Continued differentiation during a lymphopoiesis requires signals in addition to cell survival

International Immunology

Volumn 9, Issue 10, 1997, Pages 1481-1494

  Tarlinton, David M ^a   Corcoran, Lynn M ^a   Strasser, Andreas ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

Apoptosis; B cell differentiation; Immunoglobulin; Knockout mice

Indexed keywords

CD22 ANTIGEN; CD23 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN J CHAIN; IMMUNOGLOBULIN M; IMMUNOGLOBULIN RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN BCL 2; DNA; DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; IMMUNOGLOBULIN D; RAG 1 PROTEIN; RAG-1 PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL DEATH; CELL SURVIVAL; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; GENE REARRANGEMENT; IMMUNOGLOBULIN GENE; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENE; ANIMAL; C57BL MOUSE; CELL DIFFERENTIATION; CELL DIVISION; CYTOLOGY; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL; IMMUNOLOGY; MALE; MOLECULAR GENETICS; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; TRANSGENIC MOUSE;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; CELL DIVISION; CELL SURVIVAL; DNA; DNA-BINDING PROTEINS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; IMMUNOGLOBULIN D; IMMUNOGLOBULIN M; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 0030608977     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.10.1481     Document Type: Article

References (54)

1. Metcalf, D. 1989. The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells. Nature 339:27.
2. Rolink, A., Karasuyama, H., Haasner, D., Grawunder, U., Martensson, I. L., Kudo, A. and Melchers, F. 1994. Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development. Immunol. Rev. 137:185.
3. Hardy, R. R., Carmack, C. E., Shinton, S. A., Kemp, J. D. and Hayakawa, K. 1991. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173:1213.
4. Ehlich, A., Martin, V., Muller, W. and Rajewsky, K. 1994. Analysis of the B-cell progenitor compartment at the level of single cells. Curr. Biol. 4:573.
5. 5 surrogate light chain in early bone marrow precursor B cells of normal and B cell-deficient mutant mice. Cell 77:133.
6. Nemazee, D. A. and Burki, K. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody gene. Nature 337:562.
7. Hartley, S. B., Crosbie, J., Brink, R., Kantor, A. B., Basten, A. and Goodnow, C. C. 1991. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature 353:765.
8. Gu, H., Tarlinton, D., Muller, W., Rajewsky, K. and Forster, I. 1991. Most peripheral B cells in mice are ligand selected. J. Exp. Med. 173:1357.
9. Cyster, J. G., Hartley, S. B. and Goodnow, C. C. 1994. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature 371:389.
10. Torres, R. M., Flaswinkel, H., Reth, M. and Rajewsky, K. 1996. Aberrant B cell development and immune response in mice with a compromised BCR complex. Science 272:1804.
11. Mombaerts, P., Iacomini, J., Johnson, R. S., Herrup, K., Tonegawa, S. and Papaioannou, V. E. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869.
12. Shinkai, Y., Rathbun, G., Lam, K.-P., Oltz, E. M., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. M. and Alt, F. W. 1992. RAG-2- deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangements. Cell 68:855.
13. Bosma, G. C., Custer, R. P. and Bosma, M. J. 1983. A severe combined immunodeficiency mutation in the mouse. Nature 301:527.
14. Schuler, W., Weiler, I. J., Schuler, A., Phillips, R. A., Rosenberg, N., Mak, T. W., Kearney, J. F., Perry, R. P. and Bosma, M. J. 1986. Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46:963.
15. H joints in B cell progenitors in severe combined immunodeficiency mice. J. Exp. Med. 178:1007.
16. Kitamura, D., Roes, J., Kuhn, R. and Rajewsky, K. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ. chain gene. Nature 350:423.
17. Kitamura, D. and Rajewsky, K. 1992. Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356:154.
18. Gong, S. C. and Nussenzweig, M. C. 1996. Regulation of an early developmental checkpoint in the B cell pathway by lgb. Science 272:411.
19. H element reading frames. Cell 65:47.
20. Meek, K. 1990. Analysis of junctional diversity during B lymphocyte development. Science 250:820.
21. Kaartinen, M. and Makel, O. 1985. Reading of D genes in variable frames as a source of antibody diversity, Immunol. Today 6:324.
22. Reth, M. G. and Alt, F. W. 1984. Novel immunoglobulin heavy chains are produced from DJH gene segment rearrangements in lymphoid cells. Nature 312:418.
23. H element reading frame selection is influenced by an Ig heavy chain transgene, but not by bcl-2. J. Immunol. 154:3341.
24. Rolink, A., Kudo, A., Karasuyama, H., Kikuchi, Y. and Melchers, F. 1991. Long-term proliferating early pre B cell lines and clones with the potential to develop to surface Ig-positive, mitogen reactive B cells in vitro and in vivo. EMBO J. 10:327.
25. Peschon, J. J., Morrissey, P. J., Grabstein, K. H., Ramsdell, F. J., Maraskovsky, E., Gliniak, B. C., Park, L. S., Ziegler, S. F., Williams, D. E., Ware, C. B., et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180:1955.
26. Kodama, H., Nose, M., Hamaguchi, Y., Tsunoda, J.-i., Suda, T., Nishikawa, N. and Nishikawa, S.-i. 1992. In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand. J. Exp. Med. 176:351.
27. 5 protein in B cell development. Cell 69:823.
28. Grawunder, U., Leu, T. M. J., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F. and Winkler, T. H. 1995. Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 3:601.
29. Osmond, D. G. 1993. The turnover of B-cell populations. Immunol Today 14:34.
30. Reichman-Fried, M., Hardy, R. R. and Bosma, M. J. 1990. Development of B-lineage cells in the bone marrow of scid/scid mice following the introduction of functionally rearranged immunoglobulin transgenes. Proc. Natl Acad. Sci. USA 87:2730.
31. Spanopoulou, E., Roman, C. A. J., Corcoran, L. M., Schlissel, M. S., Silver, D. P., Nemazee, D., Nussenzweig, M. C., Shinton, S. A., Hardy, R. A. and Baltimore, D. 1994. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8:1030.
32. Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T. K., Mendelshon, M., Rolink, A., Melchers, F. and Alt, F. W. 1994. Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation. Genes Dev. 8:1043.
33. Strasser, A., Harris, A. W., Corcoran, L. M. and Cory, S. 1994. bcl-2 expression promotes B but not T lymphoid development in scid mice. Nature 368:457.
34. Strasser, A., Whittingham, S., Vaux, D. L., Bath, M. L., Adams, J. M., Cory, S. and Harris, A. W. 1991 Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl Acad. Sci. USA 88:8661.
35. Strasser, A., Harris, A. W., Huang, D. C. S., Krammer, P. H. and Cory, S. 1995. Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EMBO J. 14:6136.
36. Strasser, A., Harris, A. W. and Cory, S. 1991. Bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship. Cell 67:889.
37. Tarlinton, D., Mclean, M. and Nossal, G. J. V. 1995. B1 and B2 cells differ in their potential to switch immunoglobulin isotype. Eur. J. Immunol. 25:3388.
38. Pezzella, F., Tse, A. G. D., Cordell, J. L., Pulford, K. A. F., Gatter, K. C. and Mason, D. Y. 1990. Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation. Am. J. Pathol. 137:225.
39. Hardy, R. R., Kemp, J. D. and Hayakawa, K. 1989. Analysis of lymphoid population in scid mice; detection of a potential B lymphocyte progenitor population present at normal levels in scid mice by three color flow cytomëtry with B220 and S7. Curr. Top. Microbiol. Immunol. 152:19.
40. Bosma, M. J. and Carroll, A. M. 1991. The scid mouse mutant: definition, characterization, and potential uses. Annu. Rev. Immunol. 9:323.
41. Kubagawa, H., Cooper, M. D., Carroll, A. J. and Burrows, P. D. 1989. Light-chain gene expression before heavy-chain gene rearrangement in pre-B cells transformed by Epstein-Barr virus. Proc. Natl Acad. Sci. USA 86:2356.
42. Ehlich, A., Schaal, S., Gu, H., Kitamura, D., Muller, W. and Rajewsky, K. 1993. Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell 72:695.
43. Yuan, D. and Tucker, P. W. 1983. Transcriptional regulation of the μ-δ heavy chain locus in normal murine B lymphocytes. J. Exp. Med. 160:564.
44. Maki, R., Roeder, W., Traunecker, A., Sidman, C., Wabl, M., Raschke, W. and Tonegawa, S. 1981. The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin δ genes. Cell 24:353.
45. Iglesias, A., Lamers, M. and Kohler, G. 1987. Expression of immunoglobulin δ chain causes allelic exclusion in transgenic mice. Nature 330:482.
46. Brink, R., Goodnow, C. C., Crosbie, J., Adams, E., Eris, J., Mason, D. Y., Hartley, S. B. and Basten, A. 1992. Immunoglobulin M and D antigen receptors are both capable of mediating B lymphocyte activation, deletion, or anergy after interaction with specific antigen. J. Exp. Med. 176:991.
47. Rolink, A. and Melchers, F. 1991. Molecular and cellular origins of B lymphocyte diversity. Cell 66:1081.
48. Lassoued, K., Illges, H., Benlagha, K. and Cooper, M. D. 1996. Fate of surrogate light chains in B lineage cells. J. Exp. Med. 183:421.
49. Cyster, J. G., Healy, J. I., Kishihara, K., Mak, T. W., Thomas, M. L., Goodnow, C. C. 1996. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381:325.
50. Epstein, M. M., Di Rosa, F., Jankovic, D., Sher, A. and Matzinger, P. 1995. Successful T cell priming in B cell-deficient mice. J. Exp. Med. 182:915.
51. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1:197.
52. Strasser, A., Harris, A. W., Von Boehmer, H. and Cory, S. 1994. Positive and negative selection of T cells in T cell receptor transgenic mice expressing a bcl-2 transgene. Proc. Natl Acad. Sci. USA 91:1376.
53. Fairbairn, L. J., Cowling, G. J., Reipert, B. M. and Dexter, T. M. 1993. Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors. Cell 74:823.
54. Ichihara, Y., Hayashida, H., Miyazawa, S. and Kurosawa, Y. 1989. Only DFL16: DSP2 and DQ52 gene families exist in mouse immunoglobulin heavy chain diversity gene loci, of which DFL16 and DSP2 originate from the same primordial DH gene. Eur. J. Immunol. 19:1849.