-
1
-
-
0016063911
-
The genetics of Caenorhabditis elegans
-
Brenner, S. The genetics of Caenorhabditis elegans. Genetics 77, 71-94 (1974).
-
(1974)
Genetics
, vol.77
, pp. 71-94
-
-
Brenner, S.1
-
2
-
-
0014804012
-
Genetic control of the cell-division cycle in yeast
-
Hartwell, L. H., Culotti, J. & Reid, B. Genetic control of the cell-division cycle in yeast. I. Detection of mutants. Proc. Natl Acad. Sci. USA 66, 352-359 (1970).
-
(1970)
I. Detection of Mutants. Proc. Natl Acad. Sci. USA
, vol.66
, pp. 352-359
-
-
Hartwell, L.H.1
Culotti, J.2
Reid, B.3
-
3
-
-
0034303573
-
Role of Drosophila IKK? in a toll-independent antibacterial immune response
-
Rutschmann, S. et al. Role of Drosophila IKK? in a toll-independent antibacterial immune response. Nat. Immunol. 1, 342-347 (2000).
-
(2000)
Nat. Immunol.
, vol.1
, pp. 342-347
-
-
Rutschmann, S.1
-
4
-
-
0019133661
-
Mutations affecting segment number and polarity in Drosophila
-
Nusslein-Volhard, C. & Wieschaus, E. Mutations affecting segment number and polarity in Drosophila. Nature 287, 795-801 (1980).
-
(1980)
Nature
, vol.287
, pp. 795-801
-
-
Nusslein-Volhard, C.1
Wieschaus, E.2
-
5
-
-
12144289681
-
A large-scale RNAi screen in human cells identifies new components of the p53 pathway
-
Berns, K. et al. A large-scale RNAi screen in human cells identifies new components of the p53 pathway. Nature 428, 431-437 (2004).
-
(2004)
Nature
, vol.428
, pp. 431-437
-
-
Berns, K.1
-
6
-
-
12144288006
-
A resource for large-scale RNAinterference-based screens in mammals
-
Paddison, P. J. et al. A resource for large-scale RNAinterference-based screens in mammals. Nature 428, 427-431 (2004).
-
(2004)
Nature
, vol.428
, pp. 427-431
-
-
Paddison, P.J.1
-
7
-
-
70849098603
-
Haploid genetic screens in human cells identify host factors used by pathogens
-
Carette, J. E. et al. Haploid genetic screens in human cells identify host factors used by pathogens. Science 326, 1231-1235 (2009).
-
(2009)
Science
, vol.326
, pp. 1231-1235
-
-
Carette, J.E.1
-
8
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819-823 (2013).
-
(2013)
Science
, vol.339
, pp. 819-823
-
-
Cong, L.1
-
9
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823-826 (2013).
-
(2013)
Science
, vol.339
, pp. 823-826
-
-
Mali, P.1
-
10
-
-
84876567971
-
RNA-programmed genome editing in human cells
-
Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).
-
(2013)
ELife
, vol.2
, pp. e00471
-
-
Jinek, M.1
-
11
-
-
84974622979
-
CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes
-
Evers, B. et al. CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes. Nat. Biotechnol. 34, 631-633 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 631-633
-
-
Evers, B.1
-
12
-
-
84978790889
-
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
-
DeJesus, R. et al. Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62. eLife 5, e17290 (2016).
-
(2016)
ELife
, vol.5
, pp. e17290
-
-
DeJesus, R.1
-
13
-
-
84949233942
-
High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities
-
Hart, T. et al. High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities. Cell 163, 1515-1526 (2015).
-
(2015)
Cell
, vol.163
, pp. 1515-1526
-
-
Hart, T.1
-
14
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem, O. et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343, 84-87 (2014).
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
-
15
-
-
84892749369
-
Genetic screens in human cells using the CRISPR-Cas9 system
-
Wang, T., Wei, J. J., Sabatini, D. M. & Lander, E. S. Genetic screens in human cells using the CRISPR-Cas9 system. Science 343, 80-84 (2014).
-
(2014)
Science
, vol.343
, pp. 80-84
-
-
Wang, T.1
Wei, J.J.2
Sabatini, D.M.3
Lander, E.S.4
-
16
-
-
84928205754
-
Highthroughput functional genomics using CRISPR-Cas9
-
Shalem, O., Sanjana, N. E. & Zhang, F. Highthroughput functional genomics using CRISPR-Cas9. Nat. Rev. Genet. 16, 299-311 (2015).
-
(2015)
Nat. Rev. Genet.
, vol.16
, pp. 299-311
-
-
Shalem, O.1
Sanjana, N.E.2
Zhang, F.3
-
17
-
-
84900861730
-
High-throughput screening of a CRISPR/ Cas9 library for functional genomics in human cells
-
Zhou, Y. et al. High-throughput screening of a CRISPR/ Cas9 library for functional genomics in human cells. Nature 509, 487-491 (2014).
-
(2014)
Nature
, vol.509
, pp. 487-491
-
-
Zhou, Y.1
-
18
-
-
34147219730
-
Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
-
Evans, M. J. et al. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 446, 801-805 (2007).
-
(2007)
Nature
, vol.446
, pp. 801-805
-
-
Evans, M.J.1
-
19
-
-
60149090028
-
Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
-
Ploss, A. et al. Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 457, 882-886 (2009).
-
(2009)
Nature
, vol.457
, pp. 882-886
-
-
Ploss, A.1
-
20
-
-
84940487299
-
SEC14L2 enables pan-genotype HCV replication in cell culture
-
Saeed, M. et al. SEC14L2 enables pan-genotype HCV replication in cell culture. Nature 524, 471-475 (2015).
-
(2015)
Nature
, vol.524
, pp. 471-475
-
-
Saeed, M.1
-
21
-
-
84895904323
-
Pan-viral specificity of IFNinduced genes reveals new roles for cGAS in innate immunity
-
Schoggins, J. W. et al. Pan-viral specificity of IFNinduced genes reveals new roles for cGAS in innate immunity. Nature 505, 691-695 (2014).
-
(2014)
Nature
, vol.505
, pp. 691-695
-
-
Schoggins, J.W.1
-
22
-
-
79955542915
-
A diverse range of gene products are effectors of the type i interferon antiviral response
-
Schoggins, J. W. et al. A diverse range of gene products are effectors of the type I interferon antiviral response. Nature 472, 481-485 (2011).
-
(2011)
Nature
, vol.472
, pp. 481-485
-
-
Schoggins, J.W.1
-
23
-
-
84959344911
-
The ORFeome Collaboration: A genome-scale human ORF-clone resource
-
ORFeome Collaboration
-
ORFeome Collaboration. The ORFeome Collaboration: a genome-scale human ORF-clone resource. Nat. Methods 13, 191-192 (2016).
-
(2016)
Nat. Methods
, vol.13
, pp. 191-192
-
-
-
24
-
-
84969169377
-
Virus-host interactions: From unbiased genetic screens to function
-
Ramage, H. & Cherry, S. Virus-host interactions: from unbiased genetic screens to function. Annu. Rev. Virol. 2, 497-524 (2015).
-
(2015)
Annu. Rev. Virol.
, vol.2
, pp. 497-524
-
-
Ramage, H.1
Cherry, S.2
-
25
-
-
80052851832
-
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
-
Carette, J. E. et al. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature 477, 340-343 (2011).
-
(2011)
Nature
, vol.477
, pp. 340-343
-
-
Carette, J.E.1
-
26
-
-
84903289135
-
Lassa virus entry requires a trigger-induced receptor switch
-
Jae, L. T. et al. Lassa virus entry requires a trigger-induced receptor switch. Science 344, 1506-1510 (2014).
-
(2014)
Science
, vol.344
, pp. 1506-1510
-
-
Jae, L.T.1
-
27
-
-
84859907529
-
Ebola virus entry requires the hostprogrammed recognition of an intracellular receptor
-
Miller, E. H. et al. Ebola virus entry requires the hostprogrammed recognition of an intracellular receptor. EMBO J. 31, 1947-1960 (2012).
-
(2012)
EMBO J.
, vol.31
, pp. 1947-1960
-
-
Miller, E.H.1
-
28
-
-
80052868218
-
Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection
-
Cote, M. et al. Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection. Nature 477, 344-348 (2011).
-
(2011)
Nature
, vol.477
, pp. 344-348
-
-
Cote, M.1
-
29
-
-
84960154024
-
Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies
-
Bornholdt, Z. A. et al. Host-primed Ebola virus GP exposes a hydrophobic NPC1 receptor-binding pocket, revealing a target for broadly neutralizing antibodies. mBio 7, e02154-15 (2016).
-
(2016)
MBio
, vol.7
, pp. e02154-e02215
-
-
Bornholdt, Z.A.1
-
30
-
-
84969961924
-
Structural insights into the Niemann-Pick C1 (NPC1)-mediated cholesterol transfer and Ebola infection
-
Gong, X. et al. Structural insights into the Niemann-Pick C1 (NPC1)-mediated cholesterol transfer and Ebola infection. Cell 165, 1467-1478 (2016).
-
(2016)
Cell
, vol.165
, pp. 1467-1478
-
-
Gong, X.1
-
31
-
-
84954245042
-
Ebola viral glycoprotein bound to its endosomal receptor Niemann-Pick C1
-
Wang, H. et al. Ebola viral glycoprotein bound to its endosomal receptor Niemann-Pick C1. Cell 164, 258-268 (2016).
-
(2016)
Cell
, vol.164
, pp. 258-268
-
-
Wang, H.1
-
32
-
-
84994772159
-
Ebola virus glycoprotein with increased infectivity dominated the 2013-2016 epidemic
-
Diehl, W. E. et al. Ebola virus glycoprotein with increased infectivity dominated the 2013-2016 epidemic. Cell 167, 1088-1098.e6 (2016).
-
(2016)
Cell
, vol.167
, pp. 1088e6-1088e6
-
-
Diehl, W.E.1
-
33
-
-
84994772093
-
Human adaptation of Ebola virus during the West African outbreak
-
Urbanowicz, R. A. et al. Human adaptation of Ebola virus during the West African outbreak. Cell 167, 1079-1087.e5 (2016).
-
(2016)
Cell
, vol.167
, pp. 1079e5-1079e5
-
-
Urbanowicz, R.A.1
-
34
-
-
85014098503
-
PLA2G16 represents a switch between entry and clearance of Picornaviridae
-
Staring, J. et al. PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature 541, 412-416 (2017).
-
(2017)
Nature
, vol.541
, pp. 412-416
-
-
Staring, J.1
-
35
-
-
84957599961
-
An essential receptor for adeno-associated virus infection
-
Pillay, S. et al. An essential receptor for adeno-associated virus infection. Nature 530, 108-112 (2016).
-
(2016)
Nature
, vol.530
, pp. 108-112
-
-
Pillay, S.1
-
36
-
-
84943635310
-
Synthesis of an arrayed sgRNA library targeting the human genome
-
Schmidt, T., Schmid-Burgk, J. L. & Hornung, V. Synthesis of an arrayed sgRNA library targeting the human genome. Sci. Rep. 5, 14987 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 14987
-
-
Schmidt, T.1
Schmid-Burgk, J.L.2
Hornung, V.3
-
37
-
-
84913530543
-
Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line
-
Essletzbichler, P. et al. Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line. Genome Res. 24, 2059-2065 (2014).
-
(2014)
Genome Res.
, vol.24
, pp. 2059-2065
-
-
Essletzbichler, P.1
-
38
-
-
84963604684
-
Derivation and differentiation of haploid human embryonic stem cells
-
Sagi, I. et al. Derivation and differentiation of haploid human embryonic stem cells. Nature 532, 107-111 (2016).
-
(2016)
Nature
, vol.532
, pp. 107-111
-
-
Sagi, I.1
-
39
-
-
82755182211
-
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells
-
Elling, U. et al. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell 9, 563-574 (2011).
-
(2011)
Cell Stem Cell
, vol.9
, pp. 563-574
-
-
Elling, U.1
-
40
-
-
80455174608
-
Derivation of haploid embryonic stem cells from mouse embryos
-
Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. Nature 479, 131-134 (2011).
-
(2011)
Nature
, vol.479
, pp. 131-134
-
-
Leeb, M.1
Wutz, A.2
-
41
-
-
84930666890
-
Haploid mouse embryonic stem cells: Rapid genetic screening and germline transmission
-
Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. Annu. Rev. Cell Dev. Biol. 30, 705-722 (2014).
-
(2014)
Annu. Rev. Cell Dev. Biol.
, vol.30
, pp. 705-722
-
-
Wutz, A.1
-
42
-
-
84969257208
-
Hunting viral receptors using haploid cells
-
Pillay, S. & Carette, J. E. Hunting viral receptors using haploid cells. Annu. Rev. Virol. 2, 219-239 (2015).
-
(2015)
Annu. Rev. Virol.
, vol.2
, pp. 219-239
-
-
Pillay, S.1
Carette, J.E.2
-
43
-
-
84905262730
-
Improved vectors and genome-wide libraries for CRISPR screening
-
Sanjana, N. E., Shalem, O. & Zhang, F. Improved vectors and genome-wide libraries for CRISPR screening. Nat. Methods 11, 783-784 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 783-784
-
-
Sanjana, N.E.1
Shalem, O.2
Zhang, F.3
-
44
-
-
84957605863
-
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
-
Doench, J. G. et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nat. Biotechnol. 34, 184-191 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 184-191
-
-
Doench, J.G.1
-
45
-
-
84947471999
-
Identification and characterization of essential genes in the human genome
-
Wang, T. et al. Identification and characterization of essential genes in the human genome. Science 350, 1096-1101 (2015).
-
(2015)
Science
, vol.350
, pp. 1096-1101
-
-
Wang, T.1
-
46
-
-
85008257169
-
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
-
Liu, S. J. et al. CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells. Science 355, aah7111 (2016).
-
(2016)
Science
, vol.355
, pp. aah7111
-
-
Liu, S.J.1
-
47
-
-
85018853205
-
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
-
Joung, J. et al. Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening. Nat. Protoc. 12, 828-863 (2017).
-
(2017)
Nat. Protoc.
, vol.12
, pp. 828-863
-
-
Joung, J.1
-
48
-
-
0027228422
-
Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: Concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells
-
Burns, J. C., Friedmann, T., Driever, W., Burrascano, M. & Yee, J. K. Vesicular stomatitis virus G glycoprotein pseudotyped retroviral vectors: concentration to very high titer and efficient gene transfer into mammalian and nonmammalian cells. Proc. Natl Acad. Sci. USA 90, 8033-8037 (1993).
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 8033-8037
-
-
Burns, J.C.1
Friedmann, T.2
Driever, W.3
Burrascano, M.4
Yee, J.K.5
-
49
-
-
0031954296
-
Characterization of Ebola virus entry by using pseudotyped viruses: Identification of receptor-deficient cell lines
-
Wool-Lewis, R. J. & Bates, P. Characterization of Ebola virus entry by using pseudotyped viruses: identification of receptor-deficient cell lines. J. Virol. 72, 3155-3160 (1998).
-
(1998)
J. Virol.
, vol.72
, pp. 3155-3160
-
-
Wool-Lewis, R.J.1
Bates, P.2
-
50
-
-
0024514346
-
Sindbis virus: An efficient, broad host range vector for gene expression in animal cells
-
Xiong, C. et al. Sindbis virus: an efficient, broad host range vector for gene expression in animal cells. Science 243, 1188-1191 (1989).
-
(1989)
Science
, vol.243
, pp. 1188-1191
-
-
Xiong, C.1
-
51
-
-
0345188811
-
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
-
Lohmann, V. et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285, 110-113 (1999).
-
(1999)
Science
, vol.285
, pp. 110-113
-
-
Lohmann, V.1
-
52
-
-
0023755104
-
Translation in mammalian cells of a gene linked to the poliovirus 5? Noncoding region
-
Trono, D., Pelletier, J., Sonenberg, N. & Baltimore, D. Translation in mammalian cells of a gene linked to the poliovirus 5? noncoding region. Science 241, 445-448 (1988).
-
(1988)
Science
, vol.241
, pp. 445-448
-
-
Trono, D.1
Pelletier, J.2
Sonenberg, N.3
Baltimore, D.4
-
53
-
-
0025976987
-
An RNA hairpin at the extreme 5? End of the poliovirus RNA genome modulates viral translation in human cells
-
Simoes, E. A. & Sarnow, P. An RNA hairpin at the extreme 5? end of the poliovirus RNA genome modulates viral translation in human cells. J. Virol. 65, 913-921 (1991).
-
(1991)
J. Virol.
, vol.65
, pp. 913-921
-
-
Simoes, E.A.1
Sarnow, P.2
-
54
-
-
58149521944
-
Highly parallel identification of essential genes in cancer cells
-
Luo, B. et al. Highly parallel identification of essential genes in cancer cells. Proc. Natl Acad. Sci. USA 105, 20380-20385 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 20380-20385
-
-
Luo, B.1
-
55
-
-
35848929692
-
A probability-based approach for the analysis of large-scale RNAi screens
-
Konig, R. et al. A probability-based approach for the analysis of large-scale RNAi screens. Nat. Methods 4, 847-849 (2007).
-
(2007)
Nat. Methods
, vol.4
, pp. 847-849
-
-
Konig, R.1
-
56
-
-
84996567029
-
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
-
Li, W. et al. MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens. Genome Biol. 15, 554 (2014).
-
(2014)
Genome Biol.
, vol.15
, pp. 554
-
-
Li, W.1
-
57
-
-
84880570576
-
High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells
-
Fu, Y. et al. High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nat. Biotechnol. 31, 822-826 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 822-826
-
-
Fu, Y.1
-
58
-
-
84884165315
-
DNA targeting specificity of RNAguided Cas9 nucleases
-
Hsu, P. D. et al. DNA targeting specificity of RNAguided Cas9 nucleases. Nat. Biotechnol. 31, 827-832 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 827-832
-
-
Hsu, P.D.1
-
59
-
-
84884155038
-
High-throughput profiling of offtarget DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
-
Pattanayak, V. et al. High-throughput profiling of offtarget DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat. Biotechnol. 31, 839-843 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 839-843
-
-
Pattanayak, V.1
-
60
-
-
84947471998
-
Gene essentiality and synthetic lethality in haploid human cells
-
Blomen, V. A. et al. Gene essentiality and synthetic lethality in haploid human cells. Science 350, 1092-1096 (2015).
-
(2015)
Science
, vol.350
, pp. 1092-1096
-
-
Blomen, V.A.1
-
61
-
-
84977639708
-
Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens
-
Marceau, C. D. et al. Genetic dissection of Flaviviridae host factors through genome-scale CRISPR screens. Nature 535, 159-163 (2016).
-
(2016)
Nature
, vol.535
, pp. 159-163
-
-
Marceau, C.D.1
-
62
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
Wu, X., Li, Y., Crise, B. & Burgess, S. M. Transcription start regions in the human genome are favored targets for MLV integration. Science 300, 1749-1751 (2003).
-
(2003)
Science
, vol.300
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
63
-
-
79958114328
-
Global gene disruption in human cells to assign genes to phenotypes by deep sequencing
-
Carette, J. E. et al. Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nat. Biotechnol. 29, 542-546 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 542-546
-
-
Carette, J.E.1
-
64
-
-
84974603544
-
Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens
-
Timms, R. T. et al. Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens. Nat. Commun. 7, 11786 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11786
-
-
Timms, R.T.1
-
65
-
-
84927719625
-
Combating emerging viral threats
-
Bekerman, E. & Einav, S. Combating emerging viral threats. Science 348, 282-283 (2015).
-
(2015)
Science
, vol.348
, pp. 282-283
-
-
Bekerman, E.1
Einav, S.2
-
66
-
-
84876804736
-
The global distribution and burden of dengue
-
Bhatt, S. et al. The global distribution and burden of dengue. Nature 496, 504-507 (2013).
-
(2013)
Nature
, vol.496
, pp. 504-507
-
-
Bhatt, S.1
-
67
-
-
84978898104
-
Assessing the global threat from Zika virus
-
Lessler, J. et al. Assessing the global threat from Zika virus. Science 353, aaf8160 (2016).
-
(2016)
Science
, vol.353
, pp. aaf8160
-
-
Lessler, J.1
-
68
-
-
84961223887
-
Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: A case-control study
-
Cao-Lormeau, V. M. et al. Guillain-Barre syndrome outbreak associated with Zika virus infection in French Polynesia: a case-control study. Lancet 387, 1531-1539 (2016).
-
(2016)
Lancet
, vol.387
, pp. 1531-1539
-
-
Cao-Lormeau, V.M.1
-
69
-
-
84947048286
-
A CRISPR-based screen identifies genes essential for West-Nile-virus-induced cell death
-
Ma, H. et al. A CRISPR-based screen identifies genes essential for West-Nile-virus-induced cell death. Cell Rep. 12, 673-683 (2015).
-
(2015)
Cell Rep.
, vol.12
, pp. 673-683
-
-
Ma, H.1
-
70
-
-
84977606002
-
A CRISPR screen defines a signal peptide processing pathway required by flaviviruses
-
Zhang, R. et al. A CRISPR screen defines a signal peptide processing pathway required by flaviviruses. Nature 535, 164-168 (2016).
-
(2016)
Nature
, vol.535
, pp. 164-168
-
-
Zhang, R.1
-
71
-
-
85003706344
-
Identification of Zika virus and Dengue virus dependency factors using functional genomics
-
Savidis, G. et al. Identification of Zika virus and Dengue virus dependency factors using functional genomics. Cell Rep. 16, 232-246 (2016).
-
(2016)
Cell Rep.
, vol.16
, pp. 232-246
-
-
Savidis, G.1
-
72
-
-
84959259856
-
Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation
-
Cherepanova, N. A. & Gilmore, R. Mammalian cells lacking either the cotranslational or posttranslocational oligosaccharyltransferase complex display substrate-dependent defects in asparagine linked glycosylation. Sci. Rep. 6, 20946 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 20946
-
-
Cherepanova, N.A.1
Gilmore, R.2
-
73
-
-
0037450802
-
Substratespecific function of the translocon-associated protein complex during translocation across the ER membrane
-
Fons, R. D., Bogert, B. A. & Hegde, R. S. Substratespecific function of the translocon-associated protein complex during translocation across the ER membrane. J. Cell Biol. 160, 529-539 (2003).
-
(2003)
J. Cell Biol.
, vol.160
, pp. 529-539
-
-
Fons, R.D.1
Bogert, B.A.2
Hegde, R.S.3
-
74
-
-
84870763849
-
The mammalian endoplasmic reticulum-associated degradation system
-
Olzmann, J. A., Kopito, R. R. & Christianson, J. C. The mammalian endoplasmic reticulum-associated degradation system. Cold Spring Harb. Perspect. Biol. 5, a013185 (2013).
-
(2013)
Cold Spring Harb. Perspect. Biol.
, vol.5
, pp. a013185
-
-
Olzmann, J.A.1
Kopito, R.R.2
Christianson, J.C.3
-
75
-
-
84255169603
-
Defining human ERAD networks through an integrative mapping strategy
-
Christianson, J. C. et al. Defining human ERAD networks through an integrative mapping strategy. Nat. Cell Biol. 14, 93-105 (2011).
-
(2011)
Nat. Cell Biol.
, vol.14
, pp. 93-105
-
-
Christianson, J.C.1
-
76
-
-
85091357761
-
The ubiquitous and ancient ER membrane protein complex (EMC): Tether or not?
-
Wideman, J. G. The ubiquitous and ancient ER membrane protein complex (EMC): tether or not? F1000Res. 4, 624 (2015).
-
(2015)
F1000Res.
, vol.4
, pp. 624
-
-
Wideman, J.G.1
-
77
-
-
84928213004
-
Receptors and routes of dengue virus entry into the host cells
-
Cruz-Oliveira, C. et al. Receptors and routes of dengue virus entry into the host cells. FEMS Microbiol. Rev. 39, 155-170 (2015).
-
(2015)
FEMS Microbiol. Rev.
, vol.39
, pp. 155-170
-
-
Cruz-Oliveira, C.1
-
78
-
-
78751621217
-
Evolving epidemiology of hepatitis C virus
-
Lavanchy, D. Evolving epidemiology of hepatitis C virus. Clin. Microbiol. Infect. 17, 107-115 (2011).
-
(2011)
Clin. Microbiol. Infect.
, vol.17
, pp. 107-115
-
-
Lavanchy, D.1
-
80
-
-
84899430502
-
Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation
-
Madan, V., Paul, D., Lohmann, V. & Bartenschlager, R. Inhibition of HCV replication by cyclophilin antagonists is linked to replication fitness and occurs by inhibition of membranous web formation. Gastroenterology 146, 1361-1372.e9 (2014).
-
(2014)
Gastroenterology
, vol.146
, pp. 1361e9-1361e9
-
-
Madan, V.1
Paul, D.2
Lohmann, V.3
Bartenschlager, R.4
-
81
-
-
84869232160
-
Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors
-
Nag, A., Robotham, J. M. & Tang, H. Suppression of viral RNA binding and the assembly of infectious hepatitis C virus particles in vitro by cyclophilin inhibitors. J. Virol. 86, 12616-12624 (2012).
-
(2012)
J. Virol.
, vol.86
, pp. 12616-12624
-
-
Nag, A.1
Robotham, J.M.2
Tang, H.3
-
82
-
-
0027207885
-
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
-
Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V. & Goff, S. P. Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B. Cell 73, 1067-1078 (1993).
-
(1993)
Cell
, vol.73
, pp. 1067-1078
-
-
Luban, J.1
Bossolt, K.L.2
Franke, E.K.3
Kalpana, G.V.4
Goff, S.P.5
-
83
-
-
84881553622
-
Curing a viral infection by targeting the host: The example of cyclophilin inhibitors
-
Lin, K. & Gallay, P. Curing a viral infection by targeting the host: the example of cyclophilin inhibitors. Antiviral Res. 99, 68-77 (2013).
-
(2013)
Antiviral Res.
, vol.99
, pp. 68-77
-
-
Lin, K.1
Gallay, P.2
-
84
-
-
20344400111
-
Norovirus and its histo-blood group antigen receptors: An answer to a historical puzzle
-
Tan, M. & Jiang, X. Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle. Trends Microbiol. 13, 285-293 (2005).
-
(2005)
Trends Microbiol.
, vol.13
, pp. 285-293
-
-
Tan, M.1
Jiang, X.2
-
85
-
-
84983314890
-
Discovery of a proteinaceous cellular receptor for a norovirus
-
Orchard, R. C. et al. Discovery of a proteinaceous cellular receptor for a norovirus. Science 353, 933-936 (2016).
-
(2016)
Science
, vol.353
, pp. 933-936
-
-
Orchard, R.C.1
-
86
-
-
84991474895
-
Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells
-
Haga, K. et al. Functional receptor molecules CD300lf and CD300ld within the CD300 family enable murine noroviruses to infect cells. Proc. Natl Acad. Sci. USA 113, E6248-E6255 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E6248-E6255
-
-
Haga, K.1
-
87
-
-
84909978282
-
Enteric bacteria promote human and mouse norovirus infection of B cells
-
Jones, M. K. et al. Enteric bacteria promote human and mouse norovirus infection of B cells. Science 346, 755-759 (2014).
-
(2014)
Science
, vol.346
, pp. 755-759
-
-
Jones, M.K.1
-
88
-
-
85006469855
-
A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors
-
Park, R. J. et al. A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors. Nat. Genet. 49, 193-203 (2017).
-
(2017)
Nat. Genet.
, vol.49
, pp. 193-203
-
-
Park, R.J.1
-
89
-
-
84938744950
-
A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks
-
Parnas, O. et al. A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks. Cell 162, 675-686 (2015).
-
(2015)
Cell
, vol.162
, pp. 675-686
-
-
Parnas, O.1
-
90
-
-
84942892037
-
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
-
Shi, J. et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526, 660-665 (2015).
-
(2015)
Nature
, vol.526
, pp. 660-665
-
-
Shi, J.1
-
91
-
-
84947565955
-
The adherens junctions control susceptibility to Staphylococcus aureus ?-toxin
-
Popov, L. M. et al. The adherens junctions control susceptibility to Staphylococcus aureus ?-toxin. Proc. Natl Acad. Sci. USA 112, 14337-14342 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 14337-14342
-
-
Popov, L.M.1
-
92
-
-
84963815220
-
Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus ?-hemolysinmediated toxicity
-
Virreira Winter, S., Zychlinsky, A. & Bardoel, B. W. Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus ?-hemolysinmediated toxicity. Sci. Rep. 6, 24242 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 24242
-
-
Virreira Winter, S.1
Zychlinsky, A.2
Bardoel, B.W.3
-
93
-
-
84991577902
-
CRISPR/Cas9 screens reveal requirements for host cell sulfation and fucosylation in bacterial type III secretion system-mediated cytotoxicity
-
Blondel, C. J. et al. CRISPR/Cas9 screens reveal requirements for host cell sulfation and fucosylation in bacterial type III secretion system-mediated cytotoxicity. Cell Host Microbe 20, 226-237 (2016).
-
(2016)
Cell Host Microbe
, vol.20
, pp. 226-237
-
-
Blondel, C.J.1
-
94
-
-
84986247517
-
A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes
-
Sidik, S. M. et al. A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes. Cell 166, 1423-1435.e12 (2016).
-
(2016)
Cell
, vol.166
, pp. 1423e12-1423e12
-
-
Sidik, S.M.1
-
95
-
-
84969916078
-
A comprehensive, CRISPR-based functional analysis of essential genes in bacteria
-
Peters, J. M. et al. A comprehensive, CRISPR-based functional analysis of essential genes in bacteria. Cell 165, 1493-1506 (2016).
-
(2016)
Cell
, vol.165
, pp. 1493-1506
-
-
Peters, J.M.1
-
96
-
-
84944916655
-
Genome editing of CXCR4 by CRISPR/ cas9 confers cells resistant to HIV-1 infection
-
Hou, P. et al. Genome editing of CXCR4 by CRISPR/ cas9 confers cells resistant to HIV-1 infection. Sci. Rep. 5, 15577 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 15577
-
-
Hou, P.1
-
97
-
-
84940203001
-
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
-
Li, C. et al. Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9. J. Gen. Virol. 96, 2381-2393 (2015).
-
(2015)
J. Gen. Virol.
, vol.96
, pp. 2381-2393
-
-
Li, C.1
-
98
-
-
85000607350
-
Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection
-
Wells, M. F. et al. Genetic ablation of AXL does not protect human neural progenitor cells and cerebral organoids from Zika virus infection. Cell Stem Cell 19, 703-708 (2016).
-
(2016)
Cell Stem Cell
, vol.19
, pp. 703-708
-
-
Wells, M.F.1
-
99
-
-
84986203154
-
Using CRISPR/Cas to study gene function and model disease in vivo
-
Tschaharganeh, D. F., Lowe, S. W., Garippa, R. J. & Livshits, G. Using CRISPR/Cas to study gene function and model disease in vivo. FEBS J. 283, 3194-3203 (2016).
-
(2016)
FEBS J.
, vol.283
, pp. 3194-3203
-
-
Tschaharganeh, D.F.1
Lowe, S.W.2
Garippa, R.J.3
Livshits, G.4
-
101
-
-
84884904381
-
Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination
-
Dickinson, D. J., Ward, J. D., Reiner, D. J. & Goldstein, B. Engineering the Caenorhabditis elegans genome using Cas9-triggered homologous recombination. Nat. Methods 10, 1028-1034 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 1028-1034
-
-
Dickinson, D.J.1
Ward, J.D.2
Reiner, D.J.3
Goldstein, B.4
-
102
-
-
84892437994
-
Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system
-
Bassett, A. R., Tibbit, C., Ponting, C. P. & Liu, J. L. Highly efficient targeted mutagenesis of Drosophila with the CRISPR/Cas9 system. Cell Rep. 4, 220-228 (2013).
-
(2013)
Cell Rep.
, vol.4
, pp. 220-228
-
-
Bassett, A.R.1
Tibbit, C.2
Ponting, C.P.3
Liu, J.L.4
-
103
-
-
84880088705
-
Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease
-
Gratz, S. J. et al. Genome engineering of Drosophila with the CRISPR RNA-guided Cas9 nuclease. Genetics 194, 1029-1035 (2013).
-
(2013)
Genetics
, vol.194
, pp. 1029-1035
-
-
Gratz, S.J.1
-
104
-
-
84888355659
-
Studying immunity to zoonotic diseases in the natural host-keeping it real
-
Bean, A. G. et al. Studying immunity to zoonotic diseases in the natural host-keeping it real. Nat. Rev. Immunol. 13, 851-861 (2013).
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 851-861
-
-
Bean, A.G.1
-
105
-
-
84883819602
-
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
-
Li, D. et al. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat. Biotechnol. 31, 681-683 (2013).
-
(2013)
Nat. Biotechnol.
, vol.31
, pp. 681-683
-
-
Li, D.1
-
106
-
-
84927695100
-
Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti
-
Kistler, K. E., Vosshall, L. B. & Matthews, B. J. Genome engineering with CRISPR-Cas9 in the mosquito Aedes aegypti. Cell Rep. 11, 51-60 (2015).
-
(2015)
Cell Rep.
, vol.11
, pp. 51-60
-
-
Kistler, K.E.1
Vosshall, L.B.2
Matthews, B.J.3
-
107
-
-
84964674960
-
Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency
-
Lei, S. et al. Increased and prolonged human norovirus infection in RAG2/IL2RG deficient gnotobiotic pigs with severe combined immunodeficiency. Sci. Rep. 6, 25222 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 25222
-
-
Lei, S.1
-
108
-
-
84897594300
-
One-step generation of knockout pigs by zygote injection of CRISPR/Cas system
-
Hai, T., Teng, F., Guo, R., Li, W. & Zhou, Q. One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell Res. 24, 372-375 (2014).
-
(2014)
Cell Res.
, vol.24
, pp. 372-375
-
-
Hai, T.1
Teng, F.2
Guo, R.3
Li, W.4
Zhou, Q.5
-
109
-
-
84894081986
-
Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
-
Niu, Y. et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156, 836-843 (2014).
-
(2014)
Cell
, vol.156
, pp. 836-843
-
-
Niu, Y.1
-
110
-
-
84949107913
-
CRISPR/Cas9-mediated genome engineering of the ferret
-
Kou, Z. et al. CRISPR/Cas9-mediated genome engineering of the ferret. Cell Res. 25, 1372-1375 (2015).
-
(2015)
Cell Res.
, vol.25
, pp. 1372-1375
-
-
Kou, Z.1
-
111
-
-
84963682304
-
Targeted mutagenesis in chicken using CRISPR/Cas9 system
-
Oishi, I., Yoshii, K., Miyahara, D., Kagami, H. & Tagami, T. Targeted mutagenesis in chicken using CRISPR/Cas9 system. Sci. Rep. 6, 23980 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 23980
-
-
Oishi, I.1
Yoshii, K.2
Miyahara, D.3
Kagami, H.4
Tagami, T.5
-
112
-
-
84991408997
-
Complexities in ferret influenza virus pathogenesis and transmission models
-
Belser, J. A., Eckert, A. M., Tumpey, T. M. & Maines, T. R. Complexities in ferret influenza virus pathogenesis and transmission models. Microbiol. Mol. Biol. Rev. 80, 733-744 (2016).
-
(2016)
Microbiol. Mol. Biol. Rev.
, vol.80
, pp. 733-744
-
-
Belser, J.A.1
Eckert, A.M.2
Tumpey, T.M.3
Maines, T.R.4
-
113
-
-
84928562543
-
Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system
-
Yuan, M. et al. Efficiently editing the vaccinia virus genome by using the CRISPR-Cas9 system. J. Virol. 89, 5176-5179 (2015).
-
(2015)
J. Virol.
, vol.89
, pp. 5176-5179
-
-
Yuan, M.1
-
114
-
-
84901648428
-
High-efficiency targeted editing of large viral genomes by RNA-guided nucleases
-
Bi, Y. et al. High-efficiency targeted editing of large viral genomes by RNA-guided nucleases. PLoS Pathog. 10, e1004090 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1004090
-
-
Bi, Y.1
-
115
-
-
84923672936
-
CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells
-
Yuen, K. S. et al. CRISPR/Cas9-mediated genome editing of Epstein-Barr virus in human cells. J. Gen. Virol. 96, 626-636 (2015).
-
(2015)
J. Gen. Virol.
, vol.96
, pp. 626-636
-
-
Yuen, K.S.1
-
116
-
-
80755189331
-
Field performance of engineered male mosquitoes
-
Harris, A. F. et al. Field performance of engineered male mosquitoes. Nat. Biotechnol. 29, 1034-1037 (2011).
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 1034-1037
-
-
Harris, A.F.1
-
117
-
-
84900302189
-
Heritable strategies for controlling insect vectors of disease
-
Burt, A. Heritable strategies for controlling insect vectors of disease. Phil. Trans. R. Soc. B 369, 20130432 (2014).
-
(2014)
Phil. Trans. R. Soc. B
, vol.369
, pp. 20130432
-
-
Burt, A.1
-
118
-
-
84938787080
-
Suppression of a field population of Aedes aegypti in Brazil by sustained release of transgenic male mosquitoes
-
Carvalho, D. O. et al. Suppression of a field population of Aedes aegypti in Brazil by sustained release of transgenic male mosquitoes. PLoS Negl Trop. Dis. 9, e0003864 (2015).
-
(2015)
PLoS Negl Trop. Dis.
, vol.9
, pp. e0003864
-
-
Carvalho, D.O.1
-
119
-
-
84960074826
-
Control of mosquito-borne infectious diseases: Sex and gene drive
-
Adelman, Z. N. & Tu, Z. Control of mosquito-borne infectious diseases: sex and gene drive. Trends Parasitol. 32, 219-229 (2016).
-
(2016)
Trends Parasitol.
, vol.32
, pp. 219-229
-
-
Adelman, Z.N.1
Tu, Z.2
-
120
-
-
84953730637
-
A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae
-
Hammond, A. et al. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nat. Biotechnol. 34, 78-83 (2016).
-
(2016)
Nat. Biotechnol.
, vol.34
, pp. 78-83
-
-
Hammond, A.1
-
121
-
-
84931275663
-
A male-determining factor in the mosquito Aedes aegypti
-
Hall, A. B. et al. A male-determining factor in the mosquito Aedes aegypti. Science 348, 1268-1270 (2015).
-
(2015)
Science
, vol.348
, pp. 1268-1270
-
-
Hall, A.B.1
-
122
-
-
84929206935
-
Cas9-mediated targeting of viral RNA in eukaryotic cells
-
Price, A. A., Sampson, T. R., Ratner, H. K., Grakoui, A. & Weiss, D. S. Cas9-mediated targeting of viral RNA in eukaryotic cells. Proc. Natl Acad. Sci. USA 112, 6164-6169 (2015).
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 6164-6169
-
-
Price, A.A.1
Sampson, T.R.2
Ratner, H.K.3
Grakoui, A.4
Weiss, D.S.5
-
123
-
-
84978863697
-
CRISPR/Cas9-mediated genome editing of herpesviruses limits productive and latent infections
-
van Diemen, F. R. et al. CRISPR/Cas9-mediated genome editing of herpesviruses limits productive and latent infections. PLoS Pathog. 12, e1005701 (2016).
-
(2016)
PLoS Pathog.
, vol.12
, pp. e1005701
-
-
Van Diemen, F.R.1
-
124
-
-
84927513847
-
Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication
-
Dong, C. et al. Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication. Antiviral Res. 118, 110-117 (2015).
-
(2015)
Antiviral Res.
, vol.118
, pp. 110-117
-
-
Dong, C.1
-
125
-
-
84969706258
-
Excision of HIV-1 DNA by gene editing: A proof-of-concept in vivo study
-
Kaminski, R. et al. Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study. Gene Ther. 23, 690-695 (2016).
-
(2016)
Gene Ther.
, vol.23
, pp. 690-695
-
-
Kaminski, R.1
-
126
-
-
84929048246
-
Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/ CRISPR-associated Cas9 system to disrupt the hepatitis B virus
-
Zhen, S. et al. Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/ CRISPR-associated Cas9 system to disrupt the hepatitis B virus. Gene Ther. 22, 404-412 (2015).
-
(2015)
Gene Ther.
, vol.22
, pp. 404-412
-
-
Zhen, S.1
-
127
-
-
84937614537
-
Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome
-
Liu, X., Hao, R., Chen, S., Guo, D. & Chen, Y. Inhibition of hepatitis B virus by the CRISPR/Cas9 system via targeting the conserved regions of the viral genome. J. Gen. Virol. 96, 2252-2261 (2015).
-
(2015)
J. Gen. Virol.
, vol.96
, pp. 2252-2261
-
-
Liu, X.1
Hao, R.2
Chen, S.3
Guo, D.4
Chen, Y.5
-
128
-
-
84920095727
-
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
-
Kennedy, E. M. et al. Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease. Virology 476, 196-205 (2015).
-
(2015)
Virology
, vol.476
, pp. 196-205
-
-
Kennedy, E.M.1
-
129
-
-
84934877005
-
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
-
Ramanan, V. et al. CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus. Sci. Rep. 5, 10833 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 10833
-
-
Ramanan, V.1
-
130
-
-
84961751151
-
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
-
Deans, R. M. et al. Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification. Nat. Chem. Biol. 12, 361-366 (2016).
-
(2016)
Nat. Chem. Biol.
, vol.12
, pp. 361-366
-
-
Deans, R.M.1
-
131
-
-
62049083306
-
GSK983: A novel compound with broad-spectrum antiviral activity
-
Harvey, R. et al. GSK983: a novel compound with broad-spectrum antiviral activity. Antiviral Res. 82, 1-11 (2009).
-
(2009)
Antiviral Res.
, vol.82
, pp. 1-11
-
-
Harvey, R.1
-
132
-
-
84946558100
-
Diversity of CRISPR-Cas immune systems and molecular machines
-
Barrangou, R. Diversity of CRISPR-Cas immune systems and molecular machines. Genome Biol. 16, 247 (2015).
-
(2015)
Genome Biol.
, vol.16
, pp. 247
-
-
Barrangou, R.1
-
133
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran, F. A. et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature 520, 186-191 (2015).
-
(2015)
Nature
, vol.520
, pp. 186-191
-
-
Ran, F.A.1
-
134
-
-
84974606818
-
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
-
Abudayyeh, O. O. et al. C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science 353, aaf5573 (2016).
-
(2016)
Science
, vol.353
, pp. aaf5573
-
-
Abudayyeh, O.O.1
-
135
-
-
84991728709
-
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
-
East-Seletsky, A. et al. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. Nature 538, 270-273 (2016).
-
(2016)
Nature
, vol.538
, pp. 270-273
-
-
East-Seletsky, A.1
-
136
-
-
84929684998
-
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
-
Klein, A. M. et al. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell 161, 1187-1201 (2015).
-
(2015)
Cell
, vol.161
, pp. 1187-1201
-
-
Klein, A.M.1
-
137
-
-
84929684999
-
Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets
-
Macosko, E. Z. et al. Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets. Cell 161, 1202-1214 (2015).
-
(2015)
Cell
, vol.161
, pp. 1202-1214
-
-
Macosko, E.Z.1
-
138
-
-
85006345820
-
A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response
-
Adamson, B. et al. A multiplexed single-cell CRISPR screening platform enables systematic dissection of the unfolded protein response. Cell 167, 1867-1882. e21 (2016).
-
(2016)
Cell
, vol.167
, pp. 1867e21-1882e21
-
-
Adamson, B.1
-
139
-
-
85006488344
-
Perturb-Seq: Dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens
-
Dixit, A. et al. Perturb-Seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell 167, 1853-1866.e17 (2016).
-
(2016)
Cell
, vol.167
, pp. 1853e17-1866e17
-
-
Dixit, A.1
-
140
-
-
85006269827
-
Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNASeq
-
Jaitin, D. A. et al. Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNASeq. Cell 167, 1883-1896.e15 (2016).
-
(2016)
Cell
, vol.167
, pp. 1883e15-1896e15
-
-
Jaitin, D.A.1
-
141
-
-
84943160849
-
CRISPR-Cas immunity in prokaryotes
-
Marraffini, L. A. CRISPR-Cas immunity in prokaryotes. Nature 526, 55-61 (2015).
-
(2015)
Nature
, vol.526
, pp. 55-61
-
-
Marraffini, L.A.1
-
142
-
-
15844390228
-
CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies
-
Pourcel, C., Salvignol, G. & Vergnaud, G. CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology 151, 653-663 (2005).
-
(2005)
Microbiology
, vol.151
, pp. 653-663
-
-
Pourcel, C.1
Salvignol, G.2
Vergnaud, G.3
-
143
-
-
79953250082
-
CRISPR RNA maturation by transencoded small RNA and host factor RNase III
-
Deltcheva, E. et al. CRISPR RNA maturation by transencoded small RNA and host factor RNase III. Nature 471, 602-607 (2011).
-
(2011)
Nature
, vol.471
, pp. 602-607
-
-
Deltcheva, E.1
-
144
-
-
78149261827
-
The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA
-
Garneau, J. E. et al. The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA. Nature 468, 67-71 (2010).
-
(2010)
Nature
, vol.468
, pp. 67-71
-
-
Garneau, J.E.1
-
145
-
-
75749118174
-
Self versus nonself discrimination during CRISPR RNA-directed immunity
-
Marraffini, L. A. & Sontheimer, E. J. Self versus nonself discrimination during CRISPR RNA-directed immunity. Nature 463, 568-571 (2010).
-
(2010)
Nature
, vol.463
, pp. 568-571
-
-
Marraffini, L.A.1
Sontheimer, E.J.2
-
146
-
-
64049118040
-
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
-
Mojica, F. J., Diez-Villasenor, C., Garcia-Martinez, J. & Almendros, C. Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology 155, 733-740 (2009).
-
(2009)
Microbiology
, vol.155
, pp. 733-740
-
-
Mojica, F.J.1
Diez-Villasenor, C.2
Garcia-Martinez, J.3
Almendros, C.4
-
147
-
-
38949214103
-
Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus
-
Horvath, P. et al. Diversity, activity, and evolution of CRISPR loci in Streptococcus thermophilus. J. Bacteriol. 190, 1401-1412 (2008).
-
(2008)
J. Bacteriol.
, vol.190
, pp. 1401-1412
-
-
Horvath, P.1
-
148
-
-
84933574487
-
A Cas9-guide RNA complex preorganized for target DNA recognition
-
Jiang, F., Zhou, K., Ma, L., Gressel, S. & Doudna, J. A. A Cas9-guide RNA complex preorganized for target DNA recognition. Science 348, 1477-1481 (2015).
-
(2015)
Science
, vol.348
, pp. 1477-1481
-
-
Jiang, F.1
Zhou, K.2
Ma, L.3
Gressel, S.4
Doudna, J.A.5
-
149
-
-
84913568580
-
Programmable RNA recognition and cleavage by CRISPR/Cas9
-
O'Connell, M. R. et al. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature 516, 263-266 (2014).
-
(2014)
Nature
, vol.516
, pp. 263-266
-
-
O'Connell, M.R.1
-
150
-
-
84893157352
-
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation
-
Jinek, M. et al. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science 343, 1247997 (2014).
-
(2014)
Science
, vol.343
, pp. 1247997
-
-
Jinek, M.1
-
151
-
-
79960029056
-
RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions
-
Wiedenheft, B. et al. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc. Natl Acad. Sci. USA 108, 10092-10097 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 10092-10097
-
-
Wiedenheft, B.1
-
152
-
-
77956498326
-
Sequence-and structure-specific RNA processing by a CRISPR endonuclease
-
Haurwitz, R. E., Jinek, M., Wiedenheft, B., Zhou, K. & Doudna, J. A. Sequence-and structure-specific RNA processing by a CRISPR endonuclease. Science 329, 1355-1358 (2010).
-
(2010)
Science
, vol.329
, pp. 1355-1358
-
-
Haurwitz, R.E.1
Jinek, M.2
Wiedenheft, B.3
Zhou, K.4
Doudna, J.A.5
-
153
-
-
70449753811
-
RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex
-
Hale, C. R. et al. RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex. Cell 139, 945-956 (2009).
-
(2009)
Cell
, vol.139
, pp. 945-956
-
-
Hale, C.R.1
-
154
-
-
84880571335
-
CRISPR-mediated modular RNAguided regulation of transcription in eukaryotes
-
Gilbert, L. A. et al. CRISPR-mediated modular RNAguided regulation of transcription in eukaryotes. Cell 154, 442-451 (2013).
-
(2013)
Cell
, vol.154
, pp. 442-451
-
-
Gilbert, L.A.1
-
155
-
-
84908352138
-
Genome-scale CRISPR-mediated control of gene repression and activation
-
Gilbert, L. A. et al. Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159, 647-661 (2014).
-
(2014)
Cell
, vol.159
, pp. 647-661
-
-
Gilbert, L.A.1
-
156
-
-
84952639685
-
Beyond editing: Repurposing CRISPR-Cas9 for precision genome regulation and interrogation
-
Dominguez, A. A., Lim, W. A. & Qi, L. S. Beyond editing: repurposing CRISPR-Cas9 for precision genome regulation and interrogation. Nat. Rev. Mol. Cell Biol. 17, 5-15 (2016).
-
(2016)
Nat. Rev. Mol. Cell Biol.
, vol.17
, pp. 5-15
-
-
Dominguez, A.A.1
Lim, W.A.2
Qi, L.S.3
-
157
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann, S. et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature 517, 583-588 (2015).
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
-
158
-
-
72549101167
-
RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs
-
Landry, D. M., Hertz, M. I. & Thompson, S. R. RPS25 is essential for translation initiation by the Dicistroviridae and hepatitis C viral IRESs. Genes Dev. 23, 2753-2764 (2009).
-
(2009)
Genes Dev.
, vol.23
, pp. 2753-2764
-
-
Landry, D.M.1
Hertz, M.I.2
Thompson, S.R.3
-
159
-
-
84880309916
-
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
-
Scheel, T. K. & Rice, C. M. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies. Nat. Med. 19, 837-849 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 837-849
-
-
Scheel, T.K.1
Rice, C.M.2
-
160
-
-
24644483623
-
Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
-
Jopling, C. L., Yi, M., Lancaster, A. M., Lemon, S. M. & Sarnow, P. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309, 1577-1581 (2005).
-
(2005)
Science
, vol.309
, pp. 1577-1581
-
-
Jopling, C.L.1
Yi, M.2
Lancaster, A.M.3
Lemon, S.M.4
Sarnow, P.5
-
161
-
-
84945939067
-
HuR displaces polypyrimidine tract binding protein to facilitate la binding to the 3? Untranslated region and enhances hepatitis C virus replication
-
Shwetha, S. et al. HuR displaces polypyrimidine tract binding protein to facilitate La binding to the 3? untranslated region and enhances hepatitis C virus replication. J. Virol. 89, 11356-11371 (2015).
-
(2015)
J. Virol.
, vol.89
, pp. 11356-11371
-
-
Shwetha, S.1
-
162
-
-
84894063115
-
Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system
-
Chen, B. et al. Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system. Cell 155, 1479-1491 (2013).
-
(2013)
Cell
, vol.155
, pp. 1479-1491
-
-
Chen, B.1
-
163
-
-
84956699023
-
Enterovirus D68 receptor requirements unveiled by haploid genetics
-
Baggen, J. et al. Enterovirus D68 receptor requirements unveiled by haploid genetics. Proc. Natl Acad. Sci. USA 113, 1399-1404 (2016).
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 1399-1404
-
-
Baggen, J.1
-
164
-
-
84940856868
-
Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion
-
Kleinfelter, L. M. et al. Haploid genetic screen reveals a profound and direct dependence on cholesterol for hantavirus membrane fusion. mBio 6, e00801 (2015).
-
(2015)
MBio
, vol.6
, pp. e00801
-
-
Kleinfelter, L.M.1
-
165
-
-
84895726017
-
The major cellular sterol regulatory pathway is required for Andes virus infection
-
Petersen, J. et al. The major cellular sterol regulatory pathway is required for Andes virus infection. PLoS Pathog. 10, e1003911 (2014).
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1003911
-
-
Petersen, J.1
-
166
-
-
84876664165
-
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry
-
Jae, L. T. et al. Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. Science 340, 479-483 (2013).
-
(2013)
Science
, vol.340
, pp. 479-483
-
-
Jae, L.T.1
-
167
-
-
84958074109
-
A haploid genetic screen identifies heparan sulfate proteoglycans supporting Rift Valley Fever virus infection
-
Riblett, A. M. et al. A haploid genetic screen identifies heparan sulfate proteoglycans supporting Rift Valley Fever virus infection. J. Virol. 90, 1414-1423 (2016).
-
(2016)
J. Virol.
, vol.90
, pp. 1414-1423
-
-
Riblett, A.M.1
|