Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants

Nature

Volumn 391, Issue 6667, 1998, Pages 587-591

  Davidson, Florence F ^a,b   Steller, Hermann ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLINDNESS; CELL DEATH; DROSOPHILA; ELECTRORETINOGRAPHY; NONHUMAN; PHOTORECEPTOR CELL; PRIORITY JOURNAL; RETINA CELL; RETINA DEGENERATION;

ANIMALS; APOPTOSIS; DROSOPHILA; ELECTRORETINOGRAPHY; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MUTATION; PHOTORECEPTORS, INVERTEBRATE; VIRAL PROTEINS; VISION;

ANIMALIA;

EID: 0032484931     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35385     Document Type: Article

References (29)

1. Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462 (1995).
2. Steller, H. Mechanisms and genes of cellular suicide. Science 267, 1445-1449 (1995).
3. Hengartner, M. O. & Horvitz, H. R. Programmed cell death in Caenorhabditis elegans. Curr. Opin. Genet. Dev. 4, 581-586 (1994).
4. Jacobson, M. D., Weil, M. & Raff, M. C. Programmed cell death in animal development. Cell 88, 347-354 (1997).
5. Chang, G. Q., Hao, Y. & Wong, F. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Neuron 11, 595-605 (1993).
6. Portera-Cailliau, C., Sung, C. H., Nathans, J, & Adler, R. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Proc. Natl Acad. Sci. USA 91, 974-978 (1994).
7. Nickells, R. W. & Zack, D. J. Apoptosis in ocular disease: a molecular overview. Opthal. Genet. 17, 145-165 (1996).
8. Humphries, P., Farrar, G. J., Kenna, P. & McWilliam, P. Retinitis pigmentosa: genetic mapping in X-linked and autosomal forms of the disease. Clin. Genet. 38, 1-13 (1990).
9. Colley, N. J., Cassill, J. A., Baker, E. K. & Zuker, C. S. Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration. Proc. Natl Acad. Sci. USA 92, 3070-3074 (1995).
10. Kurada, P. & O'Tousa, J. E. Retinal degeneration caused by dominant mutations in Drosophila. Neuron 14, 571-579 (1995).
11. Richards, J. E., Scott, K. M. & Sieving, P. A. Disruption of conserved rhodopsin disulfide bond by Cys 187Tyr mutation causes early and severe autosomal dominant retinitis pigmentosa. Opthalmology 102, 669-677 (1995).
12. Steele, F. & O'Tousa, J. E. Rhodopsin activation causes retinal degeneration in Drosophila rdgC mutant. Neuron 4, 883-890 (1990).
13. Steele, F. R., Washburn, T., Rieger, R. & O'Tousa, J. E. Drosophila retinal degeneration C (rdgC) encodes a novel serine/threonine protein phosphatase. Cell 69, 669-676 (1992).
14. Byk, T., Bar-Yaacov, M., Dnza, Y. N., Minke, B. & Selinger, Z. Regulatory arrestin cycle secures the fidelity and maintenance of the fly photoreceptor cell. Proc. Natl Acad. Sci. USA 90, 1907-1911 (1993).
15. Dryja, T. P. Rhodopsin and autosomal dominant retinitis pigmentosa. Eye 6, 1-10 (1992).
16. Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16 (1997).
17. Xue, D. & Horvitz, H. R. Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baenlovirus p35 protein. Nature 377, 248-251 (1995).
18. Bump, N. J. et al. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269, 1885-1888 (1995).
19. Clem, R. J. & Miller, L. K. Control of programmed cell death by the baculovirus genes p35 and iap. Mol. Cell. Biol. 14, 5212-5222 (1994).
20. Hay, B. A., Wolff, T. & Rubin, G. M. Expression of baculovirus p35 prevents cell death in Drosophila. Development 120, 2121-2129 (1994).
21. Grether, M. E., Abrams, J. M., Agapite, J., White, K. & Steller, H. The head involution defective gene of Drosophila melanogaster functions in programmed cell death. Genes Dev. 9, 1694-1708 (1995).
22. White, K., Tahaoglu, E. & Steller, H. Cell killing by the Drosophila gene reaper. Science 271, 805-807 (1996).
23. Sugimoto, A., Friesen, P. D. & Rothman, J. H. Baculovirus p35 prevents developmentally programmed cell death and rescues a ced-9 mutant in the nematode Caenorhabditis elegans. EMBO J. 13, 2023-2028 (1994).
24. Rabizadeh, S., La Count, D. J., Friesen, P. D. & Bredeson, D. E. Expression of the baculovirus p35 gene inhibits mammalian neural cell death. J. Neurochem. 61, 2318-2321 (1993).
25. Beidler, D. R., Tewari, M., Friesen, P. D., Poirier, G. & Dixit, V. M. The baculovirus p35 protein inhibits Fas-and tumor necrosis factor-induced apoptosis. J. Biol. Chem. 270, 16526-16528 (1995).
26. Martinou, I. et al. Viral proteins E1B19K and p35 protect sympathetic neurons from cell death induced by NGF deprivation. J. Cell Biol. 128, 201-208 (1995).
27. Rendahl, K. G., Jones, K. R., Kulkarni, S. J., Bagully, S. H. & Hall, J. C. The dissonance mutation at the no-on-transient-A locus of D. melanogaster. genetic control of courtship song and visual behaviors by a protein with putative RNA-binding motifs. J. Neurosci. 12, 390-407 (1992).
28. Ranganathan, R., Malicki, D. M. & Zuker, C. S. Signal transduction in Drosophila photoreceptors. Annu. Rev. Neurosci. 18, 283-317 (1995).
29. Wyllie, A. H. Apoptosis and carcinogenesis. Eur. J. Cell Biol. 73, 189-197 (1997).