p53 Prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1923-1928

  Jiang, Di ^a   Lenardo, Michael J ^a   Zúñiga Pflücker, Juan Carlos ^b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; PROTEIN P53;

ANIMAL CELL; ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; DNA DAMAGE; GENE ACTIVATION; GENE LOCATION; GENE REARRANGEMENT; GENETIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOMATIC MUTATION; T LYMPHOCYTE; THYMOCYTE;

ANIMALS; CHOLERA TOXIN; ILEUM; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; INTESTINE, SMALL; JEJUNUM; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; PEYER'S PATCHES; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTES; TETANUS TOXOID; VACCINATION;

EID: 0029880454     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1923     Document Type: Article

References (30)

1. Bosma, G.C., R.P. Custer, and M.J. Bosma. 1983. A severe combined immunodeficiency mutation in Lhe mouse. Nature (Lond.). 301:527-530.
2. Shinkai, Y., G. Rathbun, K.-P. Lam, E.M. Oltz, V. Stewart, M. Mendelsohn, J. Charron, M. Datta, F. Young, A.M. Stall, and F.W. Alt. 1992. RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 68:855-867.
3. Mombaerts, P., J. Iacomini, R.S. Johnson, K. Herrup, S. Tonegawa, and V.E. Papaioannou. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 68:869-877.
4. Shinkai, Y., S. Koyasu, K.-I. Nakayama, K.M. Murphy, D.Y. Loh, E.L. Reinherz, and F.W. Alt. 1993. Restoration of T cell development in RAG-2-deficierit mice by functional TCR transgenes. Science (Wash. DC). 259:822-825.
5. Mombaerts, P., A.R. Clarke, M.A. Rudnicki, J. Iacomini, S. Itohara, J.J. Lafaille, L. Wang, Y. Ichikawa, R. Jaenisch, M.L. Hooper, and S. Tonegawa. 1992. Mutations in the T-cell antigen receptor genes α and β block thymocyte development at different stages. Nature (Lond.). 360:225-231.
6. Saint-Ruf, C., K. Ungewiss, M. Groettrup, L. Bruno, H.J. Fehling, and H. von Boehmer. 1994. Analysis and expression of a cloned pre-T cell receptor gene. Science (Wash. DC). 266:1208-1212.
7. Godfrey, D.I., and A. Zlotnik. 1993. Control points in early T-cell development. Immunol. Today. 14:547-553.
8. Levelt, C.N., P. Mombaerts, A. Iglesias, S. Tonegawa, and K. Eichmann. 1993. Restoration of early thymocyte differentiation in T cell receptor β-chain-deficient mutant mice by transmembrane signalling through CD3∈. Proc. Natl. Acad. Sci. USA. 90:11401-11405.
9. Kisielow, P., and H. von Boehmer. 1990. Negative and positive selection on immature thymocytes: timing and the role of ligand for γ/β T cell receptor. Semin. Immunol. 2:35-44.
10. Zúñiga-Pflücker, J.C., L.A. Jones, L.T. Chin, and A.M. Kruisbeek. 1990. CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire. Semin. Immunol. 3: 167-172.
11. + thymocytes without T cell receptor β rearrangement in recombinase activation gene 2-/- mice. J. Exp. Med. 180:1517-1521.
12. Vogelstein, B., and K.W. Kinzler. 1992. p53 function and dysfunction. Cell. 70:523-526.
13. Lee, J.M., and A. Bernstein. 1993. p53 mutations increase resistance to ionizing radiation. Proc. Natl. Acad. Sci. USA. 90: 5742-5746.
14. Lavigueur, A., V. Maltby, D. Mock, J. Rossant, T. Pawson, and A. Bernstein. 1989. High incidence of lung, bone, and lymphoid tumors in transgenic mice overexpressing mutant alleles of the p53 oncogene. Mol. Cell Biol. 9:3982-3991.
15. Brathwaite, O., W. Bayona, and E.W. Newcomb. 1992. p53 mutations in C57BL/6J murine thymic lymphomas induced by γ-irradiation and N-methylnitrosourea. Cancer Res. 52: 3791-3795.
16. Zúñiga-Pflücker, J.C., and A.M. Kruisbeek. 1990. Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation. J Immunol. 144:3736-3740.
17. neg thymocytes resembles antigen-activated mature T cells. J. Exp. Med. 178:1139-1149.
18. + thymocytes in RAG-deficient mice through a T cell receptor β chain-independent pathway J. Exp Med. 181:1187-1195.
19. Reiss, M., D.E. Brash, T. Munoz-Antonia, J.A. Simon, A. Ziegler, V.F. Vellucci, and Z.L. Zhou. 1992. Status of the p53 tumor suppressor gene in human squamous carcinoma cell lines. Oncol. Res. 4:349-357.
20. Lowe, S.W., E.M. Schmitt, S.W. Smith, B.A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature (Lond.). 362:847-849.
21. lck in thymopoiesis. EMBO (Eur. Mol. Biol. Organ.) J. 12:1671-1680.
22. lck. Nature (Lond.). 357:161-164.
23. Mombaerts, P., S.J. Anderson, R.M. Perlmutter, T.W. Mak, and S. Tonegawa. 1994. An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. Immunity. 1:261-267.
24. lck and CD3ζ in early thymic selection. Immunity. 3:215-222.
25. + stage during positive selection and promotes thymocyte differentiation at several control points. Immunity. 1:197-205.
26. Oltvai, Z.N., C.L. Milliman, and S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 74:609-619.
27. Oltvai, Z.N., and S.J. Korsmeyer. 1994. Checkpoints of dueling dimers foil death wishes. Cell. 79:189-192.
28. Yin, X.M., Z.N. Oltvai, and S.J. Korsmeyer. 1994. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature (Lond.). 369: 321-323.
29. Miyashita, T., S. Krajewski, M. Krajewska, H.G. Wang, H.K. Lin, D.A. Liebermann, B. Hoffman, and J.C. Reed. 1994. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1799-1805.
30. Miyashita, T., and J.C. Reed. 1995. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell. 80:293-299.