulin-secreting pancreatic β-cells
263. Effects of nimesulide and its reduced metabolite on mitochondria
264. In vitro interaction of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation of rat kidney mitochondria: Respiration and ATP synthesis
265. Mitochondrial role in cell aging
266. Mitochondrial dysfunction in Parkinson's disease
267. Sulfonylureas: A new class of cancer chemotherapeutic agents
268. Effects of amiodarone on cardiac function and mitochondrial oxidative phosphorylation during ischemia and reperfusion
269. Inhibition and uncoupling of oxidative phosphorylation by nonsteroidal anti-inflammatory drugs: Study in mitochondria, submitochondrial particles, cells, and whole heart
270. The role of reactive oxygen species in Adriamycin and menadione-induced glomerular toxicity
271. Mitochondria as target for antiischemic drugs
272. + channel openers and suppression of airway hyperreactivity
273. Anthracycline-derived chemotherapeutics in apoptosis and free radical cytotoxicity
274. Bcl-2 inhibits Box translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells
275. Drug delivery to mitochondria: The key to mitochondrial medicine
276. Regulation of the activity of caspases by L-carnitine and palmitoylcarnitine
277. Effect of L-aminocarnitine, an inhibitor of mitochondrial fatty acid oxidation, on the exocrine pancreas and liver in fasted rats
278. Carnitine - A known compound, a novel function in neuronal cells
279. Box interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria
280. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation
281. Purification and enzymatic identity of mitochondrial contraction-factors I and II
282. Thermogenic mechanisms in brown fat
283. Critical aspects of the antioxidant function of coenzyme Q in biomembranes
284. Mechanism of Adriamycin cardiotoxicity: Evidence for oxidative stress
285. Pathophysiological and protective roles of mitochondrial ion channels
286. Protection of rabbit retina from ischemic injury by flupirtine
287. Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism
288. Alpha-lipoic acid as a biological antioxidant
289. ATP channel triggers the preconditioning state by generating free radicals
290. Mitochondrial carrier proteins
291. Mitochondrial substrate carriers
292. Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells
293. Medium chain fatty acid metabolism and energy expenditure: Obesity treatment implications
294. Peripheral-type benzodiazepine receptors
295. Alpha v integrins as receptors for tumor targeting by circulating ligands
296. Effect of sulfonylureas on hepatic fatty acid oxidation
297. + channel from rat liver and beef heart mitochondria
298. Effects of carnitine on the ischemic arrested heart
299. Improvement of myocardial function in diabetic rats after treatment with L-carnitine
300. Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system
301. Flupirtine increases the levels of glutathione and Bcl-2 in hNT (human Ntera/D1) neurons: Mode of action of the drug-mediated anti-apoptotic effect
302. Hepatotoxicity due to mitochondrial dysfunction
303. Disruption of the outer mitochondrial membrane as result of large amplitude swelling: The impact of irreversible permeability transition
304. Implication of mitochondria in apoptosis
305. Uncoupling effects of diclofenac and aspirin in the perfused liver and isolated hepatic mitochondria of rat
306. Influence of nonsteroidal anti-inflammatory drugs on calcium efflux in isolated rat renal cortex mitochondria and aspects of the mechanisms involved
307. Non-steroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract: Potential role of the pentose phosphate pathways
308. Recent perspectives in the design of antiasthmatic agents
309. Mitochondrial contributions to cancer cell physiology: Potential for drug development
310. Changes in membrane potential induced by local anesthetic bupivacaine on mitochondria within Ehrlich ascites tumor cells
311. Mitochondrial damage by the "pro-oxidant" peroxisomal proliferator clofibrate
312. Mechanism of clofibrate hepatotoxicity: Damage and oxidative stress in hepatocytes
313. Potassium channel openers: Pharmacological and clinical aspects
314. Cellular pharmacology of potassium channel openers in vascular smooth muscle
315. Superoxides from mitochondrial complex III: The role of manganese dismutase
316. Mitochondria, oxygen free radicals, disease and ageing
317. Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore
318. Cytochrome c: Can't live with it - Can't live without it
319. The uncoupling protein hemologues: UCP1, UCP2, UCP3, StUCP and AtUCP
320. Hydroxyl radicals as a potent intracellular mediator of polymorphonuclear neutrophil apoptosis
321. 2-Aryl-3-indoleacetamides (FGIN-1): A new class of potent and specific ligands for the mitochondrial DBI receptor (MDR)
322. Metabolism, mitochondrial uptake and toxicity of 2′,3′-dideoxycytidine
323. Energy balance and brown fat activity in rats fed cafeteria diets or high-fat, semisynthetic diets at several levels of intake
324. The impact of immunosuppressive drugs on the analysis of T cell activation
325. The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy
326. Effects of diarylsulfonylurea antitumor agents on the function of mitochondria isolated from rat liver and GC3/c1 cells
327. Calcineurin: Form and function
328. Anandamide induces apoptosis of PC-12 cells: Involvement of superoxide and caspase-3
329. Mitochondria, oxidative stress and aging
330. + channels by protein kinase C
331. Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels
332. Propionyl-L-carnitine as potent protective agent against induced-induced impairment of fatty acid β-oxidation in isolated heart mitochondria
333. Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochandrial permeability transition
334. Maintenance of energy-linked functions in rat-liver mitochondria aged in the presence of nupercaine
335. New ideas for treating hypertension
336. Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia
337. The protein import system of mitochondria
338. Cyclosporin A significantly ameliorates cortical damage following experimental traumatic brain injury in rodents
339. The effect of local anesthetics on the hydrolysis of free and membrane-bound phospholipds catalyzed by various phospholipases
340. Protection of mitochondrial integrity from oxidative stress by the triaminopyridine derivative flupirtine
341. Effects of hypolipidaemics cetaben and clofibrate on mitochondrial and peroxisomal enzymes of rat liver
342. On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids
343. Anandamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte proliferation and induces apoptosis
344. Mitochondrial effects of L-ropivacaine, a new local anesthetic
345. Processing of artificial peptide-DNA-conjugates by the mitochondrial intermediate peptidase (MIP)
346. Transfection of mitochondria: Strategy towards a gene therapy of mitochondrial DNA diseases
347. ATP-sensitive potassium channels: A model of heteromultimeric potassium channel/receptor assemblies
348. Inhibition of mitochondrial anion permeability by local anesthetics
349. Dynamics of antioxidant action of ubiquinol: A reappraisal
350. Antioxidant functions of vitamins. Vitamins E and C, β-carotene, and other carotenoids
351. Carnitine: Metabolism and clinical chemistry
352. Adriamycin cardiomyopathy: Pathophysiology and prevention
353. Adriamycin-induced heart failure: Mechanism and modulation
354. Local anaesthetics: An overview of current drugs
355. Thia fatty acids, metabolism and metabolic effects
356. Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
357. Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants
358. Molecular mechanism of the short-term cardiotoxicity caused by 2′,3′-dideoxycytidine (ddC): Modulation of reactive oxygen species levels and ADP-ribosylation reactions
359. The role of intracellular oxidants in apoptosis
360. Mitochondrial metabolite carrier family, topology, structure and functional properties: An overview
361. Noxious effects of oxygen reactive species on energy coupling processes in Ehrlich ascites tumor mitochondria and the protection by pantothenic acid
362. Pantothenic acid protects Jurkat cells against ultraviolet-induced apoptosis
363. Pantothenic acid and its derivatives protect Ehrlich ascites tumor cells against lipid peroxidation
364. Selective targeting of an antioxidant to mitochondria
365. The peripheral-type benzodiazepine receptor: A protein of mitochondrial outer membranes utilizing porphyrins as endogenous ligands
366. Regulation of the degree of coupling of oxidative phosphorylation in intact rat liver
367. Interactions of Adriamycin aglycones with mitochondria may mediate Adriamycin cardiotoxicity
368. Mitochondrial damage: A possible mechanism of the "topical" phase of NSAID induced injury to the rat intestine
369. Uncoupling of intestinal mitochondrial oxidative phosphorylation and inhibition of cyclooxygenase are required for the development of NSAID-enteropathy in the rat
370. Long-term acetyl-L-carnitine treatment in Alzheimer's disease
371. Inhibition by local anesthetics of adenine nucleotide translocation in rat liver mitochondria
372. Novel chemotherapeutic agents in early clinical development
373. Pharmacological basis for the therapy of pain and inflammation with nonsteroidal anti-inflammatory drugs
374. Nonsteroidal anti-inflammatory drugs (NSAIDs) in the prevention of colorectal cancer
375. Clinical toxicity of antiretroviral nucleoside analogs
376. - generation in reduction and oxidation cycle of ubiquinones in a model of mitochondrial electron transport systems
377. Mitochondria a target for myocardial protection
378. Cyclosporin A attenuates acute mitochondrial dysfunction following traumatic brain injury
379. Continuous infusion of cyclosporin A postinjury significantly ameliorates cortical damage following traumatic brain injury
380. On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes
381. Mitochondria as regulators of apoptosis: Doubt no more
382. Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat
383. Intracellular targets for antidiabetic sulfonylureas and potassium channel openers
384. + channel in mitochondria: Pharmacology and function
385. + channel openers?
386. + channel
387. + uniports induced by magnesium depletion
388. The mitochandrial sulfonylurea receptor: Identification and characterization
389. Modification of the mitochondrial sulfonylurea receptor by thiol reagents
390. Potassium channel opener, RP 66471, induces membrane depolarization of rat liver mitochondria
391. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics
392. Absence of stereospecific effects of bupivacaine isomers on heart mitochondrial bioenergetics
393. Effects of the local anesthetic bupivacaine on mitochondrial energy metabolism: Change from uncoupling to decoupling depending on the respiration state
394. Apoptosis in the absence of cytochrome c accumulation in the cytosol
395. Apoptosis in neurodegenerative diseases: The role of mitochondria
396. In-vitro genetic modification of mitochondrial function
397. The pharmacology of local anesthetics
398. Effect of antitumor diarylsulfanylureas on in vivo and in vitro mitochondrial structure and functions
399. 2+-ATPase
400. + conductance in pancreatic zymogen granules: Block by glyburide and activation by diazoxide
401. Improved pacing tolerance of the ischemic human myocardium after administration of carnitine
402. Primary changes in liver damage by aspirin in rats
403. 2+
404. Cyclosporin a inhibits creatine uptake by altering surface expression of the creatine transporter
405. The mitochondrial permeability transition: A new pathophysiological mechanism for Reye's syndrome and toxic liver injury
406. Role of the mitochondrial permeability transition in salicylate toxicity to cultured rat hepatocytes: Implications for the pathogenesis of Reye's syndrome
407. The development of brown adipose tissue during experimental overnutrition in rats
408. Phospholipid hydroperoxide glutathione peroxidase
409. Diclofenac sodium and mefenamic acid: Potent inducers of the membrane permeability transition in renal cortex mitochondria
410. AZT inhibition of the ADP/ATP antiport in isolated rat heart mitochondria
411. Inhibition of nucleoside diphosphate kinase in rat liver mitochondria by added 3′-azido-3′-deoxythymidine
412. L regulates the membrane potential and volume homeostasis of mitochandria
413. Cytochrome c oxidase inhibition by anesthetics: Thermodynamic analysis
414. On the mechanism of action of anesthetics. Direct inhibition of mitochondrial F1-ATPase by N-butanol and tetracaine
415. The molecular biology of apoptosis
416. Influence of L-carnitine administration on maximal physical exercise
417. The role of reactive oxygen species in mitochondrial permeability transition
418. Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones
419. Porphyrins are endogenous ligands for the mitochandrial (peripheral-type) benzodiazepine receptor
420. Effect of local anesthetics on phospholipase from mitochandria and lysosomes. A probe into the role of the calcium ion phospholipid hydrolysis
421. Mitochondrial targets of drug toxicity
422. 2+ overload injury in rat myocardium
423. + channel for cardiac protection against ischemic injury is dependent on protein kinase C activity
424. Recognition and management of pulmonary hypertension
425. Reye's syndrome: An update
426. Cyclosporin A rescues thymocytes from apoptosis induced by very low concentrations of thapsigargin: Effects on mitochondrial function
427. Bupivacaine inhibits acylcarnithine exchange in cardiac mitochondria
428. Sulfonylureas inhibit metabolic flux through rat liver pyruvate carboxylase reaction
429. Cardiomyopathy in childhood, mitochondrial dysfunction, and the role of L-carnitine
430. Effect of fatty acids on energy-coupling processes in mitochondria
431. The mechanisms of fatty acid-induced proton permeability of the inner mitochondrial membrane
432. Aryl-substituted 2-oxirane carboxylic acids: A new group of antidiabetic drugs
433. Multiple forms and localization for the peripheral-type benzodiazepine receptor
434. Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked
435. Amiodarone-induced lymphocyte toxicity and mitochondrial function
436. Effect of salicylic acid and calcium on mitochondrial functions
437. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
438. Phosphatidylserine decarboxylase is located on the external side of the inner mitochondrial membrane
439. Phospholipid synthesis in rat-liver mitochondria
440. The effect of peroxisome proliferators on mitochondrial bioenergetics
441. 2+ homeostasis in the regulation of apoptotic and necrotic cell death
442. Roles of calcium in the regulation of apoptosis in HL-60 promyelocytic leukemia cells
443. The mitochondrial permeability transition