ATP-sensitive potassium channels: A review of their cardioprotective pharmacology

Journal of Molecular and Cellular Cardiology

Volumn 32, Issue 4, 2000, Pages 677-695

  Grover, Gary J ^a   Garlid, Keith D ^b  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

ATP sensitive potassium channels; Heart; Mitochondria; Myocardial Ischemia; Preconditioning

Indexed keywords

ADENOSINE TRIPHOSPHATE; APRIKALIM; CROMAKALIM; DIAZOXIDE; GLIBENCLAMIDE; LACTATE DEHYDROGENASE; N (4 CHLOROPHENYL) N' CYANO N'' (6 CYANO 3,4 DIHYDRO 3 HYDROXY 2,2 DIMETHYL 2H 1 BENZOPYRAN 4 YL)GUANIDINE; NICORANDIL; PINACIDIL; POTASSIUM CHANNEL; POTASSIUM CHANNEL STIMULATING AGENT; POTASSIUM ION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOPLEGIA; CONTROLLED STUDY; DRUG MECHANISM; HEART ARRHYTHMIA; HEART MITOCHONDRION; HEART MUSCLE POTENTIAL; HEART PROTECTION; HUMAN; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 0033837022     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1111     Document Type: Article

References (136)

1. + channels in cardiac muscle
2. The pharmacology of ATP-sensitive potassium channels
3. Potassium channels in cardiac cells activated by arachidonic acid and phospholipids
4. 1 receptors by G proteins in rat ventricular myocytes
5. Effects of thiolmodifying agents on K(ATP) channels in guinea pig ventricular cells
6. Beta 2-adrenergic dilation of resistance coronary vessels involves K(ATP) channels and nitric oxide in conscious dogs
7. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA
8. Voltage-dependent ATP-sensitive potassium channels of skeletal muscle membrane
9. + channels that are blocked by hypoglycemia-inducing sulfonylureas in insulin-secreting cells are activated by galanin. A hyperglycemia-inducing hormone
10. The regional distribution of sulphonylurea binding sites in rat brain
11. The sulphonylurea receptor may be an ATP-sensitive potassium channel
12. Interaction of diazoxide, tolbutamide and STP on nucleotide-dependent K+ channels in an insulin-secreting cell line
13. Glucose induces closure of single potassium channels in isolated rat pancreatic ε-bgr-cells
14. Preconditioning of isolated rat heart is mediated by protein kinase C
15. + channels
16. Effects of intracoronary cromakalim on post-ischaemic contractile function and action potential duration
17. Electrophyiosologic effects of acute myocardial ischemia: A theoretical study of altered cell excitability and action potential duration
18. + channels in guinea pig ventricular cells and its modulation by glycolysis
19. + loss during hypoxia, ischemia, and metabolic inhibition in mammalian ventricle
20. Glibenclamide attenuates peaked T wave in early phase of myocardial ischemia
21. Reconstitution of IK(ATP): An inward rectifier subunit plus the sulfonylurea receptor
22. + channels
23. + channels
24. + channels
25. ATP-sensitive potassium channels: Molecular structure and therapeutic potential in smooth muscle
26. Studies of the unitary properties of adenosine-5'-triphosphate-regulated potassium channels of frog skeletal muscle
27. + channel activity in rat ventricular myocytes by phosphorylation of tyrosine and serine/threonine residues
28. + channels
29. + current in human and rabbit ventricular myocytes
30. Prostacyclin-induced vasodilation in rabbit heart is mediated by ATP-sensitive potassium channels
31. 2 receptors and cAMP-dependent protein kinase
32. Enhancement of ATP-sensitive potassium current in cat ventricular myocytes by ε-bgr-adrenergic stimulation
33. + current by extracellular ATP in rat ventricular myocytes. Involvement of adenylyl cyclase-induced subsarcolemmal ATP depletion
34. Activators of protein kinase C depolarize insulin-secreting cells by closing potassium channels
35. + channels protect the myocardium against ischemia/reperfusion damage
36. Cardioselective anti-ischemic ATP-sensitive potassium channel openers
37. Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive potassium channels: Possible mechanism of cardioprotection
38. Improved recovery of myocardial segmental function following a short coronary occlusion in dogs by nicorandil. A potential new antianginal agent, and nifedipine
39. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide
40. The protective effects of cromakalim and pinacidil on reperfusion function and infarct size in isolated perfused rat hearts and anesthetized dogs
41. Cardioprotective effects of the potassium channel opener cromakalim: Stereoselectivity and effects on myocardial adenine nucleotides
42. Reduction of ischemic damage in isolated rat hearts by the potassium channel opener RP 52891
43. Cardioprotective effects of the cyanoguanidine potassium channel opener P-1075
44. Cardioprotective effects of KRN2391 and nicorandil on ischemic dysfunction in perfused rat heart
45. Effects of potassium channel modulation during global ischaemia in isolated rat heart with and without cardioplegia
46. Protective effects of ATP-sensitive potassium-channel openers in experimental myocardial ischemia
47. BMS-280448. A glyburide-reversible cardioprotective agent with minimal vasodilator activity
48. Ischaemic preconditioning delays ischaemia induced cellular electrical uncoupling in rabbit myocardium by activation of ATP sensitive potassium channels
49. Amelioration of ischemia/reperfusion injury in isolated rats hearts by the ATP-sensitive potassium channel opener BMS-180448
50. Potassium channels and preconditioning of isolated rabbit cardiomyocytes: Effects of glyburide and pinacidil
51. 1 receptor and K(ATP) channel
52. + channel? Studies of contractile function after simulated ischemia in an atrial in vitro model
53. Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning
54. + channel opener aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes
55. Involvement of ATP-sensitive potassium channels in preconditioning protection
56. Involvement of activation of ATP-dependent potassium channels in ischemic preconditioning in swine
57. Limitation of myocardial injury with the potassium channel opener cromakalim and the nonvasoactive analog U-89.232: Vascular vs. cardiac actions in vitro and in vivo
58. Comparative effects of nitroprusside and pinacidil on myocardial blood flow and infarct size in awake dogs with acute myocardial infarction
59. Potassium channel activators cromakalim and celikalim (WAY-120,491) fail to decrease myocardial infarct size in the anesthetized canine
60. Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode
61. Does protein kinase C play a pivotal role in the mechanisms of ischemic preconditioning
62. 0-ATPase
63. Toward the heart of preconditioning
64. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts
65. Ischaemic preconditioning: Present position and future directions
66. Preconditioning protects ischemic rabbit heart by protein kinase C activation
67. Signal transduction in ischemic preconditioning
68. Protein tyrosine kinase inhibitor, genistein, blocks preconditioning in isolated rabbit hearts
69. Ischemic preconditioning triggers the activation of MAP kinases and MAPKAP kinase 2 in rat hearts
70. Activation of ATP-sensitive potassium channels lowers threshold for ischemic preconditioning in dogs
71. Blockade of ATP-sensitive potassium channels prevents myocardial preconditioning in dogs
72. Blockade of ischemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate
73. Role of the K(ATP) channel in ischemic preconditioning
74. The ischemia-selective channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart
75. + channels in rat heart
76. + channel blocker
77. 1-receptors
78. Cardioprotection provided by adenosine receptor activation is abolished by blockade of the K(ATP) channel
79. 1 receptors. K(ATP) channels, and ischemic preconditioning in dogs
80. Protection from ischaemic-reperfusion injury with adenosine treatment is reversed by inhibition of ATP-sensitive potassium channels
81. + channel
82. - channels in cerebral ischemic preconditioning
83. 1 receptor stimulation
84. Infarct size-limiting effect of ischemic preconditioning is blunted by inhibition of 5'-nucleotidase activity and attenuation of adenosine release
85. 1 receptor blockade does not abolish the cardioprotective effects of the adenosine triphosphate-sensitive potassium channel opener bimakalim
86. Protein kinase C mediates Ca2+-induced cardioadaptation to ischemia-reperfusion injury
87. Cardiac preconditioning with calcium: Clinically accessible myocardial protection
88. 2+ as a mediator of ischemic preconditioning
89. Isoproterenol mimics calcium preconditioning-induced protection against ischemia
90. Calcium preconditioning elicits strong protection against ischemic injury via protein kinase C signalling pathway
91. KATP channels are common mediators of ischemic and calcium preconditioning in rabbits
92. Glibenclamide-induced blockade of ischemic pre-conditioning is time dependent in intact rat heart
93. Specific block of the anti-ischemic actions of cromakalim by sodium 5-hydroxydecanoate
94. Effect of potassium channel blockade on the anti-schemic actions of mechanistically diverse agents
95. Bimakalim, an ATP-sensitive potassium channel opener, mimics the effects of ischemic preconditioning to reduce infarct size, adenosine release, and neutrophil function in dogs
96. Effect of timing of treatment on the glyburide-reversible cardioprotective effects of BMS-180448
97. Protective effect of K(ATP) openers in ischemic rat hearts treated with a potassium cardioplegic solution
98. + channels involves high-energy phosphate preservation
99. Cardioprotective effects of the ATP-sensitive potassium channel opener BMS-180448: Functional and energetic considerations
100. + channel modulator aprikalim (RP 52891): Improved cardioprotection in isolated ischemic rabbit hearts
101. Effects of the K(ATP) channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs
102. Cardioprotection with the K(ATP) opener cromakalim is not correlated with ischemic myocardial action potential duration
103. Shortening of action potential duration is not a prerequisite for cardiac protection by ischemic preconditioning or a K(ATP) channel opener
104. Glyburide-reversible cardioprotective effect of BMS-180448 is independent of action potential shortening
105. Mechanical and electrophysiological effects of preconditioning in isolated ischemic/reperfused rat hearts
106. Potassium channel blocker dofetilide does not abolish ischaemic preconditioning
107. Different effects of K(ATP) channel blockers on ischemic preconditioning
108. Binding of ATP-sensitive potassium channel openers to cardiac membranes: Correlation of binding affinities with cardioprotective and smooth muscle relaxing potencies
109. A specific binding site for K(ATP) channel openers in rat aorta
110. Coupling of phosphorylation to electron and hydrogen transfer by a chemiosmotic type of mechanism
111. Chemiosmotic coupling in oxidative and photosynthetic phosphorylation
112. +-loss
113. + exchanger
114. Mitochondrial Volume Control
115. + antiporter from rat liver mitochondria
116. + channel in the mitochondrial inner membrane
117. - channel from rat liver and beef heart mitochondria
118. The nucleotide regulatory sites on the mitochondrial K(ATP) channel face the cytosol
119. + uniport in intact mitochondria by adenine nucleotides and nucleotide analogs
120. State-dependent inhibition of the mitochondrial K(ATP) channel by glyburide and 5-hydroxydecanoate
121. The mitochondrial K(ATP) channel as a receptor for potassium channel openers
122. Inhibition of the mitochondrial K(ATP) channel by long-chain acyl-CoA esters and activation by guanine nucleotides
123. Potassium channel pharmacology
124. + channels in mitochondria
125. Mitochondrial ATP-dependent potassium channels: Novel effectors of cardioprotection?
126. - channels by protein kinase
127. Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death
128. Electrophysiologic and arrhythmogenic effects of the potassium channel agonist BRL 38227 in anesthetized dogs
129. Effects of BMS-191095. A nonvasodilating KATP opener, on hemodynamics, electrophysiology, cardioprotection, and arrhythmias in naive and myocardial infarcted dogs
130. + channels modify ischaemia-induced ventricular arrhythmias in anaesthetized dogs?
131. Electrophysiological effects of ATP senstivie potassium channel modulation: Implications for arrhythmogenesis
132. Pro-arrhythmic effect of nicorandil in isolated rabbit atria and its suppression by tolbutamide and quinidine
133. Influence of ATP-sensitive potassium channel modulators on ischemia-induced fibrillation in isolated rat hearts
134. Acute adenosine treatment is effective in augmentation of ischemic tolerance in muscle flaps in the pig
135. Effector mechanism of adenosine in acute ischemic preconditioning of skeletal muscle against infarction
136. + channels in ischemic preconditioning of skeletal muscle against infarction