Mitochondrion is the principal target for nutritional and pharmacological control of triglyceride metabolism

Journal of Lipid Research

Volumn 38, Issue 9, 1997, Pages 1851-1858

  Frøyland, Livar ^a,c   Madsen, Lise ^a   Vaagenes, Hege ^a   Totland, Geir K ^a   Auwerx, Johan ^b   Kryvi, Harald ^a   Staels, Bart ^b   Berge, Rolf K ^a  

^a UNIVERSITY OF BERGEN   (Norway)

^b INSTITUT PASTEUR DE LILLE   (France)

^c INSTITUTE OF MARINE RESEARCH   (Norway)

Author keywords

Fibrates; Fish oil; Hypotriglyceridemic; Liver; Mitochondria; Morphology; Peroxisomes

Indexed keywords

ANTILIPEMIC AGENT; APOLIPOPROTEIN C3; DOCOSAHEXAENOIC ACID; FENOFIBRATE; FIBRIC ACID DERIVATIVE; FISH OIL; ICOSAPENTAENOIC ACID; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FATTY ACID METABOLISM; FATTY ACID OXIDATION; GENE EXPRESSION; LIPID ANALYSIS; LIPID METABOLISM; LIVER CARCINOGENESIS; LIVER HOMOGENATE; MALE; MITOCHONDRION; NONHUMAN; PEROXISOME; PRIORITY JOURNAL; RABBIT; RAT; RNA ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FISH OILS; HUMANS; LIVER; MALE; MICROBODIES; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; PROCETOFEN; RABBITS; RATS; RATS, WISTAR; TRIGLYCERIDES;

EID: 0030764696     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Hodis, H. N., W. J. Mack, S. P. Azen, P. Alaupovic, J. M. Pogoda, L. LaBree, L. C. Hemphill, D. M. Kramsch, and D. H. Blankenhorn. 1994. Triglyceride- and cholesterol-rich lipoproteins have a different effect on mild/ moderate and severe lesion progression as assayed by quantitative coronary angiography in a controlled trial of lovastatin. Circulation. 90: 42-49.
2. Worne, H. E., and L. W. Smith. 1959. Effects of certain pure long-chain polyunsaturated fatty acid esters on the blood lipids of man. Am. J. Med. Sci. 237: 710-721.
3. Bang, H. O., J. Dyerberg, and A. B. Nielsen. 1971. Plasma lipid and lipoprotein pattern in Greenlandic West-coast Eskimos. Lancet. 710: 1143-1145.
4. Davis, R. A., and J. R. Boogaerts. 1982. Intrahepatic assembly of very low density lipoproteins. Effect of fatty acids on triacylglycerol and apolipoprotein synthesis. J. Biol. Chem. 257: 10908-10913.
5. Nestel, P. J., W. E. Connor, M. F. Reardon, S. Connor, S. Wong, and R. Boston. 1984. Suppression by diets rich in fish oil of very low density lipoprotein production in man. J. Clin. Invest. 74: 82-89.
6. Kornitzer, M., M. Dramaix, M. D. Vandenbroek, L. Everaert, and C. Gerlinger. 1994. Efficacy and tolerance of 200 mg micronised fenofibrate administered over a 6-month period in hyperlipiaemic patients: an open Belgian multicenter study. Atherosclerosis. 110: S49-S54.
7. Shepherd, J. 1994. The fibrates in clinical practise: focus on micronised fenofibrate. Atherosclerosis. 110: S55-S63.
8. Balfour, J. A., D. McTavish, and R. C. Heel. 1990. Fenofibrate: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in dyslipiaemia. Drugs. 40: 260-290.
9. Hertz, R., J. Bishara-Shieban, and J. Bar-Tana. 1995. Mode of action of peroxisome proliferators as hypolipidemic drugs. J. Biol. Chem. 270: 13470-13475.
10. Staels, B., N. Vu-Dac, V. A. Kosykh, R. Saladin, J-C. Fruchart, J. Dallongeville, and J. Auwerx. 1995. Fibrates downregulate apolipoprotein C-III expression independent of induction of peroxisomal acyl coenzyme A oxidase. A potential mechanism for the hypolipidemic action of fibrates. J. Clin. Invest. 95: 705-712.
11. Leaf, A., and P. C. Weber, 1988. Cardiovascular effects of n-3 fatty acids. N. Engl. J. Med. 318: 549-557.
12. Kinsella, J. E., B. Lokesh, and R. A. Stone. 1990. Dietary n-3 polyunsaturated fatty acids and amelioration of cardiovascular disease: possible mechanisms. Am. J. Clin. Nutr. 52: 1-28.
13. Bønaa, K. H., K. S. Bjerve, B. Straume, I. T. Gram, and D. Thelle. 1990. Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Trosmø study. N. Engl. J. Med. 322: 795-801.
14. Kobatake, Y., K. Kuroda, H. Jinnouchi, E. Nishide, and S. Innami. 1984. Differential effects of dietary eicosapentaenoic and docosahexaenoic acids on lowering of triglyceride and cholesterol levels in the serum of rats on hypercholesterolemic diet. J. Nutr. Sci. Vilaminol. Tokyo. 30: 357-372.
15. Aarsland, A., M. Lundquist, B. Børretsen, and R. K. Berge. 1990. On the effect of peroxisomal beta-oxidation and carnitine palmitoyltransferase activity by eicosapentaenoic acid in liver and heart from rats. Lipids. 25: 546-548.
16. Ikeda, I., K. Wakamatsu, A. Inayoshi, K. Imaizumi, M. Sugano, and K. Yazawa. 1994. α-Linolenic, eicosapentaenoic and docosahexaenoic acids affect lipid metabolism differently in rats. J. Nutr. 124: 1898-1906.
17. Surette, M. E., J. Whelan, K. S. Broughton, and J. E. Kinsella. 1992. Evidence for mechanisms of the hypotriglyceridemic effect of n-3 polyunsaturated fatty acids. Biochim. Biophys. Acta. 1126: 199-205.
18. Willumsen, N., J. Skorve, S. Hexeberg, A. C. Rustan, and R. K. Berge. 1993. Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats. J. Lipid Res. 34: 13-22.
19. Willumsen, N., S. Hexeberg, J. Skorve, M. Lundquist, and R. K. Berge. 1993. The hypotriglyceridemic effect of eicosapentaenoic acid in rats is reflected in increased mitochondrial fatty acid oxidation followed by diminished lipogenesis. Lipids. 28: 683-690.
20. Dagnelie, P. C., T. Rietveld, G. R. Swart, T. Stijnen, and J. W. van den Berg. 1994. Effect of dietary fish oil on blood levels of free fatty acids, ketone bodies and triacylglycerol in humans. Lipids. 29: 41-45.
21. Soutar, A. 1978. Does dietary fat influence plasma lipoprotein structure? Nature. 273: 11-12.
22. Frøyland, L., H. Vaagenes, D. K. Asiedu, A. Carras, Ø. Lie, and R. K. Berge. 1996. Chronic administration of eicosapentaenoic acid and docosahexaenoic acid as ethyl esters reduced plasma cholesterol and changed the fatty acid composition in rat blood and organs. Lipids. 31: 169-178.
23. Blane, G. F. 1987. Comparative toxicity and safety profile of fenofibrate and other fibric acid derivatives. Am. J. Med. 83: 26-36.
24. Nordoy, A., L. Barstad, W. E. Connor, and L. Hatcher. 1991. Absorption of the n-3 eicosapentaenoic and docosahexaenoic acids as ethyl esters and triglycerides by humans. Am. J. Clin. Nutr. 57: 634-639.
25. Krokan, H. E., K. S. Bjerve, and E. Mork. 1993. The enterai bioavailability of eicosapentaenoic acid and docosahexaenoic acid is as good from ethyl esters as from glyceryl esters in spite of lower hydrolytic rates by pancreatic lipase in vitro. Biochim. Biophys. Acta. 1168: 59-67.
26. Carlson, K. 1973. Lipoprotein fractionation. J. Clin. Pathol. 26 suppl. (Assoc. Clin. Pathol.) 5: 32-37.
27. Kryvi, H., A. Aarsland, and R. K. Berge. 1990. Morphological effects of sulfur-substituted fatty acids on rat hepatocytes with special reference to proliferation of peroxisomes and mitochondria. J. Struct. Biol. 103: 257-265.
28. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
29. Staels, B., J. Auwerx, L. Chan, A. van Tol, M. Rosseneu, and G. Verhoeven. 1989. Influence of development, oestrogens and food intake in apolipoprotein A-I, A-II, and E mRNA in the rat liver and intestine. J. Lipid Res. 30: 1137-1145.
30. Aasland, R., J. R. Lillehaug, R. Male, O. Josendal, J. E. Varhaug, and K. Kleppe. K. 1988. Expression of oncogenes in thyroid tumours. Coexpression of c-erB2/neu and c-erbB. Br. J. Cancer. 57: 358-363.
31. Feinberg, A. P., and B. Vogelstein. 1984. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Addendum. Anal. Biochem. 137: 266-267.
32. Frøyland, L., D. K. Asiedu, H. Vaagenes, A. Garras, Ø. Lie, G. K. Totland, and R. K. Berge. 1995. Tetradecylthioacetic acid incorporated into very low density lipoprotein: changes in the fatty acid composition and reduced plasma lipids in cholesterol-fed hamsters. J. Lipid Res. 36: 2529-2540.
33. Kunau, W. H., and P. Domines. 1978. Degradation of unsaturated fatty acids. Identification of intermediates in the degradation of cis-4-decenoyl-CoA by extracts of beef-liver mitochondria. Eur. J. Biochem. 91: 533-544.
34. Bremer, J. 1981. The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA. Biochim. Biophys. Acta. 665: 156-159.
35. Small, G. M., K. Burden, and M. J. Connock. 1985. A sensitive spectrophotometric assay for peroxisomal acyl-CoA oxidase. Biochem. J. 227: 205-210.
36. Rambjør, G. S., A. I. Wålen, S. L. Windsor, and W. S. Harris. 1996. Eicosapentaenoic acid is primarily responsible for hypotriglyceridemic effect of fish oils in humans. Lipids. 31: S-45-S-49.
37. Mannaerts, G. P., L. J. Debeer, J. Thomas, and P. J. De Schepper. 1979. Mitochondrial and peroxisomal fatty acid oxidation in liver homogenates and isolated hepatocytes from control and clofibrate-treated rats. J. Biol. Chem. 254: 4585-4595.
38. Van Veldhoven, P. P., and G. P. Mannaerts. 1985. Comparison of the activities of some peroxisomal and extraperoxisomal lipid-metabolizing enzymes in liver and extrahepatic tissues of the rat. Biochem. J. 227: 737-741.
39. Hawkins, J. M., W. E. Jones, F. W. Bonner, and G. G. Gibson. 1987. The effect of peroxisome proliferators on microsomal, peroxisomal and mitochondrial enzyme activities in the liver and kidney. Drug. Met. Rev. 18: 441-515.
40. Green, S. 1995. PPAR: a mediator of peroxisome proliferation action. Mutat. Res. 333: 101-109.
41. Schoonjans, K., B. Staels, and J. Auwerx. 1996. The peroxisome proliferator activated receptors (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta. 1302: 93-109.
42. Schoonjans, K., B. Staels, and J. Auwerx. 1996. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37: 907-925.
43. Reddy, J. K., D. L. Azarnoff, and C. E. Hignite. 1980. Hypolipidemic hepatic peroxisome proliferators form a novel class of chemical carcinogens. Nature. 283: 397-398.
44. Reddy, J. K., and N. D. Lalwani. 1983. Carcinogenesis by hepatic peroxisome proliferators: evaluation of the risk of hypolipidemic drugs and industrial plasticizers to humans. CRC Crit. Rev. Toxicol. 12: 1-58.
45. Blümcke, S., W. Schwartzkopff, H. Lobeck, N. A. Edmondson, D. E. Prentice, and G. F. Blane. 1983. Influence of fenofibrate on cellular and subcellular liver structure in hyperlipidemic patients. Atherosclerosis. 46: 105-116.
46. Hanefeld, M., C. Kemmer, and E. Kadner. 1983. Relationship between morphological changes and lipid lowering action of p-chloro-phenoxyisobutyric acid (CPIB) on hepatic mitochondria and peroxisomes in man. Atherosclerosis. 46: 239-246.