Sphingolipid metabolites in neural signalling and function

Brain Research Reviews

Volumn 46, Issue 3, 2004, Pages 328-355

  Colombaioni, Laura ^a   Garcia Gil, Mercedes ^b  

^a CNR   (Italy)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Apoptosis; Neural signalling; Sphingolipid metabolites

Indexed keywords

2 DECANOYLAMINO 3 MORPHOLINO 1 PHENYL 1 PROPANOL; 3 CHLOROALANINE; B 5354C; B 5453C; C 11AG; CALCIUM; CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; CYCLOSERINE; DESIPRAMINE; DEXTRO LEVO THREO DIHYDROSPHINGOSINE; DIMETHYLSPHINGOSINE; ENT 12; ENZYME INHIBITOR; F 12509A; FANTOFARONE; FUMONISIN B1; G PROTEIN COUPLED RECEPTOR; GW 4869; LYSOPHOSPHATIDIC ACID; MIGLUSTAT; N BUTYLDEOXYGALACTONOJIRIMYCIN; OGT 2378; PIP 2; SCYPHOSTATIN; SPHINGOLIPID; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; THERMOZYMOCIDIN; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE; UNCLASSIFIED DRUG;

APOPTOSIS; BRAIN FUNCTION; BRAIN TISSUE; CALCIUM MOBILIZATION; CELL ADHESION; CELL DIFFERENTIATION; CELL MEMBRANE; CELL PROLIFERATION; CELL SURVIVAL; CELL TYPE; DEGENERATIVE DISEASE; GENE EXPRESSION; GLIA; HUMAN; LIPID METABOLISM; LIPOGENESIS; METABOLISM; NERVE CELL; NERVE CELL EXCITABILITY; NERVOUS SYSTEM; NEUROTRANSMISSION; NONHUMAN; OLIGODENDROGLIA; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; SYNAPSE;

ANIMALS; APOPTOSIS; BRAIN; CELL DIFFERENTIATION; CELL SURVIVAL; HUMANS; NEURONS; SIGNAL TRANSDUCTION; SPHINGOLIPIDOSES; SPHINGOLIPIDS; SYNAPTIC TRANSMISSION;

EID: 9644277091     PISSN: 01650173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2004.07.014     Document Type: Review

References (385)

1. J. Abad Rodriguez, E. Piddini, T. Hasegawa, T. Miyagi, and C.G. Dotti Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture J. Neurosci. 21 2001 8387 8395
2. A. Abe, and J.A. Shayman Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity J. Biol. Chem. 19273 1998 8467 8474
3. A. Abe, J. Inokuchi, M. Jimbo, H. Shimeno, A. Nagamatsu, J.A. Shayman, G.S. Shukla, and N.S. Radin Improved inhibitors of glucosylceramide synthase J. Biochem. (Tokyo) 111 1992 191 196
4. J.H. Ahn, Y.G. Ko, W.Y. Park, Y.S. Kang, H.Y. Chung, and J.S. Seo Suppression of ceramide-mediated apoptosis by HSP70 Mol. Cells 9 1999 200 206
5. S. Albouz, M.T. Vanier, J.J. Hauw, F. Le Saux, J.M. Boutry, and N. Baumann Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells Neurosci. Lett. 36 1983 311 315
6. R. Alemany, B. Kleuser, L. Ruwisch, K. Danneberg, H. Lass, R. Hashemi, S. Spiegel, K.H. Jakobs, and D. Meyer zu Heringdorf Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate FEBS Lett. 509 2001 239 244
7. J. Allard, S. Barron, S. Trottier, P. Cervera, C. Daumas-Duport, E. Leguern, A. Brice, J.C. Schwartz, and P. Sokoloff Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot-Marie-Tooth disease Glia 26 1999 176 185
8. E. Amtmann, M. Zoller, and G. Schilling Neutral sphingomyelinase- inhibiting guanidines prevent herpes simplex virus-1 replication Drugs Exp. Clin. Res. 26 2000 57 65
9. A. Bachis, S.J. Rabin, M. Del Fiacco, and I. Mocchetti Gangliosides prevent excitotoxicity through activation of TrkB receptor Neurotox. Res. 4 2002 225 234
10. S.M. Bajjalieh, T.F. Martin, and E. Floor Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles J. Biol. Chem. 264 1989 14354 14360
11. Y. Banno, Y. Takuwa, Y. Akao, H. Okamoto, Y. Osawa, T. Naganawa, S. Nakashima, P.G. Suh, and Y. Nozawa Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3 J. Biol. Chem. 276 2001 35622 35628
12. S. Basu, S. Bayoumy, Y. Zhang, J. Lozano, and R. Kolesnick BAD enables ceramide to signal apoptosis via Ras and Raf-1 J. Biol. Chem. 273 1998 30419 30426
13. K. Bejaoui, Y. Uchida, S. Yasuda, M. Ho, M. Nishijima, R.H. Brown Jr., W.M. Holleran, and K. Hanada Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis J. Clin. Invest. 110 9 2002 (Nov.) 1301 1308
14. C. Benaud, M. Oberst, J.P. Hobson, S. Spiegel, R.B. Dickson, and C.Y. Lin Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase J. Biol. Chem. 277 2002 10539 10546
15. C.M. Berger, S. Cultaro, S. Segal, and S. Spiegel The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix-loop-helix-zipper protein Biochim. Biophys. Acta 1390 1998 225 236
16. R. Betto, A. Teresi, F. Turcato, G. Salviati, R.A. Sabbadini, K. Krown, C.C. Glembotski, L.A. Kindman, C. Dettbarn, Y. Pereon, K. Yasui, and P.T. Palade Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes Biochem. J. 322 1997 327 333
17. E. Bieberich, B. Freischutz, M. Suzuki, and R.K. Yu Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells J. Neurochem. 72 1999 1040 1049
18. E. Bieberich, S. MacKinnon, J. Silva, and R.K. Yu Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides J. Biol. Chem. 276 2001 44396 44404
19. A. Bielawska, M.S. Greenberg, D. Perry, S. Jayadev, J.A. Shayman, C. McKay, and Y.A. Hannun (1S,2R)-d-erythro-2-(N-myristoylamino)-1-phenyl-1- propanol as an inhibitor of ceramidase J. Biol. Chem. 271 1996 12646 12654
20. T.R. Bilderback, R.J. Grigsby, and R.T. Dobrowsky Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae J. Biol. Chem. 272 1997 10922 10927
21. H. Birbes, S. El Bawab, Y.A. Hannun, and L.M. Obeid Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis FASEB J. 15 2001 2669 2679
22. V.A. Blakesley, D. Beitner-Johnson, J.R. Van Brocklyn, S. Rani, Z. Shen-Orr, B.S. Stannard, S. Spiegel, and D. LeRoith Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk J. Biol. Chem. 272 1997 16211 16215
23. C. Blazquez, C. Sanchez, A. Daza, I. Galve-Roperh, and M. Guzman The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme J. Neurochem. 72 1999 1759 1768
24. C. Blazquez, I. Galve-Roperh, and M. Guzman De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase FASEB J. 14 2000 2315 2322
25. G.C. Blobe, S. Stribling, L.M. Obeid, and Y.A. Hannun Protein kinase C isoenzymes: regulation and function Cancer Surv. 27 1996 213 248
26. N.A. Bourbon, J. Yun, and M. Kester Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex J. Biol. Chem. 275 2000 35617 35623
27. I. Bock, N. Szabo, N. Gamper, C. Adams, and E. Gulbins Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms Biochem. Biophys. Res. Commun. 305 2003 890 897
28. J. Bodennec, D. Pelled, C. Riebeling, S. Trajkovic, and A.H. Futerman Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP: phosphocholine cytidylyltransferase by glucosylceramide FASEB J. 16 2002 1814 1816
29. L.C. Boujaoude, C. Bradshaw-Wilder, C. Mao, J. Cohn, B. Ogretmen, Y.A. Hannun, and L.M. Obeid Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate J. Biol. Chem. 276 2001 35258 35264
30. A.B. Brann, R. Scott, Y. Neuberger, D. Abulafia, S. Boldin, M. Fainzilber, and A.H. Futerman Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons J. Neurosci. 19 1999 8199 8206
31. A.B. Brann, M. Tcherpakov, I.M. Williams, A.H. Futerman, and M. Fainzilber Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase J. Biol. Chem. 277 2002 9812 9818
32. B. Brenner, U. Koppenhoefer, C. Weinstock, O. Linderkamp, F. Lang, and E. Gulbins Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153 J. Biol. Chem. 272 1997 22173 22181
33. J.V. Brigande, F.M. Platt, and T.N. Seyfried Inhibition of glycosphingolipid biosynthesis does not impair growth or morphogenesis of the postimplantation mouse embryo J. Neurochem. 70 1998 871 882
34. U. Brinkmann CAS, the human homologue of the yeast chromosome-segregation gene CSE1, in proliferation, apoptosis, and cancer Am. J. Hum. Genet. 62 1998 509 513
35. D.A. Brown, and E. London Functions of lipid rafts in biological membranes Annu. Rev. Cell Dev. Biol. 14 1998 111 136
36. B. Brugg, P.P. Michel, Y. Agid, and M. Ruberg Ceramide induces apoptosis in cultured mesencephalic neurons J. Neurochem. 66 1996 733 739
37. J. Brunner, M. Kronke, and S. Schutze Cathepsin D targeted by acid sphingomyelinase-derived ceramide EMBO J. 18 1999 5252 5263
38. R. Buccoliero, and A.H. Futerman The roles of ceramide and complex sphingolipids in neuronal cell function Pharmacol. Res. 47 2003 409 419
39. R. Buccoliero, J. Bodennec, and A.H. Futerman The role of sphingolipids in neuronal development: lessons from models of sphingolipid storage diseases Neurochem. Res. 27 2002 565 574
40. B.M. Buehrer, and R.M. Bell Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways J. Biol. Chem. 267 1992 3154 3159
41. B. Buzas Regulation of nociceptin/orphanin FQ gene expression in astrocytes by ceramide NeuroReport 13 2002 (Oct. 7) 1707 1710
42. C.D. Carlson, and R.P. Hart Activation of acidic sphingomyelinase and protein kinase C zeta is required for IL-1 induction of LIF mRNA in a Schwann cell line Glia 18 1996 49 58
43. P. Casaccia-Bonnefil, B.D. Carter, R.T. Dobrowsky, and M.V. Chao Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75 Nature 383 1996 716 719
44. P. Casaccia-Bonnefil, L. Aibel, and M.V. Chao Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death J. Neurosci. Res. 43 1996 382 389
45. A.L. Cavalli, N.W. O'Brien, S.B. Barlow, R. Betto, C.C. Glembotski, P.T. Palade, and R.A. Sabbadini Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes Am. J. Physiol., Cell Physiol. 284 2003 C780 C790
46. C.E. Chalfant, K. Rathman, R.L. Pinkerman, R.E. Wood, L.M. Obeid, B. Ogretmen, and Y.A. Hannun De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1 J. Biol. Chem. 277 2002 12587 12595
47. N. Chen, S. Furuya, H. Doi, Y. Hashimoto, Y. Kudo, and H. Higashi Ganglioside/calmodulin kinase II signal inducing cdc42-mediated neuronal actin reorganization Neuroscience 120 2003 163 176
48. S. Chiavegatto, J. Sun, R.J. Nelson, and R.L. Schnaar A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice Exp. Neurol. 166 2000 227 234
49. C.L. Chik, B. Li, T. Negishi, E. Karpinski, and A.K. Ho Ceramide inhibits L-type calcium channel currents in rat pinealocytes Adv. Exp. Med. Biol. 460 1999 51 59
50. C.L. Chik, B. Li, E. Karpinski, and A.K. Ho Ceramide inhibits the outward potassium current in rat pinealocytes J. Neurochem. 79 2001 339 348
51. T.Y. Chin, H.M. Hwang, and S.H. Chueh Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma×glioma cells Mol. Pharmacol. 61 2002 486 494
52. C. Choi, and E.N. Benveniste Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses Brains Res. Rev. 44 2004 65 81
53. O.H. Choi, J.-H. Kim, and J.-P. Kinet Calcium mobilization via sphingosine kinase in signalling by the FceRI antigen receptor Nature 380 1996 634 636
54. E.S. Chung, E.H. Joe, J.K. Ryu, J. Kim, Y.B. Lee, K.G. Cho, Y.J. Oh, S.H. Maeng, H.H. Baik, S.U. Kim, and B.K. Jin GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures NeuroReport 12 2001 611 614
55. T. Coetzee, N. Fujita, J. Dupree, R. Shi, A. Blight, K. Suzuki, K. Suzuki, and B. Popko Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability Cell 86 1996 209 219
56. M. Cohen-Tannoudji, P. Marchand, S. Akli, S.A. Sheardown, J.P. Puech, C. Kress, P. Gressens, M.C. Nassogne, T. Beccari, and A.L. Muggleton-Harris Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease Mamm. Genome 6 1995 844 849
57. L. Colombaioni, L. Colombini, and M. Garcia-Gil Role of mitochondria in serum withdrawal-induced apoptosis of immortalized neuronal precursors Dev. Brain Res. 134 2002 93 102
58. L. Colombaioni, L.M. Frago, I. Varela-Nieto, R. Pesi, and M. Garcia-Gil Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells Neurochem. Int. 40 2002 327 336
59. F. Condorelli, M.A. Sortino, A.M. Stella, and P.L. Canonico Relative contribution of different receptor subtypes in the response of neuroblastoma cells to tumor necrosis factor-alpha J. Neurochem. 75 2000 1172 1179
60. A. Copani, D. Melchiorri, A. Caricasole, F. Martini, P. Sale, R. Carnevale, R. Gradini, M.A. Sortino, L. Lenti, R. De Maria, and F. Nicoletti Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons J. Neurosci. 22 2002 3963 3968
61. A.E. Cremesti, F.M. Goni, and R. Kolesnick Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome? FEBS Lett. 531 2002 47 53
62. R.G. Cutler, W.A. Pedersen, S. Camandola, J.D. Rothstein, and M.P. Mattson Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis Ann. Neurol. 52 2002 448 457
63. O. Cuvillier Sphingosine in apoptosis signaling Biochim. Biophys. Acta 1585 2002 153 162
64. O. Cuvillier, G. Pirianov, B. Kleuser, P.G. Vanek, O.A. Coso, S. Gutkind, and S. Spiegel Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate Nature 381 1996 800 803
65. F. Darios, N. Lambeng, J.-D. Troadec, P. Michel, and M. Ruberg Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death J. Neurochem. 84 2003 643 654
66. J.L. Dawkins, D.J. Hulme, S.B. Brahmbhatt, M. Auer-Grumbach, and G.A. Nicholson Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I Nat. Genet. 27 3 2001 (Mar.) 309 312
67. G.S. Dbaibo, M.Y. Pushkareva, S. Jayadev, J.K. Schwarz, J.M. Horowitz, L.M. Obeid, and Y.A. Hannun Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest Proc. Natl. Acad. Sci. U. S. A. 92 1995 1347 1351
68. N.N. Desai, and S. Spiegel Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines Biochem. Biophys. Res. Commun. 181 1991 361 366
69. C. Decraene, B. Brugg, M. Ruberg, E. Eveno, C. Matingou, F. Tahi, J. Mariani, C. Auffray, and G. Pietu Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays Genome Biol. 3 2002 0042.1 0042.22 (RESEARCH0042)
70. L. De Maria, F. Lenti, F. Malisan, F. d'Agostino, B. Tomassini, A. Zeuner, M.R. Rippo, and R. Testi Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis Science 277 1997 1652 1655
71. R.T. Dobrowsky, C. Kamibayasha, M.C. Mumby, and Y.A. Hannun Ceramide activates a heterotrimeric protein phosphatase 2A J. Biol. Chem. 268 1993 15523 15530
72. R.T. Dobrowsky, M.H. Werner, A.M. Castellino, M.V. Chao, and Y.A. Hannun Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor Science 265 1994 1596 1599
73. G.P. Eckert, U. Igbavboa, W.E. Muller, and W.G. Wood Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains Brain Res. 962 2003 144 150
74. L.C. Edsall, G.G. Pirianov, and S. Spiegel Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation J. Neurosci. 17 1997 6952 6960
75. L.C. Edsall, O. Cuvillier, S. Twitty, S. Spiegel, and S. Milstien Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells J. Neurochem. 76 2001 1573 1584
76. L. Elsen, R. Betz, G. Schwarzmann, K. Sandhoff, and G. van Echten-Deckert Identification of ceramide binding proteins in neuronal cells: a critical point of view Neurochem. Res. 27 2002 717 727
77. B.A. Fenderson, G.K. Ostrander, Z. Hausken, N.S. Radin, and S. Hakomori A ceramide analogue (PDMP) inhibits glycolipid synthesis in fish embryos Exp. Cell Res. 198 1992 362 366
78. G. Ferrari, M. Fabris, and A. Gorio Gangliosides enhance neurite outgrowth in PC12 cells Dev. Brain Res. 8 1983 215 222
79. B.L. Fiebich, K. Lieb, M. Berger, and J. Bauer Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells J. Neuroimmunol. 63 1995 207 211
80. L.M. Frago, Y. Leon, E.J. de la Rosa, A. Gomez-Munoz, and I. Varela-Nieto Nerve growth factor and ceramides modulate cell death in the early developing inner ear J. Cell. Sci. 111 1998 549 556
81. L.M. Frago, S. Canon, E.J. de la Rosa, Y. Leon, and I. Varela-Nieto Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I J. Cell. Sci. 116 2003 475 486
82. V. France-Lanord, B. Brugg, P.P. Michel, Y. Agid, and M. Ruberg Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease J. Neurochem. 69 1997 1612 1621
83. K.J. French, R.S. Schrecengost, B.D. Lee, Y. Zhuang, S.N. Smith, J.L. Eberly, J.K. Yun, and C.D. Smith Discovery and evaluation of inhibitors of human sphingosine kinase Cancer Res. 63 2003 5962 5969
84. S. Fukumoto, T. Mutoh, T. Hasegawa, H. Miyazaki, M. Okada, J. Goto, K. Furukawa, and T. Urano GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation J. Biol. Chem. 275 2000 5832 5838
85. K. Furukawa, and M.P. Mattson The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons J. Neurochem. 70 1998 1876 1886
86. S. Furuya, F. Irie, T. Hashikawa, K. Nakazawa, A. Kozakai, A. Hasegawa, K. Sudo, and Y. Hirabayashi Ganglioside GD1 alpha in cerebellar Purkinje cells. Its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response to conjunctive stimuli causing long-term desensitization J. Biol. Chem. 269 1994 2418 32425
87. S. Furuya, T. Hashikawa, and Y. Hirabayashi Restricted occurrence of an unusual ganglioside GD1 alpha in rat brain and its possible involvement in dendritic growth of cerebellar Purkinje neurons J. Neurosci. Res. 44 1996 73 83
88. S. Furuya, J. Mitoma, A. Makino, and Y. Hirabayashi Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells J. Neurochem. 71 1998 366 377
89. K. Furuya, I. Ginis, H. Takeda, Y. Chen, and J.M. Hallenbeck Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia J. Cereb. Blood Flow Metab. 21 2001 226 232
90. I. Galve-Roperh, A. Haro, and I. Diaz-Laviada Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte cultures Mol. Brain Res. 52 1997 90 97
91. I. Galve-Roperh, A. Haro, and I. Diaz-Laviada Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes FEBS Lett. 415 1997 271 274
92. I. Galve-Roperh, D. Rueda, T. Gomez del Pulgar, G. Velasco, and M. Guzman Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor Mol. Pharmacol. 62 2002 1385 1392
93. C. Garcia-Ruiz, A. Colell, M. Mari, A. Morales, and J.C. Fernandez-Checa Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species, role of mitochondrial glutathione J. Biol. Chem. 272 1997 11369 11377
94. P. Ghafourifar, S.D. Klein, O. Schucht, U. Schenk, M. Pruschy, S. Rocha, and C. Richter Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state J. Biol. Chem. 274 1999 6080 6084
95. K. Ghosh, J. Bian, and H. Gill Intracellular calcium release mediated by sphingosine derivatives generated in cells Science 248 1990 1653 1656
96. J.S. Gill, and A.J. Windebank Ceramide initiates NFkappaB-mediated caspase activation in neuronal apoptosis Neurobiol. Dis. 7 2000 448 461
97. M. Glickman, R.L. Malek, A.E. Kwitek-Black, H.J. Jacob, and N.H. Lee Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein-coupled receptor, nrg-1 Mol. Cell. Neurosci. 14 1999 141 152
98. E.J. Goetzl, and S. An Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate FASEB J. 12 1998 1589 1598
99. A. Gomez-Munoz, L.M. Frago, L. Alvarez, and I. Varela-Nieto Stimulation of DNA synthesis by natural ceramide 1-phosphate Biochem. J. 325 1997 435 440
100. A. Gomez-Munoz, J.Y. Kong, B. Salh, and U.P. Steinbrecher Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages J. Lipid Res. 45 2004 99 105
101. Y. Goodman, and M.P. Mattson Ceramide protects hippocampal neurons against excitotoxic oxidative insults, and amyloid beta-peptide toxicity J. Neurochem. 66 1996 869 872
102. R. Goswami, J. Kilkus, S.A. Dawson, and G. Dawson Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli J. Neurosci. Res. 57 1999 884 893
103. R. Goswami, B. Scurlock, and G. Dawson CrmA protects against apoptosis and ceramide formation in PC12 cells Neurochem. Res. 27 2002 735 741
104. T.I. Gudz, K.Y. Tserng, and C.L. Hoppel Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide J. Biol. Chem. 272 1997 24154 24158
105. A. Guidarelli, E. Clementi, C. De Nadai, R. Bersacchi, and O. Cantoni TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation Exp. Cell Res. 270 2002 56 65
106. E. Gulbins, K.M. Coggeshall, G. Baier, D. Telford, C. Langlet, G. Baier-Bitterlich, N. Bonnefoy-Berard, P. Burn, A. Wittinghofer, and A. Altman Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides Mol. Cell. Biol. 14 1994 4749 4758
107. E. Gulbins, R. Bissonnette, A. Mahboubi, S. Martin, W. Nishioka, T. Brunner, G. Baier, G. Baier-Bitterlich, C. Byrd, and F. Lang FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway Immunity 2 1995 341 351
108. E. Gulbins, I. Szabo, K. Baltzer, and F. Lang Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases Proc. Natl. Acad. Sci. U. S. A. 94 1997 7661 7666
109. Hakomori, and K. Handa Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy FEBS Lett. 531 2002 88 92
110. A. Hamaguchi, E. Suzuki, K. Murayama, T. Fujimura, T. Hikita, K. Iwabuchi, K. Handa, D.A. Withers, S.C. Masters, H. Fu, and S. Hakomori Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta J. Biol. Chem. 278 2003 41557 41565
111. X.M. Han, D. Holtzman, D.W. McKeel Jr., J. Kelley, and J.C. Morris Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis J. Neurochem. 82 2002 809 818
112. Y.A. Hannun, and R.M. Bell Regulation of protein kinase C by sphingosine and lysosphingolipids Clin. Chim. Acta 185 1989 333 345
113. Y.A. Hannun, and C. Luberto Ceramide in the eukaryotic stress response Trends Cell Biol. 10 2000 73 80
114. Y.A. Hannun, and L.M. Obeid The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind J. Biol. Chem. 277 2002 25847 25850
115. J. Harada, M. Foley, M.A. Moskowitz, and C. Waeber Sphingosine-1- phosphate induces proliferation and morphological changes of neural progenitor cells J. Neurochem. 88 2004 1026 1039
116. T. Harder, and K. Simons Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains Curr. Opin. Cell Biol. 9 1997 534 542
117. P.J. Hartfield, G.C. Mayne, and A.W. Murray Ceramide induces apoptosis in PC12 cells FEBS Lett. 401 1997 148 152
118. T. Hasegawa, K. Yamaguchi, T. Wada, A. Takeda, Y. Itoyama, and T. Miyagi Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation J. Biol. Chem. 275 2004 8007 8015
119. M. Heinrich, J. Neumeyer, M. Jakob, C. Hallas, V. Tchikov, S. Winoto-Morbach, M. Wickel, W. Schneider-Brachert, A. Trauzold, A. Hethke, and S. Schutze Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation Cell Death Differ. 11 2004 550 563
120. H. Hering, C.C. Lin, and M. Sheng Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability J. Neurosci. 23 2003 3262 3271
121. T. Herget, H. Specht, C. Esdar, S.A. Oehrlein, and A. Maelicke Retinoic acid induces apoptosis-associated neural differentiation of a murine teratocarcinoma cell line J. Neurochem. 70 1998 47 58
122. T. Herget, C. Esdar, S.A. Oehrlein, M. Heinrich, S. Schutze, A. Maelicke, and G. van Echten-Deckert Production of ceramides causes apoptosis during early neural differentiation in vitro J. Biol. Chem. 275 2000 30344 30354
123. I. Herr, A. Martin-Villalba, E. Kurz, P. Roncaioli, J. Schenkel, M.G. Cifone, and K.M. Debatin FK506 prevents stroke-induced generation of ceramide and apoptosis signaling Brain Res. 826 1999 210 219
124. D. Hicks, V. Heidinger, S. Mohand-Said, J. Sahel, and H. Dreyfus Growth factors and gangliosides as neuroprotective agents in excitotoxicity and ischemia Gen. Pharmacol. 30 1998 265 273
125. + currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes J. Neurosci. 18 1998 8712 8719
126. H. Hida, S. Nagano, M. Takeda, and B. Soliven Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes J. Neurosci. 19 1999 7458 7467
127. K. Hirschberg, R. Zisling, G. van Echten-Deckert, and A.H. Futerman Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis J. Biol. Chem. 271 1996 14876 14882
128. T. Hla, M.J. Lee, N. Ancellin, J.H. Paik, and M.J. Kluk Lysophospholipids receptor revelations Science 294 2001 1875 1878
129. J.P. Hobson, H.M. Rosenfeldt, L.S. Barak, A. Olivera, S. Poulton, M.G. Caron, S. Milstien, and S. Spiegel Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility Science 291 2001 1800 1803
130. K. Hofmann, and V.M. Dixit Ceramide in apoptosis-does it really matter? Trends Biochem. Sci. 23 1998 374 377
131. W.M. Holleran, M.L. Williams, W.N. Gao, and P.M. Elias Serine-palmitoyl transferase activity in cultured human keratinocytes J. Lipid Res. 1990 1655 1661
132. W.C. Hung, H.C. Chang, and L.Y. Chuang Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells Biochem. J. 338 1999 161 166
133. S. Hunot, B. Brugg, D. Ricard, P.P. Michel, M.P. Muriel, M. Ruberg, B.A. Faucheux, Y. Agid, and E.C. Hirsch Nuclear translocation of NF-kappa B is increased in dopaminergic neurons of patients with parkinson disease Proc. Natl. Acad. Sci. U. S. A. 94 1997 7531 7536
134. R. Hurwitz, K. Ferlinz, and K. Sandhoff The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts Biol. Chem. Hoppe-Seyler 37 1994 447 450
135. A. Huwiler, J. Brunner, R. Hummel, M. Vervoordeldonk, S. Stabel, H. van den Bosch, and J. Pfeilschifter Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase Proc. Natl. Acad. Sci. U. S. A. 93 1996 6959 6963
136. A. Huwiler, D. Fabbro, and J. Pfeilschifter Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells Biochemistry 37 1998 14556 14562
137. A. Huwiler, B. Johansen, A. Skarstad, and J. Pfeilschifter Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release FASEB J. 15 2001 7 9
138. D.L. Hynds, R.W. Burry, and A.J. Yates Gangliosides inhibit growth factor-stimulated neurite outgrowth in SH-SY5Y human neuroblastoma cells J. Neurosci. Res. 47 1997 617 625
139. J. Igarashi, and T. Michel Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction J. Biol. Chem. 275 2000 32363 32670
140. D.S. Im, A.R. Ungar, and K.R. Lynch Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain Biochem. Biophys. Res. Commun. 279 2000 139 143
141. M. Inoue, Y. Fujii, K. Furukawa, M. Okada, K. Okumura, T. Hayakawa, K. Furukawa, and Y. Sugiura Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside J. Biol. Chem. 277 2002 28888 29881
142. F. Irie, and Y. Hirabayashi Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations J. Neurosci. Res. 54 1998 475 485
143. F. Irie, T. Hashikawa, T. Tai, Y. Seyama, and Y. Hirabayashi Distribution of cholinergic neuron-specific gangliosides (GT1a alpha and GQ1b alpha) in the rat central nervous system Brain Res. 665 1994 161 166
144. T. Ishibashi, J.L. Dupree, K. Ikenaka, Y. Hirahara, K. Honke, E. Peles, B. Popko, K. Suzuki, H. Nishino, and H. Baba A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation J. Neurosci. 22 2002 6507 6514
145. I. Ishii, B. Friedman, X. Ye, S. Kawamura, C. McGiffert, J.J. Contos, M.A. Kingsbury, G. Zhang, J.H. Brown, and J. Chun Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3 J. Biol. Chem. 276 2001 33697 33704
146. J.P. Jaffrezou, T. Levade, O. Thurneyssen, M. Chiron, C. Bordier, M. Attal, P. Chatelain, and G. Laurent In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction Cancer Res. 52 1992 1352 1359
147. W.D. Jarvis, F.A. Fornari Jr., K.L. Auer, A.J. Freemerman, E. Szabo, M.J. Birrer, C.R. Johnson, S.E. Barbour, P. Dent, and S. Grant Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine Mol. Pharmacol. 52 1997 935 947
148. K. Kagedal, M. Zhao, I. Svensson, and U.T. Brunk Sphingosine-induced apoptosis is dependent on lysosomal proteases Biochem. J. 359 2001 335 343
149. H. Kawai, K. Sango, K.A. Mullin, and R.L. Proia Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides J. Biol. Chem. 273 1998 19634 19638
150. H. Kawai, M.L. Allende, R. Wada, M. Kono, K. Sango, C. Deng, T. Miyakawa, J.N. Crawley, N. Werth, U. Bierfreund, K. Sandhoff, and R.L. Proia Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures J. Biol. Chem. 276 2001 6885 6888
151. R.W. Keane, A. Srinivasan, L.M. Foster, M.P. Testa, T. Ord, D. Nonner, H.G. Wang, J.C. Reed, D.E. Bredesen, and C. Kayalar Activation of CPP32 during apoptosis of neurons and astrocytes J. Neurosci. Res. 48 1997 168 180
152. L.A. Kindman, S. Kim, T.V. McDonald, and P. Gardner Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells J. Biol. Chem. 269 1994 13088 13091
153. C.C. King, F.T. Zenke, P.E. Dawson, E.M. Dutil, A.C. Newton, B.A. Hemmings, and G.M. Bokoch Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1 J. Biol. Chem. 275 2000 18108 18113
154. B. Kleuser, M. Maceyka, S. Milstien, and S. Spiegel Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor FEBS Lett. 503 2001 85 90
155. N. Kojima, N. Kurosawa, N. Tishi, N. Hanai, and S. Tsuji Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells J. Biol. Chem. 269 1994 30451 30456
156. R.N. Kolesnick, and M. Kronke Regulation of ceramide production and apoptosis Annu. Rev. Physiol. 60 1998 643 665
157. T. Kolter, R.L. Proia, and K. Sandhoff Combinatorial ganglioside biosynthesis J. Biol. Chem. 277 2002 25859 25862
158. M. Kolzer, C. Arenz, K. Ferlinz, N. Werth, H. Schulze, R. Klingenstein, and K. Sandhoff Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase Biol. Chem. 384 2003 1293 1298
159. M. Kolzer, N. Werth, and K. Sandhoff Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine FEBS Lett. 559 2004 96 98
160. K. Kono, M. Sugiura, and T. Kohama Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c J. Antibiot. (Tokyo) 55 2002 99 103
161. E. Korkotian, A. Schwarz, D. Pelled, G. Schwarzmann, M. Segal, and A.H. Futerman Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons J. Biol. Chem. 274 1999 21673 21678
162. P. Kovacs, M. Pinter, and G. Csaba Effect of glucosphingolipid synthesis inhibitor (PPMP and PDMP) treatment on Tetrahymena pyriformis: data on the evolution of the signaling system Cell Biochem. Funct. 18 2000 269 280
163. D. Kozireski-Chuback, G. Wu, and R.W. Ledeen Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranes J. Neurosci. Res. 57 1999 541 550
164. D. Kozireski-Chuback, G. Wu, and R.W. Ledeen Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells J. Neurosci. Res. 55 1999 107 118
165. E. Kupperman, S. An, N. Osborne, S. Waldron, and D.Y. Stainier A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development Nature 406 2000 192 195
166. D.C. Lado, C.S. Browe, A.A. Gaskin, J.M. Borden, and A.J. MacLennan Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions Gene 149 1994 331 336
167. R.W. Ledeen, and G. Wu Ganglioside function in calcium homeostasis and signaling Neurochem. Res. 27 2002 637 647
168. J.Y. Lee, Y.A. Hannun, and L.M. Obeid Ceramide inactivates cellular protein kinase C-alpha J. Biol. Chem. 271 1996 13169 13174
169. L. Lee, A. Abe, and J.A. Shayman Improved inhibitors of glucosylceramide synthase J. Biol. Chem. 274 1999 14662 14669
170. A. Lepple-Wienhues, C. Belka, T. Laun, A. Jekle, B. Walter, U. Wieland, M. Welz, L. Heil, J. Kun, G. Busch, M. Weller, M. Bamberg, E. Gulbins, and F. Lang Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids Proc. Natl. Acad. Sci. U. S. A. 96 1999 13795 13800
171. T. Levade, S. Malagarie-Cazenave, V. Gouaze, B. Segui, C. Tardy, S. Betito, N. Andrieu-Abadie, and O. Cuvillier Ceramide in apoptosis: a revisited role Neurochem. Res. 27 2002 601 607
172. R. Li, and S. Ladisch Inhibition of endogenous ganglioside synthesis does not block neurite formation by retinoic acid-treated neuroblastoma cells J. Biol. Chem. 272 1997 1349 1354
173. R. Li, Y. Kong, and S. Ladisch Nerve growth factor-induced neurite formation in PC12 cells is independent of endogenous cellular gangliosides Glycobiology 8 1998 597 603
174. S.S. Liour, and R.K. Yu Differential effects of three inhibitors of glycosphingolipid biosynthesis on neuronal differentiation of embryonal carcinoma stem cells Neurochem. Res. 27 2002 1507 1512
175. S.S. Liour, D. Kapitonov, and R.K. Yu Expression of gangliosides in neuronal development of P19 embryonal carcinoma stem cells J. Neurosci. Res. 62] 2000 363 373
176. H. Liu, N. Kojima, N. Kurosawa, and S. Tsuji Regulated expression system for GD3 synthase cDNA and induction of differentiation in Neuro2a cells Glycobiology 7 1997 1067 1076
177. Y. Liu, A. Hoffmann, A. Grinberg, H. Westphal, M.P. McDonald, K.M. Miller, J.N. Crawley, K. Sandhoff, K. Suzuki, and R.L. Proia Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment Proc. Natl. Acad. Sci. U. S. A. 94 1997 8138 8143
178. Y. Liu, R. Wada, T. Yamashita, Y. Mi, C.X. Deng, J.P. Hobson, H.M. Rosenfeldt, V.E. Nava, S.S. Chae, M.J. Lee, C.H. Liu, T. Hla, S. Spiegel, and R.L. Proia Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation J. Clin. Invest. 106 2000 951 961
179. H. Liu, R.E. Toman, S.K. Goparaju, M. Maceyka, V.E. Nava, H. Sankala, S.G. Payne, M. Bektas, I. Ishii, J. Chun, S. Milstien, and S. Spiegel Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis J. Biol. Chem. 278 2003 40330 40336
180. E. Lloyd-Evans, D. Pelled, C. Riebeling, and A.H. Futerman Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms Biochem. J. 375 2003 561 565
181. E. Lloyd-Evans, D. Pelled, C. Riebeling, J. Bodennec, A. de-Morgan, H. Waller, R. Schiffmann, and A.H. Futerman Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms J. Biol. Chem. 278 2003 23594 23599
182. J. Lozano, E. Berra, M.M. Municio, M.T. Diaz-Meco, I. Dominguez, L. Sanz, and J. Moscat Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase J. Biol. Chem. 269 1994 19200 19202
183. F.G. Lu, and C.S. Wong Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B/Akt activity Int. J. Radiat. Biol. 80 2004 39 51
184. C. Luberto, and Y.A. Hannun Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C? J. Biol. Chem. 273 1998 14550 14559
185. C. Luberto, D.F. Hassler, P. Signorelli, Y. Okamoto, H. Sawai, E. Boros, D.J. Hazen-Martin, L.M. Obeid, Y.A. Hannun, and G.K. Smith Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase J. Biol. Chem. 277 2002 41128 41139
186. C. Luberto, J.M. Kraveka, and Y.A. Hannun Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology Neurochem. Res. 27 2002 609 617
187. A.J. MacLennan, C.S. Browe, A.A. Gaskin, D.C. Lado, and G. Shaw Cloning and characterization of a putative G-protein coupled receptor potentially involved in development Mol. Cell. Neurosci. 5 1994 201 219
188. A.J. MacLennan, B.K. Devlin, L. Marks, A.A. Gaskin, K.L. Neitzel, and N. Lee Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell-cell interaction and neurite outgrowth Dev. Neurosci. 22 2000 283 295
189. A.J. MacLennan, P.R. Carney, W.J. Zhu, A.H. Chaves, J. Garcia, J.R. Grimes, K.J. Anderson, S.N. Roper, and N. Lee An essential role for the H218/AGR16/EDG-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability Eur. J. Neurosci. 14 2001 203 209
190. S. Maekawa, S. Iino, and S. Miyata Molecular characterization of the detergent-insoluble cholesterol-rich membrane microdomain (raft) of the central nervous system Biochim. Biophys. Acta 1610 2003 261 270
191. E. Malchinkhuu, K. Sato, T. Muraki, K. Ishikawa, A. Kuwabara, and F. Okajima Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function Biochem. J. 370 2003 817 827
192. F. Malisan, and R. Testi GD3 ganglioside and apoptosis Biochim. Biophys. Acta 1585 2002 179 187
193. D. Mangoura, and G. Dawson Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation J. Neurochem. 70 1998 130 138
194. 2+ release-mediating protein from endoplasmic reticulum Proc. Natl. Acad. Sci. U. S. A. 93 1996 1993 1996
195. L. Marlow, M. Cain, M.A. Pappolla, and K. Sambamurti Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP) J. Mol. Neurosci. 20 2003 233 239
196. M. Masserini, P. Palestini, and M. Pitto Glycolipid-enriched caveolae and caveolae-like domains in the nervous system J. Neurochem. 73 1999 1 11
197. C. Mathes, A. Fleig, and R. Penner Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine J. Biol. Chem. 273 1998 25020 25030
198. M. Mattie, G. Brooker, and S. Spiegel Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway J. Biol. Chem. 269 1994 3181 3188
199. M.P. Mattson, Y. Goodman, H. Luo, W. Fu, and K. Furukawa Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration J. Neurosci. Res. 49 1997 681 697
200. C. McGiffert, J.J.A. Contos, B. Friedman, and J. Chun Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis FEBS Lett. 531 2002 103 108
201. T. Megidish, J. Cooper, L. Zhang, H. Fu, and S. Hakomori A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein J. Biol. Chem. 273 1998 21834 21845
202. T. Megidish, K. Takio, K. Titani, K. Iwabuchi, A. Hamaguchi, Y. Igarashi, and S. Hakomori Endogenous substrates of sphingosine-dependent kinases (SDKs) are chaperone proteins: heat shock proteins, glucose-regulated proteins, protein disulfide isomerase, and calreticulin Biochemistry 38 1999 3369 3378
203. D. Melchiorri, F. Martini, E. Lococo, R. Gradini, E. Barletta, R. De Maria, A. Caricasole, F. Nicoletti, and L. Lenti An early increase in the disialoganglioside GD3 contributes to the development of neuronal apoptosis in culture Cell Death Differ. 9 2002 609 615
204. A.H. Merrill Jr., G. van Echten, E. Wang, and K. Sandhoff Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ J. Biol. Chem. 268 1993 27299 27306
205. D. Meyer zu Heringdorf, N. Niederdraing, E. Neumann, R. Frode, H. Lass, C.J. van Koppen, and K.H. Jakobs Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine Eur. J. Pharmacol. 354 1998 113 122
206. N.R. Michaud, M. Therrien, A. Cacace, L.C. Edsall, S. Spiegel, G.M. Rubin, and D.K. Morrison KSR stimulates Raf-1 activity in a kinase-independent manner Proc. Natl. Acad. Sci. U. S. A. 94 1997 12792 12796
207. K. Mielke, and T. Herdegen Fatal shift of signal transduction is an integral part of neuronal differentiation: JNKs realize TNFalpha-mediated apoptosis in neuronlike, but not naïve, PC12 cells Mol. Cell. Neurosci. 20 2002 211 224
208. E.I. Miklyaeva, W. Dong, A. Bureau, R. Fattahie, Y. Xu, M. Su, G.H. Fick, J.Q. Huang, S. Igdoura, N. Hanai, and R.A. Gravel Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system Brain Res. 1001 2004 37 50
209. J. Mitoma, M. Ito, S. Furuya, and Y. Hirabayashi Bipotential roles of ceramide in the growth of hippocampal neurons: promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners J. Neurosci. Res. 51 1998 712 722
210. Y. Miyake, Y. Kozutsumi, S. Nakamura, T. Fujita, and T. Kawasaki Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin Biochem. Biophys. Res. Commun. 211 1995 396 403
211. A.N. Moore, A.W. Kampfl, X. Zhao, R.L. Hayes, and P.K. Dash Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes Neuroscience 94 1999 405 415
212. V.A. Movsesyan, A.G. Yakovlev, E.A. Dabaghyan, B.A. Stoica, and A.I. Faden Ceramide induces neuronal apoptosis through the caspase-9/caspase-3 pathway Biochem. Biophys. Res. Commun. 299 2002 201 207
213. G. Muller, M. Ayoub, P. Storz, J. Rennecke, D. Fabbro, and K. Pfizenmaier PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid EMBO J. 14 1995 1961 1969
214. G. Muller, P. Storz, S. Bourteele, H. Doppler, K. Pfizenmaier, H. Mischak, A. Philipp, C. Kaiser, and W. Kolch Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling EMBO J. 17 1998 732 742
215. M.M. Municio, J. Lozano, P. Sanchez, J. Moscat, and M.T. Diaz-Meco Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta J. Biol. Chem. 270 1995 15884 15891
216. P. Nair, S.P. Tammariello, and S. Estus Ceramide selectively inhibits apoptosis-associated events in NGF-deprived sympathetic neurons Cell Death Differ. 7 2000 207 214
217. K. Nakajima, Y. Tohyama, S. Kohsaka, and T. Kurihara Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro J. Neurochem. 80 2002 697 705
218. F. Nara, M. Tanaka, T. Hosoya, K. Suzuki-Konagai, and T. Ogita Scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima: taxonomy of the producing organism, fermentation, isolation, and physico-chemical properties J. Antibiot. (Tokyo) 52 1999 525 530
219. M. Nishio, S. Fukumoto, K. Furukawa, A. Ichimura, H. Miyazaki, S. Kusunoki, T. Urano, and K. Furukawa Over-expressed GM1 suppresses NGF signals by modulating the intra-cellular localization of NGF receptors and membrane fluidity in PC12 cells J. Biol. Chem. 279 2004 33368 33378
220. T. Numakawa, H. Nakayama, S. Suzuki, T. Kubo, F. Nara, Y. Numakawa, D. Yokomaku, T. Araki, T. Ishimoto, A. Ogura, and T. Taguchi Nerve growth factor-induced glutamate release is via p75 receptor, ceramide, and Ca(2+) from ryanodine receptor in developing cerebellar neurons J. Biol. Chem. 278 2003 41259 41269
221. H. Ohta, E.A. Sweeney, A. Masamune, Y. Yatomi, S. Hakomori, and Y. Igarashi Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation Cancer Res. 55 1995 691 697
222. M. Okada, Mi. M. Itoh, M. Haraguchi, T. Okajima, M. Inoue, H. Oishi, Y. Matsuda, T. Iwamoto, T. Kawano, S. Fukumoto, H. Miyazaki, K. Furukawa, S. Aizawa, and K. Furukawa b-Series ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve J. Biol. Chem. 277 2002 1633 1636
223. H. Okamoto, N. Takuwa, T. Yokomizo, N. Sugimoto, S. Sakurada, H. Shigematsu, and Y. Takuwa Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3 Mol. Cell. Biol. 20 2000 9247 9261
224. A. Olivera, and S. Spiegel Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens Nature 365 1993 557 560
225. T. Osanai, M. Kotani, C.T. Yuen, H. Kato, Y. Sanai, and S. Takeda Immunohistochemical and biochemical analyses of GD3, GT1b, and GQ1b ganglioides during neural differentiation of P19 EC cells FEBS Lett. 537 2003 73 78
226. K. Pahan, F.G. Sheikh, M. Khan, A.M. Namboodiri, and I. Singh Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes J. Biol. Chem. 273 1998 2591 2600
227. K. Pahan, K. Dobashi, B. Ghosh, and I. Singh Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide J. Neurochem. 73 1999 513 520
228. J.H. Paik, S.-S. Chae, M.-J. Lee, S. Thangada, and T. Hla Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins J. Biol. Chem. 276 2001 11830 11837
229. M. Pap, and G.M. Cooper Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta signaling pathway Mol. Cell. Biol. 22 2002 578 586
230. G. Paratcha, and C.F. Ibanez Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme Curr. Opin. Neurobiol. 12 2002 542 549
231. S.G. Payne, S. Milstien, and S. Spiegel Sphingosine-1-phosphate: dual messenger functions FEBS Lett. 531 2002 54 57
232. A. Pebay, M. Toutant, J. Premont, C.F. Calvo, L. Venance, J. Cordier, J. Glowinski, and M. Tence Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades Eur. J. Neurosci. 13 2001 2067 2076
233. D. Pelled, T. Raveh, C. Riebeling, M. Fridkin, H. Berissi, A.H. Futerman, and A. Kimchi Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons J. Biol. Chem. 277 2002 1957 1961
234. 2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin J. Biol. Chem. 278 2003 29496 29501
235. D. Pelled, C. Riebeling, G. van Echten-Deckert, K. Sandhoff, and A.H. Futerman Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease Neuropathol. Appl. Neurobiol. 29 2003 341 349
236. B.J. Pettus, C.E. Chalfant, and Y.A. Hannun Ceramide in apoptosis: an overview and current perspectives Biochim. Biophys. Acta 1585 2002 114 125
237. B.J. Pettus, A. Bielawska, S. Spiegel, P. Roddy, Y.A. Hannun, and C.E. Chalfant Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release J. Biol. Chem. 278 2003 38206 38213
238. B.J. Pettus, J. Bielawski, A.M. Porcelli, D.L. Reames, K.R. Johnson, J. Morrow, C.E. Chalfant, L.M. Obeid, and Y.A. Hannun The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha FASEB J. 17 2003 1411 1421
239. B.J. Pettus, A. Bielawska, S. Spiegel, P. Roddy, Y.A. Hannun, and C.E. Chalfant Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release J. Biol. Chem. 278 2003 38206 38213
240. B.J. Pettus, A. Bielawska, P. Subramanian, D.S. Wijesinghe, M. Maceyka, C.C. Leslie, J.H. Evans, J. Freiberg, P. Roddy, Y.A. Hannun, and C.E. Chalfant Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2 J. Biol. Chem. 279 2004 11320 11326
241. D. Phaneuf, N. Wakamatsu, J.Q. Huang, A. Borowski, A.C. Peterson, S.R. Fortunato, G. Ritter, S.A. Igdoura, C.R. Morales, G. Benoit, B.R. Akerman, D. Leclerc, N. Hanai, J.D. Marth, J.M. Trasler, and R.A. Gravel Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases Hum. Mol. Genet. 5 1996 1 14
242. S.E. Ping, and G.L. Barrett Ceramide can induce cell death in sensory neurons, whereas ceramide analogues and sphingosine promote survival J. Neurosci. Res. 54 1998 206 213
243. F.M. Platt, G.R. Neises, R.A. Dwek, and T.D. Butters N- butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis J. Biol. Chem. 269 1994 8362 8365
244. F.M. Platt, G.R. Neises, G.B. Karlsson, R.A. Dwek, and T.D. Butters N-butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processing J. Biol. Chem. 269 1994 27108 27114
245. 2+ mobilisation and stress kinases in cultured sensory neurones Neuropharmacology 42 2002 93 106
246. M. Poppe, C. Reimertz, G. Münstermann, D. Kögel, and J.H.M. Prehn Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression J. Neurochem. 82 2002 482 494
247. E.I. Posse de Chaves, M. Bussiere, D.E. Vance, R.B. Campenot, and J.E. Vance Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons J. Biol. Chem. 272 1997 3028 3035
248. E.I. Posse de Chaves, M. Bussiere, B. MacInnis, D.E. Vance, R.B. Campenot, and J.E. Vance Ceramide inhibits axonal growth and nerve growth factor uptake without compromising the viability of sympathetic neurons J. Biol. Chem. 276 2001 36207 36214
249. F.R. Postma, K. Jalink, T. Hengeveld, and W.H. Moolenaar Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor EMBO J. 15 1996 2388 2392
250. A. Prinetti, R. Bassi, L. Riboni, and G. Tettamanti Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells FEBS Lett. 414 1997 475 479
251. A. Prinetti, V. Chigorno, S. Prioni, N. Loberto, N. Marano, G. Tettamanti, and S. Sonnino Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro J. Biol. Chem. 276 2001 21136 21145
252. S. Prioni, N. Loberto, A. Prinetti, V. Chigorno, F. Guzzi, R. Maggi, M. Parenti, and S. Sonnino Sphingolipid metabolism and caveolin expression in gonadotropin-releasing hormone-expressing GN11 and gonadotropin-releasing hormone-secreting GT1-7 neuronal cells Neurochem. Res. 27 2002 831 840
253. L. Puglielli, B.C. Ellis, A.J. Saunders, and D.M. Kovacs Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis J. Biol. Chem. 278 2003 19777 19783
254. D.P. Purpura, and K. Suzuki Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease Brain Res. 116 1976 1 21
255. K. Puranam, W.H. Qian, K. Nikbakht, M. Venable, L. Obeid, Y. Hannun, and R.M. Boustany Upregulation of Bcl-2 and elevation of ceramide in Batten disease Neuropediatrics 28 1997 37 41
256. S. Pyne, and N.J. Pyne Sphingosine 1-phosphate signalling in mammalian cells Biochem. J. 349 2000 385 402
257. A. Quillet-Mary, J.P. Jaffrezou, V. Mansat, C. Bordier, J. Naval, and G. Laurent Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis J. Biol. Chem. 272 1997 21388 21395
258. M. Raisova, G. Goltz, M. Bektas, A. Bielawska, C. Riebeling, A.M. Hossini, J. Eberle, Y.A. Hannun, C.E. Orfanos, and C.C. Geilen Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes FEBS Lett. 516 2002 47 52
259. C.S. Rani, A. Berger, J. Wu, T.W. Sturgill, D. Beitner-Johnson, D. LeRoith, L. Varticovski, and S. Spiegel Divergence in signal transduction pathways of PDGF and EGF receptors: involvement of sphingosine-1-phosphate in PDGF but not EGF signaling J. Biol. Chem. 272 1997 10777 10783
260. J.G. Reyes, I.G. Robayna, P.S. Delgado, I.H. Gonzalez, J.Q. Aguiar, F.E. Rosas, L.F. Fanjul, and C.M. Galarreta c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells J. Biol. Chem. 271 1996 21375 23180
261. L. Riboni, A. Prinetti, R. Bassi, A. Caminiti, and G. Tettamanti A mediator role of ceramide in the regulation of neuroblastoma Neuro2a cell differentiation J. Biol. Chem. 270 1995 26868 26875
262. L. Riboni, P. Viani, R. Bassi, A. Prinetti, and G. Tettamanti The role of sphingolipids in the process of signal transduction Prog. Lipid Res. 36 1997 153 195
263. L. Riboni, P. Viani, R. Bassi, P. Giussani, and G. Tettamanti Basic fibroblast growth factor-induced proliferation of primary astrocytes: evidence for the involvement of sphingomyelin biosynthesis J. Biol. Chem. 276 2001 12797 12804
264. L. Riboni, R. Bassi, V. Anelli, and P. Viani Metabolic formation of ceramide-1-phosphate in cerebellar granule cells: evidence for the phosphorylation of ceramide by different metabolic pathways Neurochem. Res. 27 2002 711 716
265. R.A. Rius, L.C. Edsall, and S. Spiegel Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors FEBS Lett. 417 1997 173 176
266. A.M. Roccamo, M.F. Pediconi, E. Aztiria, L. Zanello, A. Wolstenholme, and F.J. Barrantes Cells defective in sphingolipids biosynthesis express low amounts of muscle nicotinic acetylcholine receptor Eur. J. Neurosci. 11 1999 1615 1623
267. H. Rosner Gangliosides and brain development M. Nicolini P.F. Zatta Glycobiology of the Brain 1994 Pergamon Press 19 39
268. H. Rosner Significance of gangliosides in neuronal differentiation of neuroblastoma cells and neurite growth in tissue culture Ann. N.Y. Acad. Sci. 845 1998 200 214
269. P.P. Ruvolo Intracellular signal transduction pathways activated by ceramide and its metabolites Pharmacol. Res. 47 2003 383 392
270. P.P. Ruvolo, X. Deng, T. Ito, B.K. Carr, and W.S. May Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A J. Biol. Chem. 274 1999 20296 20300
271. P.P. Ruvolo, F. Gao, W.L. Blalock, X. Deng, and W.S. May Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX J. Biol. Chem. 276 2001 11754 11758
272. J.K. Ryu, W.H. Shin, J. Kim, E.H. Joe, Y.B. Lee, K.G. Cho, Y.J. Oh, S.U. Kim, and B.K. Jin Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia Glia 38 2002 15 23
273. H. Sakagami, and H. Kondo Molecular cloning and developmental expression of a rat homologue of death-associated protein kinase in the nervous system Mol. Brain Res. 52 1997 249 256
274. M. Salinas, R. Lopez-Valdaliso, D. Martin, A. Alvarez, and A. Cuadrado Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells Mol. Cell. Neurosci. 15 2000 156 169
275. K. Sango, S. Yamanaka, A. Hoffmann, Y. Okuda, A. Grinberg, H. Westphal, M.P. McDonald, J.N. Crawley, K. Sandhoff, and K. Suzuki Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism Nat. Genet. 11 1995 170 176
276. K. Sango, M.P. McDonald, J.N. Crawley, M.L. Mack, C.J. Tifft, E. Skop, C.M. Starr, A. Hoffmann, K. Sandhoff, K. Suzuki, and R.L. Proia Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis Nat. Genet. 14 1996 348 352
277. K. Sango, S. Yamanaka, K. Ajiki, A. Tokashiki, and K. Watabe Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease Neuropathol. Appl. Neurobiol. 28 2002 23 34
278. K. Sato, H. Tomura, Y. Igarashi, M. Ui, and F. Okajima Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells Biochem. Biophys. Res. Commun. 240 1997 329 334
279. K. Sato, M. Ui, and F. Okajima Differential roles of Edg-1 and EDG-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells Mol. Brain Res. 85 2000 151 160
280. M. Sawada, S. Nakashima, T. Kiyono, J. Yamada, S. Hara, M. Nakagawa, J. Shinoda, and N. Sakai Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells Exp. Cell Res. 273 2 2002 (Feb. 15) 157 168
281. M.P. Scheid, I.N. Foltz, P.R. Young, J.W. Schrader, and V. Duronio Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival Blood 93 1999 217 225
282. 2+ channel activated by sphingosylphosphocholine Biochem. J. 362 2002 183 189
283. A.M. Schumacher, A.V. Velentza, D.M. Watterson, and M.S. Wainwright DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury Biochim. Biophys. Acta 1600 2002 128 137
284. S. Schutze, M. Wickel, M. Heinrich, T. S.Winoto-Morbach, J. Weber, and M. Brunner Use of affinity chromatography and TID-ceramide photoaffinity labeling for detection of ceramide-binding proteins Methods Enzymol. 312 2000 429 438
285. A. Schwarz, and A.H. Futerman Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth J. Neurosci. 17 1997 2929 2938
286. B. Scurlock, and G. Dawson Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis J. Neurosci. Res. 55 1999 514 522
287. J.A. Shayman, A. Abe, and M. Hiraoka A turn in the road: how studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity Glycoconj. J. 20 2004 25 32
288. K.A. Sheikh, J. Sun, Y. Liu, H. Kawai, T.O. Crawford, R.L. Proia, J.W. Griffin, and R.L. Schnaar Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects Proc. Natl. Acad. Sci. U. S. A. 96 1999 7532 7537
289. K. Shinpo, S. Kikuchi, F. Moriwaka, and K. Tashiro Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons Brain Res. 819 1999 170 173
290. S. Siehler, Y. Wang, X. Fan, R.T. Windh, and D.R. Manning Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and EDG-5, but not Edg-1, in human embryonic kidney 293 cells J. Biol. Chem. 276 2001 48733 48739
291. K. Shirakabe, K. Yamaguchi, H. Shibuya, K. Irie, S. Matsuda, T. Moriguchi, Y. Gotoh, K. Matsumoto, and E. Nishida TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase J. Biol. Chem. 272 1997 8141 8144
292. B.M. Simon, F. Malisan, R. Testi, P. Nicotera, and M. Leist Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis Cell Death Differ. 9 2002 758 767
293. K. Simons, and J. Gruenberg Jamming the endosomal system: lipid rafts and lysosomal storage diseases Trends Cell Biol. 10 2000 459 462
294. M. Simons, E.M. Kramer, C. Thiele, W. Stoffel, and J. Trotter Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains J. Cell Biol. 151 2000 143 154
295. E.J. Smart, G.A. Graf, and M.A. McNiven Caveolins, liquid-ordered domains, and signal transduction Mol. Cell. Biol. 19 1999 7289 7304
296. M.-S. Song, and E.I. Posse de Chaves Inhibition of rat sympathetic neuron apoptosis by ceramide. Role of p75 NTR in ceramide generation Neuropharmacology 45 2003 1130 1150
297. S. Spiegel, and S. Milstien Sphingosine 1-phosphate, a key cell signaling molecule J. Biol. Chem. 277 2002 25851 25854
298. S. Spiegel, and S. Milstien Sphingosine-1-phosphate: an enigmatic signalling lipid Nat. Rev., Mol. Cell Biol. 2003 397 407
299. S. Spiegel, O. Cuvillier, L.C. Edsall, T. Kohama, R. Menzeleev, Z. Olah, A. Olivera, G. Pirianov, D.M. Thomas, Z. Tu, J.R. Van Brocklyn, and F. Wang Sphingosine-1-phosphate in cell growth and cell death Ann. N.Y. Acad. Sci. 845 1998 11 18
300. B. Stankoff, S. Barron, J. Allard, G. Barbin, F. Noel, M.S. Aigrot, J. Premont, P. Sokoloff, B. Zalc, and C. Lubetzki Oligodendroglial expression of Edg-2 receptor: developmental analysis and pharmacological responses to lysophosphatidic acid Mol. Cell. Neurosci. 20 2002 415 428
301. D. Stephenson, K. Rash, B. Smalstig, E. Roberts, E. Johnstone, J. Sharp, J. Panetta, S. Little, R. Kramer, and J. Clemens Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration Glia 27 1999 110 128
302. B.A. Stoica, V.A. Movsesyan, P.M. Lea, and A.I. Faden Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway Mol. Cell. Neurosci. 22 2003 365 382
303. M. Strazza, A. Luddi, A. Brogi, M. Carbone, M. Riccio, S. Santi, M. Melli, and E. Costantino-Ceccarini Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes Neurochem. Res. 29 2004 923 931
304. K. Subbaramaiah, W.J. Chung, and A.J. Dannenberg Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways J. Biol. Chem. 273 1998 32943 32949
305. M. Sugita, M. Willians, J.T. Dulaney, and H.W. Moser Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase Biochim. Biophys. Acta 398 1975 125 131
306. M. Sugiura, K. Kono, H. Liu, T. Shimizugawa, H. Minekura, S. Spiegel, and T. Kohama Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization J. Biol. Chem. 277 2002 23294 23300
307. K. Susen, R. Heumann, and A. Blochl Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR) FEBS Lett. 463 1999 231 234
308. K. Takamiya, A. Yamamoto, K. Furukawa, S. Yamashiro, M. Shin, M. Okada, S. Fukumoto, M. Haraguchi, N. Takeda, K. Fujimura, M. Sakae, M. Kishikawa, H. Shiku, K. Furukawa, and S. Aizawa Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system Proc. Natl. Acad. Sci. U. S. A. 93 1996 10662 10667
309. M. Taniike, S. Yamanaka, R.L. Proia, C. Langaman, T. Bone-Turrentine, and K. Suzuki Neuropathology of mice with targeted disruption of Hexa gene, a model of Tay-Sachs disease Acta Neuropathol. (Berl.) 89 1995 296 304
310. T. Taniwaki, T. Yamada, H. Asahara, Y. Ohyagi, and J. Kira Ceramide induces apoptosis to immature cerebellar granule cells in culture Neurochem. Res. 24 1999 685 890
311. S. Tavarini, L. Colombaioni, and M. Garcia-Gil Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells Neurosci. Lett. 285 2000 185 188
312. K. Terai, T. Soga, M. Takahashi, M. Kamohara, K. Ohno, S. Yatsugi, M. Okada, and T. Yamaguchi Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS Neuroscience 116 2003 1053 1062
313. F.D. Testai, M.A. Landek, and G. Dawson Regulation of sphingomyelinases in cells of the oligodendrocyte lineage J. Neurosci. Res. 75 2004 66 74
314. G. Tettamanti, and L. Riboni Gangliosides turnover and neural cells function: a new perspective Prog. Brain Res. 101 1994 77 100
315. G. Tettamanti, A. Prinetti, R. Bassi, P. Viani, P. Giussani, and L. Riboni Sphingoid bioregulators in the differentiation of cells of neural origin J. Lipid Mediators Cell Signal. 14 1996 263 275
316. G. Tettamanti, R. Bassi, P. Viani, and L. Riboni Salvage pathways in glycosphingolipid metabolism Biochimie 85 2003 423 437
317. G. Tigyi Physiological responses to lysophosphatidic acid and related glycero-phospholipids Prostaglandins Other Lipid Mediat. 64 2001 47 62
318. A. Titievsky, I. Titievskaya, M. Pasternack, K. Kaila, and K. Tornquist Sphingosine inhibits voltage-operated calcium channels in GH4C1 cells J. Biol. Chem. 273 1998 242 247
319. R.E. Toman, and S. Spiegel Lysophospholipid receptors in the nervous system Neurochem. Res. 27 2002 619 627
320. R.E. Toman, S. Spiegel, and A.I. Faden Role of ceramide in neuronal cell death and differentiation J. Neurotrauma 17 2000 891 898
321. K. Tornquist, T. Blom, R. Shariatmadari, and M. Pasternack Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH 4C 1 rat pituitary cells Biochem. J. 380 2004 661 668
322. W. Tong, D. Shah, J. Xu, J.A. Diehl, A. Hans, M. Hannink, and G.Y. Sun Involvement of lipid mediators on cytokine signaling and induction of secretory phospholipase A2 in immortalized astrocytes (DITNC) J. Mol. Neurosci. 12 1999 89 99
323. B.A. Tsui-Pierchala, M. Encinas, J. Milbrandt, and E.M. Johnson Jr. Lipid rafts in neuronal signaling and function Trends Neurosci. 25 2002 412 417
324. 2+ dependent protein kinase activity exists in the plasma membrane fraction of neuroblastoma cell line, GOTO J. Biochem. (Tokyo) 97 1985 969 972
325. M. Tuson, G. Marfany, and R. Gonzalez-Duarte Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26) Am. J. Hum. Genet. 74 2004 28 38
326. K. Uemura, E. Sugiyama, and T. Taketomi Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines J. Biochem. (Tokyo) 110 1991 96 102
327. J. Usta, S. El Bawab, P. Roddy, Z.M. Szulc, Yusuf, A. Hannun, and A. Bielawska Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase Biochemistry 40 2001 9657 9668
328. 2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue Brain Res. 635 1994 231 237
329. J.R. Van Brocklyn, M.J. Lee, R. Menzeleev, A. Olivera, L. Edsall, O. Cuvillier, D.M. Thomas, P.J. Coopman, S. Thangada, C.H. Liu, T. Hla, and S. Spiegel Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival J. Cell Biol. 142 1998 229 240
330. J.R. Van Brocklyn, Z. Tu, L.C. Edsall, R.R. Schmidt, and S. Spiegel Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218 J. Biol. Chem. 274 1999 4626 4632
331. J.R. Van Brocklyn, C.A. Letterle, P.J. Snyder, and T.W. Prior Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase b Cancer Lett. 181 2002 195 204
332. J.R. Van Brocklyn, N. Young, and R. Roof Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells Cancer Lett. 199 2003 53 60
333. G. van Echten, and K. Sandhoff Ganglioside metabolism. Enzymology, topology, and regulation J. Biol. Chem. 268 1993 5341 5344
334. C.J. van Koppen, D. Meyer zu Heringdorf, R. Alemany, and K.H. Jakobs Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors Life Sci. 68 2001 2535 2540
335. L.R. Vann, S.G. Payne, L.C. Edsall, S. Twitty, S. Spiegel, and S. Milstien Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells J. Biol. Chem. 277 2002 12649 12656
336. M. Verheij, R. Bose, X.H. Lin, B. Yao, W.D. Jarvis, S. Grant, M.J. Birrer, E. Szabo, L.I. Zon, J.M. Kyriakis, A. Haimovitz-Friedman, Z. Fuks, and R.N. Kolesnick Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis Nature 380 1996 75 79
337. P. Viani, P. Giussani, L. Riboni, R. Bassi, and G. Tettamanti Sphingosine inhibits nitric oxide synthase from cerebellar granule cells differentiated in vitro FEBS Lett. 454 1999 321 324
338. P. Viani, P. Giussani, L. Brioschi, R. Bassi, V. Anelli, G. Tettamanti, and L. Riboni Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic J. Biol. Chem. 278 2003 9592 9601
339. M. Vinson, O. Rausch, P.R. Maycox, R.K. Prinjha, D. Chapman, R. Morrow, A.J. Harper, C. Dingwall, F.S. Walsh, S.A. Burbidge, and D.R. Riddell Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons Mol. Cell. Neurosci. 22 2003 344 352
340. J. Vivekananda, D. Smith, and R.J. King Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP: phosphocholine cytidylyltransferase Am. J. Physiol., Lung Cell. Mol. Physiol. 281 2001 L98 L107
341. Z. Vukelic, W. Metelmann, J. Muthing, M. Kos, and J. Peter-Katalinic Anencephaly: structural characterization of gangliosides in defined brain regions Biol. Chem. 382 2001 259 274
342. R.R. Vunnam, and N.S. Radin Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain Chem. Phys. Lipids 26 1980 265 278
343. R. Wada, C.J. Tifft, and R.L. Proia Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation Proc. Natl. Acad. Sci. U. S. A. 97 2000 10954 10959
344. B. Wagenknecht, W. Roth, E. Gulbins, H. Wolburg, and M. Weller C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis Cell Death Differ. 8 2001 595 602
345. S.U. Walkley, M. Zervas, and S. Wiseman Gangliosides as modulators of dendritogenesis in normal and storage disease-affected pyramidal neurons Cereb. Cortex 10 2000 1028 1037
346. E. Wang, W.P. Norred, C.W. Bacon, R.T. Riley, and A.H. Merrill Jr. Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme J. Biol. Chem. 266 1991 14486 14490
347. Y.M. Wang, M.L. Seibenhener, M.L. Vandenplas, and M.W. Wooten Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival J. Neurosci. Res. 55 1999 293 302
348. Y. Wang, Z. Tsui, and F. Yang Antagonistic effect of ganglioside GM1 and GM3 on the activity and conformation of sarcoplasmic reticulum Ca(2+)-ATPase FEBS Lett. 457 1999 144 148
349. K. Watterson, H. Sankala, S. Milstien, and S. Spiegel Pleiotropic actions of sphingosine-1-phosphate Prog. Lipid Res. 42 2003 344 357
350. M. Weiss, S. Hettmer, P. Smith, and S. Ladisch Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase Cancer Res. 63 2003 3654 3658
351. E.R. Werner, A.C. Gorren, R. Heller, G. Werner-Felmayer, and B. Mayer Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects Exp. Biol. Med. 228 2003 1291 1302
352. J.K. Westwick, A.E. Bielawska, G. Dbaibo, Y.A. Hannun, and D.A. Brenner Ceramide activates the stress-activated protein kinases J. Biol. Chem. 270 1995 22689 22692
353. D.A. Wiesner, and G. Dawson Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway J. Neurochem. 66 1996 1418 1425
354. S. Willaime, P. Vanhoutte, J. Caboche, Y. Lemaigre-Dubreuil, J. Mariani, and B. Brugg Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation Eur. J. Neurosci. 13 2001 2037 2046
355. J.S. Won, M.R. Choi, and H.W. Suh Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases Brain Res. 903 2001 207 215
356. G. Wu, and R.W. Ledeen Stimulation of neurite outgrowth in neuroblastoma cells by neuraminidase: putative role of GM1 ganglioside in differentiation J J. Neurochem. 56 1991 95 104
357. G. Wu, K. Nakamura, and R.W. Ledeen Inhibition of neurite outgrowth of neuroblastoma Neuro-2a cells by cholera toxin B-subunit and anti-GM1 antibody Mol. Chem. Neuropathol. 21 1994 259 271
358. G. Wu, Z.-H. Lu, and R.W. Ledden Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membrane J. Neurosci. 15 1995 3739 3746
359. G. Wu, Z.H. Lu, X. Xie, and R. Ledeen Comparison of ganglioside profiles in nuclei and whole cells of NG108-15 and NG-CR72 lines: changes in response to different neuritogenic stimuli Dev. Brain Res. 126 2001 183 190
360. G. Wu, X. Xie, Z. Lu, and R.W. Ledeen Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium Proc. Natl. Acad. Sci. U. S. A. 98 2001 307 312
361. S.N. Wu, Y.K. Lo, B.I. Kuo, and H.T. Chiang Ceramide inhibits the inwardly rectifying potassium current in GH(3) lactotrophs Endocrinology 142 2001 4785 4794
362. Z. Xia, M. Dickens, J. Raingeaud, R.J. Davis, and M.E. Greenberg Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270 1995 1326 1331
363. P. Xia, L. Wang, P.A. Moretti, N. Albanese, F Chai, S.M. Pitson, R.J. D'Andrea, J.R. Gamble, and M.A. Vadas Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling J. Biol. Chem. 277 10 2002 (Mar. 8) 7996 8003
364. H. Xie, and G.V. Johnson Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I J. Neurochem. 69 1997 1020 1030
365. K. Yamagata, M. Tagami, Y. Torii, F. Takenaga, S. Tsumagari, S. Itoh, Y. Yamori, and Y. Nara Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes Glia 41 2003 199 206
366. M. Yamamoto, T. Hioki, T. Ishii, S. Nakajima-Iijima, and S. Uchino DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells Eur. J. Biochem. 269 2002 139 147
367. S. Yamanaka, M.D. Johnson, A. Grinberg, H. Westphal, J.N. Crawley, M. Taniike, K. Suzuki, and R.L. Proia Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease Proc. Natl. Acad. Sci. U. S. A. 91 1994 9975 9979
368. T. Yamashita, R. Wada, T. Sasaki, C. Deng, U. Bierfreund, K. Sandhoff, and R.L. Proia A vital role for glycosphingolipid synthesis during development and differentiation Proc. Natl. Acad. Sci. U. S. A. 96 1999 9142 9147
369. S.N. Yang Ceramide-induced sustained depression of synaptic currents mediated by ionotropic glutamate receptors in the hippocampus: an essential role of postsynaptic protein phosphatases Neuroscience 96 2 2000 253 258
370. B. Yao, Y. Zhang, S. Delikat, S. Mathias, S. Basu, and R. Kolesnick Phosphorylation of Raf by ceramide-activated protein kinase Nature 378 1995 307 310
371. Y. Yatomi, F. Ruan, T. Megidish, T. Toyokuni, S. Hakomori, and Y. Igarashi N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets Biochemistry 35 1996 626 633
372. T. Yokomatsu, T. Murano, T. Akiyama, J. Koizumi, S. Shibuya, Y. Tsuji, S. Soeda, and H. Shimeno Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity Bioorg. Med. Chem. Lett. 13 2003 229 236
373. S. Yoshimura, Y. Banno, S. Nakashima, K. Takenaka, H. Sakai, Y. Nishimura, N. Sakai, S. Shimizu, Y. Eguchi, Y. Tsujimoto, and Y. Nozawa Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation J. Biol. Chem. 273 1998 6921 6927
374. 2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors J. Biol. Chem. 275 2000 38532 38539
375. 2+ release Semin. Cell Dev. Biol. 12 2001 19 25
376. R.K. Yu Development regulation of ganglioside metabolism Prog. Brain Res. 101 1994 31 44
377. + current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons J. Neurochem. 73 1999 933 9341
378. Z.F. Yu, M. Nikolova-Karakashian, D. Zhou, G. Cheng, E.H. Schuchman, and M.P. Mattson Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide cytokine production, and neuronal apoptosis J. Mol. Neurosci. 15 2000 85 97
379. H. Zhang, N.E. Buckley, K. Gibson, and S. Spiegel Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway J. Biol. Chem. 265 1990 76 81
380. H. Zhang, N.N. Desai, A. Olivera, T. Seki, G. Brooker, and S. Spiegel Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation J. Cell Biol. 114 1991 155 167
381. P. Zhang, B.S. Miller, S.A. Rosenzweig, and N.R. Bhat Activation of C-jun N-terminal kinase/stress-activated protein kinase in primary glial cultures J. Neurosci. Res. 46 1996 114 121
382. Y. Zhang, B. Yao, S. Delikat, S. Bayoumy, X.H. Lin, S. Basu, M. McGinley, P.Y. Chan-Hui, H. Lichenstein, and R. Kolesnick Kinase suppressor of Ras is ceramide-activated protein kinase Cell 89 1997 63 72
383. Y.H. Zhang, M.R. Vasko, and G.D. Nicol Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons J. Physiol. 544 2002 385 3402
384. H. Zhou, S.A. Summers, M.J. Birnbaum, and R.N. Pittman Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis J. Biol. Chem. 273 1998 16568 16575
385. M.J. Zinda, C.J. Vlahos, and M.T. Lai Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells Biochem. Biophys. Res. Commun. 280 2001 1107 1115