Scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima: Taxonomy of the producing organism, fermentation, isolation, and physico-chemical properties

Journal of Antibiotics

Volumn 52, Issue 6, 1999, Pages 525-530

  Nara, Futoshi ^a   Tanaka, Masahiro ^a   Hosoya, Tsuyoshi ^a   Suzuki Konagai, Keiko ^a   Ogita, Takeshi ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; SCYPHOSTATIN; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ARTICLE; BRAIN MICROSOME; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; FERMENTATION; GRAM POSITIVE BACTERIUM; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; TAXONOMY;

TRICHOPEZIZA MOLLISSIMA;

EID: 0032817681     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.525     Document Type: Article

References (16)

1. 3 in HL-60 cells. Role in cell differentiation. J. Biol. Chem. 264: 19076-19080, 1989
2. 3-induced HL-60 cell differentiation. J. Biol. Chem. 265:15823-15831, 1990
3. 2 production in human fibroblasts. J. Exp. Med. 174: 1363-1369, 1991
4. 2 production and sphingomyelin metabolism. Evidence for the regulation of cyclooxygenase gene expression by sphingosine and ceramide. J. Biol. Chem. 267: 20044-20050, 1992
5. MATHIAS, S.; A. YOUNES, C. C. KAN, I. ORLOW, C. JOSEPH & R. N. KOLESNICK: Activation of the sphingomyelin signaling pathway in intact EL4 cells and in a cell-free system by IL-1β. Science 259: 519-522, 1993
6. WIEGMANN, K.; S. SCHUTZE, T. MACHLEIDT, D. WITTE & M. KRONKE: Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling. Cell 78: 1005-1015, 1994
7. HELLER, R. A. & M. KRONKE: Tumor necrosis factor receptor-mediated signaling pathways. J. Cell. Biol. 126: 5-9, 1994
8. DOBROWSKY, R. T.; M. H. WERNER, A. M. CASTELLINO, M. V. CHAO & Y. A. HANNUN: Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265: 1596-1599, 1994
9. CIFONE, M. G.; R. DE MARIA, P. RONCAIOLI, M. R. RIPPO, M. AZUMA, L. L. LANIER, A. SANTONI & R. TESTI: Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J. Exp. Med. 180: 1547-1552, 1994
10. TEPPER, C. G.; S. JAYADEV, B. LIU, A. BIELAWSKA, R. WOLFF, S. YONEHARA, Y. A. HANNUN & M. F. SELDIN: Role for ceramide as an endogenous mediator of Fas-induced cytotoxicity. Proc. Natl. Acad. Sci. USA 92: 8443-8447, 1995
11. TANAKA, M.; F. NARA, K. SUZUKI-KONAGAI, T. HOSOYA & T. OGITA: Structural elucidation of scyphostatin, an inhibitor of membrane-bound neutral sphingomyelinase. J. Am. Chem. Soc. 119: 7871-7872, 1997
12. NARA, F.; M. TANAKA, S. MASUDA-INOUE, Y. YAMASATO, H. DOI-YOSHIOKA, K. SUZUKI-KONAGAI, S. KUMAKURA & T. OGITA: Biological activities of scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima. J. Antibiotics 52: 531-535, 1999
13. LISTER, M. D.; C. L. CRAWFORD-REDICK & C. R. LOOMIS: Characterization of the neutral pH-optimum sphingomyelinase from rat brain: inhibition by copper II and ganglioside GM3. Biochim. Biophys. Acta 1165: 314-320, 1993
14. 3-induced HL-60 cell differentiation. J. Biol. Chem. 269: 4070-4077, 1994
15. OTANI, Y.: Notes on some cup fungi of the Hyaloscyphaceae collected in Hokkaido, Japan. Trans. Mycol. Soc. Japan 8: 33-42, 1967
16. DENNIS, R. W. G.: A reassessment of Belonidium Mont, et Dur. Persoonia 2: 171-191, 1962