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Volumn 4, Issue 5, 2003, Pages 397-407

Sphingosine-1-phosphate: An enigmatic signalling lipid

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE;

EID: 0038218405     PISSN: 14710072     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrm1103     Document Type: Review
Times cited : (1840)

References (91)
  • 2
    • 0014833032 scopus 로고
    • Metabolism of sphingoid bases, XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine-1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate
    • Stoffel, W. & Assmann, G. Metabolism of sphingoid bases, XV. Enzymatic degradation of 4t-sphingenine 1-phosphate (sphingosine-1-phosphate) to 2t-hexadecen-1-al and ethanolamine phosphate. Hoppe-Seyler's Z. Physiol. Chem. 351, 1041-1049 (1970).
    • (1970) Hoppe-Seyler's Z. Physiol. Chem. , vol.351 , pp. 1041-1049
    • Stoffel, W.1    Assmann, G.2
  • 3
    • 0026049696 scopus 로고
    • Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation
    • Zhang, H. et al. Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol. 114, 155-167 (1991).
    • (1991) J. Cell Biol. , vol.114 , pp. 155-167
    • Zhang, H.1
  • 4
    • 0027371722 scopus 로고
    • Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens
    • Olivera, A. & Spiegel, S. Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature 365, 557-560 (1993). This was a pioneering study that showed that S1P was a signalling molecule.
    • (1993) Nature , vol.365 , pp. 557-560
    • Olivera, A.1    Spiegel, S.2
  • 5
    • 0029948396 scopus 로고    scopus 로고
    • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate
    • Cuvillier, O. et el. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Nature 381, 800-803 (1996). This was the first evidence that S1P can suppress apoptosis and proposed the concept of the sphingolipid rheostat.
    • (1996) Nature , vol.381 , pp. 800-803
    • Cuvillier, O.1
  • 7
    • 0037021420 scopus 로고    scopus 로고
    • Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes
    • Hait, N. C., Fujita, K., Lester, R. L. & Dickson, R. C. Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes. FEBS Lett. 532, 97-102 (2002).
    • (2002) FEBS Lett. , vol.532 , pp. 97-102
    • Hait, N.C.1    Fujita, K.2    Lester, R.L.3    Dickson, R.C.4
  • 8
    • 0037470183 scopus 로고    scopus 로고
    • Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae
    • Funato, K., Lombardi, R., Vallée, B. & Riezman, H. Lcb4p is a key regulator of ceramide synthesis from exogenous long chain sphingoid base in Saccharomyces cerevisiae. J. Biol. Chem. 278, 7325-7334 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 7325-7334
    • Funato, K.1    Lombardi, R.2    Vallée, B.3    Riezman, H.4
  • 9
    • 0037147198 scopus 로고    scopus 로고
    • The nucleotide-binding site of human sphingosine kinase 1
    • Pitson, S. M. et al. The nucleotide-binding site of human sphingosine kinase 1. J. Biol. Chem. 277, 49545-49553 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 49545-49553
    • Pitson, S.M.1
  • 10
    • 0030671394 scopus 로고    scopus 로고
    • The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase
    • Saba, J. D., Nora, F., Bielawska, A., Garrett, S. & Hanun, Y. A. The BST1 gene of Saccharomyces cerevisiae is the sphingosine-1-phosphate lyase. J. Biol. Chem. 272, 26087-26090 (1997)
    • (1997) J. Biol. Chem. , vol.272 , pp. 26087-26090
    • Saba, J.D.1    Nora, F.2    Bielawska, A.3    Garrett, S.4    Hanun, Y.A.5
  • 11
    • 0033107874 scopus 로고    scopus 로고
    • The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae
    • Gottlieb, D., Heideman, W. & Saba, J. D. The DPL1 gene is involved in mediating the response to nutrient deprivation in Saccharomyces cerevisiae. Mol. Cell Biol. Res. Commun. 1, 66-71 (1999).
    • (1999) Mol. Cell Biol. Res. Commun. , vol.1 , pp. 66-71
    • Gottlieb, D.1    Heideman, W.2    Saba, J.D.3
  • 12
    • 0034786769 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum
    • Li, G., Foote, C., Alexander, S. & Alexander, H. Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. Development 128, 3473-3483 (2001).
    • (2001) Development , vol.128 , pp. 3473-3483
    • Li, G.1    Foote, C.2    Alexander, S.3    Alexander, H.4
  • 13
    • 0030712997 scopus 로고    scopus 로고
    • Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase
    • Mao, C., Wadleigh, M., Jenkins, G. M., Hannun, Y. A. & Obeid, L. M. Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272, 28690-28694 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 28690-28694
    • Mao, C.1    Wadleigh, M.2    Jenkins, G.M.3    Hannun, Y.A.4    Obeid, L.M.5
  • 14
    • 0031892088 scopus 로고    scopus 로고
    • Sphingoid base 1-phosphate phosphatase: A key regulator of sphingolipid metabolism and stress response
    • Mandala, S. M. et al. Sphingoid base 1-phosphate phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl Acad. Sci. USA 95, 150-155 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 150-155
    • Mandala, S.M.1
  • 15
    • 0033568278 scopus 로고    scopus 로고
    • The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses
    • Mao, C., Saba, J. D. & Obeid, L. M. The dihydrosphingosine-1-phosphate phosphatases of Saccharomyces cerevisiae are important regulators of cell proliferation and heat stress responses. Biochem. J. 342, 667-675 (1999).
    • (1999) Biochem. J. , vol.342 , pp. 667-675
    • Mao, C.1    Saba, J.D.2    Obeid, L.M.3
  • 16
    • 0034608826 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death
    • Mandala, S. M. et al. Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death. Proc. Natl Acad. Sci. USA 97, 7859-7864 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 7859-7864
    • Mandala, S.M.1
  • 17
    • 0037088581 scopus 로고    scopus 로고
    • Characterization of murine sphingosine-1-phosphate phosphohydrolase
    • Le Stunff, H. et al. Characterization of murine sphingosine-1-phosphate phosphohydrolase. J. Biol. Chem. 277, 8920-8927 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 8920-8927
    • Le Stunff, H.1
  • 18
    • 0037428384 scopus 로고    scopus 로고
    • Identification and characterization of a novel human sphingosine 1-phosphate phosphohydrolase, hSPP2
    • Ogawa, C., Kihara, A., Gokoh, M. & Igarashi, Y. Identification and characterization of a novel human sphingosine 1-phosphate phosphohydrolase, hSPP2. J. Biol. Chem. 278, 1268-1272 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 1268-1272
    • Ogawa, C.1    Kihara, A.2    Gokoh, M.3    Igarashi, Y.4
  • 19
    • 0031048876 scopus 로고    scopus 로고
    • Identification of a novel phosphatase sequence motif
    • Stukey, J. & Carman, G. M. Identification of a novel phosphatase sequence motif. Protein Sci. 6, 469-472 (1997)
    • (1997) Protein Sci. , vol.6 , pp. 469-472
    • Stukey, J.1    Carman, G.M.2
  • 20
    • 0033564681 scopus 로고    scopus 로고
    • Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters
    • Jasinska, R. et al. Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. Biochem. J. 340, 677-686 (1999)
    • (1999) Biochem. J. , vol.340 , pp. 677-686
    • Jasinska, R.1
  • 21
    • 0037119991 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis
    • Le Stunff, H., Galve-Roperh, I., Peterson, C., Milstien, S. & Spiegel, S. Sphingosine-1-phosphate phosphohydrolase in regulation of sphingolipid metabolism and apoptosis. J. Cell Biol. 158, 1039-1049 (2002).
    • (2002) J. Cell Biol. , vol.158 , pp. 1039-1049
    • Le Stunff, H.1    Galve-Roperh, I.2    Peterson, C.3    Milstien, S.4    Spiegel, S.5
  • 22
    • 0037135572 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, a key cell signaling molecule
    • Spegel, S. & Milstien, S. Sphingosine 1-phosphate, a key cell signaling molecule. J. Biol. Chem. 277, 25851-25854 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 25851-25854
    • Spegel, S.1    Milstien, S.2
  • 23
    • 0037135626 scopus 로고    scopus 로고
    • The ceramide-centric universe of lipid-mediated cell regulation: Stress encounters of the lipid kind
    • Hannun, Y. A. & Obeid, L. M. The ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind. J. Biol. Chem. 277, 25487-25850 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 25487-25850
    • Hannun, Y.A.1    Obeid, L.M.2
  • 24
    • 0036303786 scopus 로고    scopus 로고
    • The therapeutic potential of modulating the ceramide/sphingomyelin pathway
    • Kolesnick, R. The therapeutic potential of modulating the ceramide/sphingomyelin pathway J. Clin. Invest. 110, 3-8 (2002).
    • (2002) J. Clin. Invest. , vol.110 , pp. 3-8
    • Kolesnick, R.1
  • 25
    • 0033230364 scopus 로고    scopus 로고
    • Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival
    • Olivera, A. et al. Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival. J. Cell Biol. 147, 545-558 (1999).
    • (1999) J. Cell Biol. , vol.147 , pp. 545-558
    • Olivera, A.1
  • 26
    • 0034735916 scopus 로고    scopus 로고
    • An oncogenic role of sphingosine kinase
    • Xia, P. et al. An oncogenic role of sphingosine kinase. Curr. Biol. 10, 1527-1530 (2000).
    • (2000) Curr. Biol. , vol.10 , pp. 1527-1530
    • Xia, P.1
  • 27
    • 0036436697 scopus 로고    scopus 로고
    • Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells
    • Nava, V. E., Hobson, J. P., Murthy, S., Milstien, S. & Spiegel, S. Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells. Exp. Cell Res. 281, 115-127 (2002).
    • (2002) Exp. Cell Res. , vol.281 , pp. 115-127
    • Nava, V.E.1    Hobson, J.P.2    Murthy, S.3    Milstien, S.4    Spiegel, S.5
  • 28
    • 0036841720 scopus 로고    scopus 로고
    • Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
    • Shu, X., Wu, W., Mosteller, R. D. & Broek, D. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Mol. Cell. Biol. 22, 7758-7768 (2002). This important study highlights a new mechanism by which SphK1 mediates signalling from VEGF and PKC to Ras. The mechanism seems not to use a Ras-GEF but rather modulates Ras-GAP activity to favour Ras activation.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7758-7768
    • Shu, X.1    Wu, W.2    Mosteller, R.D.3    Broek, D.4
  • 29
    • 0035089286 scopus 로고    scopus 로고
    • Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells
    • Edsall, L. C., Cuvillier, O., Twitty, S., Spiegel, S. & Milstien, S. Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells. J. Neurochem. 76, 1573-1584 (2001).
    • (2001) J. Neurochem. , vol.76 , pp. 1573-1584
    • Edsall, L.C.1    Cuvillier, O.2    Twitty, S.3    Spiegel, S.4    Milstien, S.5
  • 30
    • 0037040908 scopus 로고    scopus 로고
    • Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling
    • Xia, P. et al. Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-α signaling. J. Biol. Chem. 217, 7996-8003 (2002). This paper indicates that there is a role for SphK in the signal transduction by TRAF2 leading to activation of NF-κB and survival.
    • (2002) J. Biol. Chem. , vol.217 , pp. 7996-8003
    • Xia, P.1
  • 31
    • 0035896640 scopus 로고    scopus 로고
    • Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae
    • Jenkins, G. M. & Hannun, Y. A. Role for de novo sphingoid base biosynthesis in the heat-induced transient cell cycle arrest of Saccharomyces cerevisiae. J. Biol. Chem. 276, 8574-8581 (2001). This study uncovered the role of sphingolipids in yeast heat-stress adaptation.
    • (2001) J. Biol. Chem. , vol.276 , pp. 8574-8581
    • Jenkins, G.M.1    Hannun, Y.A.2
  • 33
    • 0035957921 scopus 로고    scopus 로고
    • Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria
    • Kroesen, B. J. et al. Induction of apoptosis through B-cell receptor cross-linking occurs via de novo generated C16-ceramide and involves mitochondria. J. Biol. Chem. 276, 13606-13614 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 13606-13614
    • Kroesen, B.J.1
  • 34
    • 0034708594 scopus 로고    scopus 로고
    • Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis
    • Perry, D. K. et al. Serine palmitoyltransferase regulates de novo ceramide generation during etoposide-induced apoptosis. J. Biol. Chem. 275, 9078-9084 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 9078-9084
    • Perry, D.K.1
  • 35
    • 0029148660 scopus 로고
    • Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
    • Bose, R. et al. Ceramide synthase mediates daunorubicin-induced apoptosis: an alternative mechanism for generating death signals. Cell 82, 405-414 (1995).
    • (1995) Cell , vol.82 , pp. 405-414
    • Bose, R.1
  • 36
    • 0035956989 scopus 로고    scopus 로고
    • Organellar relationships in the Golgi region of the pancreatic β-cell line, HIT-T15, visualized by high resolution electron tomography
    • Marsh, B. J., Mastronarde, D. N., Buttle, K. F., Howell, K. E. & McIntosh, J. R. Organellar relationships in the Golgi region of the pancreatic β-cell line, HIT-T15, visualized by high resolution electron tomography. Proc. Natl Acad. Sci. USA 98, 2399-2406 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 2399-2406
    • Marsh, B.J.1    Mastronarde, D.N.2    Buttle, K.F.3    Howell, K.E.4    McIntosh, J.R.5
  • 37
    • 0035907364 scopus 로고    scopus 로고
    • Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase
    • El Bawab, S. et al. Biochemical characterization of the reverse activity of rat brain ceramidase. A CoA-independent and fumonisin B1-insensitive ceramide synthase. J. Biol. Chem. 276, 16758-16766 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 16758-16766
    • El Bawab, S.1
  • 38
    • 0031661695 scopus 로고    scopus 로고
    • Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways
    • Gillard, B. K., Clement, R. G. & Marcus, D. M. Variations among cell lines in the synthesis of sphingolipids in de novo and recycling pathways. Glycobiology 8, 885-890 (1998).
    • (1998) Glycobiology , vol.8 , pp. 885-890
    • Gillard, B.K.1    Clement, R.G.2    Marcus, D.M.3
  • 39
    • 0034659799 scopus 로고    scopus 로고
    • Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae
    • Zanolari, B. et al. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae. EMBO J. 19, 2824-2833 (2000). This is the first evidence of a physiological role for sphingoid base synthesis, other than as a precursor for ceramide or phosphorylated sphingoid base synthesis.
    • (2000) EMBO J. , vol.19 , pp. 2824-2833
    • Zanolari, B.1
  • 40
    • 0030991225 scopus 로고    scopus 로고
    • cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons
    • van Echten-Deckert, G. et al. cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J. Biol. Chem. 272, 15825-15833 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 15825-15833
    • Van Echten-Deckert, G.1
  • 41
    • 0025351642 scopus 로고
    • Intracellular calcium release mediated by sphingosine derivatives generated in cells
    • Ghosh, T. K., Bian, J. & Gill, D. L. Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248, 1653-1656 (1990).
    • (1990) Science , vol.248 , pp. 1653-1656
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 42
    • 0028128763 scopus 로고
    • Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium
    • Ghosh, T. K., Bian, J. & Gill, D. L. Sphingosine 1-phosphate generated in the endoplasmic reticulum membrane activates release of stored calcium. J. Biol. Chem. 269, 22628-22635 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 22628-22635
    • Ghosh, T.K.1    Bian, J.2    Gill, D.L.3
  • 43
    • 0027991078 scopus 로고
    • Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway
    • Mattie, M., Brooker, G. & Spiegel, S. Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway. J. Biol. Chem. 269, 3181-3188 (1994).
    • (1994) J. Biol. Chem. , vol.269 , pp. 3181-3188
    • Mattie, M.1    Brooker, G.2    Spiegel, S.3
  • 44
    • 0029996127 scopus 로고    scopus 로고
    • Calcium mobilization via sphingosine kinase in signalling by the FcεRI antigen receptor
    • Choi, O. H., Kim, J.-H. & Kinet, J.-P. Calcium mobilization via sphingosine kinase in signalling by the FcεRI antigen receptor. Nature 380, 634-636 (1996).
    • (1996) Nature , vol.380 , pp. 634-636
    • Choi, O.H.1    Kim, J.-H.2    Kinet, J.-P.3
  • 45
    • 0032717821 scopus 로고    scopus 로고
    • 2+ signalling by epidermal growth factor receptor
    • 2+ signalling by epidermal growth factor receptor. FEBS Lett. 461, 217-222 (1999).
    • (1999) FEBS Lett. , vol.461 , pp. 217-222
    • Meyer zu Heringdorf, D.1
  • 46
    • 0037052338 scopus 로고    scopus 로고
    • 2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells
    • 2+ signals triggered by different phospholipid pathways in antigen stimulation of human mast cells. J. Biol. Chem. 277, 17255-17262 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 17255-17262
    • Melendez, A.J.1    Khaw, A.K.2
  • 47
    • 0032566780 scopus 로고    scopus 로고
    • Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine
    • Mathes, C., Fleig, A. & Penner, R. Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine. J. Biol. Chem. 273, 25020-25030 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 25020-25030
    • Mathes, C.1    Fleig, A.2    Penner, R.3
  • 48
    • 2642630721 scopus 로고    scopus 로고
    • 2+ signalling by G-protein-coupled receptors
    • 2+ signalling by G-protein-coupled receptors. EMBO J. 17, 2830-2837 (1998).
    • (1998) EMBO J. , vol.17 , pp. 2830-2837
    • Meyer zu Heringdorf, D.1
  • 49
    • 0035957580 scopus 로고    scopus 로고
    • Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors
    • van Koppen, C. J., Meyer zu Heringdorf, D., Alemany, R. & Jakobs, K. H. Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors. Life Sci. 68, 2535-2540 (2001).
    • (2001) Life Sci. , vol.68 , pp. 2535-2540
    • Van Koppen, C.J.1    Meyer zu Heringdorf, D.2    Alemany, R.3    Jakobs, K.H.4
  • 50
    • 0035853760 scopus 로고    scopus 로고
    • Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation
    • Birchwood, C. J., Saba, J. D., Dickson, R. C. & Cunningham, K. W. Calcium influx and signaling in yeast stimulated by intracellular sphingosine 1-phosphate accumulation. J. Biol. Chem. 276, 11712-11718 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 11712-11718
    • Birchwood, C.J.1    Saba, J.D.2    Dickson, R.C.3    Cunningham, K.W.4
  • 51
    • 0035967125 scopus 로고    scopus 로고
    • Drought-induced guard cell signal transduction involves sphingosine-1-phosphate
    • Ng, C. K., Carr, K., McAinsh, M. R., Powell, B. & Hetherington, A. M. Drought-induced guard cell signal transduction involves sphingosine-1-phosphate. Nature 410, 596-599 (2001). This provides the first evidence that S1P is involved in the signal-transduction pathway in plants. It links the perception of the amount of drought hormone abscisic acid to reductions in guard-cell turgor.
    • (2001) Nature , vol.410 , pp. 596-599
    • Ng, C.K.1    Carr, K.2    McAinsh, M.R.3    Powell, B.4    Hetherington, A.M.5
  • 52
    • 20244387438 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate signalling in Arabidopsis guard cells involves heterotrimeric G proteins
    • in the press
    • Coursol, S. et al. Sphingosine-1-phosphate signalling in Arabidopsis guard cells involves heterotrimeric G proteins. Nature (in the press). This study shows that the heterotrimeric G protein in plants is required for S1P signals that mediate ABA regulation of stomatal function.
    • Nature
    • Coursol, S.1
  • 53
    • 0032489574 scopus 로고    scopus 로고
    • Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1
    • 1.
    • (1998) Science , vol.279 , pp. 1552-1555
    • Lee, M.J.1
  • 54
    • 0036266101 scopus 로고    scopus 로고
    • International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    • Chun, J. et al. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54, 265-269 (2002).
    • (2002) Pharmacol. Rev. , vol.54 , pp. 265-269
    • Chun, J.1
  • 55
    • 0033544870 scopus 로고    scopus 로고
    • i-coupled cell surface receptor. Potential involvement in angiogenesis
    • i-coupled cell surface receptor. Potential involvement in angiogenesis. J. Biol. Chem. 274, 35343-35350 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 35343-35350
    • Wang, F.1
  • 56
    • 0033615537 scopus 로고    scopus 로고
    • Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
    • Lee, M. J. et al. Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 99, 301-312 (1999).
    • (1999) Cell , vol.99 , pp. 301-312
    • Lee, M.J.1
  • 57
    • 0033783522 scopus 로고    scopus 로고
    • Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    • 1 is required for vascular maturation.
    • (2000) J. Clin. Invest. , vol.106 , pp. 951-961
    • Liu, Y.1
  • 58
    • 0034799675 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
    • Garcia, J. G. et al. Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J. Clin. Invest. 108, 689-701 (2001).
    • (2001) J. Clin. Invest. , vol.108 , pp. 689-701
    • Garcia, J.G.1
  • 60
    • 0037077308 scopus 로고    scopus 로고
    • The immune modulator, FTY720, targets sphingosine 1-phosphate receptors
    • Brinkmann, V. et al. The immune modulator, FTY720, targets sphingosine 1-phosphate receptors J. Biol. Chem. 277, 21453-21457 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 21453-21457
    • Brinkmann, V.1
  • 61
    • 0037066466 scopus 로고    scopus 로고
    • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
    • Mandala, S. et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 296, 346-349 (2002). References 60 and 61 provide a provocative link between the immunomodulating drug FTY720, S1P receptors and lymphocyte homing.
    • (2002) Science , vol.296 , pp. 346-349
    • Mandala, S.1
  • 62
    • 0037108378 scopus 로고    scopus 로고
    • Cutting edge: Suppression of T cell chemotaxis by sphingosine 1-phosphate
    • Graeler, M., Shankar, G. & Goetzl, E. J. Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate. J. Immunol. 169, 4084-4087 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 4084-4087
    • Graeler, M.1    Shankar, G.2    Goetzl, E.J.3
  • 63
    • 0032568874 scopus 로고    scopus 로고
    • G proteins and small GTPases: Distant relatives keep in touch
    • Hall, A. G proteins and small GTPases: distant relatives keep in touch. Science 280, 2074-2075 (1998).
    • (1998) Science , vol.280 , pp. 2074-2075
    • Hall, A.1
  • 64
    • 0035793866 scopus 로고    scopus 로고
    • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility
    • Hobson, J. P. et al. Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 291, 1800-1803 (2001). This paper proposed a new model for cross-communication between tyrosine kinase receptors and the S1P receptors.
    • (2001) Science , vol.291 , pp. 1800-1803
    • Hobson, J.P.1
  • 65
    • 0034462185 scopus 로고    scopus 로고
    • Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3
    • Okamoto, H. et al. Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol. Cell. Biol. 20, 9247-9261 (2000).
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9247-9261
    • Okamoto, H.1
  • 66
    • 0035976579 scopus 로고    scopus 로고
    • Lysophospholipids - Receptor revelations
    • Hla, T., Lee, M. J., Ancellin, N., Paik, J. H. & Kluk, M. J. Lysophospholipids - receptor revelations Science 294, 1875-1878 (2001).
    • (2001) Science , vol.294 , pp. 1875-1878
    • Hla, T.1    Lee, M.J.2    Ancellin, N.3    Paik, J.H.4    Kluk, M.J.5
  • 67
    • 0037162031 scopus 로고    scopus 로고
    • Lipid mediators of angiogenesis and the signalling pathways they initiate
    • English, D., Brindley, D. N., Spiegel, S. & Garcia, J. G. Lipid mediators of angiogenesis and the signalling pathways they initiate. Biochim. Biophys. Acta 1582, 228-239 (2002).
    • (2002) Biochim. Biophys. Acta , vol.1582 , pp. 228-239
    • English, D.1    Brindley, D.N.2    Spiegel, S.3    Garcia, J.G.4
  • 68
    • 0037067769 scopus 로고    scopus 로고
    • Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3
    • Ishii, I. et al. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3. J. Biol. Chem. 277, 25152-25159 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 25152-25159
    • Ishii, I.1
  • 70
    • 0037044854 scopus 로고    scopus 로고
    • Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS)
    • Tanimoto, T., Jin, Z. G. & Berk, B. C. Transactivation of vascular endothelial growth factor (VEGF) receptor Flk-1/KDR is involved in sphingosine 1-phosphate-stimulated phosphorylation of Akt and endothelial nitric-oxide synthase (eNOS). J. Biol. Chem. 277, 42997-43001 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 42997-43001
    • Tanimoto, T.1    Jin, Z.G.2    Berk, B.C.3
  • 71
    • 0037155905 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase
    • Benaud, C. et al. Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase. J. Biol. Chem. 277, 10539-10546 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 10539-10546
    • Benaud, C.1
  • 72
    • 0037189504 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and Crkll
    • Endo, A. et al. Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and Crkll. J. Biol. Chem. 277, 23747-23754 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 23747-23754
    • Endo, A.1
  • 73
    • 0035965242 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase-β. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways
    • Igarashi, J. & Michel, T. Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase-β. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. J. Biol. Chem. 276, 36281-36288 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 36281-36288
    • Igarashi, J.1    Michel, T.2
  • 74
    • 17944363486 scopus 로고    scopus 로고
    • Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
    • Lee, M. et al. Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol. Cell 8, 693-704 (2001).
    • (2001) Mol. Cell , vol.8 , pp. 693-704
    • Lee, M.1
  • 75
    • 0035196711 scopus 로고    scopus 로고
    • EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration
    • Rosenfeldt, H. M. et al. EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB J. 15, 2649-2659 (2001).
    • (2001) FASEB J. , vol.15 , pp. 2649-2659
    • Rosenfeldt, H.M.1
  • 76
    • 0035206388 scopus 로고    scopus 로고
    • The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility
    • Rosenfeldt, H. M., Hobson, J. P., Milstien, S. & Spiegel, S. The sphingosine-1-phosphate receptor EDG-1 is essential for platelet-derived growth factor-induced cell motility. Biochem. Soc. Trans. 29, 836-839 (2001).
    • (2001) Biochem. Soc. Trans. , vol.29 , pp. 836-839
    • Rosenfeldt, H.M.1    Hobson, J.P.2    Milstien, S.3    Spiegel, S.4
  • 77
    • 0037144434 scopus 로고    scopus 로고
    • PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA)
    • Johnson, K. R., Becker, K. P., Facchinetti, M. M., Hannun, Y. A. & Obeid, L. M. PKC-dependent activation of sphingosine kinase 1 and translocation to the plasma membrane. Extracellular release of sphingosine-1-phosphate induced by phorbol 12-myristate 13-acetate (PMA). J. Biol. Chem. 277, 35257-35262 (2002). This study provided a clue to mechanisms of activation of SphK1 by translocation to plasma membranes.
    • (2002) J. Biol. Chem. , vol.277 , pp. 35257-35262
    • Johnson, K.R.1    Becker, K.P.2    Facchinetti, M.M.3    Hannun, Y.A.4    Obeid, L.M.5
  • 78
    • 0037031922 scopus 로고    scopus 로고
    • Cloning and characterization of a protein kinase A anchoring protein (AKAP)-relatad protein that interacts with and regulates sphingosine kinase 1 activity
    • Lacana, E., Maceyka, M., Milstien, S. & Spiegel, S. Cloning and characterization of a protein kinase A anchoring protein (AKAP)-relatad protein that interacts with and regulates sphingosine kinase 1 activity. J. Biol. Chem. 277, 32947-32953 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 32947-32953
    • Lacana, E.1    Maceyka, M.2    Milstien, S.3    Spiegel, S.4
  • 79
    • 0037031948 scopus 로고    scopus 로고
    • Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein
    • Hayashi, S. et al. Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein. J. Biol. Chem. 277, 33319-33324 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 33319-33324
    • Hayashi, S.1
  • 80
    • 0032584739 scopus 로고    scopus 로고
    • The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode long chain base kinases
    • Nagiec, M. M., Skrzypek, M., Nagiec, E. E., Lester, R. L. & Dickson, R. C. The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode long chain base kinases. J. Biol. Chem. 273, 19437-19442 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 19437-19442
    • Nagiec, M.M.1    Skrzypek, M.2    Nagiec, E.E.3    Lester, R.L.4    Dickson, R.C.5
  • 81
    • 0032508706 scopus 로고    scopus 로고
    • Molecular cloning and functional characterization of murine sphingosine kinase
    • Kohama, T. et al. Molecular cloning and functional characterization of murine sphingosine kinase. J. Biol. Chem. 273, 23722-23728 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 23722-23728
    • Kohama, T.1
  • 82
    • 0032567648 scopus 로고    scopus 로고
    • Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast
    • Zhou, J. & Saba, J. D. Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem. Biophys. Res. Commun. 242, 502-507 (1998).
    • (1998) Biochem. Biophys. Res. Commun. , vol.242 , pp. 502-507
    • Zhou, J.1    Saba, J.D.2
  • 83
    • 0034721549 scopus 로고    scopus 로고
    • Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q 22(1)
    • Van Veldhoven, P. P., Gijsbers, S., Mannaerts, G. P., Vermeesch, J. R. & Brys, V. Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1). Biochim. Biophys. Acta 1487, 128-134 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1487 , Issue.1 , pp. 128-134
    • Van Veldhoven, P.P.1    Gijsbers, S.2    Mannaerts, G.P.3    Vermeesch, J.R.4    Brys, V.5
  • 84
    • 0030910237 scopus 로고    scopus 로고
    • Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids
    • Qie, L., Nagiec, M. M., Baltisbergar, J. A., Lester, R. L. & Dickson, R. C. Identification of a Saccharomyces gene, LCB3, necessary for incorporation of exogenous long chain bases into sphingolipids. J. Biol. Chem. 272, 16110-16117 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 16110-16117
    • Qie, L.1    Nagiec, M.M.2    Baltisbergar, J.A.3    Lester, R.L.4    Dickson, R.C.5
  • 85
    • 0025323167 scopus 로고
    • Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus
    • Futerman, A. H., Stieger, B., Hubbard, A. L. & Pagano, R. E. Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus. J. Biol. Chem. 265, 8650-8657 (1990).
    • (1990) J. Biol. Chem. , vol.265 , pp. 8650-8657
    • Futerman, A.H.1    Stieger, B.2    Hubbard, A.L.3    Pagano, R.E.4
  • 86
    • 0037135536 scopus 로고    scopus 로고
    • De novo sphingolipid biosynthesis: A necessary, but dangerous, pathway
    • Merrill, A. H. Jr. De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway. J. Biol. Chem. 277, 25843-25846 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 25843-25846
    • Merrill A.H., Jr.1
  • 87
    • 0030844101 scopus 로고    scopus 로고
    • Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum
    • Michel, C. & van Echten-Deckert, G. Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett. 416, 153-155 (1997).
    • (1997) FEBS Lett. , vol.416 , pp. 153-155
    • Michel, C.1    Van Echten-Deckert, G.2
  • 88
    • 0034717903 scopus 로고    scopus 로고
    • Sphingolipid transport in eukaryotic cells
    • van Meer, G. & Holthuis, J. C. Sphingolipid transport in eukaryotic cells. Biochim. Biophys. Acta 1486, 145-170 (2000).
    • (2000) Biochim. Biophys. Acta , vol.1486 , pp. 145-170
    • Van Meer, G.1    Holthuis, J.C.2
  • 89
    • 0030448021 scopus 로고    scopus 로고
    • Functions of ceramide in coordinating cellular responses to stress
    • Hannun, Y. Functions of ceramide in coordinating cellular responses to stress. Science 274, 1855-1859 (1996).
    • (1996) Science , vol.274 , pp. 1855-1859
    • Hannun, Y.1
  • 90
    • 85088171975 scopus 로고    scopus 로고
    • Bringing two hearts together
    • Dnever, W. Bringing two hearts together. Nature 406, 141-142 (2000).
    • (2000) Nature , vol.406 , pp. 141-142
    • Dnever, W.1
  • 91
    • 0036773971 scopus 로고    scopus 로고
    • FTY720: Targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and auto immunity
    • Brinkmann, V & Lynch, K. R. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Curr. Opin. Immunol. 14, 569-575 (2002).
    • (2002) Curr. Opin. Immunol. , vol.14 , pp. 569-575
    • Brinkmann, V.1    Lynch, K.R.2


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