Glutamate-induced mitochondrial depolarisation and perturbation of calcium homeostasis in cultured rat hippocampal neurones

Journal of Physiology

Volumn 519, Issue 2, 1999, Pages 451-466

  Vergun, Olga ^a   Keelan, Julie ^a   Khodorov, Boris I ^b   Duchen, Michael R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b INSTITUTE OF GENERAL PATHOLOGY AND PATHOPHYSIOLOGY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; CALCIUM ION; CYCLOSPORIN A; CYCLOSPORIN A DERIVATIVE; DIZOCILPINE; FURA 2; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID; RHODAMINE 123; EXCITATORY AMINO ACID;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CONTROLLED STUDY; FLUORESCENCE; HIPPOCAMPUS; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; NERVE CELL CULTURE; NONHUMAN; PRIORITY JOURNAL; RAT; CALCIUM TRANSPORT; CYTOPLASM; DEPOLARIZATION; FLUORESCENCE IMAGING; HIPPOCAMPAL NEURONAL CULTURE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; REPOLARIZATION;

EID: 0033199019     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1999.0451m.x     Document Type: Article

References (49)

1. ADAMEC, E., DIDIER, M. & NIXON, R. (1998). Developmental regulation of the recovery process following glutamate-induced calcium rise in rodent primary neuronal cultures. Developmental Brain Research 108, 101-110
2. ANKARCRONA, M., DYPBUKT, J. M., ORRENIUS, S. & NICOTERA, P. (1996). Calcineurin and mitochondrial function in glutamate-induced neuronal cell death. FEBS Letters 394, 321-324.
3. 2+ signalling takes the local route. Current Opinion in Neurobiology 2, 302-307.
4. BINDOKAS, V. P., JORDAN, J., LEE, C. C. & MILLER, R. J. (1996). Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. Journal of Neuroscience 16, 1324-1336.
5. BOGACHEV, A., BYKOVA, L., KHODOROV, B., ANDREEVA, N., KHASPEKOV, L., PINELIS, V. & VICTOROV, I. (1992). Stable decrease in ATP contents in cultured cerebellar and hippocampal neurons during and after toxic glutamate treatment. Biological Membranes 9, 1057-1059 (in Russian).
6. BUDD, S. L. & NICHOLLS, D. G. (1996). Mitochondria, calcium regulation, and acute glutamate excitotoxicity in cultured cerebellar granule cells. Journal of Neurochemistry 67, 2282-2291.
7. COYLE, J. T. & PUTTFARCKEN, P. (1993). Oxidative stress, glutamate, and neurodegenerative disorders. Science 262, 689-695.
8. DAWSON, T. M., STEINER, J. P., DAWSON, V. L., DINERMAN, J. L., UHL, G. R. & SNYDER, S. H. (1993). Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proceedings of the National Academy of Sciences of the USA 90, 9808-9812.
9. 2+ dynamics after toxic doses of glutamate in cerebellar granule cells. Proceedings of the National Academy of Sciences of the USA 87, 8017-8021.
10. 2+ transport in nerve fibers. Biochimica et Biophysica Acta 947, 549-569.
11. 2+-dependent changes in the mitochondrial energetics in single dissociated mouse sensory neurons. Biochemical Journal 283, 41-50.
12. DUCHEN, M. R. (1999). Contributions of mitochondria to animal physiology: from homeostatic sensor to calcium signalling and cell death. Journal of Physiology 516, 1-17.
13. 1 in type I cells isolated from the rabbit carotid body. Journal of Physiology 450, 33-61.
14. 1 in rat hippocampal pyramidal neurons in vitro. Journal of Pharmacology and Experimental Therapeutics 253, 1293-1302.
15. HARTLEY, D. M. & CHOI, D. W. (1989). Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture. Journal of Pharmacology and Experimental Therapeutics 250, 752-758.
16. HARTLEY, Z. & DUBINSKY, J. M. (1993). Changes in intracellular pH associated with glutamate excitotoxicity. Journal of Neuroscience 13, 4690-4699.
17. HYRC, K. L., BOWNIK, J. M. & GOLDBERG, M. P. (1998). BTC, fura-2FF and mag-fura-2 - in search of an ideal low affinity calcium indicator. Society for Neuroscience Abstracts 24, 1059.
18. KASHII, S., MANDAI, M., KIKUCHI, M., HONDA, Y., TAMURA, Y., KANEDA, K. & AKAIKE, A. (1996). Dual actions of nitric oxide in N-methyl-D-aspartate receptor-mediated neurotoxicity in cultured retinal neurons. Brain Research 711, 93-101.
19. 2+ as a tool to study calcium influx pathways. International Journal of Neuroscience 88, 215-241.
20. 2+ concentration after a toxic glutamate treatment of the nerve cell culture. FEBS Letters 324, 271-273.
21. 2+ overload induced by endogenous excitatory amino acids following a glutamate pulse. FEBS Letters 393, 135-138.
22. KHODOROV, B., PINELIS, V., VERGUN, O., STOROZHEVIKH, T. & VINSKAYA, N. (1996b). Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge. FEBS Letters 397, 230-234.
23. KIEDROWSKI, L. (1998). The difference between mechanisms of kainate and glutamate excitotoxicity in vitro: osmotic lesion versus mitochondrial depolarization. Restorative Neurology and Neuroscience 12, 71-79.
24. KIEDROWSKI, L., WROBLEWSKI, J. T. & COSTA, E. (1994). Intracellular sodium concentration in cultured cerebellar granule cells challenged with glutamate. Molecular Pharmacology 45, 1050-1054.
25. KOURIE, J. I. (1998). Interaction of reactive oxygen species with ion transport mechanisms. American Journal of Physiology 275, C1-24.
26. 1 studied in isolated rat cardiomyocytes. Journal of Physiology 496, 111-128.
27. LIMBRICK, D. D., CHURN, S. B., SOMBATI, S. & DELORENZO, R. J. (1995). Inability to restore resting intracellular calcium levels as an early indicator of delayed neuronal cell death. Brain Research 690, 145-156.
28. LLINAS, R., SUGIMORI, M. & SILVER, R. B. (1992). Presynaptic calcium concentration microdomains and transmitter release. Journal de Physiologie 86, 135-138.
29. MCCOSNELL, H. M., OWICKI, J. C., PARCE, J. W., MILLER, D. L., BAXTER, G. T., WADA, H. G. & PITCHFORD, S. (1992). The cytosensor microphysiometer: biological applications of silicon technology. Science 257, 1906-1912.
30. 2+ homeostasis in excitatory amino acids neurotoxicity: antagonism by glycosphyngolipids. Cell Biology International Reports 14, 3-14.
31. 2+ influx elicited by glutamate: role in neuronal death. Molecular Pharmacology 36, 106-112.
32. NICHOLLS, D. G. (1986). Intracellular calcium homeostasis. British Medical Bulletin 42, 353-358.
33. NICHOLLS, D. & ATTWELL, D. (1990). The release and uptake of excitatory amino acids. Trends in Pharmacological Science 11, 462-468.
34. NIEMINEN, A. L., PETRIE, T. G., LEMASTERS, J. J. & SELMAN, W. R. (1996). Cyclosporin A delays mitochondrial depolarization induced by N-methyl-D-aspartate in cortical neurons: evidence of the mitochondrial permeability transition. Neuroscience 75, 993-997.
35. 2+ after exposure to glutamate receptor agonist. Experimental Brain Research 73, 447-458.
36. 2+ transients in dendritic spines of hippocampal pyramidal neurons in brain slice. Neuron 14, 1223-1231.
37. PEUCHEN, S., BOLANOS, J. P., HEALES, S. J., ALMEIDA, A., DUCHEN, M. R. & CLARK, J. B. (1997). Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. Progress in Neurobiology 52, 261-281.
38. PINELIS, V., KHODOROV, B., FAJUK, D., ZAGULOVA, D., ANDREEVA, N., UVAROVA, T., KHASPEKOV, L., GOLOVINA, V. & VICTOROV, I. (1992). A persistent calcium-dependent decrease in cytoplasmic pH in cultured nerve cells induced by toxic glutamate treatment. Biological Membranes 9, 1050-1051 (in Russian).
39. PINELIS, V., SEGAL, M., GREENBERGER, V. & KHODOROV, B. (1994). Changes in cytosolic sodium caused by a toxic glutamate treatment of cultured hippocampal neurons. Biochemistry and Molecular Biology International 32, 1475-1482.
40. 2+ ions. Bulluten Experimentalnoy Biologii i Medicini 123, 162-164 (in Russian).
41. SCHINDER, A. F., OLSON, E. C., SPITZER, N. C. & MONTAL, M. (1996). Mitochondrial dysfunction is a primary event in glutamate neurotoxicity. Journal of Neuroscience 16, 6125-6133.
42. SCHREIER, M. H., BAUMANN, G. & ZENKE, G. (1993). Inhibition of T-cell signaling pathways by immunophilin drug complexes: are side effects inherent to immunosuppressive properties? Transplantation Proceedings 25, 502-507.
43. SHEU, S.-S. & BLAUSTEIN, M. P. (1992). Sodium/calcium exchange and control of cell calcium and contractility in cardiac and vascular smooth muscles. In The Heart and Cardiovascular System, ed. FOZZARD, H. A., HABER, E., JENNINGS, R. B., KATZ, A. M. & MORGAN, H. E., pp. 509-537. Raven Press.
44. STOUT, A. K. & REYNOLDS, I. J. (1999). High-affinity calcium indicators underestimate increases in intracellular calcium concentrations associated with excitotoxic glutamate stimulations. Neuroscience 89, 91-100.
45. TAKAHASHI, M., BILLUPS, B., ROSSI, D., SARANTIS, M., HAMANN, M. & ATTWELL, D. (1997). The role of glutamate transporters in glutamate homeostasis in the brain. Journal of Experimental Biology 200, 401-409.
46. 2+ loads. Journal of Neurophysiology 72, 2563-2569.
47. 2+ exchange buffer glutamate-induced calcium loads in cultured cortical neurons. Journal of Neuroscience 15, 1318-1328.
48. WHITE, R. J. & REYNOLDS, I. J. (1996). Mitochondrial depolarization in glutamate-stimulated neurons: an early signal specific to excitotoxin exposure. Journal of Neuroscience 16, 5688-5697.
49. ZORATTI, M. & SZABO, I. (1995). The mitochondrial permeability transition. Biochimica et Biophysica Ada 1241, 139-176.