Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis

Journal of Experimental Medicine

Volumn 183, Issue 4, 1996, Pages 1377-1388

  Lagresle, Chantal ^a   Mondièrc, Paul ^a   Bella, Chantal ^a   Krammer, Peter H ^b   Defrance, Thierry ^a  

^a INSERM   (France)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; PRIORITY JOURNAL;

ANTIGENS, CD; ANTIGENS, CD40; ANTIGENS, CD95; APOPTOSIS; B-LYMPHOCYTE SUBSETS; HUMANS; IMMUNOGLOBULINS; IMMUNOLOGIC CAPPING; IMMUNOLOGIC MEMORY; INTERLEUKINS; LYMPHOCYTE ACTIVATION; MEASLES VIRUS; MODELS, IMMUNOLOGICAL; RECEPTORS, ANTIGEN, B-CELL; SIGNAL TRANSDUCTION; TONSIL;

EID: 0029913687     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.4.1377     Document Type: Article

References (44)

1. MacLennan, I.C.M. 1994. Germinal centers. Annu. Rev. Immunol. 12:117-139.
2. Banchereau, J., F. Bazan, D. Blanchard, F. Brière, J.-P. Galizzi, C. Van Kooten, Y.-J. Liu, F. Rousset, and S. Saeland. 1994. The CD40 Ag and its ligand. Annu. Rev. Immunol. 12:881-922
3. Aversa, G., J. Punnonen, J.M. Carballido, B.G. Cocks, and J.E. de Vries. 1994. CD40 ligand-CD40 interaction m Ig isotype switching in mature and immature human B cells. Sem. Immunol. 6:295-301.
4. Liu, Y.-J., D.E. Joshua, G.T. Williams, G.A. Smith, J. Gordon, and I.C.M. MacLennan. 1989. Mechanism of Ag-driven selection in germinal centres. Nature (Lond.). 342:929-931.
5. Foy, T.M., J.D. Laman, J.A. Ledbetter, A. Aruffo, E. Claasen, and R.J. Noelle. 1994. gp39-CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180:157-163.
6. Gray, D., P. Dullforce, and S. Jainandunsing. 1994. Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction. J. Exp. Med. 180:141-155.
7. Bartlett, W.C., and R.J. Noelle. 1991. T cell-dependent B-cell activation. In T-Cell Dependent and Independent B-Cell Activation. E.C. Snow, editor. CRC Press, Inc., Boca Raton, FL. 11-138.
8. Castle, B.E., K. Kishimoto, C. Stearns, M.L. Brown, and M.R. Kehry. 1993. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J. Immunol. 151:1777-1788.
9. Yellin, M.J., K. Sippel, G. Inghirami, L.R. Covey, J.J. Lee, J. Sinning, E.A. Clark, L. Chess, and S. Lederman. 1994. CD40 molecules induce downmodulation and endocytosis of T cell surface T cell-B cell activating molecule/CD40L. Potential role in regulating helper effector function. J. Immunol. 152:598-608.
10. Van Kooteen, C., C. Gaillard, J.-P. Gahzzi, P. Hermann, F. Fossiez, J. Banchereau, and D. Blanchard. 1994. B cells regulate expression of CD40 ligand 011 activated T cells by lowering the mRNA level and through the release of soluble CD40. Eur. J. Immunol. 24:787-792.
11. Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins, and S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas Ag that mediates apoptosis. Nature (Lond.). 356:314-317.
12. Nagata, S., and T. Suda. 1995. Fas and Fas ligand: lpr and gld mutations. Itmnunol. Today. 16:39-43.
13. Perkins, D.I., R.M. Glaser, C.A. Mahon, J. Michaelson, and A. Marshak-Rothstein. 1990. Evidence for an intrinsic B cell defect in lpr/lpr mice apparent in neonatal chimeras. J. Immunol. 145:549-555.
14. Sobel, E.S., T. Katagiri, K. Katagiri, S.C. Morris, P.I. Cohen, and R.A. Eisenberg. 1991. An intrinsic B cell defect is required for the production of autoantibodies in the lpr model of marine systemic autoimmunity. J. Exp. Med. 173:1441-1449.
15. Ramsdell, F., M.S. Seaman, R.E. Miller, K.S. Picha, M.K. Kennedy, and D.H. Lynch. 1994. Differential ability of Till and Th2 T cells to express Fas ligand and to undergo activation induced cell death. Int. Immunol. 6:1545-1553.
16. Suda, T., T. Okazaki, Y. Naito, T. Yokota, N. Arai, S. Ozaki, K. Nakao, and S. Nagata. 1995. Expression of the Fas ligand in cells of the T cell lineage. J. Immunol. 154:3806-3813.
17. Lagresle, C., C. Bella, P.T. Daniel, P.H. Krammer, and T. Defrance. 1995. Regulation of germinal center B cell differentiation. Role of the human APO-1/Fas (CD95) molecule. J. Immunol. 154:5746-5756.
18. - B cell compartment: identification of two major tonsillar B cell subsets. Int. Immunol. 5:1259-1268.
19. Pascual, V., Y.-J. Liu, A. Magalaski, O. De Bouteiller, J. Banchereau, and J.D. Capra. 1994. Analysis of somatic mutation in five B cell subsets of human tonsil. J. Exp. Med. 180: 329-339.
20. Liu, Y.-J., C. Barthélémy, O. De Bouteiller, C. Arpin, I. Durand, and J. Banchereau. 1995. Memory B cells from human tonsils colonize mucosal epithelium and directly present Ag to T cells by rapid up-regulation of B7-1 and B7-2. Immunity. 2:239-248.
21. Wild, F., and T. Greenland. 1979. A study of the measles virus induced proteins incorporated into the cell membrane. Intervirology. 11:275-281.
22. Clark, E.A., and J. A. Ledbetter. 1986. Activation of human B cells mediated through two distinct cell surface differentiation Ags, Bp35 and Bp50. Proc. Natl. Acad. Sci. USA. 83:4494-4498.
23. Trauth, B.C., C. Klas, A.M.J. Peters, S. Matzku, P. Möller, W. Falk, K.M. Debatin, and P.H. Krammer. 1989. Monoclonal Ab mediated tumor regression by induction of apoptosis. Science (Wash. DC). 245:301-304.
24. Defrance, T., B. Vanbervliet, J. Pène, and J. Banchereau. 1988. Human recombinant IL-4 induces activated B lymphocytes to produce IgG and IgM. J. Immunol. 141:2000-2005.
25. Klas, C., K.M. Debatin, R.R. Jonker, and P.H. Krammer. 1993. Activation interferes with the APO-1 pathway in mature human T cells. Int. Immunol. 5:625-630.
26. Fluckiger, A.-C., P. Garrone, I. Durand, J.-P. Galizzi, and J. Banchereau. 1993. Interleukin 10 (IL-10) upregulates functional high affinity IL-2 receptors on normal and leukemic B lymphocytes. J. Exp. Med. 178:1473-1481.
27. - independent. Eur. J. Immunol. In press.
28. Daniel, P.T., and P.H. Krammer. 1994. Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells. J. Immunol. 152:5624-5632.
29. Rothstein, T.L., J.K.M. Wang, D.J. Panka, L.C. Foote, Z. Wang, B. Stanger, H. Cui, S.T. Ju, and A. Marshak-Rothstein, 1995. Protection against Fas-dependent Th1-mediated apoptosis by Ag receptor engagement in B cells. Nature (Lond.). 374:163-165.
30. + T cells. Nature (Lond.). 376:181-183.
31. Goodnow, C.C., J. Crosbie, H. Jorgensen, R.A. Brink, and A. Basten. 1989. Induction of self-tolerance in mature peripheral B lymphocytes. Nature (Lond.). 342:385-390.
32. Mason, D.Y., M. Jones, and C.C. Goodnow. 1992. Development and follicular localization of tolerant B lymphocytes in lysozyme/anti-lysozyme IgM/IgD transgenic mice. Int. Immunol. 4:163-175.
33. Cooke, M.P., A.W. Heath, K.M. Shokat, Y. Zeng, F.D. Finkelman, P.S. Linsley, M. Howard, and C.C. Goodnow. 1994. Immunoglobulin signal transduction guides the specificity of B cell-T cell interactions and is blocked in tolerant self-reactive B cells. J. Exp. Med. 179:425-438.
34. Bell, S.E., and C.C. Goodnow. 1994. A selective defect in IgM Ag receptor synthesis and transport causes loss of cell surface IgM expression on tolerant B lymphocytes. EMBO (Eur. Mol. Biol. Organ.) J. 13:816-826.
35. Feurllard, J., D. Taylor, M. Casamayor-Palleja, G.D. Johnson, and I.C.M. MacLennan. 1995. Isolation and characteristics of tonsil centroblasts with reference to Ig class switching. Int. Immunol. 7:121-130.
36. + memory T cells contains preformed CD40 ligand that is rapidly but transiently expressed on their surface after activation through the T cell receptor. J. Exp. Med. 181:1293-1301.
37. Pulendran, B., G. Kannourakis, S. Nouri, K.G.C. Smith, and G.J.V. Nossal. 1995. Soluble Ag can cause enhanced apoptosis of germinal centre B cells. Nature (Lond.). 375:331-334.
38. Shokat, K.M., and C.C. Goodnow. 1995. Ag-induced B cell death and elimination during germinal centre immune responses. Nature (Lond.). 375:334-338.
39. Eischen, C.M., C.J. Dick, and P.J. Leibson. 1994. Tyrosine kinase activation provides an early and requisite signal for Fas induced apoptosis. J. Immunol. 153:1947-1954.
40. Gulbins, E., R. Bissonnette, A. Mahboubi, S. Martin, W. Nishioka, T. Brunner, G. Baier, G. Baier-Bitterlich, C. Byrd, F. Lang, et al. 1995. Fas induced apoptosis is mediated via a ceramide initiated RAS signaling pathway. Immunity. 2:341-351.
41. Los, M., M. Van de Cracn, L.C. Penning, H. Schenk, M. Westendorp, P.A. Baeuerle, W. Dröge, P.H. Krammer, W. Fiers, and K. Schulze-Osthoff. 1995. Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis. Nature (Lond.). 375:81-83.
42. Enari, M., H. Hug, and S. Nagata. 1995. Involvement of an ICE-like protease in Fas mediated apoptosis. Nature (Lond.). 375:78-83.
43. Su, X., T. Zhou, Z. Wang, P. Yang, R.S. Jope, and J.D. Mountz. 1995. Defective expression of hematopoietic cell protein tyrosine phosphatase (HCP) in lymphoid cells blocks Fas mediated apoptosis. Immunity. 2:353-362.
44. Sato, T., S. Irie, S. Kitada, and J.C. Reed. 1995. FAP-1: a protein tyrosine phosphatase that associates with Fas. Science (Wash. DC). 268:411-414.