Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation

Arthritis and Rheumatism

Volumn 39, Issue 12, 1996, Pages 1998-2003

  Mahmud, Taher ^a   Rafi, Sue S ^a   Scott, David L ^a   Wrigglesworth, John M ^b   Bjarnason, Ingvar ^c  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 FLUOROPHENYL) 1 [(4 METHYLSULFONYL)PHENYL] 3 TRIFLUOROMETHYLPYRAZOLE; 5 BROMO 2 (4 FLUOROPHENYL) 3 (4 METHYLSULFONYLPHENYL)THIOPHENE; 6 METHOXY 2 NAPHTHYLACETIC ACID; ACETYLSALICYLIC ACID; AZAPROPAZONE; CYCLOOXYGENASE 2 INHIBITOR; DICLOFENAC; ETODOLAC; FENBUFEN; FLURBIPROFEN; FLURBIPROFEN DERIVATIVE; IBUPROFEN; INDOMETACIN; KETOPROFEN; NABUMETONE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; SALICYLIC ACID; SALICYLIC ACID DERIVATIVE; SULINDAC; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIGESTIVE SYSTEM INJURY; INFLAMMATION; LIVER MITOCHONDRION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; PKA; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYCLOOXYGENASE INHIBITORS; FLURBIPROFEN; MITOCHONDRIA, LIVER; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; THIOPHENES;

EID: 0030447091     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780391208     Document Type: Article

References (27)

1. Collins AJ, Davis J, Dixon ASJ: Contrasting presentation and findings between patients with rheumatic complaints taking non-steroidal anti-inflammatory drugs and a general population referred to endoscopy. Br J Rheumatol 25:50-53, 1986
2. Langman MJS: Epidemiological evidence on the association between peptic ulceration and anti-inflammatory drugs. Gastroenterology 96:640-646, 1989
3. Bjarnason I, Zanelli G, Prouse P, Smethurst P, Smith T, Levi S, Gumpel MJ, Levi AJ: Blood and protein loss via small-intestinal inflammation induced by non-steroidal anti-inflammatory drugs. Lancet ii:711-714, 1987
4. Vane JR: Inhibition of prostaglandin synthesis as mechanism of action of aspirin-like drugs. Nature 231: 232-235, 1971
5. Mahmud T, Scott DL, Bjarnason I: A unifying hypothesis for the mechanism of NSAID related gastrointestinal toxicity. Ann Rheum Dis 55:211-213, 1996
6. Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O: Prostaglandin synthase 1 gene disruption in mice reduces arachadonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell 83:483-492, 1995
7. Somasundaram S, Hayllar J, Rafi S, Wrigglesworth JM, Macpherson AJS, Bjarnason I: The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastro-intestinal tract: a review and a hypothesis. Scand J Gasteroenterol 30:289-299, 1995
8. Somasundaram S, Rafi S, Hayllar J, Price AB, Macpherson A, Mahmud T, Scott DL, Wrigglesworth JM, Bjarnason I: The importance of uncoupling of oxidative phosphorylation in the gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. Submitted for publication
9. Whitehouse MW: Biochemical properties of anti-inflammatory drugs. III. Uncoupling of oxidative phosphorylation in a connective tissue (cartilage) on liver mitochondria by salicyclate analogues: relationship of structure to activity. Biochem Pharmacol 13:319-336, 1964
10. Kawai K, Shiojiri H, Fukushima H, Norawa Y: The inhibition of mitochondrial respiration by indomethacin, a nonsteroidal anti-inflammatory agent possessing inhibitory effect on prostaglandin biosynthesis. Res Commun Chem Pathol Pharmacol 48:267-274. 1985
11. Mehlman MA, Tobin RB, Sporn EM: Oxidative phosphorylation and respiration by rat liver mitochondria from aspirin treated rats. Biochem Pharmacol 21:3279-3285, 1972
12. Tokumitsu Y, Lee S, Ui M: In vitro effects of nonsteroidal anti-inflammatory drugs on oxidative phosphorylation in rat liver mitochondria. Biochem Pharmacol 26:2101-2106, 1977
13. Boyce S, Chan CC, Gordon R, Li C-S, Rodger IW, Webb JK, Rupniak NMJ, Hill RG: L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinoception but not gastric ulceration in rats. Neuropharmacology 33:1609-1611, 1994
14. Schneider WC, Hogeboom KEO: Intracellular distribution of enzymes.V. Further studies on the distribution of cytochrome c in liver homogenate. J Biol Chem 183:123-128, 1950
15. Chance B, Williams GR: Respiratory chain and oxidative phosphorylation. Adv Enzymol 17:65-134, 1955
16. Brune K, Rainsford KD, Schweitzer A: Biodistribution of mild analgesics. Br J Clin Pharmacol 10 (suppl): 279S-284S, 1980
17. Whitehouse MW: Uncoupling of oxidative phosphorylation by some aryl acetic drugs. Nature 201: 629-630, 1964
18. McDougall P, Markham AS, Cameron I, Sweetman AJ: The mechanism of inhibition of mitochondrial oxidative phosphorylation by the nonsteroidal anti-inflammatory agent diflunisal. Biochem Pharmacol 32:2595-2598, 1983
19. Wallace JL, Reuter B, Cicala C, McKnight W, Grisham MB, Cirino G: Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 107:173-190, 1994
20. Rainsford KD, Whitehouse MW: Anti-inflammatory antipyretic-salicylic esters, with low gastric ulcerogenic activity. Agents Actions 10:451-456, 1980
21. Fuhro R, Fromm D: Effects on compounds chemically related to salicyclate on isolated antral mucosa of rabbits. Gastroenterology 75:661-667, 1978
22. Rainsford KD: Mechanism of GI toxicity of non-steroidal anti-inflammatory drugs. Scand J Gastroenterol Suppl 163:9-16, 1989
23. Daneshmend TK, Stein AG, Bhaskar NK, Hawkey CJ: Abolition by omeprazole of aspirin induced gastric mucosal injury in man. Gut 31:514-517, 1991
24. Carson JL, Strom BL, Morse ML: The relative gastrointestinal toxicity of nonsteroidal anti-inflammatory drugs. Arch Intern Med 147:1054-1059, 1987
25. Griffin MR, Piper JM, Dougherty JR, Snowden M, Ray WA: Nonsteroidal anti-inflammatory drug use and increased risk of peptic ulcer disease in elderly patients. Ann Intern Med 114:257-263, 1991
26. Roth SH, Bennett R, Caldron P, Mitchell C, Swenson C, Koepp R: A longterm endoscopic evaluation of patients with arthritis treated with nabumetone vs naproxen. J Rheumatol 21:1118-1123, 1994
27. Lister BJ, Poland M, DeLapp RE: Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis. Am J Med (suppl) 95:2S-9S, 1993