Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress - Induced death of motor neurons in amyotrophic lateral sclerosis

Annals of Neurology

Volumn 52, Issue 4, 2002, Pages 448-457

  Cutler, Roy G ^a   Pedersen, Ward A ^a   Camandola, Simonetta ^a   Rothstein, Jeffrey D ^b   Mattson, Mark P ^a,b  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE DERIVATIVE; CHOLESTEROL; CHOLESTEROL ESTER; COPPER ZINC SUPEROXIDE DISMUTASE; SPHINGOLIPID; SPHINGOMYELIN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; ENZYME DEFICIENCY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID METABOLISM; LIPOGENESIS; METABOLIC DISORDER; MOTONEURON; MOUSE; MOUSE MUTANT; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SPINAL CORD; TRANSGENIC MOUSE;

AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL DEATH; CERAMIDES; CHOLESTEROL; HUMANS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MIDDLE AGED; MOTOR NEURONS; NEUROBLASTOMA; OXIDATIVE STRESS; SPHINGOMYELINS; SPINAL CORD; SUPEROXIDE DISMUTASE; TUMOR CELLS, CULTURED;

EID: 0036789845     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10312     Document Type: Article

References (53)

1. Haverkamp LI, Appel V, Appel SH. Natural history of amyotrophic lateral sclerosis in a database population: validation of a scoring system and a model for survival prediction. Brain 1995; 118:707-719.
2. Cudkowicz ME, McKenna-Yasek D, Sapp PE, et al. Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis. Ann Neurol 1997;41:210-221.
3. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase muration. Science 1994;264:1772-1775.
4. Del Canto MC, Gurney ME. Neuroparhological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS). Brain Res 1995;676:25-40.
5. Wong PC, Pardo CA, Borchelt DR. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 1994;14:1105-1116.
6. Ferrante RJ, Browne SE, Shinobu LA, et al. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 1997;69:2064-2074.
7. Pedersen WA, Fu W, Keller JN, et al. Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients. Ann Neurol 1998;44:819-824.
8. Rothstein JD, VanKammen BA, Levey A.I., et al. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84.
9. Carriedo SG, Yin HZ, Weiss JH. Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J Neurosci 1996;16:4069-4079.
10. Kruman II, Pedersen WA, Springer JE, Mattson MP. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis. Exp Neurol 1999;160:28-39.
11. Pedersen WA, Luo H, Kruman II, et al. The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis. FASEB J 2000;14:913-924.
12. Nelson LM, Matkin C, Longstreth WT, McGuire V. Population-based case-control study of amyotrophic lateral sclerosis in western Washington state. II. Diet. Am J Epidemiol 2000;151:164-173.
13. Kronke M. Involvement of sphingomyelinases in TNF signaling pathways. Chem Phys Lipids 1999;102:157-166.
14. Billis W, Fuks Z, Kolesnick R. Signaling in and regulation of ionizing radiation-induced apoptosis in endothelial cells. Recent Prog Horm Res 1998;53:85-92.
15. Alessenko AV. The role of sphingomyelin cycle metabolites in transduction of signals of cell proliferation, differentiation and death. Membr Cell Biol 2000;13:303-320.
16. Yu Z, Nikolova-Karakashian M, Zhou D, et al. A role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis. J Mol Neurosci 2000;15:85-98.
17. Brugg B, Michel PP, Agid Y, Ruberg M. Ceramide induces apoptosis in cultured mesencephalic neurons. J Neurochem 1996;66:733-739.
18. Pedersen WA, Cashman NR, Mattson MP. The lipid peroxidation product 4-hydroxynonenal impairs glutamate and glucose transport and choline acetyltransferase activity in NSC-19 motor neuron cells. Exp Neurol 1999;155:1-10.
19. Shaikh NA. Assessment of various techniques for the quantitative extraction of lysophospholipids from myocardial tissues. Anal Biochem 1994;216:313-321.
20. Han X, Gross RW. Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometry. J Am Soc Mass Spectrom 1995;6: 1202-1210.
21. Gu M, Kerwin JL, Watts JD, Aebersold R. Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry. Anal Biochem 1997;244:347-356.
22. Duffin K, Obukowicz M, Raz A, Shieh JJ. Elecrrospray/randem mass spectrometry for quantitative analysis of lipid remodeling in essential fatty acid deficient mice. Anal Biochem 2000;279: 179-188.
23. Hsu FF, Turk J. Structural determination of glycosphingolipids as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisional-activared dissociation on a triple stage quadrupole instrument. J Am Soc Mass Spectrom 2000; 12:61-79.
24. Gouaze V, Mirault ME, Carpentier S, et al. Glutathione peroxidase-1 overexpression prevents ceramide production and partially inhibits apoptosis in doxorubicin-treated human breast carcinoma cells. Mol Pharmacol 2001;60:488-496.
25. Huwiler A, Boddinghaus B, Pautz A, et al. Superoxide potently induces ceramide formation in glomerular endothelial cells. Biochem Biophys Res Commun 2001;284:404-410.
26. Zager RA, Kalhorn TF. Changes in free and esterified cholesterol: hallmarks of acute renal tubular injury and acquired cytoresistance. Am J Pathol 2000;157:1007-1016.
27. Salomon RG, Kaur K, Podrez E, et al. HNE-derived 2-pentylpyrroles are generated during oxidation of LDL, are more prevalent in blood plasma from patients with renal disease or atherosclerosis, and are present in atherosclerotic plaques. Chem Res Toxicol 2000;13:557-564.
28. Moellering D, McAndrew J, Jo H, Darley-Usmar VM. Effects of pyrrolidine dithiocarbamate on endothelial cells: protection against oxidative stress. Free Radic Biol Med 1999;26: 1138-1145.
29. Cohen G. Enzymatic/nonenzymatic sources of oxyradicals and regulation of antioxidant defenses. Ann N Y Acad Sci 1994; 738:8-14.
30. Miyake Y, Kozutsumi Y, Nakamura S, et al. Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem Biophys Res Commun 1995;211:396-403.
31. Hanada K, Nishijima M, Fujita T, Kobayash, S. Specificity of inhibitors of serine palmitoyltransferase (SPT), a key enzyme in sphingolipid biosynthesis, in intact cells. A novel evaluation system using an SPT-defective mammalian cell mutant. Biochem Pharmacol 2000;59:1211-1216.
32. Hartfield PJ, Mayne GC, Murray AW. Ceramide induces apoptosis in PC12 cells. FEBS Lett 1997;401:148-152.
33. Kellner-Weibel G, Geng YJ, Rothblat GH. Cytotoxic cholesterol is generated by the hydrolysis of cytoplasmic cholesteryl ester and transported to the plasma membrane. Atherosclerosis 1999;146:309-319.
34. Gurney ME, Cutting FB, Zhai P, et al. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis. Ann Neurol 1996;39:147-157.
35. Liu R, Althaus JS, Ellerbrock BR, et al. Enhanced oxygen radical production in a transgenic mouse model of familial amyotrophic lateral sclerosis. Ann Neurol 1998;44:763-770.
36. Dbaibo GS, Pushkareva MY, Rachid RA, et al. p53-dependent ceramide response to genotoxic stress. J Clin Invest 1998;102: 329-339.
37. Yoshimura S, Banno Y, Nakashima S, et al. Inhibition of neutral sphingomyelinase activation and ceramide formation by glutathione in hypoxic PC12 cell death. J Neurochem 1999;73: 675-683.
38. Gudz TI, Tserng KY, Hoppel CL. Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J Biol Chem 1997;272:24154-24158.
39. Van Westerlaak MGH, Joosten EAJ, Gribnau AAM, et al. Differential cortico-motoneuron vulnerability after chronic mitochondrial inhibition in vitro and the role of glutamate receptors. Brain Res 2001;922:243-249.
40. Smyth MJ, Perry DK, Zhang J, et al. prICE: a downstream target for ceramide induced apoptosis and for the inhibitory action of Bcl-2. Biochem J 1996;316:25-28.
41. Pelled D, Raveh T, Riebeling C, et al. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. J Biol Chem 2002;277: 1957-1961.
42. Willaime S, Vanhoutte P, Caboche J, et al. Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation. Eur J Neurosci 2001;13:2037-2046.
43. Irie F, Hirabayashi Y. Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations. J Neurosci Res 1998;54:475-485.
44. Herget T, Esdar C, Oehrlein SA, et al. Production of ceramides causes apoptosis during early neural differentiation in vitro. J Biol Chem 2000;275:30344-30354.
45. Dawkins JL, Hulme DJ, Brahmbhatt SB, et al. Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I. Nat Genet 2001;27:309-312.
46. Shimabukuro M, Higa M, Zhou YT, et al. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J Biol Chem 1998;273: 32487-32490.
47. Suzukawa M, Abbey M, Clifton P, Nestel PJ. Effects of supplementing with vitamin E on the uptake of low density lipoprotein and the stimulation of cholesteryl ester formation in macrophages. Atherosclerosis 1994;110:77-86.
48. Chatterjee S. Sphingolipids in atherosclerosis and vascular biology. Arterioscler Thromb Vasc Biol 1998;18:1523-1533.
49. Gesquiere L, Loreau N, Minnich A, et al. Oxidative stress leads to cholesterol accumulation in vascular smooth muscle cells. Free Radic Biol Med 1999;27:134-145.
50. Stein O, Oette K, Dabach Y, et al. Persistence of increased cholesteryl ester in human skin fibroblasts is caused by residual exogenous sphingomyelinase and is reversed by phospholipid liposomes. Biochim Biophys Acta 1992;1165:153-159.
51. Villalba JM, Navas P. Plasma membrane redox system in the control of stress-induced apoptosis. Antioxid Redox Signal 2000;2:213-230.
52. Puglielli L, Konopka G, Pack-Chung E, et al. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol 2001;3:905-912.
53. Fassbender K, Simons M, Bergmann C, et al. Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proc Natl Acad Sci USA 2001;98:5856-5861.