Sphingosine 1-phosphate signalling in mammalian cells

Biochemical Journal

Volumn 349, Issue 2, 2000, Pages 385-402

  Pyne, Susan ^a   Pyne, Nigel J ^a  

^a UNIVERSITY OF STRATHCLYDE   (United Kingdom)

Author keywords

Endothelial differentiation gene (EDG); Lipid phosphate phosphatase; Lysosphingolipid; Sphingosine 1 phosphate lyase; Sphingosine kinase

Indexed keywords

ADENYLATE KINASE; CALCIUM ION; CASPASE; CELL ADHESION MOLECULE; CYTOKINE; CYTOSKELETON PROTEIN; G PROTEIN COUPLED RECEPTOR; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOETHANOLAMINE; PHOSPHOLIPASE C; PHOSPHOLIPASE D; PROTEIN TYROSINE KINASE; RHO FACTOR; SPHINGOSINE 1 PHOSPHATE; SPHINGOSINE KINASE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR;

ANGIOGENESIS; APOPTOSIS; CALCIUM MOBILIZATION; CANCER; CELL DIFFERENTIATION; CELL MIGRATION; DEPHOSPHORYLATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; INFLAMMATION; LIPID METABOLISM; MITOGENESIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL DIVISION; CELL MOVEMENT; CELLS, CULTURED; CERAMIDES; HUMANS; LYSOPHOSPHOLIPIDS; SIGNAL TRANSDUCTION; SPHINGOLIPIDS; SPHINGOSINE;

EID: 0034661482     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3490385     Document Type: Review

References (174)

1. 1 Mathias, S., Pena, L. A. and Kolesnick, R. N. (1998) Signal transduction of stress via ceramide. Biochem. J. 335, 465-480
2. 2 Perry, D. K. and Hannun, Y. A. (1999) The role of ceramide in cell signalling. Biochim. Biophys. Acta 1436, 233-243
3. 3 Levade, T. and Jaffrezou, J.-P. (1999) Signalling sphingomyelinases: which, where, how and why? Biochim. Biophys. Acta 1438, 1-17
4. 4 Liu, B. and Hannun, Y. A. (1997) Inhibition of the neutral magnesium-dependent sphingomyelinase by glutathione. J. Biol. Chem. 272, 16281-16287
5. 5 Liu, B., Andrieu-Abadie, N., Levade, T., Zhang, P., Obeid, L. M. and Hannun, Y. A. (1998) Glutathione regulation of neutral sphingomyelinase in tumor necrosis factor-α-induced cell death. J. Biol. Chem. 273, 11313-11320
6. 6 Bernardo, K., Hurwitz, R., Zenk, T., Desnick, R. J., Ferlinz, K., Schuchman, E. H. and Sandhoff, K. (1995) Purification, characterization, and biosynthesis of human acid ceramidase. J. Biol. Chem. 270, 11098-11102
7. 7 Koch, J., Gartner, S., Li, C M., Quintern, L. E., Bernardo, K., Levran, O., Schnabel, D., Desnick, R. J., Schuchman, E. H. and Sandhoff, K. (1996) Molecular cloning and characterization of a full-length complementary DNA encoding human acid ceramidase. Identification of the first molecular lesion causing Farber disease. J. Biol. Chem. 271, 33110-33115
8. 8 Sugita, M., Williams, M., Dulaney, J. T. and Moser, H. W. (1975) Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase. Biochim. Biophys. Acta 398, 125-131
9. 9 Ullman, M. D. and Radin, N. S. (1974) The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver. J. Biol. Chem. 249, 1506-1511
10. 10 Sundaram, K. S. and Lev, M. (1984) Inhibition of sphingolipid synthesis by cycloserine in vitro and in vivo. J. Neurochem. 42, 577-581
11. 11 Miyake, Y., Kozutsumi, Y., Nakamura, S., Fujita, T. and Kawasaki, T. (1995) Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1/myriocin. Biochem. Biophys. Res. Commun. 211, 396-403
12. 12 Wang, E., Norred, W. P., Bacon, C. W., Riley, R. T. and Merrill, Jr., A. H. (1991) Inhibition of sphingolipid biosynthesis by fumonisins Implications for diseases associated with Fusarium moniliforme. J. Biol. Chem. 266, 14486-14490
13. 13 Jeckel, D., Karrenbauer, A., Burger, K. N., van Meer, G. and Wieland, F. (1992) Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. J. Cell Biol. 117, 259-267
14. 14 Vunnam, R. R. and Radin, N. S. (1980) Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain. Chem. Phys. Lipids 26, 265-278
15. 15 Bajjalieh, S. M , Martin, T. F. and Floor, E. (1989) Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles. J. Biol. Chem. 264, 14354-14360
16. 16 Kolesnick, R. N. and Hemer, M. R. (1990) Characterization of a ceramide kinase activity from human leukemia (HL-60) cells. Separation from diacylglycerol kinase activity. J. Biol. Chem. 265, 18803-18808
17. 17 Olivera, A., Kohama, T., Tu, Z., Milstein, S. and Spiegel, S. (1998) Purification and characterization of rat kidney sphingosine kinase. J. Biol. Chem 273, 12576-12583
18. 18 Kohama, T., Olivera, A., Edsall, L., Nagiec, M. M., Dickson, R. and Spiegel, S. (1998) Molecular cloning and functional characterisation of murine sphingosine kinase. J. Biol. Chem. 273, 23722-23728
19. 19 Kozak, M. (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44, 283-292
20. 20 Nagiec, M. M., Skrzypek, M., Nagiec, E. E., Lester, R. L. and Dickson, R. L. (1998) The LCB4 (YOR171c) and LCB5 (YLR260w) genes of Saccharomyces encode sphingoid long chain base kinases. J. Biol. Chem. 273, 19437-19442
21. 21 Bunting, M., Tang, W., Zimmerman, G. A., McIntyre, T. M. and Prescott, S. M. (1996) Molecular cloning and characterization of a novel human diacylglycerol kinase ζ. J. Biol. Chem. 271, 10230-10236
22. 22 Schaap, D., Van der Wal, J. and Van Blitterswijk, W. J. (1994) Consensus sequences for ATP-binding sites in protein kinases do not apply to diacylglycerol kinases. Biochem. J. 304, 661-662
23. 23 Cuvillier, O., Pirianov, G., Kleuser, B., Vcanek, P. G., Coso, O. A., Gutkind, S. and Spiegel, S. (1996) Suppression of ceramide-mediated programmed cell death by sphingosine 1-phosphate. Nature (London) 381, 800-803
24. 24 Olivera, A., Rosenthal, J. and Spiegel, S. (1994) Sphingosine kinase from Swiss 3T3 fibroblasts: a convenient assay for the measurement of intracellular levels of free sphingoid bases. Anal. Biochem 223, 306-312
25. 25 Olivera, A., Kohama, T., Edsall, L., Nava, V., Cuvillier, O., Poulton, S. and Spiegel, S. (1999) Sphingosine kinase expression increases intracellular sphingosine 1-phosphate and promotes cell growth and survival. J. Cell Biol. 147, 545-557
26. 26 Bann, Y., Kato, M., Hara, A. and Nozawa, Y. (1998) Evidence for the presence of multiple isoforms of sphingosine kinase in human platelets. Biochem J 335, 301-304
27. 27 Van Veldhoven, P. P. and Mannaerts, G. P. (1991) Subcellular localization and membrane topology of sphingosine-1-phosphate lyase in rat liver. J. Biol. Chem. 266, 12502-12507
28. 28 Van Veldhoven, P. P. and Mannaerts, G. P. (1993) Sphingosine-phosphate lyase. Adv. Lipid Res. 26, 69-98
29. 29 Van Veldhoven, P. P. and Mannaerts, G. P. (1994) Sphinganine 1-phosphate metabolism in cultured skin fibroblasts: evidence tor the existence of a sphingosine phosphatase. Biochem. J. 299, 597-601
30. 30 Saba, J. D., Nara, F., Bielawska, A., Garrett, S. and Hannun, Y. A. (1997) The BST1 gene of Saccharomyces cerevisiae is the sphingosine 1-phosphate lyase. J. Biol. Chem. 272, 26087-26090
31. 31 Zhou, J. and Saba, J. D. (1998) Identification of the first mammalian sphingosine phosphate lyase gene and its functional expression in yeast. Biochem. Biophys. Res. Commun. 242, 502-507
32. 32 Brindley, D. N. and Waggoner, D. W (1998) Mammalian lipid phosphate phosphohydrolases. J. Biol. Chem. 273, 24281-24284
33. 33 Stoffel, W., LeKim, D. and Sticht, G. (1969) Distribution and properties of dihydrosphingosine-1-phosphate aldolase (sphinganine-1-phosphate alkanal-lyase). Hoppe-Seyler's Z. Physiol. Chem. 350, 1233-1241
34. 34 De Cuester, P., Mannaerts, G. P and Van Veldhoven, P. P. (1995) Identification and subcellular localization of sphinganine phosphatases in rat liver. Biochem. J 311, 139-146
35. 35 Mao, C., Wadleigh, M., Jenkins, G. M., Hannun, Y. A. and Obeid, L. M. (1997) Identification and characterization of Saccharomyces cerevisiae dihydrosphingosine-1-phosphate phosphatase. J. Biol. Chem. 272, 28690-28694
36. 36 Mandala, S. M., Thornton, R., Tu, Z., Kurtz, M. B., Nickels, J., Broach, J., Menzeleev, R. and Spiegel. S. (1998) Sphingoid base 1-phosphatase: a key regulator of sphingolipid metabolism and stress response. Proc. Natl. Acad. Sci. U.S.A. 95. 150-155
37. 37 Yatomi, Y., Ruan, F., Ohta, H., Welch, R. J., Hakomori, S.-I. and Igarashi, Y. (1995) Quantitative measurement of sphingosine 1-phosphate in biological samples by acylation with radioactive acetic anhydride. Anal. Biochem. 230, 315-320
38. 38 Edsall, L. C. and Spiegel, S. (1999) Enzymatic measurement of sphingosine 1-phosphate. Anal. Biochem. 272, 80-66
39. 39 Igarashi, Y. and Yatomi, Y. (1998) Sphingosine 1-phosphate is a blood constituent released from activated platelets, possibly playing a variety of physiological and pathological roles. Acta Biochim. Polon. 45, 299-309
40. 40 Yatomi, Y., Igarashi, Y., Yang, L., Hisano, N., Qi, R., Asazuma, N., Satoh, K., Ozaki, Y. and Kume, S. (1997) Sphingosine 1-phosphate, a bioactive sphingolipid abundantly stored in platelets, is a normal constituent of human plasma and serum. J. Biochem. (Tokyo) 121, 969-973
41. 41 Igarashi, Y., Yatomi, Y. and Kickler, T.S (1998) Sphingosine-phosphate content in the plasma of platelet concentrates correlates with poor platelet increments after transfusion and with occurrences of transfusion reactions in patients. Am. J. Hematol. 57, 261-262
42. 42 Buehrer, B. M. and Bell, R. M. (1992) Inhibition of sphingosine kinase in vitro and in platelets. Implications lor signal transduction pathways. J. Biol. Chem. 267, 3154-3159
43. 43 Olivera, A. and Spiegel, S. (1993) Sphingosine 1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens. Nature (London) 365, 557-560
44. 44 Pyne, S., Chapman, J., Steele, L. and Pyne, N. J. (1996) Sphingomyelin-derived lipids differentially regulate the extracellular signal-regulated kinase 2 (ERK-2) and c-Jun N-terminal kinase (JNK) signal cascades in airway smooth muscle. Eur. J. Biochem. 237, 819-826
45. 2+ signalling by G-protein-coupled receptors. EMBO J. 17, 2830-2837
46. 46 Choi, O. H., Kim, J. H. and Kinet, J. P. (1996) Calcium mobilisation via sphingosine kinase in signalling by the FcεRl antigen receptor. Nature (London) 380, 634-636
47. 47 Melendez, A., Floto, R. A., Gillooly, D. J., Harnett, M. M. and Allen, J. M. (1998) FcγRl coupling to phosphotipase D initiates sphingosine kinase-mediated calcium mobilization and vesicular trafficking. J. Biol. Chem. 273, 9393-9402
48. 48 Alemany, R., Meyer zu Heringdorf, D., van Koppen, C. J. and Jakobs, K. H (1999) Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase J. Biol. Chem. 274, 3994-3999
49. 49 Xia, P., Wang, L., Gamble, J. R. and Vadas, M. A. (1999) Activation of sphingosine kinase by tumor necrosis factor-α inhibits apoptosis in human endothelial cells. J. Biol. Chem. 274, 34499-34505
50. 50 Rani, C. S., Berger, A., Wu, J., Sturgill, T. W., Beitner-Johnson, D., Le Roith, D., Varticovski, L. and Spiegel, S. (1997) Divergence in signal transduction pathways of platelet-derived growth factor (PDGF) and epidermal growth factor (EGF) receptors: involvement of sphingosine 1-phosphate in PDGF but not EGF signalling. J. Biol. Chem. 272, 10777-10783
51. 2+ signalling by epidermal growth factor receptor. FEBS Lett. 461, 217-222
52. 52 Olivera, A., Edsall, L., Poulton, S., Kazlauskas, A. and Spiegel, S. (1999) Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCγ. FASEB J. 13, 1593-1600
53. 53 Buehrer, B. M., Bardes, E. S. and Bell, R. M. (1996) Protein kinase C-dependent regulation of human erythroleukemia (HEL) cell sphingosine kinase activity. Biochim. Biophys. Acta 1303, 233-242
54. 54 Rius, R. A., Edsall, L. C. and Spiegel, S. (1997) Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors. FEBS Lett. 417, 173-176
55. 3 inhibits programmed cell death in HL60 cells by activation of sphingosine kinase. Cancer Res. 58, 1817-1824
56. 56 Augé, N, Nikolova-Karakahian, M., Carpentier, S., Parthasarathy, S, Negre-Salvayre, A., Salvayre, R., Merrill, Jr., A. H. and Levade, T. (1999) Role of sphingosine 1-phosphate in the mitogenesis induced by oxidized low density lipoprotein in smooth muscle cells via activation of sphingomyelinase, ceramidase, and sphingosine kinase. J. Biol. Chem. 274, 21533-21538
57. 57 Machawate, M., Rodan, S. B., Rodan, G. A. and Harada, S.-I. (1998) Sphingosine kinase mediates cyclic AMP suppression of apoptosis in rat periosteal cells. Mol. Pharmacol. 54, 70-77
58. 58 Hla, T. and Macaig, T. (1990) An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J. Biol. Chem. 265, 9308-9313
59. 59 Okazaki, H., Ishizaka, N., Sakurai, T., Kurokawa, K., Goto, K., Kumada, M. and Takuwa, Y. (1993) Molecular cloning of a novel pulative G protein-coupled receptor expressed in the cardiovascular system. Biochem. Biophys. Res. Commun, 190, 1104-1109
60. 60 MacLennan, A. J., Browe, C. S., Gaskin, A. A., Lado, D. C and Shaw, G. (1994) Cloning and characterisation of a putative G-protein coupled receptor potentially involved in development. Mol. Cell. Neurosci. 5, 201-209
61. 61 Graler, M. H., Bernhardt, G. and Lipp, M. (1998) A lymphoid tissue-specific receptor, EDG6, with potential immune modulatory functions mediated by extracellular lysophospholipids. Genomics 53, 164-169
62. 2+ signalling pathway. Biochem. Biophys. Res. Commun. 268, 583-589
63. 63 Im, D-S., Heise, C. E., Ancellin, N., O'Dowd, B. F., Shei, G.-J., Heavens, R. P, Rigby, M. R., Hla, T., Mandala, S., McAllister, G. et al. (2000) Characterisation of a novel sphingosine 1-phosphate receptor, EDG8. J. Biol. Chem. 275, 14281-14286
64. 64 Glickman, M., Malek, R. L., Kwitek-Black, A. E., Jacob, H. J. and Lee, N. H. (1999) Molecular cloning, tissue-specific expression, and chromosomal localisation of a novei nerve growth factor-regulated G-protein-coupled receptor, nrg-1. Mol. Cell. Neurosci. 14, 141-152
65. 1/mitogen-activated protein kinase pathway. J. Biol. Chem. 271, 11272-11279
66. 66 Lee, M.-J, Van Brooklyn, J. R., Thangada, S., Liu, C. H., Hand, A. R., Menzeleev, R., Spiegel, S. and Hla, T. (1996) Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 279, 1552-1555
67. 67 Kon, J, Sato, K., Watanabe, T., Tomura, H., Kuwabara, A., Kimura, T., Tamama, K.-I., Ishizuka, T., Murata, N., Kanda, T. et al. (1999) Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor sub-types to regulate several signalling pathways in their cDNA-transfected Chinese hamster ovary cells. J. Biol. Chem. 274, 23940-23947
68. 2+ mobilization, ras-mitogen-activated protein kinase activation and adenylate cyclase inhibition. J. Biol. Chem. 273, 27104-27110
69. 69 Zondag, G. C., Postma, F. R., Van Etten, A., Verlaan, I. and Moolenaar, W. H. (1998) Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1. Biochem. J. 330, 605-609
70. 12 families of heterotrimeric G proteins. J. Biol. Chem. 274, 27351-27358
71. 71 Hall, A, Paterson, H. F., Adamson, P. and Ridley, A. J. (1993) Cellular responses regulated by rho-related small GTP-binding proteins. Philos. Trans. R. Soc. London B Biol. Sci. 340, 267-271
72. 72 Stam, J. C., Michiels, F., van der Kammen, R. A., Moolenaar, W. H. and Collard, J. (1998) Invasion of T-lymphoma cells: co-operation between Rho family GTPases and lysophospholipid receptor signalling. EMBO J. 17, 4066-4074
73. 73 Lee, M.-J., Thangada, S., Liu, C. H., Thompson, B. D. and Hla, T. (1998) Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J. Biol. Chem 273, 22105-22112
74. 74 Van Brocklyn, J. R., Tu, Z., Edsall, L., Schmidt, R. R. and Spiegel, S. (1999) Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. J. Biol. Chem. 274, 4626-4632
75. 1-coupled receptor EDG1 and intracellular to regulate proliferation and survival. J. Cell Biol. 142, 229-240
76. 76 An, S., Bleu, T. and Zheng, Y. (1999) Transduction of intracellular calcium signals through G protein-mediated activation of phospholipase C by recombinant sphingosine 1-phosphate receptors. Mol. Pharmacol. 55, 787-794
77. 77 An, S., Goetzl, E. J. and Lee, H. (1998) Signalling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate. J. Cell. Biochem. Suppl. 30/31, 147-157
78. 78 Ancellin, N. and Hla, T. (1999) Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5. J. Biol. Chem. 274, 18997-19002
79. 13 stimulate Rho-dependent stress libre formation and local adhesion assembly. J. Biol. Chem. 270, 24631-24634
80. 13. Science 280, 2109-2111
81. 81 Karnam, P., Standaert, M. L., Galloway. L. and Farese, R. V. (1997) Activation and translocation of Rho (and ADP ribosylation factor) by insulin in rat adipocytes: apparent involvement of phosphatidylinositol 3-kinase. J. Biol. Chem. 272, 6136-6140
82. α13. Proc. Natl. Acad. Sci. U.S.A. 95, 12973-12976
83. α13. Science 280, 2112-2114
84. 84 Hecht, J. H., Weiner, J. A., Post, S. R. and Chun, J. (1996) Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135, 1071-1083
85. 85 An, S., Bleu, T., Hallmark, O. G. and Goetzl, E. J. (1998) Characterisation of a novel subtype of human G protein-coupled receptor for lysophosphalidic acid. J. Biol. Chem. 273, 7906-7910
86. 86 An, S., Bleu, T., Zheng, Y. and Goetzl, E. J. (1998) Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization. Mol. Pharmacol. 54, 881-888
87. 87 Erickson, J. R., Wu, J. J., Goddard, J. G., Tigyi, G., Kawanishi, K., Tomei, L. D. and Kiefer, M. C. (1998) Edg-2/Vzg-1 couples to the yeast pheromone response pathway selectively in response to lysophosphatidic acid. J. Biol. Chem. 273, 1506-1510
88. 88 Bandoh, K., Aoki, J., Hosono, H., Kobayashi, S., Kobayashi, T., Murakami-Murofushi, K., Tsujimoto, M., Arai, H. and Inoue, K. (1999) Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid. J. Biol. Chem. 274, 27776-27785
89. 89 Rakhit, S., Conway, A.-M., Tale, R., Bower, T., Pyne, N. J. and Pyne, S. (1999) Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of endothelial differentiation gene-1, c-Src tyrosine kinase and phosphoinositide 3-kinase. Biochem. J. 338, 643-649
90. 90 Okamoto, H., Takuwa, N., Yatomi, Y., Gonda, K., Shigematsu, H. and Takuwa, Y. (1999) EDG3 is a functional receptor specific for Sphingosine 1-phosphate and sphingosylphosphorylcholine with signalling characterisitics distinct from EDG1 and AGR16. Biochem. Biophys. Res. Commun. 260, 203-208
91. 91 Bornfeldt, K., Graves, L. M., Raines, E. W., Igarashi, Y., Wayman, G., Yamamura, S., Yatomi, Y., Sidhu, J. S., Krebs, E. G., Hakomori, S.-I. and Ross, R. (1995) Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J. Cell Biol. 130, 193-206
92. 92 Gonda, K., Okamoto, H., Takuwa, N., Yatomi, Y., Okazaki, H., Sakura, T., Kimura, S., Sillard, R., Harii, K. and Takuwa, Y. (1999) The novel Sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. Biochem. J. 337, 67-75
93. 93 Banno, Y., Fujita, H., Ono, Y., Nakashima, S., Ito, Y., Kuzumaki, N. and Nozawa, Y. (1999) Differential phospholipase D activation by bradykinin and Sphingosine 1-phosphate in NIH 3T3 fibroblasts over-expressing gelsolin. J. Biol. Chem. 274, 27385-27391
94. 94 Pyne, S. and Pyne, N. J. (1996) The differential regulation of cyclic AMP by sphingomyelin-derived lipids and the modulation of sphingolipid-stimulated extracellular signal regulated kinase-2 in airway smooth muscle. Biochem. J. 315, 917-923
95. 95 Wu, J., Spiegel, S. and Sturgill, T. W. (1995) Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G-protein-dependent mechanism. J. Biol. Chem. 270, 11484-11488
96. ras. Proc. Natl. Acad. Sci. U.S.A. 91, 12706-12710
97. 97 Crespo, P., Xu, N., Simonds, W. F. and Gutkind, J. S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature (London) 369, 418-420
98. 98 Stephens, L. R., Smrcka, A., Cooke, F. T., Jackson, T. J., Sternweis, P. and Hawkins, P. T. (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell 77, 83-93
99. 99 Lopez-Ilasaca, M., Crespo, P., Pellici, P. G., Gutkind, J. S. and Wetzker, R. (1997) Linkage of G protein-coupled receptors to the MAPK signalling pathway through Pl 3-kinase γ. Science 275, 394-397
100. 1-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J 16, 3097-3105
101. 101 Luttrell, L. M., van Biesen, T., Hawes, B. E., Koch, W. J., Tohura, K. and Lefkowitz, R. J. (1995) Gβγ subunits mediate mitogen-activated protein kinase activation by the tyrosine kinase insulin-like growth factor 1 receptor. J. Biol. Chem. 270, 16495-16498
102. 102 Holdago-Madruga, M., Emlet, D. R., Moscatello, D. K., Godwin, A. K. and Wong, A. J. (1996) A Grb2-associated docking protein in EGF-and insulin-receptor signalling. Nature (London) 379, 560-564
103. 103 Lin, F. T., Kreuger, K. M., Kendall, H. E., Daaka, Y., Fredericks, Z. L., Pitcher, J. A. and Lefkowitz, R. J. (1997) Clathrin-mediated endocytosis of the β-adrenergic receptor is regulated by phosphorylation/dephosphorylation of β-arrestin 1. J. Biol. Chem. 272, 31051-31057
104. 104 Luttrell, L. M., Daaka, Y., Della Rocca, G. J. and Lefkowitz, R. J. (1997) G protein-coupled receptors mediate two functionally distinct pathways of tyrosine phosphorylation in rat 1a fibroblasts: She phosphorylation and receptor endocytosis correlate with activation of ERK kinases. J. Biol. Chem. 272, 31648-31656
105. 105 Daaka, Y., Luttrell, L. M., Ahn, S., Della Rocca, G. J., Ferguson, S. S. G., Caron, M. G. and Lefkowitz, R. J. (1998) Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase. J. Biol. Chem. 273, 685-688
106. 106 Guo, C., Zheng, C., Martin-Padura, I., Bian, Z. C. and Guan, J.-L. (1998) Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate. Eur. J. Biochem. 257. 403-408
107. 107 Sato, K., Tomura, H., Igarashi, Y., Ui, M. and Okajima, F. (1999) Possible involvement of cell surface receptors in sphingosine 1-phosphate-induced activation of extracellular signal-regulated kinase in C6 glioma cells. Mol. Pharmacol. 55, 126-133
108. 108 An, S., Zheng, Y. and Bleu, T. (2000) Sphingosine 1-phosphate-induced cell proliferation, survival and related events mediated by G protein-coupled receptors EDG3 and EDG5. J. Biol. Chem. 275, 288-296
109. 109 Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A. and Schlessinger, J. (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature (London) 383, 547-550
110. 110 Yang, L, Yatomi, Y., Hisano, N., Qi, R., Asazuma, N., Satoh, K., Igarashi, Y., Ozaki, Y. and Kume, S. (1996) Activation of protein-tyrosine kinase Syk in human platelets stimulated with lysophosphatidic acid or sphingosine 1-phosphate. Biochem. Biophys. Res. Commun. 229, 440-444
111. 111 Blakesley, V. A., Beitner-Johnson, D., Van Brocklyn, J. R., Rani, S., Shen-Orr, Z., Stannard, B., Spiegel, S. and LeRoith, D. (1997) Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk. J. Biol. Chem. 272, 16211-16215
112. 112 Wang, F., Nobes, C. D., Hall, A. and Spiegel, S. (1997) Sphingosine 1-phosphate stimulates Rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts. Biochem. J. 324, 481-488
113. 113 Exton, J. H. (1999) Regulation of phospholipase D. Biochim. Biophys. Acta 1439, 121-133
114. 114 Su, Y., Rosenthal, D., Smulson, M. and Spiegel, S. (1994) Sphingosine 1-phosphate, a novel signaling molecule, stimulates DNA binding activity of AP-1 in quiescent Swiss 3T3 fibroblasts. J. Biol. Chem. 269, 16512-15517
115. 115 Hill, C. S., Marais, R., John, S., Wynne, J., Dalton, S. and Treisman, R. (1993) Functional analysis of a growth factor-responsive transcription factor complex. Cell 73, 395-406
116. 116 Hill, C. S., Wynne, J. and Treisman, R. (1995) The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell 81, 1159-1170
117. + current in guinea-pig atrial myocytes by sphingosine-1-phosphate. J. Physiol. (London) 489, 701-707
118. 118 MacDonell, K. L., Severson, D. L. and Giles, W. R. (1998) Depression of excitability by sphingosine 1-phosphate in rat ventricular myocytes. Am. J. Physiol. 275, H2291-H2299
119. 119 Stukey, J. and Carmen, G. M. (1997) Identification of a novel phosphatase sequence motif. Protein Sci. 6, 469-472
120. 120 Zhang, Q.-X., Pilquil, C. S., Dewald, J., Berthiaume, L. G. and Brindley, D. N. (2000) Identification of structurally important domains of lipid phosphate phosphatase-1 : implications for sites of action. Biochem. J. 345, 181-184
121. 121 Jasinska, R., Zhang, Q.-X., Pilquil, C., Singh, I., Xu, J., Dewald, J., Dillon, D. A., Berthiaume, L. G., Carman, G. M., Waggoner, D. W. and Brindley, D. N. (1999) Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters. Biochem. J. 340, 677-686
122. 122 Tate, R. J., Tolan, D. and Pyne, S. (1999) Molecular cloning of magnesium-independent type 2 phosphatidic acid phosphatase from airway smooth muscle. Cell. Signalling 11, 515-522
123. 123 Ghosh, T. K., Bian, J. and Gill, D. L. (1990) Intracellular calcium release mediated by sphingosine derivatives generated in cells. Science 248, 1653-1656
124. 124 Ghosh, T. K., Bian, J. and Gill, D. L. (1994) Sphingosine 1-phosphale generated in the endoplasmic reticulum membrane activates release of stored calcium. J. Biol. Chem. 269, 22628-22635
125. 125 Zhang, H., Desai, N. N., Olivera, A., Seki, T., Brooker, G. and Spiegel, S. (1991) Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation. J. Cell Biol. 114, 155-167
126. 126 Goodemote, K. A., Mattie, M. E., Berger, A. and Spiegel, S. (1995) Involvement of a pertussis toxin-sensitive G protein in the mitogenic signalling pathways of sphingosine 1-phosphate. J. Biol. Chem. 270, 10272-10277
127. 127 Tolan, D., Conway, A.-M., Pyne, N. J. and Pyne, S. (1997) Sphingosine prevents diacylglycerol signalling to mitogen-activated protein kinase in airway smooth muscle. Am. J. Physiol. 273, C928-C936
128. 128 Tolan, D., Conway, A.-M., Steele, L., Pyne, S. and Pyne, N. J. (1996) The identification of DL-threo dihydrosphingosine and sphingosine as novel inhibitors of extracellular signal-regulated kinase signalling in airway smooth muscle. Br. J. Pharmacol. 119, 185-186
129. 129 Hannun, Y. A. and Bell, R. M. (1989) Functions of sphingolipids and sphingolipid breakdown products in cellular regulation. Science 243, 500-507
130. 130 Tolan, D., Conway. A.-M., Rakhit, S., Pyne, N. J. and Pyne, S. (1999) Assessment of the extracellular and intracellular actions of sphingosine 1-phosphate by using the p42/p44 mitogen-activated protein kinase cascade as a model Cell. Signalling 11, 349-354
131. 131 Conway, A.-M., Rakhit, S., Pyne, S. and Pyne, N. J. (1999) Platelet-derived growth factor-stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle: role of pertussis toxin-sensitive G-proteins, c-Src tyrosine kinases and phosphoinositide 3-kinase. Biochem. J. 337, 171-177
132. 132 Edsall, L. C., Van Brooklyn, J. R., Cuvillier, O., Kleuser, B. and Spiegel, S. (1998) N,N-dimethylspningosine is a potent competitive inhibitor of sphingosine kinase but rot of protein kinase C: modulation of cellular levels of sphingosine 1-phosphate and ceramide. Biochemistry 37, 12892-12898
133. 133 Cuvillier, O., Rosenthal, D. S., Smulson, M. E. and Spiegel, S. (1998) Sphingosine 1-phosphate inhibits activation of caspases that cleave poly(ADP-ribose) polymerase and lamins during Fas-and ceramide-mediated apoptosis in Jurkat T lymphocytes. J. Biol. Chem. 273, 2910-2916
134. 2+ signalling in transformed oligodendrocytes. J. Biol. Chem. 271, 295-301
135. 2+ signalling through modulation of sphingolipid metabolism. FASEB J. 13, 1291-1301
136. 136 Ayar, A., Thatcher, N. M., Zehavi, U., Trentham, D. R. and Scott, R. H. (1998) Mobilization of intracellular calcium by intracellular flash photolysis of caged dihydrosphingosine in cultured neonatal rat sensory neurones. Acta Biochim. Polon. 45, 311-326
137. 137 Huang, W.-C. and Cbueh, S.-H. (1996) Calcium mobilization from the intracellular mitochondrial and non-mitochondrial stores of the rat cerebellum. Brain Res. 718, 151-158
138. 138 Durieux, M E., Carlisle, S. J., Salafranca, M. N. and Lynch, K. R. (1993) Responses to sphingosine-1 -phosphate in X. laevis oocytes: similarities with lysophosphatidic acid signaling. Am. J. Physiol. 264, C1360-C1364
139. 139 Orlati, S., Hrelia, S. and Rugolo, M. (1997) Pertussis toxin-and PMA-insensitive calcium mobilization by sphingosine in CFPAC-1 cells: evidence for a phosphatidic acid-dependent mechanism. Biochim. Biophys. Acta 1358, 93-102
140. 140 Sabala, P., Wiktorek, M., Czarny, M., Chaban, V. and Baranska, J. (1996) Sphingosine stimulates calcium mobilization and modulates calcium signals evoked by thapsigargin in glioma C6 cells. Acta Neurol. Exp. 56, 507-513
141. 2+-release channel activity by sphingosine. Am. J. Physiol 272, C1465-C1474
142. 142 Betto, R., Teresi, A., Turcato, F., Salviati, G., Sabbadini, R. A., Krown, K., Glembotski, C. C., Kindman, L. A., Detlbarn, C., Pereon, Y. et al. (1997) Sphingosylphosphocholine modulates the ryanodine receptor/calcium-release channel of cardiac sarcoplasmic reticulum membranes. Biochem. J. 322, 327-333
143. 143 Orlati, S., Porcelli, A. M., Hrelia, S., Lorenzini, A. and Rugolo, M. (1998) Intracellular calcium mobilization and phospholipid degradation in sphingosylphosphorylcholine-stimulated human airway epithelial cells. Biochem. J. 334, 641-649
144. 144 Orlati, S., Porcelli, A. M , Hrelia, S. and Rugolo, M. (1998) Sphingosylphosphorylcholine and sphingosine-1-phosphate mobilise cytosolic calcium through different mechanisms in human airway epithelial cells. Cell Calcium 23, 387-394
145. 145 Zehavi, U. (1997) Synthesis of potentially caged sphingolipids, possible precursors of cellular modulators and second messengers. Chem. Phys. Lipids 90, 55-51
146. 146 Qiao, L, Kozikowski, A. P., Olivera, A. and Spiegel, S. (1998) Synthesis and evaluation of a photolyzable derivative of sphingosine 1-phosphate - caged SPP. Bioinorg. Med. Chem. Lett. 8, 711-714
147. 147 Hofmann, K. and Dixit, V. M. (1998) Ceramide in apoptosis - does it really matter? Trends Biochem. Sci. 23, 374-377
148. 148 Kolesnick, R. J. and Hannun, Y. A. (1999) Ceramide and apoptosis Trends Biochem. Sci. 24, 224-225
149. 149 Coroneos, E., Wang, Y., Panuska, J. R., Templeton, D. J. and Rester, M. (1996) Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades. Biochem. J. 316, 13-17
150. 150 Edsall, L. C., Pirianov, G. G. and Spiegel, S. (1997) Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation. J. Neurosci. 17, 6952-6960
151. 151 Coroneos, E., Martinez, M., McKenna, S. and Kester, M. (1995) Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation. J. Biol. Chem. 270, 23305-23309
152. 152 Zhang, H., Desai, N. N., Murphey, J. M. and Spiegel, S. (1990) Increases in phosphatidic acid levels accompany sphingosine-stimulated proliferation of quiescent Swiss 3T3 cells. J. Biol. Chem. 265, 21309-21316
153. 153 Tornquist, K., Saarinen, P., Vainio, M. and Ahlstrom, M. (1997) Sphingosine 1-phosphate mobilizes sequestered calcium, activates calcium entry and stimulates DNA synthesis in thyroid FRTL-5 cells. Endocrinology 138, 4049-4057
154. 154 Marshall, C. J. (1995) Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80, 179-185
155. 155 Chung, T., Crilly, K. S., Anderson, W. H. and Kiss, Z. (1997) ATP-dependent choline phosphate-induced mitogenesis in fibroblasts involves activation of p70 S6 kinase and phosphatidylinositol 3′-kinase through an extracellular site. Synergistic mitogenic effects of choline phosphate and sphingosine 1-phosphate. J. Biol. Chem. 272, 3064-3072
156. 156 Kiss, Z. and Mukherjee, J. J. (1997) Phosphocholine and sphingosine 1-phosphate synergistically stimulate DNA synthesis by a MAP kinase-dependent mechanism. FEBS Lett. 412, 197-200
157. 157 Kiss, Z., Crilly, K. S. and Anderson, W. H. (1997) Extracellular sphingosine 1-phosphate stimulates formation of ethanolamine from phosphatidylethanolamine: modulation of sphingosine 1-phosphate-induced mitogenesis by ethanolamine. Biochem. J. 328, 383-391
158. 158 Shatrov, V. A., Lehmann, V. and Chouaib, S. (1997) Sphingosine-1-phosphate mobilizes intracellular calcium and activates transcription factor NF-κB in U937 cells. Biochem. Biophys. Res. Commun. 234, 121-124
159. 1-coupled cell surface receptor. Potential involvement in angiogenesis. J. Biol. Chem. 274, 35343-35350
160. 160 Wang, F., Nohara, K., Olivera, A., Thompson, E. W. and Spiegel, S. (1999) Involvement of local adhesion kinase in inhibition of motilily of human breast cancer cells by sphingosine 1-phosphate. Exp. Cell. Res. 247, 17-28
161. 161 Xia, P., Gamble, J. R., Rye, K.-A., Wang, L. Hii, C. S. T., Cockerill, P., Khew-Goodall, Y., Bert, A. G., Barters, P. J. and Vadas, M. A. (1998) Tumor necrosis factor-alpha induces adhesion molecule expression through the sphingosine kinase pathway. Proc. Natl Acad. Sci. U.S.A. 95, 14196-14201
162. 162 Rizza, C., Leitinger, N., Yue, J., Fischer, D. J., Wang, D.-A., Shin, P. T., Lee, H., Tigyi, G. and Berliner, J. A. (1999) Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction. Lab. Invest. 79, 1227-1235
163. 163 Kozawa, O., Suzuki, A., Kaida, T., Tokuda, H. and Uematsu, T. (1997) Tumor necrosis factor-alpha autoregulates interleukin-6 synthesis via activation of protein kinase C. Function of sphingosine 1-phosphate and phosphatidylcholine-specitic phospholipase C. J. Biol. Chem. 272, 25099-25104
164. 164 Hung, W.-C. and Chuang, L.-Y. (1996) Induction of apoptosis by sphingosine 1-phosphate in human hepatoma cells is associated with increased expression of bax gene product. Biochem. Biophys. Res. Commun. 229, 11-15
165. 165 Postma, F. R., Jalink, K., Hengeveld, T. and Moolenaar, W. H. (1996) Sphingosine 1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor. EMBO J. 15, 2388-2392
166. 166 Sato, K., Tomura, H, Igarashi, Y., Di, M. and Okajima, F. (1997) Exogenous sphingosine l-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells. Biochem. Biophys. Res. Commun. 240, 329-334
167. 167 Goetzl, E. J., Kong, Y. and Mei, B. (1999) Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. J. Immunol 162, 2049-2056
168. 168 Goetzl, E. J., Dolezalova, H., Kong, Y., Hu, Y.-L, Jaffe, R. B., Kalli, K. R. and Conover, C. A. (1999) Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer. Cancer Res. 59, 5370-5375
169. 169 Goetzl, E. J., Dolezalova, H., Kong, Y. and Zeng, L. (1999) Dual mechanisms for lysophospholipid induction of proliferation of human breast carcinoma cells. Cancer Res. 59, 4732-4737
170. 170 Lee, M J., Thangada, S., Claffey, K. P., Ancellin, N., Liu, C. H., Kluk, M., Volpi, M., Sha'afi, R. I. and Hla, T. (1999) Vascular endothelial cell adheren junction assembly and morphogenesis by sphingosine 1-phosphate Cell 99, 301-312
171. 171 Lee, O.-H., Kim, Y.-M., Lee, Y. M., Moon, E.-J., Lee, D.-J., Kim, J.-H., Kim, K.-W. and Kwon, Y.-G. (1999) Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signalling mechanism in human umbilical endothelial cells. Biochem. Biophys. Res. Commun. 264, 743-750
172. 172 Kawa, S., Kimura, S., Hakomori, S.-I. and Igarashi, Y. (1997) Inhibition of chemotactic motility and trans-endothelial migration of human neutrophils by sphingosine 1-phosphate. FEBS Lett. 420, 196-200
173. 173 Prieschl, E. E., Csonga, R., Novotny, V. and Baumruker, T. (1999) The balance between sphingosine and sphingosine 1-phosphate is decisive for mast cell activation after Fcε receptor I triggering. J. Exp. Med. 190, 1-8
174. 174 Zwick, E., Hackel, P. O., Prenzel, N. and Ullrich, A. (1999) The EGF receptor as a central transducer of heterologous signalling systems. Trends Pharmacol Sci. 20, 408-412