Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism

Human Gene Therapy

Volumn 11, Issue 15, 2000, Pages 2067-2078

  Owen IV, R ^a,b   Lewin, A P ^b   Peel, A ^a,b   Wang, J ^a,b   Guy, J ^a   Hauswirth, W W ^a,b   Stacpoole, P W ^a,b   Flotte, T R ^a,b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS VECTOR;

ADENO ASSOCIATED VIRUS; AEROBIC METABOLISM; ARTICLE; GENE MUTATION; GENE THERAPY; HUMAN; HUMAN CELL; LACTIC ACIDOSIS; VIRUS RECOMBINANT;

ACIDOSIS, LACTIC; ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL LINE; CELL NUCLEUS; DEPENDOVIRUS; DNA, MITOCHONDRIAL; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, REPORTER; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOCHONDRIAL PROTON-TRANSLOCATING ATPASES; MODELS, GENETIC; MUTATION; NEURONS; OXYGEN; PYRUVATE DEHYDROGENASE COMPLEX; PYRUVATE DEHYDROGENASE COMPLEX DEFICIENCY DISEASE; RATS; RECOMBINANT FUSION PROTEINS; SPINAL CORD; TRANSDUCTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ADENO-ASSOCIATED VIRUS;

EID: 0034633616     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/104303400750001381     Document Type: Article

References (27)

1. Rapid segregation of heteroplasmic bovine mitochondria
2. Putting energy into mitochondrial protein import
3. Dichloroacetate as metabolic therapy for myocardial ischemia and failure
4. Limitations to in vivo import of hydrophobic proteins into yeast mitochondria. The case of a cytoplasmically synthesized apocytochrome b
5. Adeno-associated virus vectors for gene delivery
6. Duplication of leader sequence for protein targeting to mitochondria leads to increased import efficiency
7. A new technique for the assay of infectivity of human adenovirus 5 DNA
8. Protein sorting to mitochondria: Evolutionary conservations of folding and assembly
9. A new mitochondrial disease associated with mitochondrial DNA heteroplasmy
10. Transient expression of a mitochondrial precursor protein. A new approach to study mitochondrial protein import in cells of higher eukaryotes
11. Use of ethidium bromide to manipulate ratio of mutated and wild-type mitochondrial DNA in cultured cells
12. Isolation of human cell lines lacking mitochondrial DNA
13. Mitochondria-mediated transformation of human rho(0) cells
14. Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis
15. The protein import receptor of mitochondria
16. tRNAs and proteins are imported into mitochondria of Trypanosoma brucei by two distinct mechanisms
17. Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells
18. Lactic acidemia: Disorders of pyruvate carboxylase, pyruvate dehydrogenase
19. Lactic acidaemia
20. Lactic acidosis and other mitochondrial disorders
21. Metabolic effects of dichloroacetate in patients with diabetes mellitus and hyperliproteinemia
22. Treatment of congenital lactic acidosis with dichloroacetate
23. Mitochondrial genetics: A paradigm for aging and degenerative diseases?
24. Mitochondrial diseases in man and mouse
25. Atypical Leber's hereditary optic neuropathy with molecular confirmation
26. A 'humanized' green fluorescent protein cDNA adapted for high-level expression in mammalian cells
27. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield