FK506 prevents stroke-induced generation of ceramide and apoptosis signaling

Brain Research

Volumn 826, Issue 2, 1999, Pages 210-219

  Herr, Ingrid ^a   Martin Villalba, Ana ^b   Kurz, Elke ^a   Roncaioli, Paola ^c   Schenkel, Johannes ^b   Cifone, Maria Grazia ^c   Debatin, Klaus Michael ^a,d  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF L'AQUILA   (Italy)

^d UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

c jun; CD95 L; FADD; Ischemia reperfusion; Necrosis; TNF ; Trail

Indexed keywords

CERAMIDE; TACROLIMUS;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CONCENTRATION RESPONSE; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; LIGAND BINDING; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; REPERFUSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STROKE;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BRAIN CHEMISTRY; CEREBROVASCULAR DISORDERS; ENZYME INHIBITORS; FAS LIGAND PROTEIN; GENE EXPRESSION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; ISCHEMIC ATTACK, TRANSIENT; MALE; MEMBRANE GLYCOPROTEINS; NECROSIS; NEUROBLASTOMA; NEURONS; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPHINGOSINE; TACROLIMUS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 0033135379     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01288-3     Document Type: Article

References (31)

1. Ashkenazi A., Dixit A.M. Death receptors: signaling and modulation. Science. 281:1998;1305-1308.
2. Barinaga M. Stroke-damaged neurons may commit cellular suicide. Science. 281:1998;1302-1303.
3. Bruce A.J., Boling W., Kindy M.S., Peschon J., Kraemer P.J., Carpenter M.K., Holtsberg F.W., Mattson M.P. Altered neuronal and microglia responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat. Med. 2:1996;788-794.
4. Cheng Y., Deshmukh M., Ckosta A.D., Demaro J.A., Gidday J.M., Shah A., Sun Y., Jacquin M.F., Johnson W.M. Jr., Holtzman D.M. Caspase inhibitor affords neuroprotection with delayed administration in a rat model of neonatal hypoxic-ischemic brain injury. J. Clin. Invest. 101:1998;1992-1999.
5. Cifone M.G., Roncaioli P., De Maria R., Camarda G., Santoni A., Ruberti G., Testi R. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine-specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J. 14:1995;5859-5868.
6. Faris M., Kokot N., Latinis K., Kasibhatla S., Green D.R., Koretzky G.A., Nel A. The c-jun N-terminal kinase cascade plays a role in stress-induced apoptosis in Jurkat cells by up-regulating Fas ligand expression. J. Immunol. 160:1998;134-144.
7. Green D., Reed J.C. Mitochondria and apoptosis. Science. 281:1998;1309-1312.
8. Herdegen T., Skene P., Bähr M. The c-jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. TINS. 20:1997;227-231.
9. Herr I., Balemans L., Boehler T., Walczak H., Debatin K.-M. Monitoring of CD95 (APO-1/Fas) ligand expression in human T cells by quantitative RT-PCR. Cell Death Differ. 3:1996;299-305.
10. Herr I., Wilhelm D., Boehler T., Angel P., Debatin K.-M. Activation of CD95 (APO-1/Fas) signaling by ceramide mediates cancer therapy-induced apoptosis. EMBO J. 16:1997;6200-6208.
11. Herr I., Wilhelm D., Boehler T., Angel P., Debatin K.-M. Anticancer therapy-induced activation of JNK/SAPKs and apoptosis mediated by CD95-L, TRAIL and TNF-α Int. J. Cancer. 80:1999;417-424.
12. Hug H., Strand S., Grambihler A., Galle J., Hack V., Galle P.R. Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J. Biol. Chem. 272:1997;28191-28193.
13. Kasibhatla S., Brunner T., Genestier L., Echeverri F., Mahboudi A., Green D.R. DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-κB and AP-1. Mol. Cell. 1:1998;543-551.
14. Kramer B., Wiegmann K., Kronke M. Regulation of the human TNF promoter by the transcription factor Ets. J. Biol. Chem. 270:1995;6577-6583.
15. A. Martin-Villalba, I. Herr, I. Jeremias, M. Hahne, R. Brandt, J. Schenkel, J. Vogel, T. Herdegen, K.-M. Debatin, CD95-Ligand (Fas-Ligand/APO-1L) and TRAIL mediate ischemia-induced apoptosis in neurons, J. Neurosci. (1999), in press.
16. Morgenstern J.P., Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. NAR. 18:1990;3587-3596.
17. Pena L.A., Fuks Z., Kolesnick R. Stress-induced apoptosis and the sphingomyelin pathway. Biochem. Pharmacol. 53:1997;615-621.
18. Rosenbaum D.M., Michaelson M., Batter D.K., Doshi P., Kessler J.A. Evidence for Hypoxia-induced, programmed cell death of cultured neurons. Ann. Neurol. 36:1994;864-870.
19. Saas P., Walker P.R., Hahne M., Quiquerez A.-L., Schnuriger V., Perrin G., French L., van Meir E.G., de Tribolet N., Tschopp J., Dietrich P.-Y. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? J. Clin. Invest. 99:1997;1173-1178.
20. Sawai H., Okazaki T., Yamamoto H., Okano H., Takeda Y., Tashima M., Sawada H., Okuma M., Ishikura H., Umehara H., Domae N. Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem. 270:1995;27326-27331.
21. Sharkey J., Butcher S. Immunophilins mediate the neuroprotective effects of FK506 in focal cerebral ischaemia. Nature. 371:1994;336-339.
22. Sheridan J.P., Marsters S.A., Pitti R.M., Gurney A., Skubatch M., Baldwin D., Ramakrishnan L., Gray C.L., Baker K., Wood W.I., Godard A.D., Godowski P., Ashkenazi A. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science. 277:1997;818-820.
23. Steller H. Mechanisms and genes of cellular suicide. Science. 267:1995;1445-1449.
24. Testi R. Sphingomyelin breakdown and cell fate. TIBS. 21:1996;468-471.
25. Thornberry N.A., Yuri L. Caspases: enemies within. Science. 281:1998;1312-1316.
26. Verheij M., Bose R., Hua Lin X., Yao B., Jarvis W.D., Grant S., Birrer M.J., Szabo E., Zon L.I., Kyriakis J.M., Haimovitz-Friedman A., Fuks Z., Kolesnick R.N. Requirement for ceramide initiated JNK/SAPK signalling in stress-induced apoptosis. Nature. 380:1996;75-79.
27. Vogt M., Bauer M.K.A., Ferrari D., Schulze-Osthoff K. Oxidative stress and hypoxia/reoxygenation trigger CD95 (APO-1/Fas) ligand expression in microglial cells. FEBS Lett. 429:1998;67-72.
28. Yoshimura S.-I., Banno Y., Nakashima S., Takenaka K., Sakai H., Nishimura Y., Sakai N., Shimizu S., Eguchi Y., Tsujimoto Y., Nozawa Y. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. J. Biol. Chem. 273:1998;6921-6927.
29. Zagariya A., Mungre S., Lovis R., Birrer M., Ness S., Thimmapaya B., Pope R. Tumor necrosis factor alpha gene regulation: enhancement of C/EBP-induced activation by c-jun. Mol. Cell. Biol. 18:1998;2815-2824.
30. Zea Longa E., Weinstein P.R., Carlson S., Cummis R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:1989;84-89.
31. Zwacka R.M., Zhou W., Zhang Y., Darby C.J., Dudus L., Halldorson J., Oberley L., Engelhardt J.F. Redox gene therapy for ischemia/reperfusion injury of the liver reduces AP1 and NF-κB activation. Nat. Med. 4:1998;698-704.