메뉴 건너뛰기




Volumn 66, Issue 2, 1996, Pages 869-872

Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid β-peptide toxicity

Author keywords

Alzheimer's disease; Ceramide; Confocal laser scanning microscope imaging; Glutamate excitotoxicity; Lipid peroxidation; Neuron death; NF B; Reactive oxygen species; Transcription factor

Indexed keywords

AMYLOID BETA PROTEIN; CERAMIDE; REACTIVE OXYGEN METABOLITE;

EID: 0030026613     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66020869.x     Document Type: Article
Times cited : (216)

References (27)
  • 1
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and degenerative diseases of aging
    • Ames B. N., Shigenaga M. K., and Hagen T. M. (1993) Oxidants, antioxidants, and degenerative diseases of aging. Proc. Natl. Acad. Sci. USA 90, 7915-7922.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 3
    • 0028233494 scopus 로고
    • Hydrogen peroxide mediates amyloid β protein toxicity
    • Behl C., Davis J. B., Lesley R., and Schubert D. (1994) Hydrogen peroxide mediates amyloid β protein toxicity. Cell 77, 817-827.
    • (1994) Cell , vol.77 , pp. 817-827
    • Behl, C.1    Davis, J.B.2    Lesley, R.3    Schubert, D.4
  • 4
    • 0028178798 scopus 로고
    • Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis
    • Cheng B., Christakos S., and Mattson M. P. (1994) Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis Neuron 12, 139-153.
    • (1994) Neuron , vol.12 , pp. 139-153
    • Cheng, B.1    Christakos, S.2    Mattson, M.P.3
  • 5
    • 0024093449 scopus 로고
    • Glutamate neurotoxicity and diseases of the nervous system
    • Choi D. W. (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1, 623-634.
    • (1988) Neuron , vol.1 , pp. 623-634
    • Choi, D.W.1
  • 6
    • 0027327212 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B
    • Dbaibo G. S., Obeid L. M., and Hannun Y. A. (1993) Tumor necrosis factor-alpha (TNF-alpha) signal transduction through ceramide. Dissociation of growth inhibitory effects of TNF-alpha from activation of nuclear factor-kappa B. J. Biol. Chem. 268, 17762-17766.
    • (1993) J. Biol. Chem. , vol.268 , pp. 17762-17766
    • Dbaibo, G.S.1    Obeid, L.M.2    Hannun, Y.A.3
  • 7
    • 0028108788 scopus 로고
    • Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor
    • Dobrowsky R. T , Werner M. H., Castellino A. M., Chao M. V., and Hannun Y. A. (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265, 1596-1599.
    • (1994) Science , vol.265 , pp. 1596-1599
    • Dobrowsky, R.T.1    Werner, M.H.2    Castellino, A.M.3    Chao, M.V.4    Hannun, Y.A.5
  • 8
    • 0028169905 scopus 로고
    • Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury
    • Goodman Y. and Mattson M. P. (1994) Secreted forms of β-amyloid precursor protein protect hippocampal neurons against amyloid β-peptide-induced oxidative injury Exp. Neurol. 128, 1-12.
    • (1994) Exp. Neurol. , vol.128 , pp. 1-12
    • Goodman, Y.1    Mattson, M.P.2
  • 9
    • 0028893492 scopus 로고
    • Superoxide dismutase delays neuronal apoptosis: A role for reactive oxygen species in programmed neuronal death
    • Greenlund L. J. S., Deckwerth T. L., and Johnson E. M. Jr. (1995) Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 14, 303-315.
    • (1995) Neuron , vol.14 , pp. 303-315
    • Greenlund, L.J.S.1    Deckwerth, T.L.2    Johnson Jr., E.M.3
  • 10
    • 0026801151 scopus 로고
    • Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes
    • Heck D. E., Laskin D. L., Gardner C. R., and Laskin J. D. (1992) Epidermal growth factor suppresses nitric oxide and hydrogen peroxide production by keratinocytes. J. Biol. Chem. 267, 21277-21280.
    • (1992) J. Biol. Chem. , vol.267 , pp. 21277-21280
    • Heck, D.E.1    Laskin, D.L.2    Gardner, C.R.3    Laskin, J.D.4
  • 11
    • 0029049833 scopus 로고
    • Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation
    • Ito I. and Horigome K. (1995) Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation. J. Neurochem. 65, 463-466.
    • (1995) J. Neurochem. , vol.65 , pp. 463-466
    • Ito, I.1    Horigome, K.2
  • 12
    • 0028348885 scopus 로고
    • Hyperthermic injury of oligodendrocyte precursor cells: Implications for dysmyelination dis-orders
    • Juurlink B. H. J. and Husain J. (1994) Hyperthermic injury of oligodendrocyte precursor cells: implications for dysmyelination dis-orders. Brain Res. 641, 353-356.
    • (1994) Brain Res. , vol.641 , pp. 353-356
    • Juurlink, B.H.J.1    Husain, J.2
  • 13
    • 0028352908 scopus 로고
    • Signal transduction through the sphingomyelin pathway
    • Kolesnick R. (1994) Signal transduction through the sphingomyelin pathway. Mol. Chem. Neuropathol. 21, 287-297.
    • (1994) Mol. Chem. Neuropathol. , vol.21 , pp. 287-297
    • Kolesnick, R.1
  • 14
    • 0027221998 scopus 로고
    • NMDA-dependent superoxide production and neurotoxicity
    • Lafon-Cazal M., Pietri S., Culcasi M., and Bockaert J. (1993) NMDA-dependent superoxide production and neurotoxicity. Nature 364, 535-537.
    • (1993) Nature , vol.364 , pp. 535-537
    • Lafon-Cazal, M.1    Pietri, S.2    Culcasi, M.3    Bockaert, J.4
  • 17
    • 0028650421 scopus 로고
    • β-Amyloid precursor protein metabolites, metabolic compromise, and loss of neuronal calcium homeostasis in Alzheimer's disease
    • Mattson M. P. (1994) β-Amyloid precursor protein metabolites, metabolic compromise, and loss of neuronal calcium homeostasis in Alzheimer's disease. Ann. NY Acad. Sci. 747, 50-76.
    • (1994) Ann. NY Acad. Sci. , vol.747 , pp. 50-76
    • Mattson, M.P.1
  • 18
    • 0028916920 scopus 로고
    • Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium
    • Mattson M. P. and Goodman Y. (1995) Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium. Brain Res. 676, 219-224.
    • (1995) Brain Res. , vol.676 , pp. 219-224
    • Mattson, M.P.1    Goodman, Y.2
  • 19
    • 0029150526 scopus 로고
    • 2+ concentration, and neurotoxicity, and increase antioxidant enzyme activities in hippocampal neurons
    • 2+ concentration, and neurotoxicity, and increase antioxidant enzyme activities in hippocampal neurons. J. Neurochem. 65, 1740-1751.
    • (1995) J. Neurochem. , vol.65 , pp. 1740-1751
    • Mattson, M.P.1    Lovell, M.A.2    Furukawa, K.3    Markesbery, W.R.4
  • 20
    • 0029175202 scopus 로고
    • Calcium, free radicals, and excitotoxic neuronal death in pri-mary cell culture
    • Mattson M. P., Barger S. W., Begley J. G., and Mark R. J. (1995b) Calcium, free radicals, and excitotoxic neuronal death in pri-mary cell culture. Methods Cell Biol. 46, 187-216.
    • (1995) Methods Cell Biol. , vol.46 , pp. 187-216
    • Mattson, M.P.1    Barger, S.W.2    Begley, J.G.3    Mark, R.J.4
  • 22
    • 0027424797 scopus 로고
    • Role of nerve growth factor in oxidant homeostasis: Glutathione metabolism
    • Pan Z. and Perez-Polo R. (1993) Role of nerve growth factor in oxidant homeostasis: glutathione metabolism. J. Neurochem. 61, 1713-1721.
    • (1993) J. Neurochem. , vol.61 , pp. 1713-1721
    • Pan, Z.1    Perez-Polo, R.2
  • 23
    • 0026642042 scopus 로고
    • Tumor necrosis factor-alpha activates nuclear factor kappa B and induces manganous superoxide dismutase and phosphodiesterase mRNA in human papillary carcinoma cells
    • Pang X. P., Ross N. S., Park M., Juillard G. J., Stanley T. M., and Herschman J. M. (1992) Tumor necrosis factor-alpha activates nuclear factor kappa B and induces manganous superoxide dismutase and phosphodiesterase mRNA in human papillary carcinoma cells. J. Biol. Chem. 267, 12826-12830.
    • (1992) J. Biol. Chem. , vol.267 , pp. 12826-12830
    • Pang, X.P.1    Ross, N.S.2    Park, M.3    Juillard, G.J.4    Stanley, T.M.5    Herschman, J.M.6
  • 24
    • 0026970404 scopus 로고
    • Nuclear factor kappa B: An oxidative stress-responsive transcription factor of eukaryotic cells
    • Schreck R., Albermann K., and Baeuerle P. A. (1992) Nuclear factor kappa B: an oxidative stress-responsive transcription factor of eukaryotic cells. Free Radic. Res. Commun. 17, 221-237.
    • (1992) Free Radic. Res. Commun. , vol.17 , pp. 221-237
    • Schreck, R.1    Albermann, K.2    Baeuerle, P.A.3
  • 25
    • 0027367764 scopus 로고
    • Physiological production of the β-amyloid protein and the mechanisms of Alzheimer's disease
    • Selkoe D. J. (1993) Physiological production of the β-amyloid protein and the mechanisms of Alzheimer's disease. Trends Neurosci. 16, 403-409.
    • (1993) Trends Neurosci. , vol.16 , pp. 403-409
    • Selkoe, D.J.1
  • 26
    • 0024433864 scopus 로고
    • Ischemic injury in the brain. Role of oxygen radical-mediated processes
    • Watson B. D. and Ginsberg M. D. (1989) Ischemic injury in the brain. Role of oxygen radical-mediated processes. Ann. NY Acad. Sci. 559, 269-281.
    • (1989) Ann. NY Acad. Sci. , vol.559 , pp. 269-281
    • Watson, B.D.1    Ginsberg, M.D.2
  • 27
    • 0027232517 scopus 로고
    • Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration
    • Zhang Y., Tatsuno T., Carney J. M., and Mattson M. P. (1993) Basic FGF, NGF, and IGFs protect hippocampal and cortical neurons against iron-induced degeneration. J. Cereb. Blood Flow Metab. 13, 378-388.
    • (1993) J. Cereb. Blood Flow Metab. , vol.13 , pp. 378-388
    • Zhang, Y.1    Tatsuno, T.2    Carney, J.M.3    Mattson, M.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.