Mice Expressing Only Monosialoganglioside GM3 Exhibit Lethal Audiogenic Seizures

Journal of Biological Chemistry

Volumn 276, Issue 10, 2001, Pages 6885-6888

  Kawai, Hiromichi ^a,d   Allende, Maria Laura ^a   Wada, Ryuichi ^a,e   Kono, Mari ^a   Sango, Kazunori ^a,f   Deng, Chuxia ^a   Miyakawa, Tsuyoshi ^b,g   Crawley, Jacqueline N ^b   Werth, Norbert ^c   Bierfreund, Uwe ^c,h   Sandhoff, Konrad ^c   Proia, Richard L ^a,i  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c UNIVERSITY OF BONN   (Germany)

^d SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

^e HIROSAKI UNIVERSITY   (Japan)

^f TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^g VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h BIACORE AB   (Sweden)

ⁱ NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CELL MEMBRANES; ENZYMES; GENES; NEUROLOGY;

LETHAL SEIZURES;

BIOCHEMISTRY;

BETA 1,4 N ACETYLGALACTOSAMINYLTRANSFERASE; GANGLIOSIDE GD3 SYNTHASE; GANGLIOSIDE GM3; GLYCOSPHINGOLIPID; MONOSIALOGANGLIOSIDE; MYELIN ASSOCIATED GLYCOPROTEIN; N ACETYLGALACTOSAMINYLTRANSFERASE; SIALIC ACID; SIALYLTRANSFERASE; UNCLASSIFIED DRUG; (N ACETYLNEURAMINYL) GALACTOSYLGLUCOSYLCERAMIDE N ACETYLGALACTOSAMINYLTRANSFERASE; (N-ACETYLNEURAMINYL)-GALACTOSYLGLUCOSYLCERAMIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; ALPHA N ACETYLNEURAMINATE ALPHA 2,8 SIALYLTRANSFERASE; ALPHA-N-ACETYLNEURAMINATE ALPHA-2,8-SIALYLTRANSFERASE; GANGLIOSIDE; GLYCOSYLTRANSFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; AUDITORY STIMULATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE DISRUPTION; HISTOPATHOLOGY; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SUDDEN DEATH; AGE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CROSS BREEDING; GENE LIBRARY; GENETICS; METABOLISM; MOUSE MUTANT; MUTATION; PHYSIOLOGY; SEIZURE;

ANIMALIA;

AGE FACTORS; ANIMALS; CENTRAL NERVOUS SYSTEM; CROSSES, GENETIC; G(M3) GANGLIOSIDE; GANGLIOSIDES; GENE LIBRARY; GLYCOSYLTRANSFERASES; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MODELS, GENETIC; MUTATION; N-ACETYLGALACTOSAMINYLTRANSFERASES; PHENOTYPE; SEIZURES; SIALYLTRANSFERASES;

EID: 0035831502     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.C000847200     Document Type: Article

References (33)

1. Huwiler, A., Kolter, T., Pfeilschifter, J., and Sandhoff, K. (2000) Biochim. Biophys. Acta 1485, 63-99
2. Svennerholm, L. (1994) Prog. Brain Res. 101, x-xiv
3. Yu, R. K. (1994) Prog. Brain Res. 101, 31-44
4. Ledeen, R. W., Wu, G., Lu, Z. H., Kozireski-Chuback, D., and Fang, Y. (1998) Ann. N. Y. Acad. Sci. 845, 161-175
5. Walkley, S. U., Zervas, M., and Wiseman, S. (2000) Cereb. Cortex 10, 1028-1037
6. Futerman, A. H. (1998) Acta Biochim. Pol. 45, 469-478
7. Sango, K., Johnson, O. N., Kozak, C. A., and Proia, R. L. (1995) Genomics 27, 362-365
8. Liu, Y., Wada, R., Kawai, H., Sango, K., Deng, C., Tai, T., McDonald, M. P., Araujo, K., Crawley, J. N., Bierfreund, U., Sandhoff, K., Suzuki, K., and Proia, R. L. (1999) J. Clin. Invest. 103, 497-505
9. Takamiya, K., Yamamoto, A., Furukawa, K., Yamashiro, S., Shin, M., Okada, M., Fukumoto, S., Haraguchi, M., Takeda, N., Fujimura, K., Sakae, M., Kishikawa, M., Shiku, H., Furukawa, K., and Aizawa, S. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10662-10667
10. Sheikh, K. A., Sun, J., Liu, Y., Kawai, H., Crawford, T. O., Proia, R. L., Griffin, J. W., and Schnaar, R. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 7532-7537
11. Chiavegatto, S., Sun, J., Nelson, R. J., and Schnaar, R. L. (2000) Exp. Neurol. 166, 227-234
12. Matsuda, Y., Nara, K., Watanabe, Y., Saito, T., and Sanai, Y. (1996) Genomics 32, 137-139
13. Takashima, S., Kono, M., Kurosawa, N., Yoshida, Y., Tachida, Y., Inoue, M., Kanematsu, T., and Tsuji, S. (2000) J. Biochem. (Tokyo) 128, 1033-1043
14. Nehls, M., Kyewski, B., Messerle, M., Waldschutz, R., Schuddekopf, K., Smith, A. J., and Boehm, T. (1996) Science 272, 886-889
15. Yamashita, T., Wada, R., Sasaki, T., Deng, C., Bierfreund, U., Sandhoff, K., and Proia, R. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 9142-9147
16. Kawai, H., Sango, K., Mullin, K. A., and Proia, R. L. (1998) J. Biol. Chem. 273, 19634-19638
17. Kono, M., Takashima, S., Liu, H., Inoue, M., Kojima, N., Lee, Y. C., Hamamoto, T., and Tsuji, S. (1998) Biochem. Biophys. Res. Commun. 253, 170-175
18. Sango, K., McDonald, M. P., Crawley, J. N., Mack, M. L., Tifft, C. J., Skop, E., Starr, C. M., Hoffmann, A., Sandhoff, K., Suzuki, K., and Proia, R. L. (1996) Nat. Genet. 14, 348-352
19. Yao, J. K., and Rastetter, G. M. (1985) Anal. Biochem. 150, 111-116
20. Svennerholm, L. (1957) Biochim. Biophys. Acta 24, 604-611
21. Miettinen, T., and Takki-Luukkainen, I. T. (1959) Acta Chem. Scand. 13, 856-858
22. Datta, A. K., Sinha, A., and Paulson, J. C. (1998) J. Biol. Chem. 273, 9608-9614
23. De Maria, R., Lenti, L., Malisan, F., d'Agostino, F., Tomassini, B., Zeuner, A., Rippo, M. R., and Testi, R. (1997) Science 277, 1652-1655
24. Iber, H., Zacharias, C., and Sandhoff, K. (1992) Glycobiology 2, 137-142
25. Schnaar, R. L., Collins, B. E., Wright, L. P., Kiso, M., Tropak, M. B., Roder, J. C., and Crocker, P. R. (1998) Ann. N. Y. Acad. Sci. 845, 92-105
26. Takamiya, K., Yamamoto, A., Furukawa, K., Zhao, J., Fukumoto, S., Yamashiro, S., Okada, M., Haraguchi, M., Shin, M., Kishikawa, M., Shiku, H., and Aizawa, S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12147-12152
27. Seyfried, T. N., Todorova, M. T., and Poderycki, M. J. (1999) Adv. Neurol. 79, 279-290
28. Puranam, R. S., and McNamara, J. O. (1999) Curr. Opin. Neurobiol. 9, 281-287
29. Hakomori, S. (1990) J. Biol. Chem. 265, 18713-18716
30. Hakomori, S., Handa, K., Iwabuchi, K., Yamamura, S., and Prinetti, A. (1998) Glycobiology 8, xi-xix
31. Kasahara, K., Watanabe, Y., Yamamoto, T., and Sanai, Y. (1997) J. Biol. Chem. 272, 29947-29953
32. Kasahara, K., Watanabe, K., Takeuchi, K., Kaneko, H., Oohira, A., Yamamoto, T., and Sanai, Y. (2000) J. Biol. Chem. 275, 34701-34709
33. Miyakawa, T., Yagi, T., Taniguchi, M., Matsuura, H., Tateishi, K., and Niki, H. (1995) Brain Res. Mol. Brain Res. 28, 349-352