Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity

Journal of Experimental Medicine

Volumn 187, Issue 8, 1998, Pages 1205-1213

  Schneider, Pascal ^a   Holler, Nils ^a   Bodmer, Jean Luc ^a   Hahne, Michael ^a   Frei, Karl ^b   Fontana, Adriano ^b   Tschopp, Jürg ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; HEPATITIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; LIGAND BINDING; LIVER FAILURE; LIVER TOXICITY; MEMBRANE BINDING; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; DOWN-REGULATION; FAS LIGAND PROTEIN; HUMANS; LIVER; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, TUMOR NECROSIS FACTOR; SOLUBILITY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032550366     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.187.8.1205     Document Type: Article

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