Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro

Journal of Neurochemistry

Volumn 80, Issue 4, 2002, Pages 697-705

  Nakajima, Kazuyuki ^a   Tohyama, Yoko ^a   Kohsaka, Shinichi ^a   Kurihara, Tadashi ^a  

^a SOKA UNIVERSITY   (Japan)

Author keywords

Brain derived neurotrophic factor; Ceramide; Lipopolysaccharide; Microglia; Mitogen acivated protein kinase; Protein kinase C

Indexed keywords

BISINDOLYLMALEIMIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; CERAMIDE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; ISOPROTEIN; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROTEIN KINASE C INHIBITOR; SPHINGOSINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; ENZYME INHIBITION; GENE ACTIVATION; IN VITRO STUDY; MEDIATOR RELEASE; MICROGLIA; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELLS, CULTURED; CERAMIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; PLASMINOGEN; PROTEIN KINASE C; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0036321329     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0022-3042.2001.00752.x     Document Type: Article

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