Early lethality, functional NF-κB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

Immunity

Volumn 7, Issue 5, 1997, Pages 715-725

  Yeh, Wen Chen ^a,b   Shahinian, Arda ^a,b   Speiser, Daniel ^b   Kraunus, Janine ^a   Billia, Filio ^b   Wakeham, Andrew ^a,b   De La Pompa, José Luis ^a,b   Ferrick, David ^a,d   Hum, Betty ^a   Iscove, Norman ^b   Ohashi, Pamela ^b   Rothe, Mike ^c   Goeddel, David V ^c   Mak, Tak Wah ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c AMGEN INC   (United States)

^d RIGEL PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECOMBINANT TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; FETUS; HEMATOPOIETIC STEM CELL; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SPLEEN CELL; THYMOCYTE;

EID: 0031463025     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(00)80391-X     Document Type: Article

References (52)

1. Aizawa, S., Nakano, H. Ishida, T., Horie, R., Nagai, M., Ito, K., Yagita, H., Okumura, K., Inoue, J., and Watanabe, T. (1997). Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. J. Biol. Chem. 272, 2042-2045.
2. Amakawa, R., Hakem, A., Kundig, T.M., Matsuyama, T., Simard, J.J.L., Timms, E., Wakeham, A., Mittruecker, H.W., Griesser, H., Takimoto, H., et al. (1996). Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Cell 84, 551-562.
3. Ansieau, S., Scheffrahn, I., Mosialos, G., Brand, H., Duyster, J., Kaye, K., Harada, J., Dougall, B., Hubinger, G., Kieff, E., et al. (1996). Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. Proc. Natl. Acad. Sci. USA 93, 14053-14058.
4. Beg, A.A., and Baltimore, D. (1996). An essential role for NF-κB in preventing TNF-α-induced cell death. Science 274, 782-784.
5. Beutler, B., and Cerami, A. (1988). Tumor necrosis, cachexia, shock and inflammation: a common mediator. Annu. Rev. Biochem. 57, 505-518.
6. Boucher, L.M., Marengere, L.E., Lu, Y., Thukral, S., and Mak, T.W. (1997). Binding sites of cytoplasmic effectors TRAF1, 2, and 3 on CD30 and other members of the TNF receptor superfamily. Biochem. Biophys. Res. Commun. 233, 592-600.
7. Cao, Z., Xiong, J., Takeuchi, M., Kurama, T., and Goeddel, D.V. (1996). TRAF6 is a signal transducer for interleukin-1. Nature 383, 443-446.
8. Cheng, G., Cleary, A.M., Ye, Z.S., Hong, D.I., Lederman, S., and Baltimore, D. (1995). Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science 267, 1494-1498.
9. Devergne, O., Hatzivassiliou, E., Izumi, K.M., Kaye, K.M., Kleijnen, M.F., Kieff, E., and Mosialos, G. (1996). Association of TRAF1, TRAF2, and TRAF3 with an Epstein-Barr virus LMP1 domain important for B-lymphocyte transformation: role in NF-κB activation. Mol. Cell. Biol. 16, 7098-7108.
10. Duckett, C.S., Gedrich, R.W., Gilfillan, M.C., and Thompson, C.B. (1997). Induction of nuclear factor kappaB by the CD30 receptor is mediated by TRAF1 and TRAF2. Mol. Cell. Biol. 17, 1535-1542.
11. Erickson, S.L., de Sauvage, F.J., Kikly, K., Carver-Moore, K., Pitts-Meek, S., Gillett, N., Sheehan, K.C.F., Schreiber, R.D., Goeddel, D.V., and Moore, M.W. (1994). Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice. Nature 372, 560-563.
12. Fiers, W. (1991). Tumor necrosis factor: characterization at the molecular, cellular and in vivo level. FEBS Lett. 285, 199-212.
13. Gedrich, R.W., Gilfillan, M.C., Duckett, C.S., Van Dongen, J.L., and Thompson, C.B. (1996). CD30 contains two binding sites with different specificities for members of the tumor necrosis factor receptor-associated factor family of signal transducing proteins. J. Biol. Chem. 271, 12852-12858.
14. Hsu, H., Xiong, J., and Goeddel, D.V. (1995). The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation. Cell 81, 495-504.
15. Hsu, H., Shu, H.-B., Pan, M.-G., and Goeddel, D.V. (1996a). TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84, 299-308.
16. Hsu, H., Shu, H.-B., Baichwal, V., and Goeddel, D.V. (1996b). TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4, 387-396.
17. Hsu, H., Solovyev, I., Colombero, A., Elliott, R., Kelley, M., and Boyle, W.J. (1997). ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J. Biol. Chem. 272, 13471-13474.
18. Hu, H.M., O'Rourke, K., Boguski, M.S., and Dixit, V.M. (1994). A novel RING finger protein interacts with the cytoplasmic domain of CD40. J. Biol. Chem. 269, 30069-30072.
19. Ihida, T.K., Tojo, T., Aoki, T., Kobayashi, N., Ohishi, T., Watanabe, T., Yamamoto, T., and Inoue, J. (1996a). TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc. Natl. Acad. Sci. USA 93, 9437-9442.
20. Ishida, T., Mizushima, S., Azuma, S., Kobayashi, N., Tojo, T., Suzuki, K., Aizawa, S., Watanabe, T., Mosialos, G., Kieff, E., et al. (1996b). Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region. J. Biol. Chem. 271, 28745-28748.
21. Izumi, K.M., Kaye, K.M., and Kieff, E.D. (1997). The Epstein-Barr virus LMP1 aminoacid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc. Natl. Acad. Sci. USA 94, 1447-1452.
22. Karasuyama, H., and Melchers, F. (1988). Establishment of mouse cell lines which constitutively secrete large quantities of interleukin-2, 3, or 5 using modified cDNA expression vectors. Eur. J. Immunol. 18, 97-104.
23. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N., Kishimoto, T., and Kikutani, H. (1994). The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1, 167-178.
24. Kyriakis, J.M., Banerjee, P., Nikolakaki, E., Dai, T., Rubie, E.A., Ahmad, M.F., Avruch, J., and Woodgett, J.R. (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.
25. Lee, S.Y., Lee, S.Y., Kandala, G., Liou, M.L., Liou, H.C., and Choi, Y. (1996). CD30/TNF receptor-associated factor interaction: NF-kappa B activation and binding specificity. Proc. Natl. Acad. Sci. USA 93, 9699-9703.
26. Liu, Z.-G., Hsu, H., Goeddel, D.V., and Karin, M. (1996). Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-κB activation prevents cell death. Cell 87, 565-576.
27. Marsters, S.A., Ayres, T.M., Skubatch, M., Gray, C.L., Rothe, M., and Ashkenazi, A. (1997). Herpesvirus entry mediator, a member fo the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-κB and AP-1. J. Biol. Chem. 272, 14029-14032.
28. Montgomery, R.I., Warner, M.S., Lum, B.J., and Spear, P.G. (1996). Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. Cell 87, 426-436.
29. Mosialos, G., Birkenbach, M., Yalamanchili, R., VanArsdale, T., Ware, C., and Kieff, E. (1995). The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell 80, 389-399.
30. Nakano, H., Oshima, H., Chung, W., Williams-Abbott, L., Ware, C.F., Yagita, H., and Okumura, K. (1996). TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J. Biol. Chem. 271, 14661-14664.
31. Natoli, G., Costanzo, A., Ianni, A., Templeton, D.J., Woodgett, J.R., Balsano, C., and Levrero, M. (1997). Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway. Science 275, 200-203.
32. Nishina, H., Fischer, K.D., Radvanyi, L., Shahinian, A., Hakem, R., Rubie, E.A., Bernstein, A., Mak, T.W., Woodgett, J.R., and Penninger, J.M. (1997). Stress-signalling kinase Sek1 protectsthymocytes from apoptosis mediated by CD95 and CD3. Nature 385, 350-353.
33. Pfeffer, K., Matsuyama, T., Kundig, T.M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P.S., Kranke, M., and Mak, T.W. (1993). Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell 73, 457-467.
34. Probert, L., Keffer, J., Corbella, P., Cazlaris, H., Patsavoudi, E., Stephens, S., Kaslaris, E., Kioussis, D., and Kollias, G. (1993). Wasting, ischemia, and lymphoid abnormalities in mice expressing T cell-targeted human tumor necrosis factor transgenes. J. Immunol. 151, 1894-1906.
35. Regnier, C.H., Tomasetto, C., Moog-Lutz, C., Chenard, M.P., Wendling, C., Basset, P., and Rio, M.C. (1995). Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J. Biol. Chem. 270, 25715-25721.
36. Reinhard, C., Shamoon, B., Shyamala V., and Williams, L.T. (1997). Tumor necrosis factor α-induced activation of c-jun N-terminal kinase is mediated by TRAF2. EMBO J. 16, 1080-1092.
37. Rothe, M., Wong, S.C., Henzel, W.J., and Goeddel, D.V. (1994). A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor. Cell 78, 681-692.
38. Rothe, M., Sarma, V., Dixit, V.M., and Goeddel, D.V. (1995a). TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science 269, 1424-1427.
39. Rothe, M., Pan, M.G., Henzel, W.J., Ayres, T.M., and Goeddel, D.V. (1995b). The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 83, 1243-1252.
40. Sato, T., Irie, S., and Reed, J.C. (1995). A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 358, 113-118.
41. Schmid, I., Uittenbogaart, C.H., and Giorgi, J.V. (1994). Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. Cytometry 15, 12-20.
42. Shu, H.-B., Takeuchi, M., and Goeddel, D.V. (1996). The tumor necrosis factor receptor 2 signal transducers TRAF2 and C-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex. Proc. Natl. Acad. Sci. USA 93, 13973-13978.
43. Smith, C.A., Farrah, T., and Goodwin, R.G. (1994). The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76, 959-962.
44. Stanger, B.Z., Leder, P., Lee, T.H., Kim, E., and Seed, B. (1995). RIP: a novel protein containing a death domain that interacts with Fas/ APO-1 (CD95) in yeast and causes cell death. Cell 81, 513-523.
45. Takeuchi, M., Rothe, M., and Goeddel, D.V. (1996). Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins. J. Biol. Chem. 277, 19935-19942.
46. Tartaglia, L.A., and Goeddel, D.V. (1992). Two TNF receptors, Immunol. Today 13, 151-153.
47. Ting, A.T., Pimentel-Muinos, F.X., and Seed, B. (1996). RIP mediates tumor necrosis factor receptor 1 activation of NF-κB but not Fas/ APO-1-initiated apoptosis. EMBO J. 15, 6189-6196.
48. Tsitsikov, E.N., Wright, D.A., and Geha, R.S. (1997). CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2. Proc. Natl. Acad. Sci. USA 94, 1390-1395.
49. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R., and Verma, I.M. (1996). Suppression of TNF-α-induced apoptosis by NF-κB. Science 274, 787-789.
50. Vandenabeele, P., Declercq, W., Beyaert, R., and Fiers, W. (1995). Two tumor necrosis factor receptors: structure and function. Trends Cell Biol. 5, 392-399.
51. Wang, C.-Y., Mayo, M.W., and Baldwin, A.S., Jr. (1996). TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-κB. Science 274, 784-787.
52. Xu, Y., Cheng, G., and Baltimore, D. (1996). Targeted disruption of TRAF3 leads to postnatal lethality and defective T-dependent immune responses. Immunity 5, 407-415.