T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: The molecular basis of negative selection

EMBO Journal

Volumn 16, Issue 9, 1997, Pages 2282-2293

  Clayton, Linda K ^a,c   Ghendler, Yoseph ^a,c   Mizoguchi, Emiko ^b,c   Patch, Raymond J ^d   Ocain, Timothy D ^d   Orth, Kim ^e   Bhan, Atul K ^b,c   Dixit, Vishva M ^e   Reinherz, Ellis L ^a,c  

^a DANA FARBER CANCER INSTITUTE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d Procept Inc   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Caspase; Negative selection; Thymus

Indexed keywords

BIOTIN; CASPASE; CD4 ANTIGEN; CD8 ANTIGEN; CELL ENZYME; CORTICOSTEROID; ENZYME INHIBITOR; MONOCLONAL ANTIBODY; PEPTIDE; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL MATURATION; CELL SPECIFICITY; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE REARRANGEMENT; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; ORGAN CULTURE; PRIORITY JOURNAL; RECEPTOR BINDING; THYMOCYTE; TRANSGENIC MOUSE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CASPASE 3; CASPASE 6; CASPASE 7; CASPASES; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; ENZYME PRECURSORS; FEMALE; GLUCOCORTICOIDS; LIGANDS; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICE; MICE, INBRED C57BL; PEPTIDES; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

ANIMALIA; MUS MUSCULUS;

EID: 0030985969     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.9.2282     Document Type: Article

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