Mechanism of clofibrate hepatotoxicity: Mitochondrial damage and oxidative stress in hepatocytes

Free Radical Biology and Medicine

Volumn 31, Issue 5, 2001, Pages 659-669

  Qu, Bin ^a   Li, Qiu Tian ^a   Wong, Kim Ping ^a   Tan, Theresa M C ^a   Halliwell, Barry ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Apoptosis; Clofibrate; Free radicals; Mitochondrial membrane potential; MPT; Oxidative stress; Peroxisome proliferators

Indexed keywords

5 CARBOXY 2',7' DICHLOROFLUORESCEIN DIACETATE; 5,5',6,6'TETRACHLORO 1,1',3,3' TETRAETHYLBENZIMIDAZOLYLCARBOCYANINE IODIDE; 6 CARBOXY 2',7' DICHLOROFLUORESCEIN DIACETATE; ASCORBIC ACID; CALCEIN; CATALASE; CLOFIBRATE; CYCLOSPORIN A; DEFEROXAMINE; DIHYDRORHODAMINE 123; ESTER DERIVATIVE; FLUORESCENT DYE; METHYL GROUP; PEROXISOME PROLIFERATOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESTRUCTION; DRUG MECHANISM; LIVER CELL; LIVER TOXICITY; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ANTICHOLESTEREMIC AGENTS; CELL SURVIVAL; CELLS, CULTURED; CLOFIBRATE; CYCLOSPORINE; FREE RADICALS; HEPATOCYTES; ION CHANNELS; LIVER; MEMBRANE POTENTIALS; MEMBRANE PROTEINS; MICE; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 0035451601     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(01)00632-3     Document Type: Article

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