Pharmacologic characterization of BMS-191095, a mitochondrial KATP opener with no peripheral vasodilator or cardiac action potential shortening activity

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 3, 2001, Pages 1184-1192

  Grover, Gary J ^a   D'Alonzo, Albert J ^a   Garlid, Keith D ^b   Bajgar, Robert ^b   Lodge, Nicholas J ^a   Sleph, Paul G ^a   Darbenzio, Raymond B ^a   Hess, Thomas A ^a   Smith, Mark A ^a   Paucek, Petr ^b   Atwal, Karnail S ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYDECANOIC ACID; BMS 191095; CROMAKALIM; GLIBENCLAMIDE; LACTATE DEHYDROGENASE; N (4 CHLOROPHENYL) N' CYANO N'' (6 CYANO 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)GUANIDINE; POTASSIUM CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; DRUG POTENCY; DRUG SELECTIVITY; GUINEA PIG; HEART CONTRACTION; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART PROTECTION; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; VASODILATATION;

ACTION POTENTIALS; ANIMALS; BENZOPYRANS; CARDIOVASCULAR AGENTS; CROMAKALIM; DECANOIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYBURIDE; GUANIDINES; GUINEA PIGS; HEART; HEART CONDUCTION SYSTEM; HYDROXY ACIDS; IMIDAZOLES; MALE; MITOCHONDRIA; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; PAPILLARY MUSCLES; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; VASODILATOR AGENTS; VASOMOTOR SYSTEM;

EID: 0035015219     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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