Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 21, Issue 3, 2001, Pages 226-232

  Furuya, K ^a   Ginis, I ^a   Takeda, H ^a   Chen, Y ^a   Hallenbeck, J M ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Ceramides; Ischemic tolerance; Lipopolysaccharides; Middle cerebral artery occlusion; Tumor necrosis factor

Indexed keywords

CERAMIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ACTIVITY; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT;

EID: 0035092459     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200103000-00006     Document Type: Article

References (45)

1. Ischemic preconditioning and brain tolerance: Temporal histological and functional outcomes, protein synthesis requirement, and interleukin-receptor antagonist and early gene expression
2. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
3. Ceramide induces apoptosis in cultured mesencephalic neurons
4. Stress proteins and tolerance to focal cerebral ischemia
5. Suppression of ceramide-mediated programmed cell death by sphingosine-phosphate
6. Cerebrovascular hemodynamics and ischemic tolerance: Lipopolysaccharide-induced resistance to focal cerebral ischemia is not due to changes in severity of the initial ischemic insult, but is associated with preservation of microvascular perfusion
7. Role of dimethyl sulfoxide in prostaglandin-thromboxane and platelet systems after cerebral ischemia
8. In vivo metabolism of fluorescent ceramide in central nervous system myelin of adult rats
9. Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells
10. TNF-α pretreatment prevents subsequent activation of cultured brain cells with TNF-α and hypoxia via ceramide
11. ras/extracellular regulated kinase in neuronal ischemic preconditioning
12. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity
13. Functions of ceramide in coordinating cellular responses to stress
14. The novel second messenger ceramide: Identification, mechanism of action, and cellular activity
15. Blockade of cerebral blood flow response to insulin-induced hypoglycemia by caffeine and glibenclamide in conscious rats
16. Apoptosis induction in synovial fibroblasts by ceramide: In vitro and in vivo effects
17. Calcium-independent activation of endothelial nitric oxide synthase by ceramide
18. A synthetic ceramide analog (L-PDMP) up-regulates neuronal function
19. Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations
20. Ceramide prevents neuronal programmed cell death induced by nerve growth factor deprivation
21. Induction of apoptotic DNA damage and cell death by activation of the sphingomyelin pathway
22. Immunohistochemical localization of ubiquitin in gerbil hippocampus with induced tolerance to ischemia
23. Immunohistochemical localization of superoxide dismutase in the hippocampus following ischemia in a gerbil model of ischemic tolerance
24. Induced tolerance to ischemia in gerbil hippocampal neurons
25. 'Ischemic tolerance' phenomenon found in the brain
26. 'Ischemic tolerance' phenomenon detected in various brain regions
27. The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling
28. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage
29. Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-alpha and ceramide
30. Transient forebrain ischemia protects against subsequent focal cerebral ischemia without changing cerebral perfusion
31. Nitric oxide synthases: Which, where, how, and why?
32. L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat
33. Myocardial and endothelial protection by TMS in ischemia-reperfusion injury
34. TNF-alpha pretreatment induces protective effects against focal cerebral ischemia in mice
35. Ceramide can induce cell death in sensory neurons, whereas ceramide analogues and sphingosine promote survival
36. Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance
37. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
38. Activation of the extracellular-regulated protein kinase cascade in the hippocampal CA1 region in a rat model of global cerebral ischemia preconditioning
39. Increase in bcl-2 oncoprotein and the tolerance to ischemia-induced neuronal death in the gerbil hippocampus
40. The role of bcl-2 family genes in the induction of tolerance to focal ischemia
41. Focal cerebral ischaemia in the rat. 1. Description of technique and early neuropathological consequences following middle cerebral artery occlusion
42. Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats
43. WAF1/Cip1 and PAG608/Wig-1 in ischemic preconditioning
44. Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling
45. i in rat aortic smooth muscle