Molecular mechanism of the short-term cardiotoxicity caused by 2',3'- dideoxycytidine (ddC): Modulation of reactive oxygen species levels and ADP- ribosylation reactions

Biochemical Pharmacology

Volumn 58, Issue 12, 1999, Pages 1915-1925

  Skuta, Gabriella ^a   Fischer, Gabor M ^a   Janaky, Tamas ^b   Kele, Zoltan ^b   Szabo, Pal ^b   Tozser, Jozsef ^c   Sumegi, Balazs ^c  

^a UNIVERSITY OF PÉCS   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

ADP ribose; Cardiomyopathy; Chaperone; DdC; Desmin; Folding; Free radical; Gene expression; GRP78; HIV AIDS; HSP; Mitochondrial; mtDNA; Myopathy; Protein transport; Signalling

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CREATINE; CREATINE PHOSPHATE; CYTOCHROME C OXIDASE; DESMIN; GLUCOSE REGULATED PROTEIN; HEAT SHOCK PROTEIN 25; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; MITOCHONDRIAL DNA; MYOGLOBIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; TRIOSEPHOSPHATE ISOMERASE; ZALCITABINE;

ADENOSINE DIPHOSPHATE RIBOSYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ENERGY METABOLISM; ENZYME ACTIVATION; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ADENOSINE DIPHOSPHATE RIBOSE; ANIMALS; ANTI-HIV AGENTS; CARDIOMYOPATHIES; DNA; ELECTROCARDIOGRAPHY; ENERGY METABOLISM; HEART; HEAT-SHOCK PROTEINS; MASS SPECTROMETRY; MITOCHONDRIA; MUSCLE, SKELETAL; OXIDATION-REDUCTION; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; REVERSE TRANSCRIPTASE INHIBITORS; SEQUENCE ANALYSIS; ZALCITABINE;

EID: 0032700393     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00282-8     Document Type: Article

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