Lonidamine triggers apoptosis via a direct, Bcl-2-inhibited effect on the mitochondrial permeability transition pore

Oncogene

Volumn 18, Issue 16, 1999, Pages 2537-2546

  Ravagnan, Luigi ^a   Marzo, Isabel ^a   Costantini, Paola ^a   Susin, Santos A ^a   Zamzami, Naoufal ^a   Petit, Patrice X ^a   Hirsch, François ^a   Goulbern, Marc ^b   Poupon, Marie France ^c   Miccoli, Laurent ^c   Xie, Zhihua ^d   Reed, John C ^d   Kroemer, Guido ^a  

^a CNRS   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c INSTITUT CURIE   (France)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Lonidamine; Mitochondrial megachannel; Permeability transition; Programmed cell death

Indexed keywords

ANTINEOPLASTIC AGENT; BENZODIAZEPINE RECEPTOR; CYCLOSPORIN A; DNA; LIPOSOME; LONIDAMINE; MUTANT PROTEIN; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PROTEIN BCL 2; RECOMBINANT PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOLYSIS; DNA DEGRADATION; DNA TRANSFECTION; DRUG MECHANISM; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL-FREE SYSTEM; CYSTEINE PROTEINASE INHIBITORS; HUMANS; INDAZOLES; ION CHANNELS; ISOQUINOLINES; MITOCHONDRIA; PERMEABILITY; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; SUBCELLULAR FRACTIONS; U937 CELLS;

EID: 0033594404     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1202625     Document Type: Article

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