The sphingosine kinase 1/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-α

FASEB Journal

Volumn 17, Issue 11, 2003, Pages 1411-1421

  Pettus, Benjamin J ^a   Bielawski, Jacek ^a   Porcelli, Anna M ^c   Reames, Davis L ^a   Johnson, Korey R ^a   Morrow, Jason ^d   Chalfant, Charles E ^a,b   Obeid, Lina M ^a,b   Hannun, Yusuf A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c UNIVERSITY OF BOLOGNA   (Italy)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Ceramide; Inflammation; Prostaglandin E2; RNA interference; Sphingosine; Tumor necrosis factor

Indexed keywords

CERAMIDE; CYCLOOXYGENASE 2; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PROSTANOID; RNA; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; DRUG DERIVATIVE; ISOENZYME; LYSOPHOSPHOLIPID; MEMBRANE PROTEIN; PHOSPHOTRANSFERASE; PROSTAGLANDIN SYNTHASE; PTGS2 PROTEIN, HUMAN; SPHINGOSINE; SPHINGOSINE 1-PHOSPHATE;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INDUCTION; FIBROBLAST; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; INFLAMMATION; LIPID METABOLISM; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CELL LINE; GENETICS; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ANIMALIA;

ANIMALS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INDUCTION; HUMANS; ISOENZYMES; LYSOPHOSPHOLIPIDS; MEMBRANE PROTEINS; MICE; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHINGOSINE; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0041703016     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.02-1038com     Document Type: Article

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