Cell death control in lymphocytes

Advances in Immunology

Volumn 76, Issue , 2001, Pages 179-226

  Newton, Kim ^a   Strasser, Andreas ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; PROTEIN BCL 2; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL DEATH; CELL SELECTION; HUMAN; IMMUNE SYSTEM; LYMPHOCYTE; LYMPHOCYTE PROLIFERATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; AUTOIMMUNE DISEASES; CASPASES; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GROWTH SUBSTANCES; HOMEOSTASIS; HUMANS; IMMUNE SYSTEM; LYMPHOCYTES; LYMPHOID TISSUE; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MODELS, BIOLOGICAL; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, TUMOR NECROSIS FACTOR; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 0033746263     PISSN: 00652776     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0065-2776(01)76020-8     Document Type: Chapter

References (344)

1. Collaboration of PIM-1 and BCL-2 in lymphomagenesis
2. Lack of retease of cytochrome c from mitochondria into cytosol early in the course of Fas-mediated apoptosis of Jurkat cells
3. The Bcl-2 protein family: Arbiters of cell survival
4. CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP
5. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
6. Fas transduces activation signals in normal human T lymphocytes
7. Regulation of apoptosis and T cell activation by Fas-specific mAb
8. Fas ligand mediates activation-induced cell death in human T lymphocytes
9. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice
10. Inhibition of Bax channel-forming activity by Bcl-2
11. Apoptosis control by death and decoy receptors
12. Cloning the chromosomal breakpoint of t(14;18) human lymphomas: Clustering around J(H) on chromosome 14 and near a transcriptional unit on 18
13. B cell development: Signal transduction by antigen receptors and their surrogates
14. Mechanisms and control of programmed cell death in invertebrates
15. The kit receptor promoters cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser 136
16. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas (Apo-1/CD95)
17. TRAIL receptor 2 signals apoptosis through FADD and caspase 8
18. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes
19. bcl-x, abcl-2-related gene that functions as a dominant regulator of apoptotic cell death
20. CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-X(L)
21. A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain
22. Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death
23. The scid mouse mutant: Definition, characterization, and potential uses
24. Degranulation plays an essential part in regulating cell surface expression of Fas ligand in T cells and natural killer cells
25. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
26. Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
27. Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins
28. CAR1, a TNFR-related protein, is a cellular receptor for cytopathic avian leukosis-sarcoma viruses and mediates apoptosis
29. Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas
30. Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
31. + pro-T thymocytes
32. Apaf-1 (CED-4 homologue) regulates programmed cell death in mammalian development
33. Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2
34. BCL-XL-regulated apoptosis in T cell development
35. Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-κB pathway
36. Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis
37. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis
38. Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95
39. Molecular ordering of the cell death pathway
40. FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
41. Interaction of CED-4 with CED-3 and CED-9: A molecular framework for cell death
42. Induction of apoptosis by the Bcl-2 homologue Bak
43. T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection
44. Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18
45. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation
46. The lpr and gld genes in systemic autoimmunity: Life and death in the Fas lane
47. The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CE D-9
48. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
49. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants
50. Spontaneous development of plasmaeytoid tumors in mice with defective Fas-Fas ligand interactions
51. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain
52. Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family
53. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
54. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
55. Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)
56. RAIDD is a new 'death' adaptor molecule
57. CD30-dependent degradation of TRAF2: Implications for negative regulation of TRAF signaling and the control of cell survival
58. Genetic control of programmed cell death in the nematode C. elegans
59. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
60. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
61. Activation of the CPP32 apoptotic protease by distinct signaling pathways with differential sensitivity to Bcl-X(L)
62. Bcl-2 prevents activation of CPP32 cysteine protease and cleavage of poly (ADP-ribose) polymerase and U1-70 kD proteins in staurosporine-mediated apoptosis
63. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages
64. Frequent aberrant immunoglobulin gene rearrangements in pro-B cells revealed by a bcl-x(L) transgene
65. Self-reactive B lymphocytes overexpressing Bcl-X(L) escape negative selection and are tolerized by clonal anergy and receptor editing
66. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K
67. Crucial role of the pre-T-cell receptor alpha gene in development of alpha-beta but not gamma-delta T cells
68. Restoration of thymopoiesis in pTα(-/-) mice by anti-CD3ε antibody treatment or with transgenes encoding activated Lck or Tailless pTα
69. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains
70. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
71. An essential role for gp39, the ligand for CD40, in thymic selection
72. bcl-w, a novel member of the bcl-2 family, promotes cell survival
73. Control points in early T-cell development
74. CASH, a novel caspase homologue with death effector domains
75. bcl-2 proto-oncogene expression during human T cell development
76. TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1
77. Induction of cell death by tumor necrosis factor (TNF) receptor 2, CD40 and CD30 - A role for TNF-R1 activation by endogenous membrane-anchored TNF
78. Bcl-X(L) displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
79. bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice
80. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor β chain and a 33 kd glycoprotein
81. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-X(L) prevents this release but not tumor necrosis factor-R1/Fas death
82. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
83. V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
84. Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in scid mice
85. Differential requirement for caspase 9 in apoptotic pathways in vivo
86. Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells
87. Inactivation of Bcl-2 by phosphorylation
88. CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45
89. Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K
90. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclX(L) and initiates cell death
91. Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A
92. Elimination of self-reactive B lymphocytes proceeds in two stages: Arrested development and cell death
93. Positive selection of natural autoreactive B cells
94. Different nuclear signals are activated by the B cell receptor during positive versus negative signaling
95. Blk, a BH3-containing mouse protein that interacts with Bcl-2 and Bcl-xL, is a potent death agonist
96. Death cycle and Swiss army knives
97. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
98. The TNF receptor i-associated protein TBADD signals cell death and NF-κB activation
99. TBADD-TBAF2 and TBADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
100. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
101. I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95-induced apoptosis
102. Bcl-X(L) interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
103. WD-40 repeat region regulates Apaf-1 self-association and procaspase-9 activation
104. Bcl-2, Bcl-X(L) and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death
105. Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-X(L)
106. Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death
107. Harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)
108. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
109. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death
110. Direct physical interaction between the Caenorhabditis elegans death proteins ced-3 and ced-4
111. Inhibition of death receptor signals by cellular FLIP
112. Bcl-2 phosphorylation required for anti-apoptosis function
113. A novel protein domain required for apoptosis
114. The polypeptide encoded by the eDNA for human cell surface antigen Fas can mediate apoptosis
115. Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor
116. CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo
117. Ced-4 induces chromatin condensation in Schizosaccharomyces pombe and is inhibited by direct physical association with Ced-9
118. Effect of a bcl-2 transgene on production and localization of precursor B cells in mouse bone marrow
119. Specific cleavage of the retinoblastoraa protein by an ICE-like protease in apoptosis
120. Caspase-3 is required for α-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
121. + stage of thymocyte differentiation in the absence of T cell receptor rearrangement
122. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains
123. Fas(CD95)/FasL interactions required for programmed cell death after T-cell activation
124. The expression of V(pre-B)/λ5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice
125. Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes
126. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
127. Role for Bcl-x(L) as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis
128. Modulation of apoptosis by the widely distributed Bd-2 homologue Bak
129. Peripheral T cell survival requires continual ligation of the T cell receptor to major histocompatibility complex-encoded molecules
130. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor
131. Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase 8 to death receptors 4 and 5
132. A death-domain-containing receptor that mediates apoptosis
133. The release of cytochrome c from mitochondria - A primary site for Bcl-2 regulation of apoptosis
134. Bcl-2 and Bax function independently to regulate cell death
135. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice
136. Caspase-3-generated fragment of gelsolin: Effector of morphological change in apoptosis
137. MCL1, a gene expressed in programmed.myeloid cell differentiation, has sequence similarity to bcl-2
138. FADD is required for DR4- and DR5-mediated apoptosis: Lack of TRAIL-induced apoptosis in FADD-deficient mouse embryo fibroblasts
139. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
140. + T cells induced by cross-presentation of self-antigens involves signaling through CD95 (Fas, Apo-1)
141. Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis
142. Rapid elimination of mature autoreactive B cells demonstrated by Cre-induced change in B cell antigen receptor specificity in vivo
143. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
144. Mutations in the Fas antigen in patients with multiple myeloma
145. Enforced Bcl-2 expression inhibits antigen-mediated clonal elimination of peripheral B cells in an antigen dose-dependent manner and promotes receptor editing in autoreactive, immature B cells
146. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
147. Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)
148. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
149. Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε
150. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotie protease cascade
151. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
152. + stage during positive selection and promotes thymocyte differentiation at several control points
153. Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate-early gene nur77
154. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
155. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis
156. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors
157. Bclx regulates the survival of double-positive thymocytes
158. Targeted disruption of the flk2/flt3 gene leads to deficiencies in primitive hematopoietic progenitors
159. The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice
160. Altered T cell development in mice with a targeted mutation of the CD3-ε gene
161. Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1(-/-) mice
162. Overexpression of Bcl-2 does not rescue impaired B lymphopoiesis in IL-7 receptor-deficient mice but can enhance survival of mature B cells
163. Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB
164. A novel receptor for Apo2L/TRAIL contains a truncated death domain
165. Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHa1) death signal
166. Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell
167. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)
168. FLICE is activated by association with the CD95 death-inducing signaling complex (DISC)
169. Dying like flies
170. Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes
171. Genetics of programmed cell death in C. elegans: Past, present and future
172. Fas (CD95) participates in peripheral T cell deletion and associated apoptosis in vivo
173. RAG-1-deficient mice have no mature B and T lymphocytes
174. Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): A new receptor protecting lymphocytes from the death ligand TRAIL
175. Bcl-2 family members do not inhibit apoptosis by binding the caspase-activator Apaf-1
176. Massive cell death of immature hematopoietic cells and neurons in Bcl-x deficient mice
177. FLICE, a novel FADD homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex
178. FLICE induced apoptosis in a cell-free system
179. An induced proximity model for caspase-8 activation
180. V(D)J recombination is not required for the development of lymphoma in p53-deficient mice
181. Mutations in the p53 and SCID genes cooperate in tumorigenesis
182. The Fas death factor
183. Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice
184. Targeted disruption of bcl-2αβ in mice: Occurrence of gray hair, polycystic kidney disease, and lymphocytopenia
185. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody gene
186. A dominant interfering mutant of FADD/Mort1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes
187. FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor
188. Expression and function of mouse Fas antigen on immature and mature T cells
189. Bim - A novel member of the Bcl-2 family that promotes apoptosis
190. + thymocytes by the anti-Fas antibody
191. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
192. The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A
193. The turnover of B-cell populations
194. TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection
195. An antagonist decoy receptor and a death domain-containing receptor for TRAIL
196. The receptor for the cytotoxic ligand TRAIL
197. Identification and functional characterization of DR6, a novel death domain-containing TNF receptor
198. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signaling
199. Caspase-9, Bcl-X(L), and Apaf-1 form a ternary complex
200. A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice
201. Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice
202. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
203. Multiple rearangements in TCR-α chain genes maximize the production of useful thymocytes
204. Constitutive expression of Bcl-X(L) or Bcl-2 prevents peptide antigen-induced T cell deletion but does not influence T cell homeostasis after a viral infection
205. Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
206. Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer
207. The pro-apoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
208. Cell death attentuation by 'Usurpin,' a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex
209. Effects of the lpr mutation on elimination and inactivation of self-reactive B cells
210. + T ceils
211. Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor
212. + T cells
213. Bcl-2 transgenic Lpr mice show profound enhancement of lymphadenopathy
214. Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis
215. The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis
216. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity
217. Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo
218. Pro-thymocyte expansion by c-kit and the common cytokine receptor γ chain is essential for repertoire formation
219. Bcl-2 prolongs cell survival after Bax-induced release of cytochrome c
220. Mice lacking the tumor necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes
221. Protection against Fas-dependent Th1-mediated apoptosis by antigen receptor engagement in B cells
222. Analysis of central B cell tolerance in autoimmune-prone MRL/1pr mice bearing autoantibody transgenes
223. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2
224. Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells
225. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide
226. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
227. Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation
228. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis
229. Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation
230. The role of c-FLIP in modulation of CD95-induced apoptosis
231. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-κB
232. Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity
233. Studies of T cell deletion and T cell anergy following in vivo administration of SEB to normal and lupus-prone mice
234. TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL
235. LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing
236. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
237. Caenorhabditis elegans Ced-4 stimulates Ced-3 processing and Ced-3-induced apoptosis
238. Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities
239. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors
240. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
241. + thymocytes in RAG-2(-/-) mice in the absence of TCR β chain expression
242. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangements
243. T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway
244. The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex
245. Casper is a FADD- and caspase-related inducer of apoptosis
246. Transgenic T cell receptor interactions in the lymphoproliferative and autoimmune syndromes of lpr and gld mutant mice
247. The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice
248. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
249. BCL-2 increases memory B cell recruitment but does not perturb selection in germinal centers
250. FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen
251. CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease
252. Boo, a novel negative regulator of cell death, interacts with Apaf-1
253. Interaction between the C. elegans cell-death regulators CED-9 and CED-4
254. Tumor necrosis factor receptor p55 mediates deletion of peripheral cytotoxic T lymphocytes in vivo
255. FADD/MORT1 and caspase 8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2
256. Molecular ordering of the Fas-apoptotic pathway: The Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases
257. FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis
258. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
259. Death of a T cell
260. Fas ligand - Caught between Scylla and Charybdis
261. Apoptosis signalling
262. Novel primitive lymphoid tumors induced in trasgenic mice by cooperation between myc and bcl-2
263. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
264. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
265. Eμ-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells
266. Bcl-2 expression promotes B but not T lymphoid development in scid mice
267. Positive and negative selection of T cells in T cell receptor transgenic mice expressing a bcl-2 transgene
268. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
269. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
270. Death by a thousand cuts: An ever increasing list of caspase substrates
271. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis family
272. Apoptosis of mouse native T cells induced by recombinant soluble Fas ligand and activation-induced resistance to Fas ligand
273. Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing
274. T-cell apoptosis detected in situ during positive and negative selection in the thymus
275. Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor β
276. Normal thymic selection, superantigen-induced deletion and Fas-mediated apoptosis of T cells in IL-2 receptor β chain-deficient mice
277. The roles of Fas/APO-1 (CD95) and TNF in antigen-induced programmed cell death in T cell receptor transgenic mice
278. Inhibition of apoptosis and augmentation of lymphoproliferation in bcl-2 transgenic Fas/Fas ligand-defective mice
279. Downregulation of Fas ligand by shedding
280. Differential requirement for survival and proliferation of CD8 naive or memory T cells
281. + thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus
282. Continued differentiation during B lymphopoiesis requires signals in addition to cell survival
283. A novel domain within the 55 kd TNF receptor signals cell death
284. + T cells
285. Caspases: Enemies within
286. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
287. Monoclonal antibody-mediated tumor regression by induction of apoptosis
288. Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma
289. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
290. Bd-x(L) regulates the membrane potential and volume homeostasis of mitochondria
291. The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance
292. Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes
293. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens
294. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death
295. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally
296. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2
297. Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytes
298. Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
299. Cytokine-induced survival of activated T cells in vitro and in vivo
300. Fas-associated death domain protein interleukin-1 β-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling
301. Positive selection of lymphocytes
302. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine
303. The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression
304. Dominant-negative FADD inhibits TNFR60-Fas/Apo1- and TRAIL-R/Apo2-mediated cell death but not gene induction
305. TRAIL-B2: A novel apoptosis-mediating receptor for TRAIL
306. Exploring cell death mechanisms by analyzing signaling cascades of the TNF/NGF receptor family
307. A role for FADD in T cell activation and development
308. BID: A novel BH3 domain-only death agonist
309. 2+-induced apoptosis through calcineurin dephosphorylation of BAD
310. Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II
311. Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP
312. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
313. Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
314. In vivo evidence that caspase-3 is required for Fas-mediated apoptosis of hepatocytes
315. Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas
316. Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9
317. Interaction and regulation of subcellular localization of CED-4 by CED-9
318. KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
319. C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death
320. Cell death: The significance of apoptosis
321. The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease
322. Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor
323. Bad, a heterodimeric partner for Bcl-x(L) and Bcl-2, displaces Bax and promotes cell death
324. Prevention of apoptosis by Bcl-2 - Release of cytochrome c from mitochondria blocked
325. Autoproteolytic activation of pro-caspases by oligomerization
326. The Fas-deficient SCID mouse exhibits the development of T cells in the thymus
327. Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice
328. FADD: Essential for embryo development and signaling from some, but not all, inducers of apoptosis
329. Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development
330. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis
331. A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen co-downregulated with the receptor of tumor necrosis factor
332. Apaf1 is required for mitochondrial pathways of apoptosis and brain development
333. Constitutive Bcl-2 expression during immunoglobulin heavy chain-promoted B cell differentiation expands novel precursor B cells
334. A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis
335. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme
336. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
337. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1
338. Induction of apoptosis in mature T cells by tumor necrosis factor
339. Injected cytochrome c induces apoptosis
340. Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells
341. Greatly accelerated lymphadenopathy and autoimmune disease in lpr mice lacking tumor necrosis factor receptor 1
342. + T cells after antigen challenge in the absence of Fas (CD95)
343. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3
344. An APAF-1 - Cytochrome c multilneric complex is a functional apoptosome that activates procaspase-9