Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 2, 2003, Pages 229-236

  Yokomatsu, Tsutomu ^a   Murano, Tetsuo ^a   Akiyama, Takeshi ^a   Koizumi, Junichi ^a   Shibuya, Shiroshi ^a   Tsuji, Yoshiaki ^b   Soeda, Shinji ^b   Shimeno, Hiroshi ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b FUKUOKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

N PALMITOYLSPHINGOSINE 1 PHOSPHATE; SCHYPHOSTATIN; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELIN PHOSPHODIESTERASE INHIBITOR; SPHINGOSINE DERIVATIVE; UNCLASSIFIED DRUG; CERAMIDE; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS; ENZYME INHIBITOR; PHOSPHOLIPID;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROLYSIS; NONHUMAN; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; BACILLUS; BINDING COMPETITION; CONFORMATION; DOG; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; IN VITRO STUDY; KINETICS; MICROSOME; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SYNTHESIS;

ANIMALS; BACILLUS; BINDING, COMPETITIVE; CERAMIDES; DOGS; ENZYME INHIBITORS; INDICATORS AND REAGENTS; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICROSOMES; MOLECULAR CONFORMATION; PHOSPHOLIPIDS; SPHINGOMYELIN PHOSPHODIESTERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037212776     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00888-0     Document Type: Article

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