FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

EMBO Journal

Volumn 19, Issue 5, 2000, Pages 931-941

  Newton, Kim ^a   Harris, Alan W ^a   Strasser, Andreas ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Apoptosis; FADD MORT 1; Pre TCR; Thymocyte

Indexed keywords

ADAPTOR PROTEIN; MUTANT PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENE REARRANGEMENT; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE; THYMOCYTE; THYMUS LYMPHOMA; TUMOR SUPPRESSOR GENE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; APOPTOSIS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL DIVISION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; GENE EXPRESSION REGULATION; GENE REARRANGEMENT, BETA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, TUMOR SUPPRESSOR; MICE; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES;

ANIMALIA;

EID: 0034161282     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.5.931     Document Type: Article

References (64)

1. Akashi, K., Kondo, M., von Freeden-Jeffry, U., Murray, R. and Weissman, I.L. (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell, 89, 1033-1041.
2. Ashkenazi, A. and Dixil, V.M. (1998) Death receptors: signaling and modulation. Science, 281, 1305-1308.
3. Boehme, S.A. and Lenardo, M.J. (1996) TCR-mediated death of mature T lymphocytes occurs in the absence of p53. J. Immunol., 156, 4075-4078.
4. Bogue, M.A., Zhu, C., Aguilar-Cordova, E., Donehower, L.A. and Roth, D.B. (1996) p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in seid mouse thymocytes. Genes Dev., 10, 553-565.
5. Boldin, M.P., Varfolomeev, E.E., Paneer, Z., Mett, I.L., Camonis, J.H. and Wallach, D. (1995) A novel protein that interacts with the death domain of Fas/APO1 contains a sequence motif related to the death domain. J. Biol. Chem., 270, 7795-7798.
6. Boldin, M.P., Goncharov, T.M., Goltsev, Y.V. and Wallach, D. (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 - and TNF receptor-induced cell death. Cell, 85, 803-815.
7. Bosma, M.J. and Carroll, A.M. (1991) The scid mouse mutant: definition, characterization and potential uses. Annu. Rev. Immunol., 9, 323-350.
8. + Pro-T thymocytes. Proc. Natl Acad. Sci. USA, 95, 12522-12527.
9. Chinnaiyan, A.M., O'Rourke, K., Tewari, M. and Dixit, V.M. (1995) FADD. a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell, 81, 505-512.
10. Cohen, P.L. and Eisenberg, R.A. (1993) The lpr and gld genes in systemic autoimmunity: life and death in the Fas lane, Immunol. Today, 13, 427-428.
11. Danska, J.S., Pflumio, F., Williams, C.J., Huner, O., Dick, J.E. and Guidos, C.J. (1994) Rescue of T cell-specific V(D)J recombination in SCID mice by DNA-damaging agents. Science, 266, 450-455.
12. Davidson, W.F., Giese, T. and Fredrickson, T.N. (1998) Spontaneous development of plasmacytoid tumors in mice with defective Fas-Fas ligand interactions. J. Exp. Med., 187, 1825-1838.
13. Evan, G. and Littlewood, T. (1998) A matter of life and cell death. Science, 281, 1317-1321.
14. Fehling, H.J., Krotkova, A., Saint-Ruf, C. and von Boehmer, H. (1995) Crucial role of the pre-T-cell receptor α gene in development of α-β but not γ-δ T cells. Nature, 375, 795-798.
15. -/- mice by anti-CD3e antibody treatment or with transgenes encoding activated Lck or Tailless pTα. Immunity, 6, 703-714.
16. Godfrey, D.I. and Zlotnik, A. (1993) Control points in early T-cell development, Immunol. Today, 14, 547-553.
17. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M.J., Hayday, A.C. and von Boehmer, H. (1993) A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor βchain and a 33 kd glycoprotein. Cell, 75, 283-294.
18. + thymocytes in RAG-deficient mice through a T cell receptor βchain-independent pathway. J. Exp. Med., 181, 1187-1195.
19. Guidos, C.J., Williams, C.J., Grandal, I., Knowles, G., Huang, M.T.F. and Danska, J.S. (1996) V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors. Genes Dev., 10, 2038-2054.
20. Habu, S., Kimura, M., Katsuki, M., Hioki, K. and Nomura, T. (1987) Correlation of T cell receptor gene rearrangements to T cell surface antigen expression and to serum immunoglobulin level in scid mice. Eur. J. Immunol., 17, 1467-1471.
21. Haks, M.C, Krimpenfort, P., van den Brakel, J.H.N. and Kruisbeek, A.M. (1999) Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells. Immunity, 11, 91-101.
22. Hoffman, E.S., Passoni, L., Crompton, T. Leu, T.M.J., Schatz, D.G., Koff, A., Owen, M.J. and Hayday, A.C. (1996) Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev., 10, 948-962.
23. Hsu, H., Xiong, J. and Goeddel, D.V. (1995) The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell, 81, 495-504.
24. Irmler, M. et al. (1997) Inhibition of death receptor signals by cellular FLIP. Nature, 388, 190-194.
25. Jacobs, H., Vandeputte, D., Tolkamp, L., de Vries, E., Borst, J. and Berns, A. (1994) CD3 components at the surface of pro-T cells can mediate pre-T cell development in vivo. Eur. J. Immunol., 24, 934-939.
26. + stage of thymocyte differentiation in the absence of T cell receptor rearrangement. J. Exp. Med., 183, 1923-1928.
27. Levelt, C.N., Mombaerts, P., Iglesias, A., Tonegawa, S. and Eichmann, K. (1993) Restoration of early thymocyte differentiation in T-cell receptor β-chain-deficient mutant mice by transmembrane signaling through CD3ε. Proc. Natl Acad. Sci. USA, 90, 11401-11405.
28. Malissen, M., Gillet, A., Ardouin, L., Bouvier, G., Trucy, J., Ferrier, P., Vivier, E. and Malissen, B. (1995) Altered T cell development in mice with a targeted mutation of the CD3-ε gene. EMBO J., 14, 4641-4653.
29. -/- mice. Cell, 89, 1011-1019.
30. Martin, D.A., Siegel, R.M., Zheng, L. and Lenardo, M.J. (1998) Membrane oligomerization and cleavage activates the caspase-8 (FLICE/ MACHαI) death signal. J. Biol. Chem., 273, 4345-4349.
31. Mombaerts, P., Iacomin, J., Johnson, R.S., Herrup, K., Tonegawa, S. and Papaioannou, V.E. (1992a) RAG-1-deficient mice have no mature B and T lymphocytes. Cell, 68, 869-877.
32. Mombaerts, P. et al. (1992b) Mutations in T-cell antigen receptor genes a and ß block thymocyte development at different stages. Nature. 360, 225-231.
33. Murphy, W.J. et al. (1994) Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID). J. Immunol, 153, 1004-101 4.
34. Muzio, M. et al. (1996) FLICE, a novel FADD homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/Apo-1) death-inducing signaling complex. Cell, 85, 817-827.
35. Muzio, M, Stockwell, B.R., Stennicke, H.R., Salvesen, G.S. and Dixit, V.M. (1998) An induced proximity model for caspase-8 activation. J. Biol Chem., 273, 2926-2930.
36. Nacht, M. and Jacks, T. (1998) V(D)J recombination is not required for the development of lymphoma in p53-deficient mice. Cell Growth Diff., 9, 131-138.
37. Nacht, M., Strasser, A., Chan, Y.R., Harris, A.W., Schlissel, M., Bronson, R.T. and Jacks, T. (1996) Mutations in the p53 and SCID genes cooperate in tumorigenesis. Genes Dev., 10, 2055-2066.
38. Nagata, S. and Golstein, P. (1995) The Fas death factor. Science, 267, 1449-1456.
39. Newton, K., Harris, A.W., Bath, M.L., Smith, K.G.C. and Strasser, A. (1998) A dominant interfering mutant of FADD/Mort 1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes. EMBO J., 17, 706-718.
40. Nishimura, Y, Ishii, A., Kobayashi, Y., Yamasaki, Y. and Yonehara, S. (1995) Expression and function of mouse Fas antigen on immature and mature T cells. J. Immunol, 154, 4395-4403.
41. O'Connor, L. and Strasser, A. (1999) Fas, p53 and apoptosis. Science, 284, 143 0.
42. + thymocytes by the anti-Fas antibody. J. Exp. Med., 181, 485-491.
43. Peng, S, L., Robert, M.E., Hayday, A.C and Craft, J. (1996) A tumor-suppressor function for Fas (CD95) revealed in T cell-deficient mice. J. Exp. Med., 184, 1149-1154.
44. Penit, C. Lucas, B. and Vasseur, F. (1995) Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. J. Immunol, 154, 5103-5113.
45. Petrie, H.T., Livak, F., Schatz, D.G., Strasser, A., Crispe, N.I. and Shortman, K. (1993) Multiple rearangements in TCR-α chain genes maximize the production of useful thymocytes. J. Exp. Med., 178, 615-622.
46. Rodewald, H.-R. and Fehling, H.J. (1998) Molecular and cellular events in early thymocyte development. Adv. Immunol, 69, 1-112.
47. -/- mice in the absence of TCR β chain expression. Int. Immunol., 6, 995-1001.
48. Shinkai, Y. et al. (1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangements. Cell, 68, 855-867.
49. Shores, E, W., Sharrow, S.O., Uppenkamp, I. and Singer, A. (1990) T cell receptor-negative thymocytes from SCID mice can be induced to enter the CD4/CD8 differentiation pathway. Eur. J. Immunol., 20, 69-77.
50. Singer, G.G. and Abbas, A.K. (1994) The fas antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity, 1, 365-371.
51. Strasser, A., Harris, A.W., Corcoran, L.M. and Cory.S. (1994a) bcl-2 expression promotes B but not T lymphoid development in scid mice. Nature, 368, 457-460.
52. Strasser, A., Harris, A.W., Jacks, T. and Cory, S. (1994b) DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell. 79, 329-33 9.
53. Strasser, A., Harris, A.W., Huang, D.C.S., Krammer, P.H. and Cory, S. (1995) Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J., 14, 6136-6147.
54. Strasser, A., Huang, D.C.S. and Vaux, D.L. (1997) The role of the bcl-2/ ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy. Biochim. Biophys. Acta, 1333, F151-F178.
55. Vanhaesebroeck, B., Reed, J.C., de Valck, D., Grooten, J., Miyashita, T., Tanaka, S., Beyaert, R., van Roy, F. and Fiers, W. (1993) Effect of bcl-2 proto-oncogene expression on cellular sensitivity to tumor necrosis factor-mediated cytotoxicity. Oncogene, 8, 1075-1081.
56. von Boehmer, H. (1994) Positive selection of lymphocytes. Cell, 76, 219-228.
57. von Boehmer, H., Aifantis, I., Feinberg, J., Lechner, O., Saint-Ruf, C, Walter, U., Buer, J. and Azogui, O. (1999) Pleiotropic changes controlled by the pre-T-cell receptor. Curr. Opin. Immunol, 11, 135-142.
58. Walsh, C.M., Wen, B.G., Chinnaiyan, A.M., O'Rourke, K., Dixit, V.M. and Hedrick, S.M. (1998) A role for FADD in T cell activation and development. Immunity, 8, 439-449.
59. Wu, G.S., Burns, T.F, Zhan, Y, Alnemri, E.S. and el-Deiry, W.S. (1999) Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor. Cancer Res., 59, 2770-2775.
60. Yang, X., Chang, H.Y. and Baltimore, D. (1998) Autoproteolytic activation of pro-caspases by oligomerization. Mol. Cell, 1, 319-325.
61. Yasutomo, K., Maeda, K.-I., Hisaeda, H., Good, R.A., Kuroda, Y. and Himeno, K. (1997) The Fas-deficient SCID mouse exhibits the development of T cells in the thymus. J. Immunol, 158, 4729-4733.
62. Yeh, W.C. et al. (1998) FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science, 279, 1954-1958.
63. Zhang, J., Cado, D., Chen, A., Kabra, N.H. and Winoto, A. (1998) Fasmediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort 1. Nature, 392, 296-300.
64. Zú̈niga-Pflücker, J.C., Jiang, D., Schwartzberg, P.L. and Lenardo, M.J. (1994) Sublethal γ-radiation induces differentiation of CD4+/CD8+ into CD4+/CD84+ thymocytes without T cell receptor βrearrangement in recombinase activation gene 2-/- mice. J. Exp. Med., 180, 1517-1521.