Mitochondrial metabolite carrier family, topology, structure and functional properties: An overview

Acta Biochimica Polonica

Volumn 43, Issue 2, 1996, Pages 349-360

  Sluse, Francis E ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Carrier family; Mitochondrial metabolite

Indexed keywords

CARRIER PROTEIN;

ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; KINETICS; MITOCHONDRION; PHYSIOLOGY; REVIEW;

ANIMALS; BINDING SITES; CARRIER PROTEINS; KINETICS; MITOCHONDRIA; MODELS, BIOLOGICAL; MODELS, MOLECULAR;

EID: 0030330291     PISSN: 0001527X     EISSN: None     Source Type: Journal    
DOI: 10.18388/abp.1996_4504     Document Type: Review

References (63)

1. Mitchell, P. (1961) Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type mechanism. Nature (London) 191, 144-148.
2. Chappell, J.B. (1968) Systems used for the transport of substrates into mitochondria. Brit. Med. Bull. 24, 150-157.
3. Klingenberg, M. & Pfaff, E. (1966) Structural and functional compartmentation in mitochondria; in Regulation of Metabolic Processes in Mitochondria (Tager, J.M., Quagliariello, E. & Slater, E.C., eds.) pp. 180-201, Elsevier, Amsterdam.
4. Pfaff, E. & Klingenberg, M. (1968) Adenine nucleotide translocation of mitochondria. I. Specificity and control. Eur. J. Biochem. 6, 66-79.
5. Palmieri, F. (1994) Mitochondrial carrier proteins. FEBS Lett. 346, 48-54.
6. Kuan, J. & Saier, M.H., Jr. (1993) The mitochondrial carrier family of transport proteins: Structural, functional, and evolutionary relationships. Crit. Rev. Biochem. Mol. Biol. 28, 209-233.
7. Walker, J.E. & Runswick, M.J. (1993) The mitochondrial transport protein superfamily. J. Bioenerg. Biomembr. 25, 435-446.
8. Krämer, R. & Palmieri, F. (1992) Metabolite carriers in mitochondria; in Molecular Mechanisms in Bioenergetics (Ernster, L., ed.) pp. 359-384, Elsevier Science Publishers, Amsterdam.
9. Pedersen, P.L. (1993) An introduction to the mitochondrial anion carrier family. J. Bioenerg. Biomembr. 25, 431-434.
10. Sluse, F.E., Meijer, A.J. & Tager, J.M. (1971) Anion translocators in rat-heart mitochondria. FEBS Lett. 18, 149-153.
11. Sluse, F.E., Ranson, M. & Liébecq, C. (1972) Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the exchange reactions between 2-oxoglutarate, malate and malonate. Eur. J. Biochem. 25, 207-217.
12. Sluse, F.E., Goffart, G. & Liébecq, C. (1973) Mechanism of the exchanges catalyzed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition. Eur. J. Biochem. 32, 283-291.
13. Sluse, F.E., Sluse-Goffart, C.M., Duyckaerts, C. & Liébecq, C. (1975) Evidence for cooperative effects in the exchange reaction catalysed by the oxoglutarate translocator of rat-heart mitochondria. Eur. J. Biochem. 56, 1-14.
14. Sluse, F.E., Duyckaerts, C., Liébecq, C. & Sluse-Goffart, C.M. (1979) Kinetic and binding properties of the oxoglutarate translocator of rat-heart mitochondria. Eur. J. Biochem. 100, 3-17.
15. Sluse-Goffart, C.M., Sluse, F.E., Duyckaerts, C., Richard, M., Hengesch, P. & Liébecq, C. (1983) Conformational changes and possible structure of the oxoglutarate translocator of rat-heart mitochondria revealed by the kinetic study of malate and oxoglutarate uptake. Eur. J. Biochem. 134, 397-406.
16. Holzhütter, H.-G., Sluse-Goffart, C.M. & Sluse, F.E. (1994) Multiphase saturation curves of the oxoglutarate carrier: a mathematical model. Math. Comput. Modelling 19, 263-272.
17. Erdelt, H., Weidemann, M.J., Buchholz, M. & Klingenberg, M. (1972) Some principle effect of bongkrekic acid on the binding of adenine nucleotide to the mitochondrial membranes. Eur. J. Biochem. 30, 107-122.
18. Klingenberg, M. (1974) The mechanism of the mitochondrial ADP, ATP carrier as studied by the kinetics of ligand binding; in Dynamics of Energy-Transducing Membranes (Ernster, L., Estabrook, R.W. & Slater, E.C., eds.) pp. 511-528, Elsevier, Amsterdam.
19. Klingenberg, M. (1976) The ADP-ATP carrier in mitochondrial membranes; in The Enzymes of Biological Membranes (Martonosi, A., ed.) vol. 3, pp. 383-438, Plenum Press, NewYork.
20. Brandolin, G., Le Saux, A., Trezeguet, V., Lauquin, G.J.M. & Vignais, P.V. (1993) Chemical, immunological, enzymatic and genetic approaches to studying the arrangement of the peptide chain of the ADP/ATP carrier in the mitochondrial membrane. J. Bioenerg. Biomembr. 25, 459-472.
21. Krämer, R. & Klingenberg, M. (1982) Electrophoretic control of reconstituted adenine nucleotide translocation. Biochemistry 21, 1082-1089.
22. Duyckaerts, C., Sluse-Goffart, C.M., Fux, J.P., Sluse, F.E. & Liébecq, C. (1980) Kinetic mechanism of the exchanges catalysed by the adenine-nucleotide carrier. Eur. J. Biochem. 106, 1-6.
23. Sluse, F.E., Sluse-Goffart, C.M. & Duyckaerts, C. (1989) Kinetic mechanisms of the adenylic and the oxoglutaric carriers: a comparison; in Anion Carriers of Mitochondrial Membranes (Azzi, A., Nałe + (combining ogonek)cz, K.A., Nałe + (combining ogonek)cz, M.J. & Wojtczak, L., eds.) pp. 183-195, Springer-Verlag, Berlin.
24. Dierks, T. & Krämer, R. (1988) Asymmetric orientation of the reconstituted aspartate/ glutamate carrier from mitochondria. Biochim. Biophys. Acta 937, 112-126.
25. Sluse, F.E., Evens, A., Dierks, T., Duyckaerts, C., Sluse-Goffart, C.M. & Krämer, R. (1991) Kinetic study of the aspartate/glutamate carrier in intact rat heart mitochondria and comparison with a reconstituted system. Biochim. Biophys. Acta 1058, 329-338.
26. Palmieri, F., Bisaccia, F., Capobianco, L., Iacobazzi, V., Indiveri, C. & Zara, V. (1990) Structural and functional properties of mitochondrial anion carriers. Biochim. Biophys. Acta 1018, 147-150.
27. Nałe + (combining ogonek)cz, K.A. (1994) The mitochondrial pyruvate carrier: The mechanism of substrate binding; in Molecular Biology of Mitochondrial Transport Systems. (Forte, M. & Colombini, M., eds.) pp. 67-79, Springer Verlag, Berlin, Heidelberg.
28. Sluse, F.E., Duyckaerts, C., Evens, A. & Sluse-Goffart, C.M. (1994) Initial rate kinetic study of the pyruvate translocator in intact rat-heart mitochondria; in Biothermokinetics (Westerhoff, H.V., ed.) pp. 173-178, Intercept, Andover.
29. Indiveri, C., Dierks, T., Krämer, R. & Palmieri, F. (1991) Reaction mechanism of the reconstituted oxoglutarate carrier from bovine heart mitochondria. Eur. J. Biochem. 198, 339-347.
30. Indiveri, C., Prezioso, G., Dierks, T., Krämer, R. & Palmieri, F. (1993) Kinetic characterization of the reconstituted dicarboxylate carrier from mitochondria: a four-binding-site sequential transport system. Biochim. Biophys. Acta 1143, 310-318.
31. Bisaccia, F., De Palma, A., Dierks, T., Krämer, R., & Palmieri, F. (1993) Reaction mechanism of the reconstituted tricarboxylate carrier from rat liver mitochondria. Biochim. Biophys. Acta 1142, 139-145.
32. Indiveri, C., Palmieri, L. & Palmieri, F. (1994) Kinetic characterization of the reconstituted ornithine carrier from rat liver mitochondria. Biochim. Biophys. Acta 1188, 293-301.
33. Indiveri, C., Tonazzi, A. & Palmieri, F. (1994) The reconstituted carnitine carrier from rat liver mitochondria - evidence for a transport mechanism different from that of the other mitochondrial translocators. Biochim. Biophys. Acta 1189, 65-73.
34. Kamińska, J., Nał + (combining ogonek)ecz, K.A. & Nał + (combining ogonek)ecz, M.J. (1995) Mechanism of carnitine transport catalyzed by carnitine carrier from rat brain mitochondria. Ada Neurobiol. Exp. 55, 1-9.
35. Palmieri, F., Indiveri, C., Bisaccia, F. & Krämer, R. (1993) Functional properties of purified and reconstituted mitochondrial metabolite carriers. J. Bioenerg. Biomembr. 25, 525-535.
36. Klingenberg, M. (1993) Dialectics in carrier research: The ADP/ATP carrier and the uncoupling protein. J. Bioenerg. Biomembr. 25, 447-457.
37. Krämer, R. & Palmieri, F. (1989) Molecular aspects of isolated and reconstituted carrier proteins from animal mitochondria. Biochim. Biophys. Acta 974, 1-23.
38. Aquila, H., Misra, D., Eulitz, M. & Klingenberg, M. (1982) Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria. Hopper-Seyler's Z. Physiol Chem. 363, 345-349.
39. Capobianco, L., Bisaccia, F., Michel, A., Sluse, RE. & Palmieri, F. (1995) The N- and C-termini of the tricarboxylate carrier are exposed to the cytoplasmic side of the inner mitochondrial membrane. FEBS Lett. 357, 297-300.
40. Winkler, E. & Klingenberg, M. (1992) Photoaffinity labeling of the nucleotide-binding site of the uncoupling protein from hamster brown adipose tissue. Eur. J. Biochem. 203, 295-304.
41. Ferreira, G.G. & Pedersen, P.L. (1993) Phosphate transport in mitochondria: Past accomplishments, present problems and future challenges. J. Bioenerg. Biomembr. 25, 483-492.
42. Block, M.R. & Vignais, P.V. (1984) Substrate-site interactions in the membrane-bound adenine-nucleotide carrier as disclosed by ADP and ATP analogs. Biochim. Biophys. Acta 767, 369-376.
43. Klingenberg, M. (1981) Membrane protein oligomeric structure and transport function. Nature (London) 290, 449-454.
44. Klingenberg, M. & Appel, M. (1989) The uncoupling protein dimer can form a disulfide cross-link between the mobile C-terminal SH groups. Eur. J. Biochem. 180, 123-131.
45. Palmieri, R, Bisaccia, F., Capobianco, L., Dolce, V., Iacobazzi, V., Indiveri, C. & Zara, V. (1992) Structural and functional properties of two mitochondrial transport proteins: The phosphate carrier and the oxoglutarate carrier; in Molecular Mechanisms of Transport (Quagliariello, E. & Palmieri, R, eds.) pp. 151-158, Elsevier Science Publishers, Amsterdam.
46. Sluse, F.E., Evens, A., Duyckaerts, C., Hautecler, J. & Sluse-Goffart, C.M. (1993) Cooperativities in steady-state translocation of ADP by mitochondrial adenylic carrier. 2nd IUBMB Conf. Biochemistry of Cell Membranes, Bari, Abstr. p. 353.
47. Saier, M.H., Jr. & Reizer, J. (1991) Families and superfamilies of transport proteins common to prokaryotes and eukaryotes. Curr. Opin. Struct. Biol. 1, 362-368.
48. Weber, A., Menzlaff, E., Arbinger, B., Gutensohn, M., Eckerskorn, C. & Flügge, U.I. (1995) The 2-oxoglutarate/malate translocator of chloroplast envelope membranes: Molecular cloning of a transporter containing a 12-helix motif and expression of the functional protein in yeast cells. Biochemistry 34, 2621-2627.
49. Bairoch, A. (1992) PROSITE: A dictionary of sites and patterns in proteins. Nucleic Acids Res. 20, 2013-2018.
50. Wiesenberger, G., Link, T.A., Ahsen, U., Waldherr, M. & Schweyen, R.J. (1991) MRS3 and MRS4, two suppressors of mtRNA splicing defects in yeast, are new members of the mitochondrial carrier family. J. Mol. Biol. 217, 23-37.
51. Van Dyck, E., Jank, B., Ragnin, A., Schweyen, R.J., Duyckaert, C., Sluse, F.E. & Four, F. (1995) Overexpression of a novel member of the mitochondrial carrier family rescues defects in both DNA and RNA metabolism in yeast mitochondria. Mol. Gen. Genet. 246, 426-436.
52. Feng, D.F. & Doolittle, R.F. (1990) A nearest neighbor procedure for relating progressively aligned amino acid sequences. Methods Enzymol. 183, 375-387.
53. Kuan, J. & Saier, M.H., Jr. (1993) Expansion of the mitochondrial carrier family. Res. Microbiol. 144, 671-672.
54. Nelson, D.R., Lawson, J.E., Klingenberg, M. & Douglas, M.G. (1993) Site-directed mutagenesis of the yeast mitochondrial ADP/ATP translocator. Six arginines and one lysine are essential. J. Mol. Biol. 230, 1159-1170.
55. Adrian, G.S., McCammon, M.T., Montgomery, D.L. & Douglas, M.G. (1986) Sequences required for delivery and localization of the ADP/ATP translocator to the mitochondrial inner membrane. Mol. Cell. Biol. 6, 626-634.
56. Leblanc, P. & Clauser, H. (1972) ADP-dependent inhibition of sacrosomal adenine nucleotide translocase by N-ethylmaleimide. FEBS Lett. 23, 107-113.
57. Vignais, P.V. & Vignais, P.M. (1972) Effect of SH reagents on atractyloside binding to mitochondria and ADP translocation. Potentiation by ADP and its prevention by Uncoupler FCCP. FEBS Lett. 26, 27-31.
58. Aquila, H., Eiermann, W. & Klingenberg, M. (1982) Incorporation of N-ethylmaleimide into the membrane-bound ADP/ATP translocator. Isolation of the protein labeled with N-[3H]ethykmaleimide. Eur. J. Biochem. 122, 133-139.
59. Nelson, D.R. & Douglas, M.G. (1993) Function-based mapping of the yeast mitochondrial ADP/ATP translocator by selection for second site revertants. J. Mol. Biol. 230, 1171-1182.
60. Klingenberg, M. & Nelson, D.R. (1994) Structure-function relationships of the ADP/ATP carrier. Biochim. Biophys. Acta 1187, 241-244.
61. Wohlrab, H. & Briggs, C. (1994) Yeast mitochondrial phosphate transport protein expressed in Escherichia coli. Site-directed mutations at threonine-43 and at a similar location in the second tandem repeat (isoleucine-141). Biochemistry 33, 9371-9375.
62. Fiermonte, G., Walker, J.E. & Palmieri, F. (1993) Abundant bacterial expression and reconstitution of an intrinsic membrane-transport protein from bovine mitochondria. Biochem. J. 294, 293-299.
63. Kaplan, R.S., Mayor, J.A., Gremse, D.A. & Wood, D.O. (1995) High level expression and characterization of the mitochondrial citrate transport protein from the yeast Saccharomyces cerevisiae. J. Biol. Chem. 270, 4108-4114.