Binding characteristics of [3H]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors

European Journal of Pharmacology

Volumn 371, Issue 2-3, 1999, Pages 197-204

  Chaki, Shigeyuki ^a   Funakoshi, Takeo ^a   Yoshikawa, Ryoko ^a   Okuyama, Shigeru ^a   Okubo, Taketoshi ^a   Nakazato, Atsuro ^a   Nagamine, Masashi ^b   Tomisawa, Kazuyuki ^a  

^a Medicinal Research Laboratories   (Japan)

^b Discovery Research Laboratories II   (Japan)

Author keywords

Benzodiazepine receptor, peripheral; DAA1106; PK11195; Receptor binding

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; BACLOFEN; BENZODIAZEPINE RECEPTOR; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BICUCULLINE; CARBACHOL; DIAZEPAM; FAMOTIDINE; HALOPERIDOL; LIGAND; MEPYRAMINE MALEATE; MUSCIMOL; N (2,5 DIMETHOXYBENZYL) N (5 FLUORO 2 PHENOXYPHENYL)ACETAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PRAZOSIN; PROPRANOLOL; RITANSERIN; UNCLASSIFIED DRUG; YOHIMBINE; 4 AMINOBUTYRIC ACID A RECEPTOR; ACETAMIDE DERIVATIVE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANXIOLYTIC AGENT; DAA 1106; DIPHENYL ETHER DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; BRAIN MITOCHONDRION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG RECEPTOR BINDING; MALE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; AUTORADIOGRAPHY; BRAIN; CEREBELLUM; DRUG INTERACTION; IN VITRO STUDY; MACACA; METABOLISM; MITOCHONDRION; OLFACTORY BULB; RAT; WISTAR RAT;

ACETAMIDES; ANIMALS; ANTI-ANXIETY AGENTS; AUTORADIOGRAPHY; BINDING SITES; BRAIN; CEREBELLUM; CEREBRAL CORTEX; DRUG INTERACTIONS; LIGANDS; MACACA MULATTA; MALE; MITOCHONDRIA; NEUROTRANSMITTER AGENTS; OLFACTORY BULB; PHENYL ETHERS; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0032586711     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00118-1     Document Type: Article

References (28)

1. Anholt R.R., De Souza E.B., Oster-Granite M.L., Snyder S.H. Peripheral-type benzodiazepine receptors: autoradiographic localization in whole-body sections of neonatal rats. J. Pharmacol. Exp. Ther. 233:1985;517-526.
2. Auta J., Romeo E., Kozikowski A.P., Ma D., Costa E., Guidotti A. Participation of mitochondrial DBI receptors in the anticonflict, antineophobic, and anticonvulsant action of 2-aryl-3-indoleacetamide and imidazopyridine derivatives. J. Pharmacol. Exp. Ther. 265:1993;649-656.
3. 3H ]PK11195, an isoquinoline carboxamide derivative: kinetic studies and autoradiographic localization J. Neurochem. 41:1983;1744-1750.
4. 3H ]diazepam binding Proc. Natl. Acad. Sci. USA. 74:1977;3805-3809.
5. Carter R.B., Wood P.L., Wieland S., Hawkinson J.E., Belelli D., Lambert J.J., White H.S., Wolf H.H., Mirsadeghi S., Tahir H., Bolger M.B., Lan N.C., Gee K.W. Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acid A receptor. J. Pharmacol. Exp. Ther. 280:1997;1284-1295.
6. 50) of an enzymatic reaction. Biochem. Pharmacol. 22:1973;3099-3108.
7. Doble A., Ferris O., Burgevin M.C., Menager J., Uzan A., Dubroeucq M.C., Renault C., Gueremy C., Le Fur G. Photoaffinity labeling of peripheral-type benzodiazepine-binding sites. Mol. Pharmacol. 31:1987;42-49.
8. Garnier M., Dimchev A.B., Boujrad N., Price J.M., Musto N.A., Papadopoulos V. In vitro reconstitution of a functional peripheral-type benzodiazepine receptor from mouse Leydig tumor cells. Mol. Pharmacol. 45:1994;201-211.
9. 3H ]dopa in various regions of the brain J. Neurochem. 13:1966;655-669.
10. Krueger K.E., Papadopoulos V. Peripheral-type benzodiazepine receptors mediate translocation of cholesterol from outer to inner mitochondrial membranes in adrenocortical cells. J. Biol. Chem. 265:1990;15015-15022.
11. Krueger K.E., Papadopoulos V. Mitochondrial benzodiazepine receptors and the regulation of steroid biosynthesis. Annu. Rev. Pharmacol. Toxicol. 32:1992;211-237.
12. A receptor function. Trends Pharmacol. Sci. 16:1995;295-303.
13. 3H ]PK11195, by thermodynamic studies Life Sci. 33:1983;449-457.
14. McEnery M.W., Snowman A.M., Trifiletti R.R., Snyder S.H. Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier. Proc. Natl. Acad. Sci. USA. 89:1992;3170-3174.
15. Mohler H., Okada T. Benzodiazepine receptor: demonstration in the central nervous system. Science. 25:1977;849-851.
16. Okuyama S., Chaki S., Yoshikawa R., Ogawa S., Suzuki Y., Okubo T., Nakazato A., Nagamine M., Tomisawa K. Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA 1097 and DAA 1106. Life Sci. 64:1999;1455-1464.
17. Papadopoulos V., Berkovich A., Krueger K.E., Costa A., Guidotti A. Diazepam binding inhibitor and its processing products stimulate mitochondrial steroid biosynthesis via an interaction with mitochondrial benzodiazepine receptors. Endocrinology. 129:1991;1481-1488.
18. Parola A.L., Yamamura H.I., Laird II H.E. Peripheral-type benzodiazepine receptors. Life Sci. 52:1993;1329-1342.
19. Riond J., Leplatois P., Laurent P., Le Fur G., Caput D., Loison G., Ferrara P. Expression and pharmacological characterization of the human peripheral-type benzodiazepine receptor in yeat. Eur. J. Pharmacol. 208:1991;307-312.
20. Romeo E., Auta J., Kozikowski A., Ma D., Papadopoulos V., Puia G., Guidotti A. 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligand for the mitochondrial DBI receptor (MDR). J. Pharmacol. Exp. Ther. 262:1992;971-978.
21. Romeo E., Cavallaro S., Korneyev A., Kozikowski A.P., Ma D., Polo A., Costa E., Guidotti A. Stimulation of brain steroidogenesis by 2-aryl-indole-3-acetamide derivatives acting at the mitochondrial diazepam-binding inhibitor receptor complex. J. Pharmacol. Exp. Ther. 267:1993;462-471.
22. 3H ]Ro5-4864 benzodiazepine binding sites in rat cerebral cortex Eur. J. Pharmacol. 71:1981;173-175.
23. 3H ]Ro 5-4864 in rat brain and kidney J. Pharmacol. Exp. Ther. 225:1983;61-69.
24. Tallman J.F., Thomas J.W., Gallager D.W. GABAergic modulation of benzodiazepine binding site sensitivity. Nature. 274:1978;383-385.
25. Tallman J.F., Paul S.M., Skolick P., Gallager D.W. Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science. 207:1980;274-281.
26. Wieland S., Belluzzi J., Stein L., Lan N.C. Comparative behavioral characterization of the neuroactive steroids 3α-OH, 5α-pregnan-20-one and 3α-OH, 5β-pregnan-20-one in rodents. Psychopharmacology. 118:1995;65-71.
27. Wieland S., Belluzzi J., Hawkinson J.E., Hogenkamp D., Upasani R., Stein L., Wood P.L., Gee K.W., Lan N.C. Anxiolytic and anticonvulsant activity of a synthetic neuroactive steroid Co 3-5093. Psychopharmacology. 134:1997;46-54.
28. Wu F., Gibbs T.T., Farb D.H. Pregnenolone sulfate: a positive allosteric modulator at the N-methyl-D-aspartate receptor. Mol. Pharmacol. 40:1991;333-336.