메뉴 건너뛰기




Volumn 44, Issue 3, 2000, Pages 496-503

Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; DIDANOSINE; NUCLEOSIDE ANALOG; STAVUDINE; ZALCITABINE; ZIDOVUDINE;

EID: 0033996463     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.44.3.496-503.2000     Document Type: Article
Times cited : (119)

References (45)
  • 1
    • 0030972845 scopus 로고    scopus 로고
    • 3′-Azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator
    • Barile, M., D. Valenti, S. Passarella, and E. Quagliariello. 1997. 3′-Azido-3′-deoxythmidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator. Biochem. Pharmacol. 53:913-920.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 913-920
    • Barile, M.1    Valenti, D.2    Passarella, S.3    Quagliariello, E.4
  • 2
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M. M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 0027157404 scopus 로고
    • Inhibition of mammalian DNA polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine
    • Bridges, E. G., A. Faraj, and J.-P. Sommadossi. 1993. Inhibition of mammalian DNA polymerase-associated 3′ to 5′ exonuclease activity by 5′-monophosphates of 3′-azido-3′-deoxythymidine and 3′-amino-3′-deoxythymidine. Biochem. Pharmacol. 45:1571-1576.
    • (1993) Biochem. Pharmacol. , vol.45 , pp. 1571-1576
    • Bridges, E.G.1    Faraj, A.2    Sommadossi, J.-P.3
  • 7
    • 0023890340 scopus 로고
    • A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system
    • Burchell, A., R. Hume, and B. Burchell. 1988. A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system. Clin. Chim. Acta 173:183-191.
    • (1988) Clin. Chim. Acta , vol.173 , pp. 183-191
    • Burchell, A.1    Hume, R.2    Burchell, B.3
  • 8
    • 0029745087 scopus 로고    scopus 로고
    • The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction
    • Casademont, J., A. Barrientos, J. M. Grau, E. Pedrol, X. Estivill. A. Urbano-Marquez, and V. Nunes. 1996. The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction. Brain 119:1357-1364.
    • (1996) Brain , vol.119 , pp. 1357-1364
    • Casademont, J.1    Barrientos, A.2    Grau, J.M.3    Pedrol, E.4    Estivill, X.5    Urbano-Marquez, A.6    Nunes, V.7
  • 9
    • 0029591610 scopus 로고
    • Cytochrome c oxidase deficiency in zidovudine myopathy affects perifascicular muscle fibres and arterial smooth muscle cells
    • Chariot, P., F. Le Maguet, F. J. Authier, D. Labes, F. Poron, and R. Gherardi. 1995. Cytochrome c oxidase deficiency in zidovudine myopathy affects perifascicular muscle fibres and arterial smooth muscle cells. Neuropathol. Appl. Neurobiol. 21:540-547.
    • (1995) Neuropathol. Appl. Neurobiol. , vol.21 , pp. 540-547
    • Chariot, P.1    Le Maguet, F.2    Authier, F.J.3    Labes, D.4    Poron, F.5    Gherardi, R.6
  • 10
    • 0027494110 scopus 로고
    • Cytochrome c oxidase reaction improves histopathological assessment of zidovudine myopathy
    • Chariot, P., I. Monnet, and R. Gherardi. 1993. Cytochrome c oxidase reaction improves histopathological assessment of zidovudine myopathy. Ann. Neurol. 34:561-565.
    • (1993) Ann. Neurol. , vol.34 , pp. 561-565
    • Chariot, P.1    Monnet, I.2    Gherardi, R.3
  • 11
    • 0025729392 scopus 로고
    • Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity
    • Chen, C. H., M. Vazquez-Padua, and Y. C. Cheng. 1991. Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity. Mol. Pharmacol. 39:625-628.
    • (1991) Mol. Pharmacol. , vol.39 , pp. 625-628
    • Chen, C.H.1    Vazquez-Padua, M.2    Cheng, Y.C.3
  • 13
    • 0030981260 scopus 로고    scopus 로고
    • Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells
    • Cui, L., L. Locatelli, M. Y. Xie, and J.-P. Sommadossi. 1997. Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells. J. Pharmacol. Exp. Ther. 280:1228-1234.
    • (1997) J. Pharmacol. Exp. Ther. , vol.280 , pp. 1228-1234
    • Cui, L.1    Locatelli, L.2    Xie, M.Y.3    Sommadossi, J.-P.4
  • 14
    • 0028861575 scopus 로고
    • Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil in human liver cells
    • Cui, L., S. Yoon, R. S. Schinazi, and J.-P. Sommadossi. 1995. Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodouracil in human liver cells. J. Clin. Investig. 95: 555-563.
    • (1995) J. Clin. Investig. , vol.95 , pp. 555-563
    • Cui, L.1    Yoon, S.2    Schinazi, R.S.3    Sommadossi, J.-P.4
  • 15
    • 0028221762 scopus 로고
    • Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage
    • Dalakas, M. C., M. E. Leon-Monzon, I. Bernardini, W. A. Gahl, and C. A. Jay. 1994. Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage. Ann. Neurol. 35:482-487.
    • (1994) Ann. Neurol. , vol.35 , pp. 482-487
    • Dalakas, M.C.1    Leon-Monzon, M.E.2    Bernardini, I.3    Gahl, W.A.4    Jay, C.A.5
  • 17
    • 0002471883 scopus 로고
    • Reconstitution and molecular analysis of the respiratory chain
    • V. M. Darley-Usmar, D. Rickwood, and M. T. Wilson (ed.), IRL press, Oxford, England
    • Darley-Usmar, V. M., R. A. Capaldi, S. Takamiya, F. Millett, M. T. Wilson, F. Malatesta, and P. Sarti. 1987. Reconstitution and molecular analysis of the respiratory chain, p. 113-126. In V. M. Darley-Usmar, D. Rickwood, and M. T. Wilson (ed.), Mitochondria: a practical approach. IRL press, Oxford, England.
    • (1987) Mitochondria: A Practical Approach , pp. 113-126
    • Darley-Usmar, V.M.1    Capaldi, R.A.2    Takamiya, S.3    Millett, F.4    Wilson, M.T.5    Malatesta, F.6    Sarti, P.7
  • 18
    • 0030707553 scopus 로고    scopus 로고
    • Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions
    • Davey, G. P., L. Canevari, and J. B. Clark. 1997. Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions. J. Neurochem. 69:2564-2570.
    • (1997) J. Neurochem. , vol.69 , pp. 2564-2570
    • Davey, G.P.1    Canevari, L.2    Clark, J.B.3
  • 19
    • 0032557511 scopus 로고    scopus 로고
    • Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration
    • Davey, G. P., S. Peuchen, and J. B. Clark. 1998. Energy thresholds in brain mitochondria. Potential involvement in neurodegeneration. J. Biol. Chem. 273:12753-12757.
    • (1998) J. Biol. Chem. , vol.273 , pp. 12753-12757
    • Davey, G.P.1    Peuchen, S.2    Clark, J.B.3
  • 20
    • 0024451358 scopus 로고
    • Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′,3′-dideoxycytidine (ddC)
    • Dubinsky, R. M., R. Yarchoan, M. Dalakas, and S. Broder. 1989. Reversible axonal neuropathy from the treatment of AIDS and related disorders with 2′,3′-dideoxycytidine (ddC). Muscle Nerve 12:856-860.
    • (1989) Muscle Nerve , vol.12 , pp. 856-860
    • Dubinsky, R.M.1    Yarchoan, R.2    Dalakas, M.3    Broder, S.4
  • 21
    • 0028008640 scopus 로고
    • Fialuridine toxicity: New hopes and false downs
    • Dusheiko, G. M. 1994. Fialuridine toxicity: new hopes and false downs. Int. Antiviral News 2:22-23.
    • (1994) Int. Antiviral News , vol.2 , pp. 22-23
    • Dusheiko, G.M.1
  • 22
    • 0029154249 scopus 로고
    • Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy
    • Fortgang, I. S., P. C. Belitsos, R. E. Chaisson, and R. D. Moore. 1995. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy. Am. J. Gastroenterol. 90:1433-1436.
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 1433-1436
    • Fortgang, I.S.1    Belitsos, P.C.2    Chaisson, R.E.3    Moore, R.D.4
  • 23
    • 0027510616 scopus 로고
    • Hepatomegaly with severe steatosis in HIV-seropositive patients
    • Freiman, J. P., K. E. Helfert, M. R. Hamrell, and D. S. Stein. 1993. Hepatomegaly with severe steatosis in HIV-seropositive patients. AIDS 7:379-385.
    • (1993) AIDS , vol.7 , pp. 379-385
    • Freiman, J.P.1    Helfert, K.E.2    Hamrell, M.R.3    Stein, D.S.4
  • 25
    • 0028865886 scopus 로고
    • The intracellular phosphorylation of (-)-2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase gamma
    • Gray, N. M., C. L. Marr, C. R. Penn, J. Cameron, and R. C. Bethell. 1995. The intracellular phosphorylation of (-)-2′-deoxy-3′-thiacytidine (3TC) and the incorporation of 3TC 5′-monophosphate into DNA by HIV-1 reverse transcriptase and human DNA polymerase gamma. Biochem. Pharmacol. 50:1043-1051.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 1043-1051
    • Gray, N.M.1    Marr, C.L.2    Penn, C.R.3    Cameron, J.4    Bethell, R.C.5
  • 26
    • 0029119381 scopus 로고
    • Cellular targets of 3′-azido-3′-deoxythymidine: An early (non-delayed) effect on oxidative phosphorylation
    • Hobbs, G. A., S. A. Keilbaugh, P. M. Rief, and M. V. Simpson. 1995. Cellular targets of 3′-azido-3′-deoxythymidine: an early (non-delayed) effect on oxidative phosphorylation. Biochem. Pharmacol. 50:381-390.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 381-390
    • Hobbs, G.A.1    Keilbaugh, S.A.2    Rief, P.M.3    Simpson, M.V.4
  • 27
    • 0032408418 scopus 로고    scopus 로고
    • Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging
    • Kovalenko, S. A., G. Kopsidas, J. Kelso, F. Rosenfeldt, and A. W. Linnane. 1998. Tissue-specific distribution of multiple mitochondrial DNA rearrangements during human aging. Ann. N. Y. Acad. Sci. 854:171-181.
    • (1998) Ann. N. Y. Acad. Sci. , vol.854 , pp. 171-181
    • Kovalenko, S.A.1    Kopsidas, G.2    Kelso, J.3    Rosenfeldt, F.4    Linnane, A.W.5
  • 28
    • 0028148674 scopus 로고
    • Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis
    • Martin, J. L., C. E. Brown, N. Matthews-Davis, and J. E. Reardon. 1994. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob. Agents Chemother. 38:2743-2749.
    • (1994) Antimicrob. Agents Chemother. , vol.38 , pp. 2743-2749
    • Martin, J.L.1    Brown, C.E.2    Matthews-Davis, N.3    Reardon, J.E.4
  • 30
    • 0001587762 scopus 로고
    • Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides
    • Mitsuya, H., and S. Broder. 1986. Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2′,3′-dideoxynucleosides. Proc. Natl. Acad. Sci. USA 83:1911-1915.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 1911-1915
    • Mitsuya, H.1    Broder, S.2
  • 31
    • 0031001263 scopus 로고    scopus 로고
    • The content of intracellular mitochondrial DNA is decreased by 1-methyl-4-phenylpyridinium ion (MPP+)
    • Miyako, K., Y. Kai, T. Irie, K. Takeshige, and D. Kang. 1997. The content of intracellular mitochondrial DNA is decreased by 1-methyl-4-phenylpyridinium ion (MPP+). J. Biol. Chem. 272:9605-9608.
    • (1997) J. Biol. Chem. , vol.272 , pp. 9605-9608
    • Miyako, K.1    Kai, Y.2    Irie, T.3    Takeshige, K.4    Kang, D.5
  • 32
    • 0028805297 scopus 로고
    • Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine
    • Olano, J. P., M. J. Borucki, J. W. Wen, and A. K. Haque. 1995. Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine. Clin. Infect. Dis. 21:973-976.
    • (1995) Clin. Infect. Dis. , vol.21 , pp. 973-976
    • Olano, J.P.1    Borucki, M.J.2    Wen, J.W.3    Haque, A.K.4
  • 33
    • 0027417551 scopus 로고
    • Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS
    • Peters, B. S., J. Winer, D. N. Landon, A. Stotter, and A. J. Pinching. 1993. Mitochondrial myopathy associated with chronic zidovudine therapy in AIDS. Q. J. Med. 86:5-15.
    • (1993) Q. J. Med. , vol.86 , pp. 5-15
    • Peters, B.S.1    Winer, J.2    Landon, D.N.3    Stotter, A.4    Pinching, A.J.5
  • 34
    • 0001883657 scopus 로고
    • Isolation and characteristics of intact mitochondria
    • V. M. Darley-Usmar, D. Rickwood, and M. T. Wilson (ed.), IRL Press, Oxford, England
    • Rickwood, D., M. T. Wilson, and V. M. Darley-Usmar. 1987. Isolation and characteristics of intact mitochondria, p. 6. In V. M. Darley-Usmar, D. Rickwood, and M. T. Wilson (ed.), Mitochondria: a practical approach. IRL Press, Oxford, England.
    • (1987) Mitochondria: A Practical Approach , pp. 6
    • Rickwood, D.1    Wilson, M.T.2    Darley-Usmar, V.M.3
  • 35
    • 0001525440 scopus 로고
    • An enzymatic approach to the study of the Krebs tricarboxylic acid cycle
    • V. M. Darley-Usmar, D. Rickwood, and M. T. Wilson (ed.), IRL Press, Oxford, England
    • Robinson, J. B., L. G. Brent, B. Sumegi, and P. A. Srere. 1987. An enzymatic approach to the study of the Krebs tricarboxylic acid cycle, p. 160-161. In V. M. Darley-Usmar, D. Rickwood, and M. T. Wilson (ed.), Mitochondria: a practical approach. IRL Press, Oxford, England.
    • (1987) Mitochondria: A Practical Approach , pp. 160-161
    • Robinson, J.B.1    Brent, L.G.2    Sumegi, B.3    Srere, P.A.4
  • 36
    • 0030900269 scopus 로고    scopus 로고
    • Mitochondrial and cellular toxicity induced by fialuridine in human muscle in vitro
    • Semino-Mora, C. M., M. Leon-Monzon, and M. C. Dalakas. 1997. Mitochondrial and cellular toxicity induced by fialuridine in human muscle in vitro. Lab. Investig. 76:487-495.
    • (1997) Lab. Investig. , vol.76 , pp. 487-495
    • Semino-Mora, C.M.1    Leon-Monzon, M.2    Dalakas, M.C.3
  • 37
    • 0029159782 scopus 로고
    • Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy
    • Sinnwell, T. M., K. Sivakumar, S. Soueidan, C. Jay, J. A. Frank, A. C. McLaughlin, and M. C. Dalakas. 1995. Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy. J. Clin. Investig. 96:126-131.
    • (1995) J. Clin. Investig. , vol.96 , pp. 126-131
    • Sinnwell, T.M.1    Sivakumar, K.2    Soueidan, S.3    Jay, C.4    Frank, J.A.5    McLaughlin, A.C.6    Dalakas, M.C.7
  • 38
    • 0026022784 scopus 로고
    • Deficiency of complex III of the mitochondrial respiratory chain in a patient with facioscapulohumeral disease
    • Slipetz, D. M., J. R. Aprille, P. R. Goodyer, and R. Rozen. 1991. Deficiency of complex III of the mitochondrial respiratory chain in a patient with facioscapulohumeral disease. Am. J. Hum. Genet. 48:502-510.
    • (1991) Am. J. Hum. Genet. , vol.48 , pp. 502-510
    • Slipetz, D.M.1    Aprille, J.R.2    Goodyer, P.R.3    Rozen, R.4
  • 39
    • 0024353932 scopus 로고
    • Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells
    • Sommadossi, J.-P., R. Carlisle, and Z. Zhou. 1989. Cellular pharmacology of 3′-azido-3′-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells. Mol. Pharmacol. 36:9-14.
    • (1989) Mol. Pharmacol. , vol.36 , pp. 9-14
    • Sommadossi, J.-P.1    Carlisle, R.2    Zhou, Z.3
  • 41
    • 0030793323 scopus 로고    scopus 로고
    • Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: Report of two patients and review of the literature
    • Sundar, K., M. Suarez, P. E. Banogon, and J. M. Shapiro. 1997. Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: report of two patients and review of the literature. Crit. Care Med. 25:1425-1430.
    • (1997) Crit. Care Med. , vol.25 , pp. 1425-1430
    • Sundar, K.1    Suarez, M.2    Banogon, P.E.3    Shapiro, J.M.4
  • 42
    • 0030790843 scopus 로고    scopus 로고
    • Human cytochrome c oxidase: Structure, function, and deficiency
    • Taanman, J. W. 1997. Human cytochrome c oxidase: structure, function, and deficiency. J. Bioenerg. Biomembr. 29:151-163.
    • (1997) J. Bioenerg. Biomembr. , vol.29 , pp. 151-163
    • Taanman, J.W.1
  • 43
    • 0002030697 scopus 로고
    • HBV-drug deaths prompt restudy of similar antivirals
    • Touchette, N. 1993. HBV-drug deaths prompt restudy of similar antivirals. J. NIH Res. 5:33-35.
    • (1993) J. NIH Res. , vol.5 , pp. 33-35
    • Touchette, N.1
  • 44
    • 0025694701 scopus 로고
    • 3′-Azido-3′-deoxythymidine inhibits globin gene transcription in butyric acid-induced K562 human leukemia cells
    • Weidner, D. A., and J.-P. Sommadossi. 1990. 3′-Azido-3′-deoxythymidine inhibits globin gene transcription in butyric acid-induced K562 human leukemia cells. Mol. Pharmacol. 38:797-804.
    • (1990) Mol. Pharmacol. , vol.38 , pp. 797-804
    • Weidner, D.A.1    Sommadossi, J.-P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.