Nicorandil, a potent cardioprotective agent, acts by opening mitochondrial ATP-dependent potassium channels

Journal of the American College of Cardiology

Volumn 35, Issue 2, 2000, Pages 514-518

  Sato, Toshiaki ^a   Sasaki, Norihito ^a   O'Rourke, Brian ^a   Marbán, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYDECANOIC ACID; CLAMIKALANT; NICORANDIL; POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL DEATH; DRUG MECHANISM; HEART INFARCTION PREVENTION; HEART MUSCLE CELL; HEART PROTECTION; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0034048933     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(99)00552-5     Document Type: Article

References (32)

1. N. Taira Nicorandil as a hybrid between nitrates and potassium channel activators Am J Cardiol 63 1989 18J 24J
2. Krumenacker M, Roland E. Clinical profile of nicorandil: an overview of its haemodynamic properties and therapeutic efficacy. J Cardiovasc Pharmacol 1992;20:S93–102.
3. G.J. Gross The cardioprotective effects of nicorandil Rev Contemp Pharmacother 4 1993 199 206
4. T. Mizumura K. Nithipatikom G.J. Gross Effects of nicorandil and glyceryl trinitrate on infarct size, adenosine release, and neutrophil infiltration in the dog Cardiovasc Res 29 1995 482 489
5. J. Imagawa G.F. Baxter D.M. Yellon Myocardial protection afforded by nicorandil and ischaemic preconditioning in a rabbit infarct model in vivo J Cardiovasc Pharmacol 31 1998 74 79
6. S. Saito T. Mizumura T. Takayama Antiischemic effects of nicorandil during coronary angioplasty in humans Cardiovasc Drugs Ther 9 1995 257 263
7. Y. Kobayashi Y. Goto S. Daikoku Cardioprotective effect of intravenous nicorandil in patients with successful reperfusion for acute myocardial infarction Jpn Circ J 62 1998 183 189
8. H. Ito Y. Taniyama K. Iwakura Intravenous nicorandil can preserve microvascular integrity and myocardial viability in patients with reperfused anterior wall myocardial infarction J Am Coll Cardiol 33 1999 654 660
9. ATPchannel in unstable angina is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization Eur Heart J 20 1999 51 57
10. C.G. Nichols W.J. Lederer Adenosine triphosphate-sensitive potassium channels in the cardiovascular system Am J Physiol 261 1991 H1675 H1686
11. +channels possible mechanism of cardioprotection Circ Res 81 1997 1072 1082
12. Y. Liu T. Sato B. O’Rourke E. Marban Mitochondrial ATP-dependent potassium channels novel effectors of cardioprotection? Circulation 97 1998 2463 2469
13. +channels by protein kinase C Circ Res 83 1998 110 114
14. K. Sakai Y. Tsuchiya S. Kitajima H. Hamada Myocardial distribution and biotransformation in vitro and in vivo of nicorandil in rats, with special reference to mitochondria J Cardiovasc Pharmacol 33 1999 163 168
15. +currents by protein kinase C and adenosine implications for ischemic preconditioning Circ Res 78 1996 443 454
16. R.S.V. Vander Heide D. Rim C.M. Hohl C.E. Ganote An in vitro model of myocardial ischemia utilizing isolated adult rat myocytes J Mol Cell Cardiol 22 1990 165 181
17. Sato T, Sasaki N, Seharaseyon J, O’Rourke B, Marbán E. Selective pharmalogical agents implicate mitochondrial, but not sarcolemmal, K atp channels in ischemic cardioprotection. Circulation. In Press.
18. ATPchannel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs Circulation 89 1994 1769 1775
19. ATPopener cromakalim is not correlated with ischemic myocardial action potential duration J Cardiovasc Pharmacol 26 1995 145 152
20. +blocker dofetilide Am J Physiol 40 1996 H1207 H1214
21. S.C. Armstrong J.M. Downey C.E. Ganote Preconditioning of isolated rabbit cardiomyocytes induction by metabolic stress and blocked by the adenosine antagonist SPT and calphostin C, a protein kinase C inhibitor Cardiovasc Res 28 1994 72 77
22. Y. Liu W.D. Gao B. O’Rourke E. Marban Cell-type specificity of preconditioning in an in vitro model Basic Res Cardiol 91 1996 450 457
23. +channels and protects against simulated ischemia in rabbit myocytes J Mol Cell Cardiol 29 1997 1123 1130
24. Sasaki N, Sato T, Ohler A, et al. Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation. In Press.
25. C.E. Murry R.B. Jenings K.A. Reimer Preconditioning with ischemia a delay of lethal cell injury in ischemic myocardium Circulation 74 1986 1124 1136
26. M.V. Cohen J.M. Downey Ischemic preconditioning can the protection be bottled? Lancet 342 1993 6
27. D.M. Yellon A.M. Alkhulaifi W.B. Pugsley Preconditioning the human myocardium Lancet 342 1993 276 277
28. R.A. Kloner D.M. Yellon Does ischemic preconditioning occur in patients? J Am Coll Cardiol 24 1994 1133 1142
29. ATPchannels and actin cytoskeleton Am J Physiol 276 1999 H1361 H1368
30. J.A. Auchampach G.J. Grover G.J. Gross Blockade of ischaemic preconditioning in dogs by the novel ATP dependent potassium channel antagonist sodium 5-hydroxydecanoate Cardiovasc Res 26 1992 1054 1062
31. E.J. Hide C. Thiemermann Limitation of myocardial infarct size in the rabbit by ischaemic preconditioning is abolished by sodium 5-hydroxydecanoate Cardiovasc Res 31 1996 941 946
32. L. Chi A.C. Uprichard B.R. Lucchesi Profibrillatory actions of pinacidil in a conscious canine model of sudden coronary death J Cardiovasc Pharmacol 15 1990 452 464