Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations

Journal of Neuroscience Research

Volumn 54, Issue 4, 1998, Pages 475-485

  Irie, Fumitoshi ^a   Hirabayashi, Yoshio ^a  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

Author keywords

Apoptosis; Axonal growth; Ceramide; Motoneurons; Survival

Indexed keywords

BACTERIAL ENZYME; CERAMIDE; CERAMIDE DERIVATIVE; HEXSANOYLSPHINGOSINE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; HIPPOCAMPUS; NERVE CELL NECROSIS; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAT; SPINAL CORD MOTONEURON;

1-DEOXYNOJIRIMYCIN; ANIMALS; APOPTOSIS; AXONS; CELL NUCLEUS; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; CERAMIDES; CHROMATIN; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSYLCERAMIDES; MOTOR NEURONS; RATS; SPHINGOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE; SPINAL CORD; STEREOISOMERISM; TIME FACTORS;

EID: 0032534016     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19981115)54:4<475::AID-JNR5>3.0.CO;2-P     Document Type: Article

References (37)

1. Ankarcorna M, Dypbukt JM, Bonfoco E, Zhivotovsky B, Orrenius S, Lipton SA, Nicotera P (1995): Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15:961-973.
2. Bielawska A, Crane HM, Liotta D, Obeido LM, Hannun YA (1993): Selectivity of ceramide-mediated biology. J Biol Chem 268: 26226-26232.
3. Brugg B, Mochel PP, Agid Y, Ruberg M (1996): Ceramide induces apoptosis in cultured mesencephalic neurons. J Neurochem 66:733-739.
4. Camu W, Henderson CE (1992): Purification of embryonic rat motoneurons by panning on a monoclonal antibody to the low-affinity NGF receptor. J Neurosci Methods 44:59-70.
5. Casaccia-Bonnefil P, Carter BD, Dobrowsky RT, Chao MV (1996): Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75. Nature 383:716-719.
6. Chandler CE, Parsons LM, Hosang M, Shooter EM (1984): A monoclonal antibody modulates the interaction of nerve growth factor with PC-12 cells. J Biol Chem 259:6882-6889.
7. Comella JX, Sanz-Rodriguez C, Aldea M, Esquerda JE (1994): Skeletal muscle-derived trophic factors prevent motoneurons from entering an active cell death program in vitro. J Neurosci 14:2674-2686.
8. Coroneos E, Wang Y, Panuska JR, Templeton DJ, Kester M (1996): Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades. Biochem J 316:13-17.
9. Cuvillier O, Pirianov G, Kleuser B, Vanek PG, Coso OA, Gutkind JS, Spiegel S (1996): Supression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381: 800-803.
10. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA (1994): Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265:1596-1599.
11. Dobrowsky RT, Jenkins GM, Hannun YA (1995): Neurotrophins induce sphingomyelin hydrolysis. J Biol Chem 270:22135-22142.
12. Ericson J, Thor S, Edlund T, Jessell TM, Yamada T (1992): Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256:1555-1560.
13. Furuya S, Ono K, Hirabayashi Y (1995): Sphingolipid biosynthesis is necessary for dendrite growth and survival of cerebellar Purkinje cells in culture. J Neurochem 65:1551-1561.
14. Goodman Y, Mattson MP (1996): Ceramide protects hippocampal neurons against exitotoxic and oxidative insults, and amyloid β-peptide toxicity. J Neurochem 66:869-872.
15. Hannun YA (1994): The sphingomyelin cycle and second messenger function of ceramide. J Biol Chem 269:3125-3128.
16. Hannun YA (1996): Functions of ceramide in coordinating cellular responses to stress. Science 271:1855-1859.
17. Henderson CE, Camu W, Mettling C, Gouin A, Poulsen K, Karihaloo M, Rullamas J, Evans T, McMahon SB, Armanini MP, Berkemeier L, Phillips HS, Rosenthal A (1993): Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363:266-270.
18. Henderson CE, Phillips HS, Pollock RA, Davies AM, Lemeulle C, Armanini M, Simpson LC, Moffet B, Vandlen RA, Koliatsos VE, Rosenthal A (1994): GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064.
19. Hirabayashi Y, Nakao T, Irie F, Whittaker VP, Kon K, Ando S (1992): Structural characterization of a novel cholinergic neuronspecific ganglioside in bovine brain. J Biol Chem 267:12973-12978.
20. Irie F, Hirabayashi Y (1997): Sphingolipids regulate survival and death of cultured spinal cord motoneurons. Soc Neurosci Abstr 23:1156.
21. Ito A, Horigome K (1995): Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation. J Neurochem 65:463-466.
22. Ji L, Zhang G, Uematsu S, Akahori Y, Hirabayashi Y (1995): Induction of apoptotic DNA fragmentation and cell death by natural ceramide. FEBS Lett 358:211-214.
23. Lee K-F, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R (1992): Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69:737-749.
24. Mitoma J, Ito M, Furuya S, Hirabayashi Y (1998): Bipotential roles of J ceramide in the growth of hippocampal neurons:Promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners. J Neurosci Res 51:712-722.
25. Obeid LM, Linardic CM, Karolak LA, Hannun YA (1993): Programmed cell death induced by ceramide. Science 259:1769-1771.
26. Oppenheim RW (1991): Cell death during development of the nervous system. Annu Rev Neurosci 14:453-501.
27. Oppenheim RW (1996): Neurotrophic survival molecules for motoneurons: An embarrassment of riches. Neuron 17:195-197.
28. Pagano RE, Martin OC (1988): A series of fluorescent N-acylsphingosines: Synthesis, physical properties, and studies in cultured cells. Biochemistry 27:4439-4445.
29. Paul P, Kamisaka Y, Marks DL, Pagano RE (1996): Purification and characterization of UDP-glucose: Ceramide glucosyltransferase from rat liver Golgi membranes. J Biol Chem 271:2287-2293.
30. Pennica D, Arce V, Swanson TA, Vejsada R, Pollock RA, Armanini M, Dudley K, Phillips HS, Rosenthal A, Kato AC, Henderson CE (1996): Cardiotrophin-1, a cytokine present in embryonic muscle, supports long-term survival of spinal motoneurons. Neuron 17:63-74.
31. Platt FM, Neises GR, Karisson GB, Dwek RA, Butters TD (1994): N-butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processing. J Biol Chem 269:27108-27114.
32. Schwanz A, Futerman AH (1997): Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth. J Neurosci 17:2929-2938.
33. Spence MW, Burgess JK (1978): Acid and neutral sphingomyelinases of rat brain: Activity in developing brain and regional distribution in adult brain. J Neurochem 30:917-919.
34. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Kyriakis JM, Haimovitz-Friedman A, Fuks Z, Kolesnick RN (1996): Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380:75-79.
35. Westwick JK, Bielawska AE, Dbaido G, Hannun YA, Brenner DA (1995): Ceramide activates the stress-activated protein kinases. J Biol Chem 270:22689-22692.
36. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995): Opposing effects of Erk and JNK-p38 MAP kinase on apoptosis. Science 270:1326-1331.
37. Yan Q, Johnson EJ (1988): An immunohistochemical study of the nerve growth factor receptor in developing rats. J Neurosci 8:3481-3498.