Absence of stereospecific effects of bupivacaine isomers on heart mitochondrial bioenergetics

Anesthesiology

Volumn 93, Issue 2, 2000, Pages 456-462

  Sztark, François ^a,b,c   Nouette Gaulain, Karine ^a,b   Malgat, Monique ^a   Dabadie, Philippe ^a,b   Mazat, Jean Pierre ^a  

^a UNIVERSITÉ DE BORDEAUX   (France)

^b HÔPITAL PELLEGRIN   (France)

^c INSERM   (France)

Author keywords

Local anesthetics; Mitochondria; Stereoisomers.

Indexed keywords

BUPIVACAINE;

ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HEART MITOCHONDRION; HEART MUSCLE OXYGEN CONSUMPTION; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; STEREOSPECIFICITY;

EID: 0033853187     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200008000-00025     Document Type: Article

References (32)

1. Studies on the mechanism of uncoupling by amide local anesthetics
2. Uncoupling effects of local anesthetics on rat liver mitochondria
3. Effects of the local anesthetic bupivacaine on oxidative phosphorylation in mitochondria
4. In vitro study on mechanisms of bupivacaine-induced depression of myocardial contractility
5. Experimental evidence in favor of role of intracellular actions of bupivacaine in myocardial depression
6. Effects of bupivacaine on cellular oxygen consumption and adenine nucleotide metabolism
7. Is bupivacaine a decoupler, a protonophore or a proton-leak-inducer?
8. On the mechanism by which bupivacaine conducts protons across the membranes of mitochondria and liposomes
9. Multiples sites of inhibition of mitochondrial electron transport by local anesthetics
10. Comparison of the effects of bupivacaine and ropivacaine on heart cell mitochondrial bioenergetics
11. Fundamental properties of local anesthetics. II. Measured octanol: Buffer partition coefficients and pKa values of clinically used drugs
12. Acute toxicity of ropivacaine compared with that of bupivacaine
13. Stereoisomerism and differential activity in excitation block by local anesthetics
14. Stereoselective inhibition of neuronal sodium channels by local anesthetics: Evidence for two sites of action?
15. Stereoselective block of cardiac sodium channels by bupivacaine in guinea pig ventricular myocytes
16. Toxicological and local anaesthetic effects of optically active isomers of two local anaesthetic compounds
17. Stereospecific effect of bupivacaine isomers on atrioventricular conduction in the isolated perfused guinea pig heart
18. Cardiovascular and central nervous system effects of intravenous levobupivacaine and bupivacaine in sheep
19. Effects of the local anesthetic bupivacaine on mitochondrial energy metabolism: Change from uncoupling to decoupling depending on the respiration state
20. Enzymatic and polarographic measurements of the respiratory chain complexes, Mitochondrial Diseases
21. Stereoselective effects of the enantiomers of bupivacaine on the electrophysiological properties of the guinea-pig papillary muscle
22. Slipping pumps or proton leaks in oxidative phosphorylation: The local anesthetic bupivacaine causes slip in cytochrome c oxydase of mitochondria
23. Uptake and retention of the enantiomers of a local anaesthetic in isolated nerve in relation to different degrees of blocking of nervous conduction
24. Myocardial uptake of bupivacaine: II. Pharmacokinetics and pharmacodynamics of bupivacaine enantiomers in the isolated perfused rabbit heart
25. Systemic and regional pharmacokinetics of levobupivacaine and bupivacaine enantiomers in sheep
26. Isolation and characterisation of subcomplexes of the mitochondrial NADH:ubiquinone oxidoreductase (complex I)
27. Effect of anesthetics on mitochondrial function
28. The effects of forane and fluroxene on mitochondrial respiration: Correlation with lipid solubility and in-vivo potency
29. Mechanisms of inhibition and uncoupling of respiration in isolated rat liver mitochondria by the general anesthetic 2,6-diisopropylphenol
30. GAS-1: A mitochondrial protein controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans
31. Physical and chemical properties of drug molecules governing their diffusion though the spinal meninges
32. Bupivacaine inhibits acylcarnitine exchange in cardiac mitochondria