Mechanism of extracellular signal-regulated kinase activation by the CB1 cannabinoid receptor

Molecular Pharmacology

Volumn 62, Issue 6, 2002, Pages 1385-1392

  Galve Roperh, Ismael ^a   Rueda, Daniel ^a   Del Pulgar, Teresa Gómez ^a   Velasco, Guillermo ^a   Guzmán, Manuel ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABIS; CERAMIDE; DEXANABINOL; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAF PROTEIN; WORTMANNIN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSACTIVATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; APOPTOSIS; ASTROCYTOMA; CELL SURVIVAL; CERAMIDES; ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SRC-FAMILY KINASES; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED;

EID: 0036893729     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.6.1385     Document Type: Article

References (40)

1. Agbotounou WK, Levitzky A, Jacquemin-Sablon A, and Pierre J (1994) Effects of tyrphostins on the activated c-src protein in NIH/3T3 cells. Mol Pharmacol 45: 922-931.
2. Alessandrini A, Namura S, Moskowitz MA, and Bonventre JV (1999) MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc Natl Acad Sci USA 96:12866-12869.
3. Bouaboula M, Perrachon S, Milligan L, Canat X, Rinaldi-Carmona M, Portier M, Barth F, Calandra B, Pecceu F, Lupker J, et al. (1997) A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J Biol Chem 272:22330-2233
4. Bouaboula M, Poinot Chazel C, Bourrie B, Canat X, Calandra B, Rinaldi-Carmona M, Le Fur G, and Casellas P (1995) Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem J 312:637-641. 9.
5. Brazil DP and Hemmings B (2001) Ten years of protein kinase B signaling: A hard Akt to follow. Trends Biochem Sci 26:657-664.
6. Chaudhary A, King WG, Mattaliano MD, Frost JA, Dia B, Morrison DK, Cobb MH, Marshall MS, and Brugge JS (2000) Phosphatidylinositol 3-kinase regulates Rafl through Pak phosphorylation of serine 338. Curr Biol 10:551-554.
7. Davies SP, Reddy H, Caivano M, and Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105.
8. Derkinderen P, Toutant M, Burgaya F, Le Bert M, Siciliano JC, de Franciscis V, Gelman M, and Girault J (1996) Regulation of a neuronal form of focal adhesion kinase by anandamide. Science (Wash DC) 273:1719-1723.
9. +6, 7 by cannabinoids in hippocampus. J Biol Chem 276:38289-38296.
10. Fanton CP, McMahon M, and Pieper RO (2001) Dual growth arrest pathways in astrocytes and astrocytic tumors in response to Raf-1 activation. J Biol Chem 276:18871-18877.
11. Galve-Roperh I, Sánchez C, Cortés ML, Gómez del Pulgar T, Izquierdo M, and Guzmán M (2000) Antitumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med 6:313-319.
12. 1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt. Biochem J 347:369-373.
13. Gómez del Pulgar T, Velasco G, Sánchez C, Haro A, and Guzmán M (2002) De novo-synthesized ceramide is involved in cannabinoid-induced apoptosis. Biochem J 363:183-188.
14. Grewal SS, York RD, and Stork PJS (1999) Extracellular-signal regulated kinase signalling in neurons. Curr Opin Neurobiol 9:544-553.
15. Gschwind A, Zwick E, Prenzel N, Leserer M, and Ullrich A (2001) Cell communication networks: Epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission. Oncogene 20:1594-600.
16. Guzmán M, Galve-Roperh I, and Sánchez C (2001a) Ceramide, a new second messenger of cannabinoid action. Trends Pharmacol Sci 22:9-22.
17. Guzmán M, Sánchez C, and Galve-Roperh I (2001b) Control of the cell survival/death decision by cannabinoids. J Mol Med 78:613-625.
18. Howlett AC (1995) Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35:607-634.
19. King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, and Marshall MS (1998) The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature (Lond) 396:180-183.
20. Kolch W (2000) Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351:289-305.
21. Levitzki A (1999) Protein tyrosine kinase inhibitors as novel therapeutic agents. Pharmacol Ther 82:231-239.
22. 1 cannabinoid receptors in human vascular endothelial cells. Biochem J 346:835-840.
23. Lopez-Ilasaca M, Crespo P, Pellici PG, Gutkind JS, and Wetzker R (1997) Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science (Wash DC) 275:394-397.
24. Marinissen MJ and Gutkind JS (2001) G-protein-coupled receptors and signaling networks: Emerging paradigms. Trends Pharmacol Sci 22:368-376.
25. Martin GS (2001) The hunting of the Src. Nat Rev Mol Cell Biol 2:467-473.
26. Matsuda LA, Lolait SJ, Brownstein M, Young A, and Bonner TI (1990) Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature (Lond) 346:561-564.
27. Munro S, Thomas KL, and Abu Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Lond) 365:61-65.
28. Nowak F, Jacquemin-Sablon A, and Pierre J (1997) Epidermal growth factor receptor signalling cascade as target for thyrphostin (RG50864) in epithelial cells. Biochem Pharmacol 53:287-298.
29. Piomelli D, Giuffrida A, Calignano A, and Rodríguez de Fonseca F (2000) The endocannabinoid system as a target for therapeutic drugs. Trends Pharmacol Sci 21:218-224.
30. Pierce KL, Luttrell LM, and Lefkowitz RJ (2001) New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades. Oncogene 20: 1532-1539.
31. Porter AC and Felder CC (2001) The endocannabinoid nervous system: Unique opportunities for therapeutic intervention. Pharmacol Ther 90:45-60.
32. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, and Ullrich A (1999) EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature (Lond) 402:884-888.
33. Redemann N, Holzmann B, von Ruden T, Wagner EF, Schlessinger J, and Ullrich A (1992) Anti-oncogenic activity of signalling-defective epidermal growth factor receptor mutants. Mol Cell Biol 12:491-498.
34. Roche JP, Bounds S, Brown S, and Mackie K (1999) A mutation in the second transmembrane region of the CB1 receptor selectively disrupts G protein signaling and prevents receptor internalization. Mol Pharmacol 56:611-618.
35. 1 cannabinoid receptor is coupled to the action of c-Jun N-terminal kinase. Mol Pharmacol 58:814-820.
36. Sánchez C, Galve-Roperh I, Rueda D, and Guzmán M (1998) Involvement of sphingomyelin hydrolysis and the mitogen-activated protein kinase cascade in the Δ9-tetrahydrocannabinol-induced stimulation of glucose metabolism in primary astrocytes. Mol Pharmacol 54:834-843.
37. 1 cannabinoid receptor of astrocytes is coupled to sphingomyelin hydrolisis through the adaptor protein Fan. Mol Pharmacol 59:955-959.
38. Susa M, Missbach M, and Green J (2000) Src inhibitors: Drugs for the treatment of osteoporosis, cancer or both? Trends Pharmacol Sci 21:489-495.
39. Wang H, Ubl JJ, Stricker R, and Reisser G (2002) Thrombin (PAR-1)-induced proliferation in astrocytes via MAP kinase involves multiple signalling pathways. Am J Physiol Cell Physiol 10.1152/ajpcell. 00001.2002.
40. Zang M, Waelde CA, Xiang X, Rana A, Wen R, and Luo Z (2001) Microtubule integrity regulates Pak leading to Ras-independent activation of Raf-1. J Biol Chem 276:25157-25165.