Direct effects of diazoxide on mitochondria in pancreatic B-cells and on isolated liver mitochondria

British Journal of Pharmacology

Volumn 123, Issue 5, 1998, Pages 781-788

  Grimmsmann, T ^a   Rustenbeck, I ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ATP; Ca2+; Diazoxide; Insulin secretion; K(ATP) channel openers; Mitochondria; Mitochondrial membrane potential; Pancreatic B cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM ION; DIAZOXIDE; GALLOPAMIL; HYPERGLYCEMIC AGENT; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; RHODAMINE 123;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; ENERGY METABOLISM; LIVER MITOCHONDRION; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CROMAKALIM; DIAZOXIDE; GALLOPAMIL; GUANIDINES; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; MICE; MICE, OBESE; MITOCHONDRIA; MITOCHONDRIA, LIVER; OXIDATIVE PHOSPHORYLATION; PINACIDIL; POTASSIUM CHANNELS; RATS; RHODAMINE 123; RHODAMINES;

EID: 0031883631     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701663     Document Type: Article

References (43)

1. + channel Kir6.1 expressed in human embryonic kidney cells. J. Physiol., 494, 709 - 714.
2. ASHCROFT, S.J.H., HEDESKOV, C.J. & RANDLE, P.J. (1970). Glucose metabolism in mouse pancreatic islets. Biochem. J., 118, 143 - 154.
3. + fluxes in rat liver mitochondria. Biochem. Mol. Biol. Int., 31, 493 - 500.
4. BJÖRKLUND, A. & GRILL, V. (1993). B-cell insensitivity in vitro: reversal by diazoxide entails more than one event in stimulussecretion coupling. Endocrinology, 132, 1319 -1328.
5. CHAN, S.L.F. & MORGAN, N.G. (1990). Stimulation of insulin secretion of efaroxun may involve interaction with potassium channels. Eur. J. Pharmacol., 176, 97 - 101.
6. CHEN, L.B. (1988). Mitochondrial membrane potential in living cells. Ann. Rev. Cell. Biol., 4, 155 - 181.
7. DETIMARY, P., GILON, P., NENQUIN, M. & HENQUIN, J.C. (1994). Two sites of glucose control of insulin release with distinct dependence on the energy state of pancreatic B-cells. Biochem. J., 297, 455 - 461.
8. DUCHEN, M., SMITH, P.A. & ASHCROFT, F.M. (1993). Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic β-cells. Biochem. J., 294, 35 -42.
9. EDWARDS, G. & WESTON, A.H. (1993). The pharmacology of ATP-sensitive potassium channels. Ann. Rev. Pharmacol. Toxicol., 33, 597 - 637.
10. ERECINSKA, M., BRYLA, J., MICHALIK, M., MEGLASSON, M. & NELSON, D. (1992). Energy metabolism in islets of Langerhans. Biochim. Biophys. Acta, 1101, 273 - 295.
11. FRERICHS, H., GERBER, R. & CREUTZFELDT, W. (1966). Insulinsekretion in vitro. II. Hemmung der Glucose-induzierten Insulinabgabe durch Diazoxid. Diabetologia, 2, 269 - 276.
12. ATp channel as a receptor for potassium channel openers. J. Biol. Chem., 271, 8796 -8799.
13. + channels in mouse pancreatic islets. Br. J. Pharmacol., 98, 957 -965.
14. + channels in mouse B cells. J. Clin. Invest., 89, 1288 -1295.
15. 2+ indicators with greatly improved properties. J. Biol. Chem., 260, 3440 -3450.
16. GUNTER, T.E. & PFEIFFER, D.R. (1990). Mechanisms by which mitochondria transport calcium. Am. J. Physiol., 258, C755 - C786.
17. HELLMAN, B. (1965). Studies in obese-hyperglycemic mice. Ann. New York Acad. Sci., 131, 541 - 558.
18. HELLMAN, B., IDAHL, L.A., LERNMARK, A., SEHLIN, J. & TÄLJEDAL, I.B. (1974). The pancreatic β-cell recognition of secretagogues. Biochem. J., 138, 33 -45.
19. + fluxes and membrane potential in pancreatic β-cells. Biochem. Pharmacol., 31, 1407 - 1415.
20. HENQUIN, J.C., CHARLES, S., NENQUIN, M., MATHOT, F. & TAMAGAWA, T. (1982). Diazoxide and D 600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli. Diabetes, 31, 776 - 778.
21. + channel in the mitochondrial inner membrane. Nature, 352, 244 - 247.
22. KAMO, N., MURATSUGU, M., HONGOH, R. & KOBATAKE, Y. (1979). Membrane potential of mitochondria measured with an electrode sensitive to tetraphenylphosphonium and relationship between electrochemical potential and phosphorylation potential in steady state. J. Membrane Biol., 49, 105 - 121.
23. 2+ in aequorin-expressing INS-1 cells. J. Clin. Invest., 98, 2524 - 2538.
24. + currents recorded from an insulin-secreting cell line. Br. J. Pharmacol., 97, 1039 -1050.
25. LENZEN, S. & PANTEN, U. (1983). Characterization of succinate dehydrogenase and α-glycerophosphate dehydrogenase in pancreatic islets. Biochem. Medicine, 30, 349 - 356.
26. 2+ transport. Biochem. J., 286, 597 -602.
27. MACCORMACK, J.G. HALESTRAP, A.P. & DENTON, R. (1990). Role of calcium ions in regulation of mammalian intramitochondial metabolism. Physiol. Rev., 70, 391 - 425.
28. MACDONALD, M. (1981). High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. J. Biol. Chem., 256, 8287 - 8290.
29. MCDONALD, M. (1984). The use of calcium uptake by small amounts of mitochondria from pancreatic islets to study mitochondrial respiration: The effects of diazoxide and sodium. Biochem. Int., 8, 771 - 778.
30. MURATSUGU, M., KAMO, N., KURIHARA, K. & KOBATAKE, Y. (1977). Selective electrode for dibenzyl dimethyl ammonium cation as indicator of the membrane potential in biological systems. Biochim. Biophys. Acta. 464, 613 - 619.
31. NICHOLS, C.G., SHYNG, S.L., NESTOROWICZ, A., GLASER, B., CLEMENT, J.P., GONZALEZ, G., AGUILAR-BRYAN, L., PERMUTT, M.A. & BRYAN, J. (1996). Adenosine diphosphate as an intracellular regulator of insulin secretion. Science, 272, 1785 - 1787.
32. 2 consumption by isolated pancreatic islets as measured in a microincubation system with a Clark-type electrode. Endocrinology. 111, 1595 - 1600.
33. PANTEN, U. BIERMANN, J. & GRAEN, W. (1981). Recognition of insulin-releasing fuels hy pancreatic B-cells. α-Ketoisocaproic acid is an appropriate model compound to study the role of B-cell metabolism. Mol. Pharmacol., 20, 76 -82.
34. PORTENHÄUSER, R., SCHÄFER, G. & TROLP, R (1971). Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide II: interaction with energy conservation and ion transport. Biochem. Pharmacol., 20, 2623 -2632.
35. RITCHIE R.J. (1984). A critical assessment of the use of lipophilic cations as membrane potential probes. Prog. Biophys. Mol. Biol., 43, 1 -32.
36. RUSTENBECK, I., HERRMANN, C & GRIMMSMANN, T. (1997). Energetic requirement of insulin secretion distal to calcium influx. Diabetes, 46, 1305 -1311.
37. 2+ release in isolated liver mitochondria. Biochim. Biophys. Acta. 1304, 129 -138.
38. SCHÄFER, G., PORTENHÄUSER, R. & TROLP, R. (1971). Inhibition of mitochondrial metabolism by the diabetogenic thiadiazine diazoxide I: action on succinate dehydrogenase and TCA-cycle oxidations. Biochem. Pharmacol., 20, 1271 -1280.
39. SELTZER, M.S. & ALLEN, E.W. (1965). Inhibition of insulin secretion in "diazoxide diabetes" Diabetes. 14, 439 (abstr.).
40. STURGESS, N.C., ASHFORD, M.L.J., COOK, D.L. & HALES, C.N. (1985). The sulfonylurea receptor may be an ATP-sensitive K channel. Lancet. ii, 474 -475.
41. + channel-independent glucose action. Endocrinology, 136, 3942 -3948.
42. + channel in mouse pancreatic β-cells. Pflügers Arch., 407, 493 -499.
43. + currents in pancreatic B-cells. Naunyn-Schmiedeberg's Arch. Pharmacol., 337, 225 -230.