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b (thus excluding association with endogenous CD79a-CD79b) and the cytoplasmic tails of CD79a or CD79b. Expression of these chimeras restored both B cell development to mature B cells and allelic exclusion as well as allowing for B cell activation. Although expression of both chimeras induces optimal activity, the individual CD79a or CD79b chimeras were sufficient to mediate many of the essential functions of the BCR.
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Surrogate or conventional light chains are required for membrane immunoglobulin mu to activate the precursor B cell transition
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Papavasiliou, F.1
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