An early increase in the disialoganglioside GD3 contributes to the development of neuronal apoptosis in culture

Cell Death and Differentiation

Volumn 9, Issue 6, 2002, Pages 609-615

  Melchiorri, D ^a   Martini, F ^a   Lococo, E ^a   Gradini, R ^a   Barletta, E ^a   De Maria, R ^a   Caricasole, A ^a   Nicoletti, F ^a   Lenti, L ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Apoptosis; Cerebellar granule neurons; GD3; Neuronal cultures

Indexed keywords

GANGLIOSIDE GD 1A; GANGLIOSIDE GD3; MONOSIALOGANGLIOSIDE; POTASSIUM; STAUROSPORINE; SYNTHETASE; GANGLIOSIDE; GANGLIOSIDE, GD3;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CELL GROWTH; CELL INCLUSION; CELL LEVEL; CELL NUCLEUS; CELLULAR DISTRIBUTION; CEREBELLUM; CONTROLLED STUDY; CULTURE MEDIUM; EXTRACELLULAR SPACE; GRANULE CELL; IMMUNOFLUORESCENCE TEST; LIPOGENESIS; NERVE CELL CULTURE; NEURITE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; FLUORESCENT ANTIBODY TECHNIQUE; NERVE CELL; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANIMALS; APOPTOSIS; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIOSIDES; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 85047681952     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401020     Document Type: Article

References (43)

1. Apoptosis in Alzheimer's disease
2. Programmed cell death in cerebral ischemia
3. Does apoptosis have a role in neurodegeneration?
4. Requirement for GD3 gaglioside in CD95- and ceramide-induced apoptosis
5. Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis in lymphoid cells
6. GD3 ganglioside directly targets mitochondria in a bcl-2-controlled fashion
7. Lipid signaling in CD95-mediated apoptosis
8. Apoptogenic GD3 directly induces the mitochondrial permeability transition
9. Commitment to apoptosis by GD3 ganglioside depends on opening of the mitochondrial permeability transition pore
10. Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway
11. The role of depolarization in the survival and differentiation of cerebellar granule cells in culture
12. N-Methyl-D-aspartate receptor promotes the survival of cerebellar granule cells in culture
13. Induction of apoptosis in cerebellar granule cells by low potassium: Inhibition of death by insulin-like growth factor-I and cAMP
14. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: Possible involvement of PI-3-kinase in IGF-I signalling
15. Activation of metabotropic glutamate receptors prevents neuronal apoptosis in culture
16. An enhanced expression of the immediate early gene, Egr-1, is associated with neuronal apoptosis in culture
17. Serum and depolarising agents cause acute neurotoxicity in cultured cerebellar granule cells: Role of glutamate receptors responsive to N-methyl-D-aspartate
18. Gangliosides in human fetal brain
19. Glycosphingolipid glycosyltransferases in human fetal brain
20. A reappraisal of ganglioside GD3 expression in the CNS
21. Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides
22. Regional distribution of brain gangliosides in Alzheimer's disease
23. Alterations in brain gangliosides and other lipids of patients with Creutzfeld-Jakob disease and subacute sclerosing panencephalitis (SSPE)
24. GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation
25. Down regulation of GD3 ganglioside and its O-acetylated derivative by stable transfection with antisense vector against GD3-synthase gene expression in hamster melanoma cells: Effects on cellular growth, melanogenesis, and dendricity
26. New evidence for the occurrence of a glycolipid-mediated signal transduction system
27. Ganglioside GD3 in radial glia and astrocytes in situ in brain of young and adult mice
28. Immunocytochemical analysis of gangliosides in rat primary cerebellar cultures using specific monoclonal antibodies
29. The semisynthetic ganglioside LIGA20 potently protects neurons against apoptosis
30. Gangliosides attenuate ethanol-induced apoptosis in rat cerebellar granule neurons
31. Attenuation of cortical neuronal apoptosis by gangliosides
32. Characterization of ceramide-induced apoptotic death in cerebellar granule cells in culture
33. Ceramide induces apoptosis to immature cerebellar granule cells in culture
34. Partial lithium-associated protection against apoptosis induced by C2-ceramide in cerebellar granule neurons
35. Upregulation of death pathway molecules in rat cerebellar granule neurons undergoing apoptosis
36. Withdrawal of survival factors results in the activation of the JNK pathway in neuronal cells leading to fas ligand induction and cell death
37. Cascade of caspase activation in potassium-deprived cerebellar ranule neurons: Targets for treatment with peptide and protein inhibitors of apoptosis
38. The activation of inositol phospholipid hydrolysis as a signal transducing system for excitatory amino acids in primary cultures of cerebellar granule cells
39. A new method for the cytofluorimetric analysis of mitochindrial membrane potential using the J-aggregate forming lipophilic cation 5,5′,6,6′-tetrachloro-1 -1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide (JC-1)
40. A procedure for the quantitative isolation of brain gangliosides
41. The GM2-1 ganglioside islet autoantigen in insulin-dependent diabetes mellitus is expressed in secretory granules and is not β-cell specific
42. Purification of mouse immunoglobulin heavy chain messenger RNAs from total myeloma tumor RNA
43. Expression of TGF-beta and their receptors during implantation and organogenesis of the mouse embryo