The mitochondrial permeability transition: A new pathophysiological mechanism for Reye's syndrome and toxic liver injury

Journal of Pharmacology and Experimental Therapeutics

Volumn 278, Issue 3, 1996, Pages 1000-1005

  Trost, Lawrence C ^a   Lemasters, John J ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 MERCAPTOPROPIONIC ACID; 4 PENTENOIC ACID; ACETYLSALICYLIC ACID; ADIPIC ACID; BENZOIC ACID; ISOVALERIC ACID; NEEM OIL; VALPROIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; LIVER MITOCHONDRION; LIVER TOXICITY; MALE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NONHUMAN; PATHOGENESIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REYE SYNDROME; VOMITING;

ANIMALS; ASPIRIN; CARBOXYLIC ACIDS; CYCLOSPORINE; HEPATITIS, TOXIC; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; RATS; RATS, SPRAGUE-DAWLEY; REYE SYNDROME; RUTHENIUM RED; STRUCTURE-ACTIVITY RELATIONSHIP; VALPROIC ACID;

EID: 0030440961     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. APRILLE, J. R.: Reye's syndrome: Patient serum alters mitochondrial function and morphology in vivo. Science 197: 908-910, 1977.
2. BERNARDI, P.: Modulation of the mitochondrial cyclosporin A-sensitive permeability transition pore by the proton electrochemical gradient. J. Biol. Chem. 267: 8834-8839, 1992.
3. BERNARDI, P., BROEKEMEIER, K. M. AND PFEIFFER, D. R.: Recent progress on regulation of the mitochondrial permeability transition pore: A cyclosporin sensitive pore in the inner-mitochondrial membrane. J. Bioenerg. Biomembr. 26: 509-517, 1994.
4. BERNARDI, P., VASSANELLI, S., VERONESE, P., COLONNA, R., SZABO, I. AND ZORATTI, M.: Modulation of the mitochondrial permeability transition pore: effect of protons and divalent cations. J. Biol. Chem. 267: 2934-2939, 1992.
5. 2+. Biochem. Pharmacol. 50: 497-500, 1995.
6. BRODY, T. M.: Action of sodium salicylate and related compounds on tissue metabolism in vitro. J. Pharmacol. Exp. Ther. 117: 39-51, 1956.
7. 2+ and oxidative stress. FEBS Lett. 304: 192-194, 1992.
8. BROEKEMEIER, K. M., DEMPSEY, M. E. AND PFEIFFER, D. R.: Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria. J. Biol. Chem. 264: 7826-7830, 1989.
9. BROEKEMEIER, K. M. AND PFEIFFER, D. R.: Inhibition of the mitochondrial permeability transition by cyclosporin A during long timeframe experiments: a relationship between pore opening and the activity of mitochondrial phospholipases. Biochemistry. 34: 16440-16445, 1995.
10. 2+ release from mitochondria. J. Biol. Chem. 260: 105-113, 1985.
11. BROWN, R. E. AND FORMAN, D. T.: The biochemistry of Reye's syndrome. CRC Crit. Rev. Clin. Lab. Sci. 17: 247-297, 1982.
12. COSTANTINI, P., PETRONILLI, V., COLONNA, R. AND BERNARDI, P.: On the effects of paraquat on isolated mitochondria, evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide. Toxicology 99: 77-88, 1995.
13. +2-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress. Biochem. J. 255: 357-360, 1988.
14. DUCHEN, M. P., MCGUINNESS, O., BROWN, L. A. AND CROMPTON, M.: On the involvement of cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury. Cardiovasc. Res. 27: 1790-1794, 1993.
15. ELPELEG, O. N., CHRISTENSEN, E., HURVITZ, H. AND BRANSKI, D.: Recurrent, familial Reye-like syndrome with a new complex amino and organic aciduria. Eur. J. Pediatr. 149: 709-712, 1990.
16. EMAUS, R. K., GRUNWALD, R. AND LEMASTERS, J. J.: Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: Spectral and metabolic properties. Biochim. Biophys. Acta 850: 436-448, 1986.
17. FLOWER, R. J., MONCADA, S. AND VANE, J. R.: Analgesic-antipyretics and anti-inflammatory agents: Drugs employed in the treatment of gout. In The Pharmacological Basis of Therapeutics, ed. by A. G. Gillman, L. S. Goodman, T. W. Rall and F. Murad, 7 ed., pp. 674-715, Macmillan, New York, 1985.
18. FOURNIER, N., DUCET, G. AND CREVAT, A.: Action of cyclosporine on mitochondrial calcium fluxes. J. Bioenerg. Biomembr. 19: 297-303, 1987.
19. GERBER, N., DICKINSON, R. G., HARLAND, R. C., LYNN, R. K., HOUGHTON, D., ANTONIAS, J. I. AND SCHIMSCHOCK, J. C.: Reye-like syndrome associated with valproic acid therapy. J. Pediatr. 95: 142-144, 1979.
20. GLASGOW, A. M. AND CHASE, H. P.: Production of the features of Reye's syndrome in rats with 4-pentenoic acid. Pediatr. Res. 9: 133-138, 1975.
21. GORNALL, A. G., BARDAWILL, D. J. AND DAVID, M. M.: Determination of serum proteins by means of the biuret reaction. J. Biol. Chem. 177: 751-766, 1949.
22. GUNTER, T. E. AND PFEIFFER, D. R.: Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258: C755-C786, 1990.
23. HEUBI, J. E., PARTIN, J. C., PARTIN, J. S. AND SCHUBERT, W. K.: Reye's syndrome: Current concepts. Hepatology 7: 155-164, 1987.
24. HUNTER, D. R., HAWORTH, R. A. AND SOUTHARD, J. H.: Relationship between configuration, function, and permeability in calcium-treated mitochondria. J. Biol. Chem. 251: 5069-5077, 1976.
25. IMBERTI, R., NIEMINEN, A.-L., HERMAN, B. AND LEMASTERS, J. J.: Synergism of cyclosporin A and phospholipase inhibitors in protection against lethal injury to rat hepatocytes from oxidant chemicals. Res. Commun. Chem. Pathol. Pharmacol. 78: 27-38, 1992.
26. IMBERTI, R., NIEMINEN, A.-L., HERMAN, B. AND LEMASTERS, J. J.: Mitochondrial and glycolytic dysfunction in lethal injury to hepatocytes by t-butylhydroperoxide: Protection by fructose, cyclosporin A and trifluoperazine. J. Pharmacol. Exp. Ther. 265: 392-400, 1993.
27. KOGA, Y., YOSHIDA, I., KIMURA, A., YOSHINO, M., YAMASHITA, F. AND SINNIAH, D.: Inhibition of mitochondrial function by margosa oil: Possible implications in the pathogenesis of Reye's syndrome. Pediatr. Res. 22: 184-187, 1987.
28. LEMASTERS, J. J., GRUNWALD, R. AND EMAUS, R. K.: Thermodynamic limits to the ATP/Site of oxidative phosphorylation by rat liver mitochondria. J. Biol. Chem. 259: 3058-3063, 1984.
29. LICHTENSTEIN, P. K., HEUBI, J. E., DAUGHTERTY, C. C., FARRELL, M. K., SOKOL, R. J., ROTHBAUM, R. J., SUCHY, F. J. AND BALISTRERI, W. F.: Grade I Reye's syndrome. A frequent cause of vomiting and liver dysfunction after varicella and upper-respiratory-tract infection. N. Engl. J. Med. 309: 133-139, 1983.
30. 2+ release induced by Reye's plasma, allantoin, and salicylate. Arch. Biochem. Biophys. 244: 773-786, 1986.
31. MARTENS, M. E. AND LEE, C.-P.: Reye's syndrome: Salicylates and mitochondrial functions. Biochem. Pharmacol. 33: 2869-2876, 1984.
32. NIEMINEN, A.-L., SAYLOR, A. K., TESFAI, S. A., HERMAN, B. AND LEMASTERS, J. J.: Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem. J. 307: 99-106, 1995.
33. NOVGORODOV, S. A., GUDZ, T. I., BRIERLEY, G. P. AND PFEIFFER, D. R.: Magnesium ion modulates the sensitivity of the mitochondrial permeability transition pore to cyclosporin A and ADP. Arch. Biochem. Biophys. 311: 219-228, 1994.
34. PARTIN, J. C., SHUBERT, W. K. AND PARTIN, J. S.: Mitochondrial ultrastructure in Reye's syndrome (encephalopathy and fatty degeneration of the viscera). N. Engl. J. Med. 285: 1339-1343, 1971.
35. 2+ depletion prevents anoxic death of hepatocytes by inhibiting the mitochondrial permeability transition. Am. J. Physiol. 268: C676-C685, 1995.
36. PETRONILLI, V., COSTANTINI, P., SCORRANO, L., COLONNA, R., PASSAMONTI, S. AND BERNARDI, P.: The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. J. Biol. Chem. 269: 16638-16642, 1994.
37. PINSKY, P. F., HURWITZ, E. S., SCHONBERGER, L. B. AND GUNN, W. J.: Reye's syndrome and aspirin. Evidence for a dose-response effect. J. Am. Med. Assoc. 260: 657-661, 1988.
38. REYE, R. D. K., MORGAN, G. AND BARAL, J.: Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood. Lancet 2: 749-752, 1963.
39. SAXENA, K., HENRY, T. R., SOLEM, L. E. AND WALLACE, K. B.: Enhanced induction of the mitochondrial permeability transition following acute menadione administration. Arch. Biochem. Biophys. 317: 79-84, 1995.
40. SEGALMAN, T. Y. AND LEE, C. P.: Reye's syndrome: plasma-induced alterations in mitochondrial structure and function. Arch. Biochem. Biophys. 214: 522-530, 1982.
41. SHERRATT, H. S. A.: Hypoglycin, the famous toxin of the unripe Jamaican Ackee fruit. Trends Pharmacol. Sci. 7: 186-191, 1986.
42. TANAKA, K., ISSELBACHER, K. J. AND SHIH, V.: Isovaleric and alpha-methybutyric acidemias induced by hypoglycin A: Mechanism of Jamaican vomiting sickness. Science 175: 69-71, 1972.
43. TONSGARD, J. H. AND GETZ, G. S.: Effect of Reye's syndrome serum on isolated chinchilla liver mitochondria. J. Clin. Invest. 76: 816-825, 1985.
44. TROST, L. C. AND LEMASTERS, J. J.: Induction of the permeability transition by agents implicated in Reye's syndrome and Reye's-like drug toxicity: A possible pathogenesis of mitochondrial dysfunction. Hepatology 22: 383A, 1995.
45. WALDMAN, R. J., HALL, W. N., MCGEE, H. AND VANAMBURG, G.: Aspirin as a risk factor in Reye's syndrome. J. Am. Med. Assoc. 247: 3089-3094, 1982.
46. YAMAMOTO, M. AND NAKAMURA, Y.: Inhibition of β-oxidation by 3-mercaptopropionic acid produces features of Reye's syndrome in perfused rat liver. Gastroenterology 107: 517-524, 1994.
47. YOU, K.-S.: Salicylate and mitochondrial injury in Reye's syndrome. Science 221: 163-165, 1983.
48. ZORATTI, M. AND SZABO, I.: The mitochondrial permeability transition. Biochim. Biophys. Acta 1241: 139-176, 1995.