메뉴 건너뛰기




Volumn 63, Issue 13, 2003, Pages 3654-3658

Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; GANGLIOSIDE; GLUCOSYLCERAMIDE; GLYCOSPHINGOLIPID; OGT 2378; UNCLASSIFIED DRUG;

EID: 0038079762     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (80)

References (38)
  • 1
    • 0030480250 scopus 로고    scopus 로고
    • Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism
    • Hakomori, S. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res., 56: 5309-5318, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 5309-5318
    • Hakomori, S.1
  • 2
    • 0020607644 scopus 로고
    • Shedding and immunoregulatory activity of YAC-1 lymphoma cell gangliosides
    • Ladisch, S., Gillard, B., Wong, C., and Ulsh, L. Shedding and immunoregulatory activity of YAC-1 lymphoma cell gangliosides. Cancer Res., 43: 3808-3813, 1983.
    • (1983) Cancer Res. , vol.43 , pp. 3808-3813
    • Ladisch, S.1    Gillard, B.2    Wong, C.3    Ulsh, L.4
  • 3
    • 0021991312 scopus 로고
    • Detection of a tumour-associated ganglioside in plasma of patients with neuroblastoma
    • Ladisch, S., and Wu, Z. L. Detection of a tumour-associated ganglioside in plasma of patients with neuroblastoma. Lancet, 1: 136-138, 1985.
    • (1985) Lancet , vol.1 , pp. 136-138
    • Ladisch, S.1    Wu, Z.L.2
  • 5
    • 0028174143 scopus 로고
    • Increased GD3 ganglioside in plasma of children with T-cell acute lymphoblastic leukemia
    • Merritt, W. D., Der-Minassian, V., and Reaman, G. H. Increased GD3 ganglioside in plasma of children with T-cell acute lymphoblastic leukemia. Leukemia (Baltimore), 8: 816-822, 1994.
    • (1994) Leukemia (Baltimore) , vol.8 , pp. 816-822
    • Merritt, W.D.1    Der-Minassian, V.2    Reaman, G.H.3
  • 6
    • 0029863643 scopus 로고    scopus 로고
    • Intercellular transfer of shed tumor cell gangliosides
    • Olshefski, R., and Ladisch, S. Intercellular transfer of shed tumor cell gangliosides. FEBS Lett., 386: 11-14, 1996.
    • (1996) FEBS Lett. , vol.386 , pp. 11-14
    • Olshefski, R.1    Ladisch, S.2
  • 7
    • 0030579132 scopus 로고    scopus 로고
    • Immunosuppression by YAC-lymphoma: Role of shed gangliosides
    • Lu, P., and Sharom, F. J. Immunosuppression by YAC-lymphoma: role of shed gangliosides. Cell. Immunol., 173: 22-32, 1996.
    • (1996) Cell. Immunol. , vol.173 , pp. 22-32
    • Lu, P.1    Sharom, F.J.2
  • 9
    • 0026531614 scopus 로고
    • Immunosuppression by human gangliosides. II. Carbohydrate structure and inhibition of human NK activity
    • Grayson, G., and Ladisch, S. Immunosuppression by human gangliosides. II. Carbohydrate structure and inhibition of human NK activity. Cell. Immunol., 139: 18-29, 1992.
    • (1992) Cell. Immunol. , vol.139 , pp. 18-29
    • Grayson, G.1    Ladisch, S.2
  • 11
    • 0032697563 scopus 로고    scopus 로고
    • Gangliosides influence angiogenesis in an experimental mouse brain tumor
    • Manfredi, M. G., Lim, S., Claffey, K. P., and Seyfried, T. N. Gangliosides influence angiogenesis in an experimental mouse brain tumor. Cancer Res., 59: 5392-5397, 1999.
    • (1999) Cancer Res. , vol.59 , pp. 5392-5397
    • Manfredi, M.G.1    Lim, S.2    Claffey, K.P.3    Seyfried, T.N.4
  • 12
    • 0034541197 scopus 로고    scopus 로고
    • Suppression of ganglioside GD3 expression in a rat F-tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production
    • Zeng, G., Gao, L., Birkle, S., and Yu, R. K. Suppression of ganglioside GD3 expression in a rat F-tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production. Cancer Res., 60: 6670-6676, 2000.
    • (2000) Cancer Res. , vol.60 , pp. 6670-6676
    • Zeng, G.1    Gao, L.2    Birkle, S.3    Yu, R.K.4
  • 13
    • 0034805531 scopus 로고    scopus 로고
    • Ganglioside GD1a enhances VEGF-induced endothelial cell proliferation and migration
    • Lang, Z., Guerrera, M., Li, R., and Ladisch, S. Ganglioside GD1a enhances VEGF-induced endothelial cell proliferation and migration. Biochem. Biophys. Res. Commun., 282: 1031-1037, 2001.
    • (2001) Biochem. Biophys. Res. Commun. , vol.282 , pp. 1031-1037
    • Lang, Z.1    Guerrera, M.2    Li, R.3    Ladisch, S.4
  • 14
    • 0035900742 scopus 로고    scopus 로고
    • Enhancement of epidermal growth factor signaling and activation of SRC kinase by gangliosides
    • Li, R., Liu, Y., and Ladisch, S. Enhancement of epidermal growth factor signaling and activation of SRC kinase by gangliosides. J. Biol. Chem., 276: 42782-42792, 2001.
    • (2001) J. Biol. Chem. , vol.276 , pp. 42782-42792
    • Li, R.1    Liu, Y.2    Ladisch, S.3
  • 16
    • 0028902896 scopus 로고
    • Immunosuppressive activity of chemically synthesized gangliosides
    • Ladisch, S., Hasegawa, A., Li, R., and Kiso, M. Immunosuppressive activity of chemically synthesized gangliosides. Biochemistry, 34: 1197-1202, 1995.
    • (1995) Biochemistry , vol.34 , pp. 1197-1202
    • Ladisch, S.1    Hasegawa, A.2    Li, R.3    Kiso, M.4
  • 17
    • 0025232372 scopus 로고
    • Shed tumor gangliosides and progression of human neuroblastoma
    • Valentino, L., Moss, T., Olson, E., Wang, H. J., Elashoff, R., and Ladisch, S. Shed tumor gangliosides and progression of human neuroblastoma. Blood, 75: 1564-1567, 1990.
    • (1990) Blood , vol.75 , pp. 1564-1567
    • Valentino, L.1    Moss, T.2    Olson, E.3    Wang, H.J.4    Elashoff, R.5    Ladisch, S.6
  • 18
    • 0023353680 scopus 로고
    • Gangliosides shed by tumor cells enhance tumor formation in mice
    • Ladisch, S., Kitada, S., and Hays, E. F. Gangliosides shed by tumor cells enhance tumor formation in mice. J. Clin. Investig., 79: 1879-1882, 1987.
    • (1987) J. Clin. Investig. , vol.79 , pp. 1879-1882
    • Ladisch, S.1    Kitada, S.2    Hays, E.F.3
  • 19
    • 0034616635 scopus 로고    scopus 로고
    • Influence of cellular ganglioside depletion on tumor formation
    • Deng, W., Li, R., and Ladisch, S. Influence of cellular ganglioside depletion on tumor formation. J. Natl. Cancer Inst. (Bethesda), 92: 912-917, 2000.
    • (2000) J. Natl. Cancer Inst. (Bethesda) , vol.92 , pp. 912-917
    • Deng, W.1    Li, R.2    Ladisch, S.3
  • 20
    • 0035917656 scopus 로고    scopus 로고
    • N-butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours
    • Ranes, M. K., El-Abbadi, M., Manfredi, M. G., Mukherjee, P., Platt, F. M., and Seyfried, T. N. N-butyldeoxynojirimycin reduces growth and ganglioside content of experimental mouse brain tumours. Br. J. Cancer, 84: 1107-1114, 2001.
    • (2001) Br. J. Cancer , vol.84 , pp. 1107-1114
    • Ranes, M.K.1    El-Abbadi, M.2    Manfredi, M.G.3    Mukherjee, P.4    Platt, F.M.5    Seyfried, T.N.6
  • 21
    • 0036259133 scopus 로고    scopus 로고
    • Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation
    • Deng, W., Li, R., Guerrera, M., Liu, Y., and Ladisch, S. Transfection of glucosylceramide synthase antisense inhibits mouse melanoma formation. Glycobiology, 12: 145-152, 2002.
    • (2002) Glycobiology , vol.12 , pp. 145-152
    • Deng, W.1    Li, R.2    Guerrera, M.3    Liu, Y.4    Ladisch, S.5
  • 23
    • 0028176432 scopus 로고
    • N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis
    • Platt, F. M., Neises, G. R., Dwek, R. A., and Butters, T. D. N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis. J. Biol. Chem., 269: 8362-8365, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 8362-8365
    • Platt, F.M.1    Neises, G.R.2    Dwek, R.A.3    Butters, T.D.4
  • 24
    • 0030814767 scopus 로고    scopus 로고
    • Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin
    • Platt, F. M., Reinkensmeier, G., Dwek, R. A., and Butters, T. D. Extensive glycosphingolipid depletion in the liver and lymphoid organs of mice treated with N-butyldeoxynojirimycin. J. Biol. Chem., 272: 19365-19372, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19365-19372
    • Platt, F.M.1    Reinkensmeier, G.2    Dwek, R.A.3    Butters, T.D.4
  • 26
    • 0035399826 scopus 로고    scopus 로고
    • Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity
    • Olshefski, R. S., and Ladisch, S. Glucosylceramide synthase inhibition enhances vincristine-induced cytotoxicity. Int. J. Cancer, 93: 131-138, 2001.
    • (2001) Int. J. Cancer , vol.93 , pp. 131-138
    • Olshefski, R.S.1    Ladisch, S.2
  • 27
    • 0021954882 scopus 로고
    • A solvent partition method for microscale ganglioside purification
    • Ladisch, S., and Gillard, B. A solvent partition method for microscale ganglioside purification. Anal. Biochem., 146: 220-231, 1985.
    • (1985) Anal. Biochem. , vol.146 , pp. 220-231
    • Ladisch, S.1    Gillard, B.2
  • 28
    • 0014665068 scopus 로고
    • Quantitative densitometric thin-layer chromatography of lipids using copper acetate reagent
    • Fewster, M. E., Burns, B. J., and Mead, J. F. Quantitative densitometric thin-layer chromatography of lipids using copper acetate reagent. J. Chromatogr., 43: 120-126, 1969.
    • (1969) J. Chromatogr. , vol.43 , pp. 120-126
    • Fewster, M.E.1    Burns, B.J.2    Mead, J.F.3
  • 29
    • 0034629305 scopus 로고    scopus 로고
    • Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance
    • Liu, Y. Y., Han, T. Y., Giuliano, A. E., Hansen, N., and Cabot, M. C. Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance. J. Biol. Chem., 275: 7138-7143, 2000.
    • (2000) J. Biol. Chem. , vol.275 , pp. 7138-7143
    • Liu, Y.Y.1    Han, T.Y.2    Giuliano, A.E.3    Hansen, N.4    Cabot, M.C.5
  • 30
    • 0019751507 scopus 로고
    • Protein determination in membrane and lipoprotein samples: Manual and automated procedures
    • Markwell, M. A., Haas, S. M., Tolbert, N. E., and Bieber, L. L. Protein determination in membrane and lipoprotein samples: manual and automated procedures. Methods Enzymol., 72: 296-303, 1981.
    • (1981) Methods Enzymol. , vol.72 , pp. 296-303
    • Markwell, M.A.1    Haas, S.M.2    Tolbert, N.E.3    Bieber, L.L.4
  • 31
    • 0020009821 scopus 로고
    • Gangliosides: Structure, isolation, and analysis
    • Ledeen, R. W., and Yu, R. K. Gangliosides: structure, isolation, and analysis. Methods Enzymol., 83: 139-191, 1982.
    • (1982) Methods Enzymol. , vol.83 , pp. 139-191
    • Ledeen, R.W.1    Yu, R.K.2
  • 32
    • 0028846188 scopus 로고
    • Three parameter flow cytometric analysis for simultaneous detection of cytokeratin, proliferation associated antigens and DNA content
    • Schutte, B., Tinnemans, M. M., Pijpers, G. F., Lenders, M. H., and Ramaekers, F. C. Three parameter flow cytometric analysis for simultaneous detection of cytokeratin, proliferation associated antigens and DNA content. Cytometry, 21: 177-186, 1995.
    • (1995) Cytometry , vol.21 , pp. 177-186
    • Schutte, B.1    Tinnemans, M.M.2    Pijpers, G.F.3    Lenders, M.H.4    Ramaekers, F.C.5
  • 33
    • 0029043888 scopus 로고
    • A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V
    • Vermes, I., Haanen, C., Steffens-Nakken, H., and Reutelingsperger, C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labeled Annexin V. J. Immunol. Methods, 184: 39-51, 1995.
    • (1995) J. Immunol. Methods , vol.184 , pp. 39-51
    • Vermes, I.1    Haanen, C.2    Steffens-Nakken, H.3    Reutelingsperger, C.4
  • 34
    • 0027355755 scopus 로고
    • Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances
    • Radin, N. S., Shayman, J. A., and Inokuchi, J. Metabolic effects of inhibiting glucosylceramide synthesis with PDMP and other substances. Adv. Lipid Res., 26: 183-213, 1993.
    • (1993) Adv. Lipid Res. , vol.26 , pp. 183-213
    • Radin, N.S.1    Shayman, J.A.2    Inokuchi, J.3
  • 35
    • 0034602159 scopus 로고    scopus 로고
    • Cellular gangliosides promote growth factor-induced proliferation of fibroblasts
    • Li, R., Manela, J., Kong, Y., and Ladisch, S. Cellular gangliosides promote growth factor-induced proliferation of fibroblasts. J. Biol. Chem., 275: 34213-34223, 2000.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34213-34223
    • Li, R.1    Manela, J.2    Kong, Y.3    Ladisch, S.4
  • 36
    • 0025027772 scopus 로고
    • Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action
    • Inokuchi, J., Jimbo, M., Momosaki, K., Shimeno, H., Nagamatsu, A., and Radin, N. S. Inhibition of experimental metastasis of murine Lewis lung carcinoma by an inhibitor of glucosylceramide synthase and its possible mechanism of action. Cancer Res., 50: 6731-6737, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 6731-6737
    • Inokuchi, J.1    Jimbo, M.2    Momosaki, K.3    Shimeno, H.4    Nagamatsu, A.5    Radin, N.S.6
  • 37
    • 0032698788 scopus 로고    scopus 로고
    • Effects of the glucolipid synthase inhibitor, P4, on functional and phenotypic parameters of murine myeloma cells
    • Manning, L. S., and Radin, N. S. Effects of the glucolipid synthase inhibitor, P4, on functional and phenotypic parameters of murine myeloma cells. Br. J. Cancer, 81: 952-958, 1999.
    • (1999) Br. J. Cancer , vol.81 , pp. 952-958
    • Manning, L.S.1    Radin, N.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.