The role of environmental antigens in the spontaneous development of autoimmunity in MRL-lpr mice

Journal of Immunology

Volumn 162, Issue 11, 1999, Pages 6322-6330

  Maldonado, Michael A ^a   Kakkanaiah, Vellalore ^b   MacDonald, Glen C ^b   Chen, Fangqi ^a   Reap, Elizabeth A ^b   Balish, Edward ^c   Farkas, Walter R ^d   Jennette, J Charles ^b   Madaio, Michael P ^a   Kotzin, Brian L ^e   Cohen, Philip L ^b   Eisenberg, Robert A ^a,f  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

^e UNIVERSITY OF COLORADO   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY TITER; ARTICLE; AUTOIMMUNITY; ENVIRONMENTAL EXPOSURE; FLOW CYTOMETRY; GERMFREE ANIMAL; HISTOPATHOLOGY; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS; ANTIGENS, BACTERIAL; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DIET; ENVIRONMENT, CONTROLLED; FEMALE; GERM-FREE LIFE; HOUSING, ANIMAL; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED MRL LPR; NEPHRITIS;

EID: 0033153482     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Putterman, C., W. Limpanasithikul, M. Edelman, and B. Diamond. 1996. The double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibody. J. Clin. Immunol. 97:2251.
2. Gilkeson, G. S., A. M. Pippen, and D. S. Pisetsky. 1995. Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA. J. Clin. Immunol. 95:1398.
3. Krieg, A. M. 1995. CpG DNA: a pathogenic factor in systemic lupus erythematosus? J. Clin. Immunol. 15:284.
4. Murakami, K., H. Muruyama, M. Hosono, K. Sinagawa, J. Yamada, K. Kuribayashi, and T. Masuda. 1992. Germ-free condition and the susceptibility of BALB/c mice to post-thymectomy autoimmune gastritis [letter]. Autoimmunity 12:69.
5. Goverman, J., A. Woods, L. Larson, L. P. Weiner, L. Hood, and D. M. Zaller. 1993. Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell 72:551.
6. East, J., P. R. Prosser, E. J. Holborow, and H. Jaquet. 1967. Autoimmune reactions and virus-like particles in germ-free NZB mice. Lancet 1:755.
7. Unni, K. K., K. E. Holley, F. C. McDuffie, and J. L. Titus. 1975. Comparative study of NZB mice under germfree and conventional conditions. J. Rheumatol. 2:36.
8. Suzuki, T., T. Yamada, T. Takao, T. Fujimura, E. Kawamura, Z. M. Shimizu, R. Tamashita, and K. Nomoto. 1987. Diabetogenic effects of lymphocyte transfusion on the NOD or NOD nude mouse. In Immune-Deficient Animals in Biomedical Research. J. Rygaard, and M. Sprang-Thomsen, eds. Karger, Basel.
9. Olson, G. B., and B. S. Wostmann. 1956. Lymphocytopoiesis, plasmacytopoiesis and cellular proliferation in nonantigenically stimulated germfree mice. J. Immunol. 97:267.
10. Wostmann, B. S., J. R. Pleasants, and P. Bealmear. 1971. Dietary stimulation of immune mechanisms. Fed. Proc. 30:1779.
11. Pleasants, J. R., B. S. Reddy, and B. S. Wostmann. 1970. Qualitative adequacy of a chemically defined liquid diet for reproducing germfree mice. J. Nutr. 100: 498.
12. Wostmann, B. S., and J. R. Pleasants. 1991. The germ-free animal fed chemically defined diet: a unique tool. Proc. Soc. Exp. Biol. Med. 198:539.
13. Greenstein, J. P., S. M. Birnbaum, M. Winitz, and M. C. Otey. 1957. Quantitative nutritional studies with water soluble, chemically defined diets. I. Growth, reproduction and lactation in rats. Arch. Biochem. Biophys. 72:396.
14. Pleasants, J. R., M. H. Johnson, and B. S. Wostmann. 1986. Adequacy of chemically defined, water-soluble diet for germfree BALB/c mice through successive generations and litters. J. Nutr. 116:1949.
15. Hashimoto, K., H. Handa, K. Umehara, and S. Sasaki. 1978. Germfree mice reared on an "antigen-free" diet. Lab. Anim. Sci. 28:38.
16. Hooijkaas, H., R. Benner, J. R. Pleasants, and B. S. Wostmann. 1984. Isotypes and specificities of immunoglobulins produced by germ-free mice fed chemically defined ultrafiltered "antigen-free" diet. Eur. J. Immunol. 14:1127.
17. Haury, M., A. Sundblad, A. Grandien, C. Barreau, A. Coutinho, and A. Nobrega. 1997. The repertoire of serum IgM in normal mice is largely independent of external antigenic contact. Eur. J. Immunol. 27:1557.
18. Bos, N. A., and V. A. Ploplis. 1994. Humoral immune response to 2,4-dinitrophenyl: keyhole limpet hemocyanin in antigen-free, germ-free and conventional BALB/c mice. Eur. J. Immunol. 24:59.
19. Bakker, R., E. Lasonder, and N. A. Bos. 1995. Measurement of affinity in serum samples of antigen-free, germ-free and conventional mice after hyperimmunization with 2,4-dinitrophenyl keyhole limpet hemocyanin, using surface plasmon resonance. Eur J. Immunol. 25:1680.
20. Etlinger, H. M., and C. H. Heusser. 1986. T15 dominance in BALB/c mice is not controlled by environmental factors. J. Immunol. 136:1988.
21. Bos, N. A., and C. G. Meeuwsen. 1989. B cell repertoire in adult antigen-free and conventional neonatal BALB/c mice. I. Preferential utilization of the CH-proximal VH gene family PC7183. Eur. J. Immunol. 19:1811.
22. Bos, N. A., C. G. Meeuwsen, P. Van Wijngaarden, and R. Benner. 1989. B cell repertoire in adult antigen-free and conventional neonatal BALB/c mice. II. Analysis of antigen-binding capacities in relation to VH gene usage. Eur. J. Immunol. 19:1817.
23. Pereira, P., L. Forni, E. L. Larsson, M. Cooper, C. Heusser, and A. Coutinho. 1986. Autonomous activation of B and T cells in antigen-free mice. Eur. J. Immunol. 16:685.
24. Hooper, D. C., E. H. Molowitz, N. A. Bos, V. A. Ploplis, and J. J. Cebra. 1995. Spleen cells from antigen-minimized mice are superior to spleen cells from germ-free and conventional mice in the stimulation of primary in vitro proliferative responses to nominal antigens. Eur. J. Immunol. 25:212.
25. Vos, Q., L. A. Jones, and A. M. Kruisbeek. 1992. Mice deprived of exogenous antigenic stimulation develop a normal repertoire of functional T cells. J. Immunol. 149:1204.
26. lpr mice. J. Clin. Invest. 101:696.
27. Marks, T., and W. R. Farkas. 1997. Effects of a diet deficient in tyrosine and queuine on germfree mice. Biochem. Biophys. Res. Commun. 230:233.
28. Reyniers, J. P., E. A. Machado, and W. R. Farkas. 1984. Hepatotoxicity of chemically defined diets containing polysorbate-80 in germfree and conventional mice. In Germfree Research: Microflora Control and its Application to the Biomedical Sciences. B. S. Wostmann, ed. Alan R. Liss, Inc., New York, p. 351.
29. Hooijkaas, H., A. A. van der Linde-Preesman, W. M. Bitter, R. Benner, J. R. Pleasants, and B. S. Wostmann. 1985. Frequency analysis of functional immunoglobulin C-and V-gene expression by mitogen-reactive B cells in germ-free mice fed chemically denned ultra-filtered "antigen-free" diet. J. Immunol. 134:2223.
30. Hammes, W. P., N. Weiss, and W. Holzapfel. 1992. The genera Lactobacillus and Carnobacterium. In The Prokaryotes. A. Balows, H. G. Trüper, M. Dworkin, W. Harder, and K. H. Schleifer, eds. Springer Verlag, New York, p. 1535.
31. Maldonado, M. A., R. A. Eisenberg, E. Roper, P. L. Cohen, and B. L. Kotzin. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J. Exp. Med. 181:641.
32. Herron, L. R., R. A. Eisenberg, E. Roper, V. N. Kakkanaiah, P. L. Cohen, and B. L. Kotzin. 1993. Selection of the T cell receptor repertoire in lpr mice. J. Immunol. 151:3450.
33. Sobel, E. S., T. Katagiri, K. Katagiri, S. C. Morris, P. L. Cohen, and R. A. Eisenberg. 1991. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of murine systemic autoimmunity. J. Exp. Med. 173:1441.
34. Morris, S. C., R. L. Cheek, P. L. Cohen, and R. A. Eisenberg. 1990. Allotype-specific immunoregulation of autoantibody production by host B cells in chronic graft-versus host disease. J. Immunol. 144:916.
35. Izui, S., T. Berney, T. Shibata, and T. Fulpius. 1993. IgG3 cryoglobulins in autoimmune MSL-lpr/lpr mice: immunopathogenesis, therapeutic approaches and relevance to similar human diseases. Ann. Rheum. Dis. 1:S48.
36. Foster, M. H., M. MacDonald, K. J. Barrett, and M. P. Madaio. 1991. VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies. J. Immunol. 147:1504.
37. Bradley, D. S., J. C. Jennette, P. L. Cohen, and R. A. Eisenberg. 1994. Chronic graft versus host disease-associated autoimmune manifestations are independently regulated by different MHC class II loci. J. Immunol. 152:1960.
38. Sobel, E. S., P. L. Cohen, and R. A. Eisenberg. 1993. lpr T cells are necessary for autoantibody production in lpr mice. J. Immunol. 150:4160.
39. Shlomchik, M. J., M. P. Madaio, D. Ni, M. Trounstein, and D. Huszar. 1994. The role of B cells in lpr/lpr-induced autoimmunity. J. Exp. Med. 180:1295.
40. Wosttnann, B. S., E. Bruckner-Kardoss, and J. R. Pleasants. 1982. Oxygen consumption and thyroid hormones in germfree mice fed glucose-amino acid liquid diet. J. Nutr. 112:552.
41. Keen, C. L., B. J. German, J. P. Mareschi, and M. E. Gershwin. 1991. Nutritional modulation of murine models of autoimmunity. Rheum. Dis. Clin. N. Am. 17:223.
42. Fernandes, G., and R. A. Good. 1984. Inhibition by restricted-calorie diet of lymphoproliferative disease and renal damage in MRL/lpr mice. Proc. Natl. Acad. Sci. USA 81:6144.
43. Morrow, W. J., J. Homsy, C. A. Swanson, Y. Ohashi, J. Estes, and J. A. Levy. 1986. Dietary fat influences the expression of autoimmune disease in MRL/lpr/ lpr mice. Immunology 59:439.
44. Hall, A. V., A. Parbtani, W. F. Clark, E. Spanner, M. Keeney, I. Chin-Yee, D. J. Philbrick, and B. J. Holub. 1993. Abrogation of MRL/lpr lupus nephritis by dietary flaxseed. Am. J. Kidney Dis. 22:326.
45. Dubois, E. L., and L. Strain. 1973. Effect of diet on survival and nephropathy of NZB-NZW hybrid mice. Biochem. Med. 7:336.
46. Godfrey, D. G., W. H. Stimson, J. Watson, J. F. Belch, and R. D. Sturrock. 1986. Effects of dietary supplementation on autoimmunity in the MRL/lpr mouse: a preliminary investigation. Ann. Rheum. Dis. 45:1019.
47. Kubo, C., N. K. Day, and R. A. Good. 1984. Influence of early or late dietary restriction on life span and immunological parameters in MRL/Mp-lpr/lpr mice. Proc. Natl. Acad. Sci. USA 81:5831.
48. 1 mice. Clin. Immunol. Immunopathol. 15:293.
49. Watson, J., D. Godfrey, W. H. Stimson, J. J. Belch, and R. D. Sturrock. 1988. The therapeutic effects of dietary fatty acid supplementation in the autoimmune disease of the MRL-mp-lpr/lpr mouse. Int. J. Immunopharmacol. 10:467.
50. Batsford, S., M. Schwerdtfeger, R. Rohrbach, C. Cambiaso, and R. Kluthe. 1984. Synthetic amino-acid diet prolongs survival in autoimmune murine disease. Clin. Nephrol. 21:60.
51. Tiwari, R. K., J. T. Venkatraman, B. Cinader, J. Flory, A. Wierzbicki, Y. K. Goh, and M. T. Clandinin. 1988. Influence of genotype on the phospholipid fatty acid composition of splenic T and B lymphocytes in MRL/MpJ-lpr/lpr mice. Immunol. Lett. 17:151.
52. + double-negative T cells as the predominant populations in enlarged lymph nodes. J. Immunol. 154:4986.
53. Morrow, W. J., J. Homsy, C. Swanson, and J. A. Levy. 1993. The influence of nutrition on experimental autoimmune disease. In Nutrient Modulation of the Immune Response. S. Cunningham-Rundles, ed. Marcel Dekker, Inc., New York, p. 153.
54. Umehara, K., K. Tazume, K. Hashimoto, and S. Sasaki. 1984. The effect of the antigenic stimuli derived from the diet and microbial flora on immunoglobulin levels. In Germfree Research: Microflora Control and its Application to the Biomedical Sciences. B. S. Wostmann, ed. Alan R. Liss, Inc., New York, p. 351.
55. Shan, H., M. J. Shlomchik, A. Marshak-Rothstein, D. S. Pisetsky, S. Litwin, and M. G. Weigert. 1994. The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. J. Immunol. 153:5104.
56. Desai-Mehta, A., C. Mao, S. Rajagopalan, T. Robinson, and S. K. Datta. 1995. Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus. J. Clin. Invest. 95:531.
57. Retter, M. W., P. L. Cohen, R. A. Eisenberg, and S. H. Clarke. 1996. Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice. J. Immunol 156:1296.
58. Fatenejad, S., W. Brooks, A. Schwartz, and J. Craft. 1994. Pattern of anti-small nuclear ribonucleoprotein antibodies in MRL/Mp-lpr/lpr mice suggests that the intact U1 snRNP particle is their auloimmunogenic target. J. Immunol. 152:5523.
59. Shlomchik, M. J., A. Marshak-Rothstein, C. B. Wolfowicz, T. L. Rothstein, and M. G. Weigert. 1987. The role of clonal selection and somatic mutation in autoimmunity. Nature 328:805.
60. van Snick, J. L., and P. L. Masson. 1980. Incidence and specificities of IgA and IgM anti-IgG autoantibodies in various mouse strains and colonies. J. Exp. Med. 151:45.
61. Peng, S. L., M. P. Madaio, D. P. Hughes, I. N. Crispe, M. J. Owen, L. Wen, A. C. Hayday, and J. Craft. 1996. Murine lupus in the absence of αβ T cells. J. Immunol. 156:4041.
62. Stinnett, J. D. 1983. Nutrition and the immnune response. CRC Press, Inc., Boca Raton.
63. Shlomchik, M. J., M. P. Madaio, D. Ni, M. Trounstein, and D. Huszar. 1994. The role of B cells in lpr/lpr-induced autoimmunity. J. Exp. Med. 180:1295.
64. Chan, O., and M. J. Shlomchik. 1998. A new role for B cells in systemic autoimmunity: B cells promote spontaneous T cell activation in MRL-lpr/lpr mice. J. Immunol. 160:51.
65. Izui, S., P. J. McConahey, A. N. Theofilopoulos, and F. J. Dixon. 1979. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. J. Exp. Med. 149:1099.
66. 1 hybrid mice. J. Exp. Med. 154:1116.
67. Datta, S. K., P. J. McConahey, N. Manny, A. N. Theofilopoulos, F. J. Dixon, and R. S. Schwartz. 1978. Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice. II. The viral envelope glycoprotein gp70. J. Exp. Med. 147:872.
68. Andrews, J., L. Hang, A. N. Theofilopoulos, and F. J. Dixon. 1986. Lack of relationship between serum gp70 levels and the severity of systemic lupus erythematosus in MRL/1 mice. J. Exp. Med. 163:458.