Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: Role of ceramide in apoptosis

Journal of Neuroscience Research

Volumn 55, Issue 4, 1999, Pages 514-522

  Scurlock, Bobbie ^a   Dawson, Glyn ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Apoptosis; Ceramide; Cytokines receptor; Oligodendrocytes; Tumor necrosis factor

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CERAMIDE; CILIARY NEUROTROPHIC FACTOR; CYTOKINE; DIMETHYL SULFOXIDE; DNA FRAGMENT; GAMMA INTERFERON; INTERLEUKIN 1BETA CONVERTING ENZYME; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE C; PROTEINASE; SPHINGOLIPID; SPHINGOMYELIN; SPHINGOMYELIN PHOSPHODIESTERASE; STAUROSPORINE; TUMOR NECROSIS FACTOR; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; LIPID METABOLISM; MULTIPLE SCLEROSIS; NERVE CELL LESION; NERVE CELL NECROSIS; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CASPASE 3; CASPASES; CELLS, CULTURED; CERAMIDES; DNA FRAGMENTATION; ENZYME ACTIVATION; OLIGODENDROGLIA; RATS; SPHINGOMYELINS; STAUROSPORINE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033558337     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19990215)55:4<514::AID-JNR11>3.0.CO;2-V     Document Type: Article

References (45)

1. Arcaro A, Wymann MP. 1993. The fungal alkaloid wortmannin inhibits phosphatidylinositol 3-kinase. Biochem J 296:297-301.
2. Back SA, Gan X, Li Y, Rosenberg PA, Volpe JJ. 1998. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced cell death caused by glutathione depletion. J Neurosci 18:6241-6253.
3. Bondeva T, Pirola L, Bulgarelli-Leva G, Rubio I, Wetzker R, Wymann MP. 1998. Bifurcation of lipid and protein kinase signals of PI3Kγ to the protein kinases PKB and MAPK. Science 282: 293-296.
4. Dawson G, Dawson SA, Goswami R. 1997. Chronic exposure to kappa opioids enhances the susceptibility of immortalized neurons (F-11K7) to apoptosis-inducing drugs by a mechanism that involves ceramide. J Neurochem 68:2363-2370.
5. Gottschalk AR, McShan C, Kilkus J, Dawson G, Quintans J. 1995. Physiological cell death in B-lymphocytes. II Resistance to anti-IgM-induced apoptosis in a WEHI-231 subline is due to deficient generation of the killer lipid ceramide. Eur J Immunol 25:1032-1038.
6. Green D, Kroemer G. 1998. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 8:267-271.
7. Hannun YA. 1994. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 269:3125-3128.
8. Hansen M, Nielsen S, Berg K. 1989. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J Immunol Methods 119:203-210.
9. Jalava A, Akerman K, Heikkila J. 1993. Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH-SY5Y human neuroblastoma cells through an alpha-, beta-, and zeta-protein kinase C-independent pathway. J Cell Physiol 155:301-312.
10. Jarvis W, Kolesnick RN, Fernery FA, Trailer RS, Gewirtz DA, Grant S. 1994. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway. Proc Natl Acad Sci USA 91:73-77.
11. Kendler A, Dawson G. 1990. Progressive hypoxia inhibits the de novo synthesis of galactosylceramide in cultured oligodendrocytes. J Biol Chem 265:12259-12266.
12. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, Hay N. 1997. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 11:701-713.
13. Kolesnick R, Golde D. 1994. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalling. Cell 77:325-328.
14. Kuida K, Zheng T, Na S, Kuan C, Yang D, Karasuyama H, Rakic P, Flavell A. 1996. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice. Nature 384:368-370.
15. Louis JC, Magal E, Takayama S, Varon S. 1993. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science 259:689-692.
16. Mangoura DM, Dawson G. 1998. Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation. J Neurochem 70:130-138.
17. McCarthy K, de Vellis J. 1980. Preparation of separate astroglial and oligodendrogial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902.
18. Nakao J, Shinoda J, Nakai Y, Murase S-I, Uyemura K. 1997. Apoptosis regulates the number of Schwann cells at the premyelinating stage. J Neurochem 68:1853-1862.
19. Olivier ML, Otter I, Poirier GG, Borner C. 1998. Role of an acidic compartment in tumor-necrosis-factor-alpha-induced production of ceramide, activation of caspase-3 and apoptosis. Eur J Biochem 251:295-303.
20. Pastorino JG, Simbula G, Yamamoto K, Glascott PA, Rothman R J, Farber JL. 1996. The cytotoxicity of tumor necrosis factor depends on induction of the mitochondrial permeability transition. J Biol Chem 271:29792-29798.
21. Qi Y, Dawson G. 1993. Effects of hypoxia on oligodendrocyte signal transduction. J Neurochem 61:1097-1104.
22. Qi Y, Dawson G. 1994. Hypoxia specifically and reversibly induces the synthesis of ferritin in oligodendrocytes and human oligodendrogliomas. J Neurochem 63:1485-1490.
23. Quintans J, Kilkus J, McShan JL, Gottschalk AR, Dawson G. 1994. Ceramide mediates the apoptotic response of WEHI cells to anti-immunoglobulin, corticosteroids and irradiation. Biochem Biophys Res Commun 202:710-714.
24. Raff M, Barres B, Burne J, Coles H, Ishizaki Y, Jacobson M. 1993. Programmed cell death and the control of cell survival: Lessons from the nervous system. Science 262:695-700.
25. Schutze S, Potthoff T, Machleidt D, Berkovic K, Wiegmann H, Kronke M. 1992. TNF activates NF-kappa B by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71:765-776.
26. Sillence DJ, Allan D. 1998. Evidence against an early signalling role for ceramide in fas-mediated apoptosis. Biochem J 324:29-32.
27. 2. Biochem J 316:25-28.
28. Soliven B, Szuchet S. 1995. Signal transduction pathways in oligodendrocytes: role of tumor necrosis factor-α. Int J Dev Neurosci 13:351-367.
29. Straub SG, Sharp GWG. 1996. A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide. J Biol Chem 271:1660-1668.
30. Susin SA, Kroemer G. 1997. The central executioner of apoptosis: multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med 186:25-37.
31. Tomiuk S, Hofmann K, Nix M, Zumbansen M, Stoffel W. 1998. Cloned mammalian neutral sphingomyelinase: function in sphingolipid signaling? Proc Natl Acad Sci USA 957: 3638-3643.
32. Van Antwerp DJV, Martin SJ, Verma I, Green DR. 1998. Inhibition of TNF-induced apoptosis by NF-KB. Trends Cell Biol 8:107-110.
33. Verheij M, Bose R, Lin XH, Yao B, Jarvis WD, Grant S, Birrer MJ, Szabo E, Zon LI, Dyriakis J M, Halmovity-Friedman A, Fuks Z, Kolesnick RN. 1996. Requirement for ceramide-initiated SAPK/ JNK signalling in stress-induced apoptosis. Nature 380:75-79.
34. Vemuri, GS, McMorris FA. 1996. Oligodendrocytes and their precursors require phosphatidylinositol 3-kinase signalling for survival. Development 122:2529-2537.
35. Wiesner DA, Dawson G. 1996a. Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway. J Neurochem 66:1418-1425.
36. Wiesner DA, Dawson G. 1996b. Programmed cell death in neurotumor cells involves the generation of ceramide. Glycoconjugate J 13:327-333.
37. xL. J Biol Chem 272:9868-9876.
38. Xiang L, Chao DT, Korsmeyer SJ. 1996. Bax-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci USA 9325:14559-14563.
39. Xu J, Yeh C-H, Chen S, He L, Sensi SL, Canzoniero LMT, Choi D, Hsu CY. 1998. Involvement of de novo ceramide biosynthesis in tumor necrosis factor-α/cyclohexamide-induced cerebral endothelial cell death. J Biol Chem 273:16521-16526.
40. Yanaga F, Watson SP. 1992. Tumor necrosis factor alpha stimulates sphingomyelin through the 55 kDa receptor in HL-60 cells. FEBS Lett 314:297-300.
41. Yao R, Cooper GM. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 2675:2003-2006.
42. 2 interrupts the ceramide-mediated pathway of cell death. Proc Natl Acad Sci USA 93:5325-5328.
43. Zhang P, Andrews T, Bhat NR 1998. TNF-α potentiates INF-γ induced oligodendrocyte cell death. J Neurochem 70(suppl):S9.
44. Zhou H, Summers SA, Birnbaum MJ, Pittman R. 1998. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. J Biol Chem 273:16568-16575.
45. Zundel W, Giaccia A. 1998. Inhibition of the anti-apoptotic PI(3)K/Akt/ Bad pathway by stress. Genes Dev 12:1941-1946.